Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.

Journal Article (Journal Article)

Bacterial pathogen-associated molecular pattern molecules (PAMPs) such as LPS activate the endothelium and can lead to lung injury, but the signaling pathways mediating endothelial injury remain incompletely understood. In a recent issue of the JCI, Gandhirajan et al. identify STIM1, an ER calcium sensor, as a key link between LPS-induced ROS, calcium oscillations, and endothelial cell (EC) dysfunction. In addition, they report that BTP2, an inhibitor of calcium channels, attenuates lung injury. This study identifies a novel endothelial signaling pathway that could be a future target for the treatment of lung injury.

Full Text

Duke Authors

Cited Authors

  • Seeley, EJ; Rosenberg, P; Matthay, MA

Published Date

  • March 2013

Published In

Volume / Issue

  • 123 / 3

Start / End Page

  • 1015 - 1018

PubMed ID

  • 23434597

Pubmed Central ID

  • PMC3582152

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI68093


  • eng

Conference Location

  • United States