Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow Cardiology (Congestive Heart Failure, Cardiac Transplantation, Molecular Cardiology), Medicine, University of Texas at Dallas 1999 - 2002
  • Fellow in Clinical Cardiology, Molecular and Cellular Cardiology, Medicine, Icahn School of Medicine at Mount Sinai 1995 - 1999
  • Medical Resident, Medicine, Montefiore Medical Center 1993 - 1995
  • Medical Intern, Medicine, Brown University 1992 - 1993
  • M.D., University of Medicine and Dentistry of New Jersey 1992
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2002 - 2012
• Research
• 

  Selected Grants

  • STIM1 and metabolic flexibility awarded by National Institutes of Health 2017 - 2022
  • Sfrp2 induces in situ c-Kit cell differentiation into cardiomyocytes via Wnt11-Fzd5 mediated b-catenin inhibition awarded by National Institutes of Health 2018 - 2022
  • Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
  • Novel strategy for Enhancing miRNA as a Therapeutic for Cardiac Regeneration awarded by National Institutes of Health 2016 - 2020
  • REHAB awarded by Wake Forest University Health Sciences 2014 - 2018
  • STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health 2015 - 2017
  • Contribution of store-operated calcium entry to calcium dysregulation in spinocerebellar ataxias awarded by National Ataxia Foundation 2016
  • Delivery of miR Through Biodegradable Scaffolds awarded by The Plastic Surgery Foundation 2014 - 2016
  • Sfrp2 and Cardiac Progenitor Cells in Regenerative Response to Ischemic Injury awarded by National Institutes of Health 2005 - 2016
  • The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
  • Characterization of TRPC6 As A Cause for Focal and Segmental Glomerulosclerosis awarded by National Institutes of Health 2006 - 2012
  • Role of Homer Proteins in Calcium Signaling in Muscle awarded by National Institutes of Health 2005 - 2011
  • Skeletal Muscle Plasticity Following LVAD Support awarded by National Institutes of Health 2006 - 2009
  • Exercise-Induced Mitochondrial Biogenesis awarded by National Institutes of Health 2005 - 2008
  • Calcium Dependent Gene Expression awarded by National Institutes of Health 2002 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Stiber, JA, and Rosenberg, PB. "Skeletal muscle store-operated Ca²⁺ entry and STIM/Orai signaling in skeletal muscle." In Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology, 435-447. November 1, 2013.  Full Text

  • Conference Papers

    • Zhang, H, Sun, AY, Kim, JJ, Graham, V, Finch, EA, Nepliouev, I, Zhao, G, Li, T, Lederer, WJ, Stiber, JA, Pitt, GS, Bursac, N, and Rosenberg, PB. "STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node." October 2015.  Full Text

  • Journal Articles

    • Warraich, HJ, Lu, D, Cobb, S, Cooper, LB, DeVore, A, Patel, CB, Rosenberg, PB, Schroder, JN, Daneshmand, MA, Milano, CA, Hernandez, AF, Rogers, JG, and Mentz, RJ. "Trends and outcomes of cardiac transplantation from donors dying of drug intoxication (Accepted)." American Heart Journal 199 (May 1, 2018): 92-96.  Full Text
    • Pastva, AM, Duncan, PW, Reeves, GR, Nelson, MB, Whellan, DJ, O'Connor, CM, Eggebeen, JD, Hewston, LA, Taylor, KM, Mentz, RJ, Rosenberg, PB, and Kitzman, DW. "Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial." Contemporary clinical trials 64 (January 2018): 118-127.  Full Text
    • Hutson, MR, Keyte, AL, Hernández-Morales, M, Gibbs, E, Kupchinsky, ZA, Argyridis, I, Erwin, KN, Pegram, K, Kneifel, M, Rosenberg, PB, Matak, P, Xie, L, Grandl, J, Davis, EE, Katsanis, N, Liu, C, and Benner, EJ. "Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects." Science signaling 10, no. 500 (October 10, 2017).  Full Text
    • Feldman, CH, Grotegut, CA, and Rosenberg, PB. "The role of STIM1 and SOCE in smooth muscle contractility." Cell calcium 63 (May 2017): 60-65. (Review)  Full Text
    • Reeves, GR, Whellan, DJ, Duncan, P, O'Connor, CM, Pastva, AM, Eggebeen, JD, Hewston, LA, Morgan, TM, Reed, SD, Rejeski, WJ, Mentz, RJ, Rosenberg, PB, Kitzman, DW, and REHAB-HF Trial Investigators, . "Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale." American heart journal 185 (March 2017): 130-139.  Full Text
    • Stiber, JA, Wu, J-H, Zhang, L, Nepliouev, I, Zhang, Z-S, Bryson, VG, Brian, L, Bentley, RC, Gordon-Weeks, PR, Rosenberg, PB, and Freedman, NJ. "The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia." Arteriosclerosis, thrombosis, and vascular biology 36, no. 5 (May 2016): 984-993.  Full Text
    • Song, T, Zheng, Y-M, Vincent, PA, Cai, D, Rosenberg, P, and Wang, Y-X. "Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30, no. 1 (January 2016): 214-229.  Full Text
    • Zhao, G, Li, T, Brochet, DXP, Rosenberg, PB, and Lederer, WJ. "STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes." Proceedings of the National Academy of Sciences of the United States of America 112, no. 34 (August 10, 2015): E4792-E4801.  Full Text
    • Daneshmand, MA, Krishnamoorthy, A, Samsky, MD, Felker, GM, Pura, JA, Lokhnygina, Y, Hernandez, AF, Rosenberg, PB, Blue, LJ, Schroder, JN, Rogers, JG, Milano, CA, and Patel, CB. "Comparison of 2-Year Outcomes of Extended Criteria Cardiac Transplantation Versus Destination Left Ventricular Assist Device Therapy Using Continuous Flow." The American journal of cardiology 116, no. 4 (August 2015): 573-579.  Full Text
    • Wang, L, Jirka, G, Rosenberg, PB, Buckley, AF, Gomez, JA, Fields, TA, Winn, MP, and Spurney, RF. "Gq signaling causes glomerular injury by activating TRPC6." The Journal of clinical investigation 125, no. 5 (May 2015): 1913-1926.  Full Text
    • Singh, K, Luo, N, and Rosenberg, P. "TRP Channels in Cardiovascular Disease." (April 8, 2015): 365-383. (Chapter)  Full Text
    • Jayawardena, TM, Finch, EA, Zhang, L, Zhang, H, Hodgkinson, CP, Pratt, RE, Rosenberg, PB, Mirotsou, M, and Dzau, VJ. "MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function." Circulation research 116, no. 3 (January 2015): 418-424.  Full Text
    • Jayawardena, TM, Finch, EA, Zhang, L, Zhang, H, Hodgkinson, CP, Pratt, RE, Rosenberg, PB, Mirotsou, M, and Dzau, VJ. "MicroRNA induced cardiac reprogramming in vivo evidence for mature cardiac myocytes and improved cardiac function." Circulation Research 116, no. 3 (October 28, 2014): 418-424.  Full Text
    • Samsky, MD, Patel, CB, Owen, A, Schulte, PJ, Jentzer, J, Rosenberg, PB, Felker, GM, Milano, CA, Hernandez, AF, and Rogers, JG. "Ten-year experience with extended criteria cardiac transplantation." Circ Heart Fail 6, no. 6 (November 2013): 1230-1238.  Full Text  Link to Item
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 Activates Islet α- and β-Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 25, 2013): 4017-4029.  Full Text
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2." Mol Cell Biol 33, no. 20 (October 2013): 4017-4029.  Full Text  Link to Item
    • Jensen, MV, Haldeman, JM, Zhang, H, Lu, D, Huising, MO, Vale, WW, Hohmeier, HE, Rosenberg, P, and Newgard, CB. "Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion." J Biol Chem 288, no. 32 (August 9, 2013): 23128-23140.  Full Text  Link to Item
    • Eckel, J, Lavin, PJ, Finch, EA, Mukerji, N, Burch, J, Gbadegesin, R, Wu, G, Bowling, B, Byrd, A, Hall, G, Sparks, M, Zhang, ZS, Homstad, A, Barisoni, L, Birbaumer, L, Rosenberg, P, and Winn, MP. "TRPC6 enhances angiotensin II-induced albuminuria (Journal of the American Society of Nephrology (2011) 22 (526-535))." Journal of the American Society of Nephrology 24, no. 1 (2013): 160--.  Full Text
    • Seeley, EJ, Rosenberg, P, and Matthay, MA. "Calcium flux and endothelial dysfunction during acute lung injury: A STIMulating target for therapy." Journal of Clinical Investigation 123, no. 3 (2013): 1015--.  Full Text
    • Singh, K, and Rosenberg, P. "Anti-tumour activity and store operated calcium entry: New roles in immunology." EMBO Molecular Medicine 5, no. 9 (2013): 1297-1299.  Full Text
    • Stiber, JA, Tang, Y, Li, T, and Rosenberg, PB. "Cytoskeletal regulation of TRPC channels in the cardiorenal system." Curr Hypertens Rep 14, no. 6 (December 2012): 492-497. (Review)  Full Text  Link to Item
    • Li, T, Finch, EA, Graham, V, Zhang, Z-S, Ding, J-D, Burch, J, Oh-hora, M, and Rosenberg, P. "STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice." Mol Cell Biol 32, no. 15 (August 2012): 3009-3017.  Full Text  Link to Item
    • Jayawardena, TM, Egemnazarov, B, Finch, EA, Zhang, L, Payne, JA, Pandya, K, Zhang, Z, Rosenberg, P, Mirotsou, M, and Dzau, VJ. "MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes." Circ Res 110, no. 11 (May 25, 2012): 1465-1473.  Full Text  Link to Item
    • Seth, M, Li, T, Graham, V, Burch, J, Finch, E, Stiber, JA, and Rosenberg, PB. "Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation." Dev Dyn 241, no. 4 (April 2012): 639-647.  Full Text  Link to Item
    • Wang, C, Hennessey, JA, Kirkton, RD, Wang, C, Graham, V, Puranam, RS, Rosenberg, PB, Bursac, N, and Pitt, GS. "Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts." Circ Res 109, no. 7 (September 16, 2011): 775-782.  Full Text  Link to Item
    • Stiber, JA, and Rosenberg, PB. "The role of store-operated calcium influx in skeletal muscle signaling." Cell Calcium 49, no. 5 (May 2011): 341-349. (Review)  Full Text  Link to Item
    • Eckel, J, Lavin, PJ, Finch, EA, Mukerji, N, Burch, J, Gbadegesin, R, Wu, G, Bowling, B, Byrd, A, Hall, G, Sparks, M, Zhang, ZS, Homstad, A, Barisoni, L, Birbaumer, L, Rosenberg, P, and Winn, MP. "TRPC6 enhances angiotensin II-induced albuminuria." J Am Soc Nephrol 22, no. 3 (March 2011): 526-535.  Full Text  Link to Item
    • Rosenberg, P. "Socking it to cardiac hypertrophy: STIM1-Mediated Ca²⁺ entry in the cardiomyocyte." Circulation 124, no. 7 (2011): 766-768.  Full Text
    • Seth, M, Zhang, Z-S, Mao, L, Graham, V, Burch, J, Stiber, J, Tsiokas, L, Winn, M, Abramowitz, J, Rockman, HA, Birnbaumer, L, and Rosenberg, P. "TRPC1 channels are critical for hypertrophic signaling in the heart." Circ Res 105, no. 10 (November 6, 2009): 1023-1030.  Full Text  Link to Item
    • Stiber, JA, Seth, M, and Rosenberg, PB. "Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore." J Cardiovasc Pharmacol 54, no. 2 (August 2009): 116-122. (Review)  Full Text  Link to Item
    • Rosenberg, PB. "Calcium entry in skeletal muscle." J Physiol 587, no. Pt 13 (July 1, 2009): 3149-3151. (Review)  Full Text  Link to Item
    • Kanatous, SB, Mammen, PPA, Rosenberg, PB, Martin, CM, White, MD, DiMaio, JM, Huang, G, Muallem, S, and Garry, DJ. "Hypoxia reprograms calcium signaling and regulates myoglobin expression." American Journal of Physiology - Cell Physiology 296, no. 3 (2009): C393-C402.  Full Text
    • Wang, L, Flannery, PJ, Rosenberg, PB, Fields, TA, and Spurney, RF. "Gq-dependent signaling upregulates COX2 in glomerular podocytes." J Am Soc Nephrol 19, no. 11 (November 2008): 2108-2118.  Full Text  Link to Item
    • Stiber, J, Hawkins, A, Zhang, Z-S, Wang, S, Burch, J, Graham, V, Ward, CC, Seth, M, Finch, E, Malouf, N, Williams, RS, Eu, JP, and Rosenberg, P. "STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle." Nat Cell Biol 10, no. 6 (June 2008): 688-697.  Full Text  Link to Item
    • Stiber, JA, Zhang, Z-S, Burch, J, Eu, JP, Zhang, S, Truskey, GA, Seth, M, Yamaguchi, N, Meissner, G, Shah, R, Worley, PF, Williams, RS, and Rosenberg, PB. "Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity." Mol Cell Biol 28, no. 8 (April 2008): 2637-2647.  Full Text  Link to Item
    • Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284-16289.  Full Text  Link to Item
    • Leloudis, DH, Kittleson, MM, Felker, GM, Rosenberg, PB, Hernandez, AF, Yager, JE, and Russell, SD. "Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial." J Heart Lung Transplant 25, no. 9 (September 2006): 1164-1166.  Full Text  Link to Item
    • Milano, CA, Lodge, AJ, Blue, LJ, Smith, PK, Felker, GM, Hernandez, AF, Rosenberg, PB, and Rogers, JG. "Implantable left ventricular assist devices: new hope for patients with end-stage heart failure." N C Med J 67, no. 2 (March 2006): 110-115.  Link to Item
    • Konhilas, JP, Watson, PA, Maass, A, Boucek, DM, Horn, T, Stauffer, BL, Luckey, SW, Rosenberg, P, and Leinwand, LA. "Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy." Circulation Research 98, no. 4 (2006): 540-548.  Full Text
    • Stiber, JA, Tabatabaei, N, Hawkins, AF, Hawke, T, Worley, PF, Williams, RS, and Rosenberg, P. "Homer modulates NFAT-dependent signaling during muscle differentiation." Dev Biol 287, no. 2 (November 15, 2005): 213-224.  Full Text  Link to Item
    • Rosenberg, PB, Vriesendorp, AE, Drazner, MH, Dries, DL, Kaiser, PA, Hynan, LS, Dimaio, JM, Meyer, D, Ring, WS, and Yancy, CW. "Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation." J Heart Lung Transplant 24, no. 9 (September 2005): 1327-1331.  Full Text  Link to Item
    • Du, W, Stiber, JA, Rosenberg, PB, Meissner, G, and Eu, JP. "Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction." J Biol Chem 280, no. 28 (July 15, 2005): 26287-26294.  Full Text  Link to Item
    • Winn, MP, Conlon, PJ, Lynn, KL, Farrington, MK, Creazzo, T, Hawkins, AF, Daskalakis, N, Kwan, SY, Ebersviller, S, Burchette, JL, Pericak-Vance, MA, Howell, DN, Vance, JM, and Rosenberg, PB. "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis." Science 308, no. 5729 (June 17, 2005): 1801-1804.  Full Text  Link to Item
    • Akimoto, T, Pohnert, SC, Li, P, Zhang, M, Gumbs, C, Rosenberg, PB, Williams, RS, and Yan, Z. "Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway." J Biol Chem 280, no. 20 (May 20, 2005): 19587-19593.  Full Text  Link to Item
    • Rosenberg, P, Hawkins, A, Stiber, J, Shelton, JM, Hutcheson, K, Bassel-Duby, R, Shin, DM, Yan, Z, and Williams, RS. "TRPC3 channels confer cellular memory of recent neuromuscular activity." Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9387-9392.  Full Text  Link to Item
    • Dietze, EC, Troch, MM, Bean, GR, Heffner, JB, Bowie, ML, Rosenberg, P, Ratliff, B, and Seewaldt, VL. "Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity." Oncogene 23, no. 21 (May 6, 2004): 3851-3862.  Full Text  Link to Item
    • Felker, GM, Hernandez, AF, Rogers, JG, Russell, SD, Reinsmoen, NL, Rosenberg, P, Hata, JA, Lodge, AJ, and Milano, CA. "Cardiac transplantation at Duke University Medical Center." Clin Transpl (2004): 235-241.  Link to Item
    • Rosenberg, P. "Mitochondrial dysfunction and heart disease." Mitochondrion 4, no. 5-6 SPEC. ISS. (2004): 621-628.  Full Text
    • Drazner, MH, Thompson, B, Rosenberg, PB, Kaiser, PA, Boehrer, JD, Baldwin, BJ, Dries, DL, and Yancy, CW. "Comparison of impedance cardiography with invasive hemodynamic measurements in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy." Am J Cardiol 89, no. 8 (April 15, 2002): 993-995.  Link to Item
    • Williams, RS, and Rosenberg, P. "Calcium-dependent gene regulation in myocyte hypertrophy and remodeling." Cold Spring Harb Symp Quant Biol 67 (2002): 339-344. (Review)  Link to Item
    • Wu, H, Rothermel, B, Kanatous, S, Rosenberg, P, Naya, FJ, Shelton, JM, Hutcheson, KA, DiMaio, JM, Olson, EN, Bassel-Duby, R, and Williams, RS. "Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway." EMBO J 20, no. 22 (November 15, 2001): 6414-6423.  Full Text  Link to Item
    • Rosenberg, P, and Yancy, CW. "Noninvasive assessment of hemodynamics: an emphasis on bioimpedance cardiography." Curr Opin Cardiol 15, no. 3 (May 2000): 151-155. (Review)  Link to Item

  • Other Articles

    • Patel, CB, MacKinnon, ML, Smith, AD, Felker, GM, Vikraman-Sushama, D, Sudan, DL, Rosenberg, PB, Hernandez, AF, Milano, CA, and Rogers, JG. "Successful organ donation after long-term circulatory support with nonpulsatile mechanical support." Am J Transplant 12, no. 7 (July 2012): 1962-1963. (Letter)  Full Text  Link to Item

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