Current Appointments & Affiliations
Professor of Medicine
·
2024 - Present
Medicine, Cardiology,
Medicine
Associate Professor of Pathology
·
2022 - Present
Pathology,
Clinical Science Departments
Member of Duke Molecular Physiology Institute
·
2013 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.
Journal Article Kidney Int · February 7, 2025 Chronic kidney disease (CKD) is a global health epidemic that greatly increases mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiac injury in CKD. High serum levels of fibroblast growth factor (F ... Full text Link to item CiteThe D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice.
Journal Article J Clin Invest · February 1, 2024 Stromal interaction molecule 1 (STIM1) is a Ca2+ sensor located in the sarcoplasmic reticulum (SR) of skeletal muscle, where it is best known for its role in store-operated Ca2+ entry (SOCE). Genetic syndromes resulting from STIM1 mutations are recognized ... Full text Link to item CiteAPOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease.
Journal Article J Clin Invest · January 16, 2024 Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and ... Full text Open Access Link to item CiteRecent Grants
The Role of Calcium Homeostasis in Regulating Uterine Contractility and Tone
ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2020 - 2024STIM1 and mitochondrial quality control
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2024Duke Training Grant in Nephrology
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1995 - 2023View All Grants
Education, Training & Certifications
University of Medicine and Dentistry of New Jersey ·
1992
M.D.