Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow Cardiology (Congestive Heart Failure, Cardiac Transplantation, Molecular Cardiology), Medicine, University of Texas at Dallas 1999 - 2002
  • Fellow in Clinical Cardiology, Molecular and Cellular Cardiology, Medicine, Icahn School of Medicine at Mount Sinai 1995 - 1999
  • Medical Resident, Medicine, Montefiore Medical Center 1993 - 1995
  • Medical Intern, Medicine, Brown University 1992 - 1993
  • M.D., University of Medicine and Dentistry of New Jersey 1992
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2002 - 2012
• Research
• 

  Selected Grants

  • HEART-FID awarded by Luitpold Pharmaceuticals 2017 - 2023
  • Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
  • STIM1 and metabolic flexibility awarded by National Institutes of Health 2017 - 2022
  • Sfrp2 induces in situ c-Kit cell differentiation into cardiomyocytes via Wnt11-Fzd5 mediated b-catenin inhibition awarded by National Institutes of Health 2018 - 2022
  • Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
  • Novel strategy for Enhancing miRNA as a Therapeutic for Cardiac Regeneration awarded by National Institutes of Health 2016 - 2020
  • REHAB awarded by Wake Forest University Health Sciences 2014 - 2019
  • STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health 2015 - 2017
  • Contribution of store-operated calcium entry to calcium dysregulation in spinocerebellar ataxias awarded by National Ataxia Foundation 2016
  • Delivery of miR Through Biodegradable Scaffolds awarded by The Plastic Surgery Foundation 2014 - 2016
  • Sfrp2 and Cardiac Progenitor Cells in Regenerative Response to Ischemic Injury awarded by National Institutes of Health 2005 - 2016
  • The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
  • Characterization of TRPC6 As A Cause for Focal and Segmental Glomerulosclerosis awarded by National Institutes of Health 2006 - 2012
  • Role of Homer Proteins in Calcium Signaling in Muscle awarded by National Institutes of Health 2005 - 2011
  • Skeletal Muscle Plasticity Following LVAD Support awarded by National Institutes of Health 2006 - 2009
  • Exercise-Induced Mitochondrial Biogenesis awarded by National Institutes of Health 2005 - 2008
  • Calcium Dependent Gene Expression awarded by National Institutes of Health 2002 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Rosenberg, P, Katz, D, and Bryson, V. "SOCE and STIM1 signaling in the heart: Timing and location matter." Cell Calcium 77 (January 2019): 20-28. (Review)  Full Text
    • Kim, J, Grotegut, CA, Wisler, JW, Li, T, Mao, L, Chen, M, Chen, W, Rosenberg, PB, Rockman, HA, and Lefkowitz, RJ. "β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility." Skeletal Muscle 8, no. 1 (December 27, 2018): 39-null.  Full Text
    • Warraich, HJ, Lu, D, Cobb, S, Cooper, LB, DeVore, A, Patel, CB, Rosenberg, PB, Schroder, JN, Daneshmand, MA, Milano, CA, Hernandez, AF, Rogers, JG, and Mentz, RJ. "Trends and outcomes of cardiac transplantation from donors dying of drug intoxication." American Heart Journal 199 (May 2018): 92-96.  Full Text
    • Pastva, AM, Duncan, PW, Reeves, GR, Nelson, MB, Whellan, DJ, O'Connor, CM, Eggebeen, JD, Hewston, LA, Taylor, KM, Mentz, RJ, Rosenberg, PB, and Kitzman, DW. "Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial." Contemporary Clinical Trials 64 (January 2018): 118-127.  Full Text
    • Hutson, MR, Keyte, AL, Hernández-Morales, M, Gibbs, E, Kupchinsky, ZA, Argyridis, I, Erwin, KN, Pegram, K, Kneifel, M, Rosenberg, PB, Matak, P, Xie, L, Grandl, J, Davis, EE, Katsanis, N, Liu, C, and Benner, EJ. "Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects." Science Signaling 10, no. 500 (October 10, 2017).  Full Text
    • Feldman, CH, Grotegut, CA, and Rosenberg, PB. "The role of STIM1 and SOCE in smooth muscle contractility." Cell calcium 63 (May 2017): 60-65. (Review)  Full Text
    • Reeves, GR, Whellan, DJ, Duncan, P, O'Connor, CM, Pastva, AM, Eggebeen, JD, Hewston, LA, Morgan, TM, Reed, SD, Rejeski, WJ, Mentz, RJ, Rosenberg, PB, Kitzman, DW, and REHAB-HF Trial Investigators, . "Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale." American heart journal 185 (March 2017): 130-139.  Full Text
    • Stiber, JA, Wu, J-H, Zhang, L, Nepliouev, I, Zhang, Z-S, Bryson, VG, Brian, L, Bentley, RC, Gordon-Weeks, PR, Rosenberg, PB, and Freedman, NJ. "The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia." Arteriosclerosis, Thrombosis, and Vascular Biology 36, no. 5 (May 2016): 984-993.  Full Text
    • Song, T, Zheng, Y-M, Vincent, PA, Cai, D, Rosenberg, P, and Wang, Y-X. "Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 30, no. 1 (January 2016): 214-229.  Full Text
    • Zhao, G, Li, T, Brochet, DXP, Rosenberg, PB, and Lederer, WJ. "STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes." Proceedings of the National Academy of Sciences of the United States of America 112, no. 34 (August 10, 2015): E4792-E4801.  Full Text
    • Daneshmand, MA, Krishnamoorthy, A, Samsky, MD, Felker, GM, Pura, JA, Lokhnygina, Y, Hernandez, AF, Rosenberg, PB, Blue, LJ, Schroder, JN, Rogers, JG, Milano, CA, and Patel, CB. "Comparison of 2-Year Outcomes of Extended Criteria Cardiac Transplantation Versus Destination Left Ventricular Assist Device Therapy Using Continuous Flow." The American journal of cardiology 116, no. 4 (August 2015): 573-579.  Full Text
    • Wang, L, Jirka, G, Rosenberg, PB, Buckley, AF, Gomez, JA, Fields, TA, Winn, MP, and Spurney, RF. "Gq signaling causes glomerular injury by activating TRPC6." The Journal of Clinical Investigation 125, no. 5 (May 2015): 1913-1926.  Full Text
    • Singh, K, Luo, N, and Rosenberg, P. "TRP Channels in Cardiovascular Disease." (April 8, 2015): 365-383. (Chapter)  Full Text
    • Jayawardena, TM, Finch, EA, Zhang, L, Zhang, H, Hodgkinson, CP, Pratt, RE, Rosenberg, PB, Mirotsou, M, and Dzau, VJ. "MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function." Circulation Research 116, no. 3 (January 2015): 418-424.  Full Text
    • Jayawardena, TM, Finch, EA, Zhang, L, Zhang, H, Hodgkinson, CP, Pratt, RE, Rosenberg, PB, Mirotsou, M, and Dzau, VJ. "MicroRNA induced cardiac reprogramming in vivo evidence for mature cardiac myocytes and improved cardiac function." Circulation Research 116, no. 3 (October 28, 2014): 418-424.  Full Text
    • Eckel, J, Lavin, PJ, Finch, EA, Mukerji, N, Burch, J, Gbadegesin, R, Wu, G, Bowling, B, Byrd, A, Hall, G, Sparks, M, Zhang, ZS, Homstad, A, Barisoni, L, Birbaumer, L, Rosenberg, P, and Winn, MP. "TRPC6 enhances angiotensin II-induced albuminuria (Journal of the American Society of Nephrology (2011) 22 (526-535))." Journal of the American Society of Nephrology 24, no. 1 (December 28, 2013): 160-null.  Full Text
    • Samsky, MD, Patel, CB, Owen, A, Schulte, PJ, Jentzer, J, Rosenberg, PB, Felker, GM, Milano, CA, Hernandez, AF, and Rogers, JG. "Ten-year experience with extended criteria cardiac transplantation." Circulation. Heart Failure 6, no. 6 (November 2013): 1230-1238.  Full Text
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 Activates Islet  - and  -Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 15, 2013): 4017-4029.  Full Text
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 2013): 4017-4029.  Full Text
    • Jensen, MV, Haldeman, JM, Zhang, H, Lu, D, Huising, MO, Vale, WW, Hohmeier, HE, Rosenberg, P, and Newgard, CB. "Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion." The Journal of Biological Chemistry 288, no. 32 (August 2013): 23128-23140.  Full Text
    • Seeley, EJ, Rosenberg, P, and Matthay, MA. "Calcium flux and endothelial dysfunction during acute lung injury: A STIMulating target for therapy." Journal of Clinical Investigation 123, no. 3 (2013): 1015--.  Full Text
    • Singh, K, and Rosenberg, P. "Anti-tumour activity and store operated calcium entry: New roles in immunology." EMBO Molecular Medicine 5, no. 9 (2013): 1297-1299.  Full Text
    • Stiber, JA, Tang, Y, Li, T, and Rosenberg, PB. "Cytoskeletal regulation of TRPC channels in the cardiorenal system." Curr Hypertens Rep 14, no. 6 (December 2012): 492-497. (Review)  Full Text  Link to Item
    • Li, T, Finch, EA, Graham, V, Zhang, Z-S, Ding, J-D, Burch, J, Oh-hora, M, and Rosenberg, P. "STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice." Molecular and Cellular Biology 32, no. 15 (August 2012): 3009-3017.  Full Text
    • Jayawardena, TM, Egemnazarov, B, Finch, EA, Zhang, L, Payne, JA, Pandya, K, Zhang, Z, Rosenberg, P, Mirotsou, M, and Dzau, VJ. "MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes." Circulation Research 110, no. 11 (May 2012): 1465-1473.  Full Text
    • Seth, M, Li, T, Graham, V, Burch, J, Finch, E, Stiber, JA, and Rosenberg, PB. "Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation." Dev Dyn 241, no. 4 (April 2012): 639-647.  Full Text  Link to Item
    • Wang, C, Hennessey, JA, Kirkton, RD, Wang, C, Graham, V, Puranam, RS, Rosenberg, PB, Bursac, N, and Pitt, GS. "Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts." Circulation Research 109, no. 7 (September 2011): 775-782.  Full Text
    • Stiber, JA, and Rosenberg, PB. "The role of store-operated calcium influx in skeletal muscle signaling." Cell Calcium 49, no. 5 (May 2011): 341-349. (Review)  Full Text
    • Eckel, J, Lavin, PJ, Finch, EA, Mukerji, N, Burch, J, Gbadegesin, R, Wu, G, Bowling, B, Byrd, A, Hall, G, Sparks, M, Zhang, ZS, Homstad, A, Barisoni, L, Birbaumer, L, Rosenberg, P, and Winn, MP. "TRPC6 enhances angiotensin II-induced albuminuria." J Am Soc Nephrol 22, no. 3 (March 2011): 526-535.  Full Text  Link to Item
    • Rosenberg, P. "Socking it to cardiac hypertrophy: STIM1-Mediated Ca²⁺ entry in the cardiomyocyte." Circulation 124, no. 7 (2011): 766-768.  Full Text
    • Seth, M, Zhang, Z-S, Mao, L, Graham, V, Burch, J, Stiber, J, Tsiokas, L, Winn, M, Abramowitz, J, Rockman, HA, Birnbaumer, L, and Rosenberg, P. "TRPC1 channels are critical for hypertrophic signaling in the heart." Circulation Research 105, no. 10 (November 2009): 1023-1030.  Full Text
    • Stiber, JA, Seth, M, and Rosenberg, PB. "Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore." Journal of Cardiovascular Pharmacology 54, no. 2 (August 2009): 116-122. (Review)  Full Text
    • Rosenberg, PB. "Calcium entry in skeletal muscle." J Physiol 587, no. Pt 13 (July 1, 2009): 3149-3151. (Review)  Full Text  Link to Item
    • Kanatous, SB, Mammen, PPA, Rosenberg, PB, Martin, CM, White, MD, Dimaio, JM, Huang, G, Muallem, S, and Garry, DJ. "Hypoxia reprograms calcium signaling and regulates myoglobin expression." American Journal of Physiology. Cell Physiology 296, no. 3 (March 2009): C393-C402.  Full Text
    • Wang, L, Flannery, PJ, Rosenberg, PB, Fields, TA, and Spurney, RF. "Gq-dependent signaling upregulates COX2 in glomerular podocytes." Journal of the American Society of Nephrology : Jasn 19, no. 11 (November 2008): 2108-2118.  Full Text
    • Stiber, J, Hawkins, A, Zhang, Z-S, Wang, S, Burch, J, Graham, V, Ward, CC, Seth, M, Finch, E, Malouf, N, Williams, RS, Eu, JP, and Rosenberg, P. "STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle." Nature Cell Biology 10, no. 6 (June 2008): 688-697.  Full Text
    • Stiber, JA, Zhang, Z-S, Burch, J, Eu, JP, Zhang, S, Truskey, GA, Seth, M, Yamaguchi, N, Meissner, G, Shah, R, Worley, PF, Williams, RS, and Rosenberg, PB. "Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity." Molecular and Cellular Biology 28, no. 8 (April 2008): 2637-2647.  Full Text
    • Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proceedings of the National Academy of Sciences of the United States of America 103, no. 44 (October 23, 2006): 16284-16289.  Full Text
    • Leloudis, DH, Kittleson, MM, Felker, GM, Rosenberg, PB, Hernandez, AF, Yager, JE, and Russell, SD. "Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation 25, no. 9 (September 2006): 1164-1166.  Full Text
    • Milano, CA, Lodge, AJ, Blue, LJ, Smith, PK, Felker, GM, Hernandez, AF, Rosenberg, PB, and Rogers, JG. "Implantable left ventricular assist devices: new hope for patients with end-stage heart failure." N C Med J 67, no. 2 (March 2006): 110-115.  Link to Item
    • Konhilas, JP, Watson, PA, Maass, A, Boucek, DM, Horn, T, Stauffer, BL, Luckey, SW, Rosenberg, P, and Leinwand, LA. "Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy." Circulation Research 98, no. 4 (2006): 540-548.  Full Text
    • Stiber, JA, Tabatabaei, N, Hawkins, AF, Hawke, T, Worley, PF, Williams, RS, and Rosenberg, P. "Homer modulates NFAT-dependent signaling during muscle differentiation." Dev Biol 287, no. 2 (November 15, 2005): 213-224.  Full Text  Link to Item
    • Rosenberg, PB, Vriesendorp, AE, Drazner, MH, Dries, DL, Kaiser, PA, Hynan, LS, Dimaio, JM, Meyer, D, Ring, WS, and Yancy, CW. "Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation 24, no. 9 (September 2005): 1327-1331.  Full Text
    • Du, W, Stiber, JA, Rosenberg, PB, Meissner, G, and Eu, JP. "Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction." J Biol Chem 280, no. 28 (July 15, 2005): 26287-26294.  Full Text  Link to Item
    • Winn, MP, Conlon, PJ, Lynn, KL, Farrington, MK, Creazzo, T, Hawkins, AF, Daskalakis, N, Kwan, SY, Ebersviller, S, Burchette, JL, Pericak-Vance, MA, Howell, DN, Vance, JM, and Rosenberg, PB. "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis." Science (New York, N.Y.) 308, no. 5729 (June 2005): 1801-1804.  Full Text
    • Akimoto, T, Pohnert, SC, Li, P, Zhang, M, Gumbs, C, Rosenberg, PB, Williams, RS, and Yan, Z. "Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway." The Journal of Biological Chemistry 280, no. 20 (May 2005): 19587-19593.  Full Text
    • Rosenberg, P. "Mitochondrial dysfunction and heart disease." Mitochondrion 4, no. 5-6 (September 2004): 621-628.  Full Text
    • Rosenberg, P, Hawkins, A, Stiber, J, Shelton, JM, Hutcheson, K, Bassel-Duby, R, Shin, DM, Yan, Z, and Williams, RS. "TRPC3 channels confer cellular memory of recent neuromuscular activity." Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9387-9392.  Full Text  Link to Item
    • Dietze, EC, Troch, MM, Bean, GR, Heffner, JB, Bowie, ML, Rosenberg, P, Ratliff, B, and Seewaldt, VL. "Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity." Oncogene 23, no. 21 (May 6, 2004): 3851-3862.  Full Text  Link to Item
    • Felker, GM, Hernandez, AF, Rogers, JG, Russell, SD, Reinsmoen, NL, Rosenberg, P, Hata, JA, Lodge, AJ, and Milano, CA. "Cardiac transplantation at Duke University Medical Center." Clin Transpl (2004): 235-241.  Link to Item
    • Drazner, MH, Thompson, B, Rosenberg, PB, Kaiser, PA, Boehrer, JD, Baldwin, BJ, Dries, DL, and Yancy, CW. "Comparison of impedance cardiography with invasive hemodynamic measurements in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy." Am J Cardiol 89, no. 8 (April 15, 2002): 993-995.  Link to Item
    • Williams, RS, and Rosenberg, P. "Calcium-dependent gene regulation in myocyte hypertrophy and remodeling." Cold Spring Harb Symp Quant Biol 67 (2002): 339-344. (Review)  Link to Item
    • Wu, H, Rothermel, B, Kanatous, S, Rosenberg, P, Naya, FJ, Shelton, JM, Hutcheson, KA, DiMaio, JM, Olson, EN, Bassel-Duby, R, and Williams, RS. "Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway." The Embo Journal 20, no. 22 (November 2001): 6414-6423.  Full Text
    • Rosenberg, P, and Yancy, CW. "Noninvasive assessment of hemodynamics: an emphasis on bioimpedance cardiography." Curr Opin Cardiol 15, no. 3 (May 2000): 151-155. (Review)  Link to Item

  • Book Sections

    • Stiber, JA, and Rosenberg, PB. "Skeletal muscle store-operated Ca²⁺ entry and STIM/Orai signaling in skeletal muscle." In Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology, 435-447. November 1, 2013.  Full Text

  • Other Articles

    • Patel, CB, MacKinnon, ML, Smith, AD, Felker, GM, Vikraman-Sushama, D, Sudan, DL, Rosenberg, PB, Hernandez, AF, Milano, CA, and Rogers, JG. "Successful organ donation after long-term circulatory support with nonpulsatile mechanical support." Am J Transplant 12, no. 7 (July 2012): 1962-1963. (Letter)  Full Text  Link to Item

  • Conference Papers

    • Zhang, H, Sun, AY, Kim, JJ, Graham, V, Finch, EA, Nepliouev, I, Zhao, G, Li, T, Lederer, WJ, Stiber, JA, Pitt, GS, Bursac, N, and Rosenberg, PB. "STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node." October 2015.  Full Text

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