Superactivated platelets: thrombus regulators, thrombin generators, and potential clinical targets.
Journal Article (Journal Article;Review)
Platelets contribute to hemostasis by forming the platelet plug and then contributing to coagulation by providing a catalytic surface where thrombin generation occurs efficiently. This catalytic activity, known as the platelet procoagulant response, is being recognized as a nuanced response. This review examines platelets' response to strong stimuli, which results in the formation of a platelet subpopulation (superactivated platelets) with several unique properties, including enhanced procoagulant activity. These platelets contribute uniquely to thrombus architecture and seem to have thrombus regulatory activity. Superactivated platelets' role in diseases of thrombosis and hemostasis, as either potentiating or mitigating factors, is not currently known, but may be an important pharmacological target.
Full Text
Duke Authors
Cited Authors
- Mazepa, M; Hoffman, M; Monroe, D
Published Date
- August 2013
Published In
Volume / Issue
- 33 / 8
Start / End Page
- 1747 - 1752
PubMed ID
- 23864724
Electronic International Standard Serial Number (EISSN)
- 1524-4636
Digital Object Identifier (DOI)
- 10.1161/ATVBAHA.113.301790
Language
- eng
Conference Location
- United States