Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.

Journal Article (Journal Article)

Children with ataxia-telangiectasia (A-T) and cancer have a poorer prognosis due in part to increased treatment-related toxicity. We piloted a curative intent approach in five children with A-T who presented with advanced stage (III, n = 2; IV, n = 3) B-NHL (diffuse large B-cell lymphoma, n = 4; Burkitt leukemia, n = 1) using a modified LMB-based protocol. Two achieved sustained CCR (one, CCR at 6 years; one, pulmonary death after 3 years in CCR). Two died from toxicity during induction and 1 failed induction with progressive disease. Novel therapeutic approaches which overcome drug resistance and are less toxic are needed for children with A-T and B-NHL.

Full Text

Duke Authors

Cited Authors

  • Sandlund, JT; Hudson, MM; Kennedy, W; Onciu, M; Kastan, MB

Published Date

  • February 2014

Published In

Volume / Issue

  • 61 / 2

Start / End Page

  • 360 - 362

PubMed ID

  • 23900766

Pubmed Central ID

  • PMC4254821

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.24696


  • eng

Conference Location

  • United States