Superactivated platelets: thrombus regulators, thrombin generators, and potential clinical targets.

Published

Journal Article (Review)

Platelets contribute to hemostasis by forming the platelet plug and then contributing to coagulation by providing a catalytic surface where thrombin generation occurs efficiently. This catalytic activity, known as the platelet procoagulant response, is being recognized as a nuanced response. This review examines platelets' response to strong stimuli, which results in the formation of a platelet subpopulation (superactivated platelets) with several unique properties, including enhanced procoagulant activity. These platelets contribute uniquely to thrombus architecture and seem to have thrombus regulatory activity. Superactivated platelets' role in diseases of thrombosis and hemostasis, as either potentiating or mitigating factors, is not currently known, but may be an important pharmacological target.

Full Text

Duke Authors

Cited Authors

  • Mazepa, M; Hoffman, M; Monroe, D

Published Date

  • August 2013

Published In

Volume / Issue

  • 33 / 8

Start / End Page

  • 1747 - 1752

PubMed ID

  • 23864724

Pubmed Central ID

  • 23864724

Electronic International Standard Serial Number (EISSN)

  • 1524-4636

International Standard Serial Number (ISSN)

  • 1079-5642

Digital Object Identifier (DOI)

  • 10.1161/atvbaha.113.301790

Language

  • eng