Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.
Publication
, Journal Article
Seeley, EJ; Rosenberg, P; Matthay, MA
Published in: J Clin Invest
March 2013
Bacterial pathogen-associated molecular pattern molecules (PAMPs) such as LPS activate the endothelium and can lead to lung injury, but the signaling pathways mediating endothelial injury remain incompletely understood. In a recent issue of the JCI, Gandhirajan et al. identify STIM1, an ER calcium sensor, as a key link between LPS-induced ROS, calcium oscillations, and endothelial cell (EC) dysfunction. In addition, they report that BTP2, an inhibitor of calcium channels, attenuates lung injury. This study identifies a novel endothelial signaling pathway that could be a future target for the treatment of lung injury.
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Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
March 2013
Volume
123
Issue
3
Start / End Page
1015 / 1018
Location
United States
Related Subject Headings
- Stromal Interaction Molecule 1
- NADPH Oxidases
- NADPH Oxidase 2
- Membrane Glycoproteins
- Male
- Immunology
- Female
- Calcium Channels
- Animals
- Acute Lung Injury
Citation
APA
Chicago
ICMJE
MLA
NLM
Seeley, E. J., Rosenberg, P., & Matthay, M. A. (2013). Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest, 123(3), 1015–1018. https://doi.org/10.1172/JCI68093
Seeley, Eric J., Paul Rosenberg, and Michael A. Matthay. “Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.” J Clin Invest 123, no. 3 (March 2013): 1015–18. https://doi.org/10.1172/JCI68093.
Seeley EJ, Rosenberg P, Matthay MA. Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest. 2013 Mar;123(3):1015–8.
Seeley, Eric J., et al. “Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.” J Clin Invest, vol. 123, no. 3, Mar. 2013, pp. 1015–18. Pubmed, doi:10.1172/JCI68093.
Seeley EJ, Rosenberg P, Matthay MA. Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest. 2013 Mar;123(3):1015–1018.
Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
March 2013
Volume
123
Issue
3
Start / End Page
1015 / 1018
Location
United States
Related Subject Headings
- Stromal Interaction Molecule 1
- NADPH Oxidases
- NADPH Oxidase 2
- Membrane Glycoproteins
- Male
- Immunology
- Female
- Calcium Channels
- Animals
- Acute Lung Injury