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Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes.

Publication ,  Journal Article
Mayer, SB; Jeffreys, AS; Olsen, MK; McDuffie, JR; Feinglos, MN; Yancy, WS
Published in: Diabetes Obes Metab
January 2014

We analysed participants with type 2 diabetes (n = 46) within a larger weight loss trial (n = 146) who were randomized to 48 weeks of a low-carbohydrate diet (LCD; n = 22) or a low-fat diet + orlistat (LFD + O; n = 24). At baseline, mean body mass index (BMI) was 39.5 kg/m(2) (s.d. 6.5) and haemoglobin A1c (HbA1c) 7.6% (s.d. 1.3). Although the interventions reduced BMI similarly (LCD -2.4 kg/m(2) ; LFD + O -2.7 kg/m(2) , p = 0.7), LCD led to a relative improvement in HbA1c: -0.7% in LCD versus +0.2% in LFD + O [difference -0.8%, 95% confidence interval (CI) = -1.6, -0.02; p = 0.045]. LCD also led to a greater reduction in antiglycaemic medications using a novel medication effect score (MES) based on medication potency and total daily dose; 70.6% of LCD versus 30.4% LFD + O decreased their MES by ≥50% (p = 0.01). Lowering dietary carbohydrate intake demonstrated benefits on glycaemic control beyond its weight loss effects, while at the same time lowering antiglycaemic medication requirements.

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Published In

Diabetes Obes Metab

DOI

EISSN

1463-1326

Publication Date

January 2014

Volume

16

Issue

1

Start / End Page

90 / 93

Location

England

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Patient Compliance
  • Middle Aged
  • Male
  • Hypoglycemic Agents
  • Humans
  • Glycated Hemoglobin
  • Female
  • Endocrinology & Metabolism
 

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Mayer, S. B., Jeffreys, A. S., Olsen, M. K., McDuffie, J. R., Feinglos, M. N., & Yancy, W. S. (2014). Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes. Diabetes Obes Metab, 16(1), 90–93. https://doi.org/10.1111/dom.12191
Mayer, S. B., A. S. Jeffreys, M. K. Olsen, J. R. McDuffie, M. N. Feinglos, and W. S. Yancy. “Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes.Diabetes Obes Metab 16, no. 1 (January 2014): 90–93. https://doi.org/10.1111/dom.12191.
Mayer SB, Jeffreys AS, Olsen MK, McDuffie JR, Feinglos MN, Yancy WS. Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes. Diabetes Obes Metab. 2014 Jan;16(1):90–3.
Mayer, S. B., et al. “Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes.Diabetes Obes Metab, vol. 16, no. 1, Jan. 2014, pp. 90–93. Pubmed, doi:10.1111/dom.12191.
Mayer SB, Jeffreys AS, Olsen MK, McDuffie JR, Feinglos MN, Yancy WS. Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes. Diabetes Obes Metab. 2014 Jan;16(1):90–93.
Journal cover image

Published In

Diabetes Obes Metab

DOI

EISSN

1463-1326

Publication Date

January 2014

Volume

16

Issue

1

Start / End Page

90 / 93

Location

England

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Patient Compliance
  • Middle Aged
  • Male
  • Hypoglycemic Agents
  • Humans
  • Glycated Hemoglobin
  • Female
  • Endocrinology & Metabolism