Maureane Hoffman | Scholars@Duke

Maureane Hoffman
Professor of Pathology

The blood coagulation system is a delicately balanced homeostatic mechanism. Inappropriate clotting is a major cause of morbidity and mortality, resulting in strokes, heart attacks, thrombophlebitis and pulmonary embolism. My research is directed toward understanding basic mechanisms in hemostasis, and the connections between inflammation/immunity and coagulation responses to injury. We are also committed to translating our basic finding into clinical practice.

We have developed a cell-based model of tissue factor-initiated coagulation. This model is a powerful tool for understanding and studying basic mechanisms in hemostasis. It has taught us that the cellular LOCATION of activation of the clotting factors is critically important in determining their ability to initiate and support formation of a hemostatic clot. Using this model system we have been able to explain why factors VIII and IX (the factors that are deficient in hemophilia A and B) are essential for hemostasis in vivo, and also how high dose FVIIa can bypass the need for FVIII or FIX and restore hemostasis in hemophiliacs. We have also modeled the hemostatic defects in dilutional coagulopathy, liver disease and anticoagulant treatment. These models are helping us understand why the common clinical coagulation tests do not predict the risk of bleeding well in these conditions.

We have also examined the role of the coagulation process in wound healing. Clinicians have long felt that wound healing is delayed in hemophiliacs. We have now ascertained that hemophilia B mice do indeed have delayed wound healing. They have poor influx of phagocytic cells into the wound area and delayed clearance of debris and iron from hemorrhage. Surprisingly, the mice with defective hemostasis have greater angiogenesis during the healing process. This is a result of the inflammatory effects of iron in the tissues. The excess angiogenesis may be one reason why hemophiliacs often have recurrent bleeding into their joints - the healing process produces a large number of fragile vessels.

Anticoagulation also impairs wound healing. Patients are often anti coagulated after surgery to prevent deep vein thrombosis and pulmonary embolism. However, the impact of this therapy on tissue repair is not well understood. Our aim is to define the extent and time frame of hemostatic function that is needed for optimal healing, thereby setting the stage for scientifically based strategies for anticoagulation.

Current Appointments & Affiliations

Professor of Pathology, Pathology, Clinical Science Departments 2002
Assistant Professor of Immunology, Immunology, Basic Science Departments 1994

Contact Information

Duke Box 3712, Durham, NC 27710
F3184 VA Med Ctr, 508 Fulton St, Durham, NC 27705
maureane@duke.edu (919) 286-6994

Background
Education, Training, & Certifications
- Assistant Professor, Pathology, Duke University 1991 - 1995
- Assistant Professor of Pathology, Pathology, University of North Carolina - Chapel Hill 1987 - 1991
- Resident, Pathology, Duke University 1982 - 1985
- M.D., University of Iowa 1982
- Ph.D., University of Iowa 1982
Medical Licensure
- 27205. North Carolina. 1983
Duke Appointment History
- Associate Professor of Pathology, Pathology, Clinical Science Departments 1997 - 2002
- Associate Professor of Pathology, Pathology, Clinical Science Departments 1995 - 1997
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 1991 - 1995
Leadership & Clinical Positions at Duke
- Attending Physician, Transfusion Medicine
Academic Positions Outside Duke
- Adjunct Assistant Professor of Medicine, University of North Carolina. 1993 - 2019
- Member , The Center for Cardiovascular Biology, University of North Carolina. 1988 - 2018
Recognition
Awards & Honors
- Duke CTSI Pilot Award. Duke Clinical and Translational Science Institute. 2017
- Stewart-Niewiarowski Award for Women in Vascular Biology. Temple University and Wyeth Research. 2006
Expertise
Subject Headings
Research
Selected Grants
- Understanding and Enhancing the Therapeutic Efficacy of Factor VIIa for Emergency Hemostasis awarded by Hemostasis & Thrombosis Research Society 2020 - 2022
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- PC-ChFVIIa Proof of Concept Studies awarded by Otello Medical, Inc. 2019 - 2020
- Duke-UNC Clinical Hematology and Transfusion Research Career Development Program awarded by National Institutes of Health 2006 - 2019
- Molecular Biology Of Human Coagulation Factor V awarded by National Institutes of Health 1991 - 2012
- Sauls IPA awarded by Veterans Administration Medical Center 2010 - 2011
- Sauls IPA awarded by Institute of Medical Research 2008 - 2009
- Pathogenesis of Thrombosis in HIT awarded by National Institutes of Health 1999 - 2004
- Cellular Tissue Factor: Regulation And Activity awarded by National Institutes of Health 1997 - 2001
External Relationships
- Novo Nordisk
- Shire Pharmaceuticals
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Nandi, Seema, Laura Sommerville, Kimberly Nellenbach, Emily Mihalko, Mary Erb, Donald O. Freytes, Maureane Hoffman, Dougald Monroe, and Ashley C. Brown. “Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects.” J Colloid Interface Sci 577 (October 1, 2020): 406–18. https://doi.org/10.1016/j.jcis.2020.05.088.
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  - Chee, Eunice, Seema Nandi, Kimberly Nellenbach, Emily Mihalko, Douglas B. Snider, Landon Morrill, Andrew Bond, et al. “Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles.” J Biomed Mater Res B Appl Biomater 108, no. 6 (August 2020): 2599–2609. https://doi.org/10.1002/jbm.b.34592.
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  - Sung, Anthony D., Richard C. Yen, Yiqun Jiao, Alyssa Bernanke, Deborah A. Lewis, Sara E. Miller, Zhiguo Li, et al. “Fibrinogen-Coated Albumin Nanospheres Prevent Thrombocytopenia-Related Bleeding.” Radiat Res 194, no. 2 (August 1, 2020): 162–72. https://doi.org/10.1667/RADE-20-00016.
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  - Monroe, Dougald, and Maureane Hoffman. “EPCR knockout: inflaming the discussion.” Blood 135, no. 25 (June 18, 2020): 2201–2. https://doi.org/10.1182/blood.2020006001.
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  - Negrier, Claude, Midori Shima, and Maureane Hoffman. “The central role of thrombin in bleeding disorders.” Blood Rev 38 (November 2019): 100582. https://doi.org/10.1016/j.blre.2019.05.006.
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  - Nimjee, Shahid M., David Dornbos, George A. Pitoc, Debra G. Wheeler, Juliana M. Layzer, Nicholas Venetos, Allyson Huttinger, et al. “Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.” Mol Ther 27, no. 7 (July 3, 2019): 1228–41. https://doi.org/10.1016/j.ymthe.2019.03.016.
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  - Sommerville, Laura J., Kristen L. Gorman, Stacey A. Snyder, Dougald M. Monroe, and Maureane Hoffman. “A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes.” J Thromb Haemost 17, no. 4 (April 2019): 670–80. https://doi.org/10.1111/jth.14399.
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  - Hoffman, Maureane, Joshua N. Goldstein, and Jerrold H. Levy. “The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review.” Int J Emerg Med 11, no. 1 (December 3, 2018): 55. https://doi.org/10.1186/s12245-018-0215-6.
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  - Fager, Ammon M., and Maureane Hoffman. “Biology of Coagulation and Coagulopathy in Neurologic Surgery.” Neurosurg Clin N Am 29, no. 4 (October 2018): 475–83. https://doi.org/10.1016/j.nec.2018.05.001.
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  - Hoffman, M. “The next best thing in factor VIIa.” J Thromb Haemost 16, no. 10 (October 2018): 1911–13. https://doi.org/10.1111/jth.14250.
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  - Fager, A. M., K. R. Machlus, M. Ezban, and M. Hoffman. “Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity.” J Thromb Haemost 16, no. 9 (September 2018): 1817–29. https://doi.org/10.1111/jth.14165.
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  - Heath, Michele, Julie Walker, Atilio Barbeito, Adam Williams, Ian Welsby, Cory Maxwell, Mani Daneshmand, John Haney, and Maureane Hoffman. “Differentiating between cold agglutinins and rouleaux: a case series of seven patients.” Perfusion 33, no. 2 (March 2018): 164–69. https://doi.org/10.1177/0267659117727593.
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  - Hoffman, Maureane. “The Tissue Factor Pathway and Wound Healing.” Semin Thromb Hemost 44, no. 2 (March 2018): 142–50. https://doi.org/10.1055/s-0037-1606181.
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  - Hoffman, Maureane, and Dougald M. Monroe. “Impact of Non-Vitamin K Antagonist Oral Anticoagulants From a Basic Science Perspective.” Arterioscler Thromb Vasc Biol 37, no. 10 (October 2017): 1812–18. https://doi.org/10.1161/ATVBAHA.117.306995.
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  - Sun, Junjiang, Baolai Hua, Eric W. Livingston, Sarah Taves, Peter B. Johansen, Maureane Hoffman, Mirella Ezban, Dougald M. Monroe, Ted A. Bateman, and Paul E. Monahan. “Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.” Blood 129, no. 15 (April 13, 2017): 2161–71. https://doi.org/10.1182/blood-2016-08-734053.
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  - Ahmadzia, H. K., E. L. Lockhart, S. M. Thomas, I. J. Welsby, M. R. Hoffman, A. H. James, A. P. Murtha, G. K. Swamy, and C. A. Grotegut. “Using antifibrinolytics in the peripartum period - concern for a hypercoagulable effect?” J Neonatal Perinatal Med 10, no. 1 (2017): 1–7. https://doi.org/10.3233/NPM-16139.
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  - Stephen, Caldwell, Intagliata Nicolas, and Intagliata Coagulation in Liver Disease 2015 Group. “A Summary of The 6th International Conference on Coagulation in Liver Disease: Discussion, Debate, Deliberations.” Ann Hepatol 16, no. 1 (January 2017): 12–15. https://doi.org/10.5604/16652681.1226811.
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  - Ansell, Jack E., Bryan E. Laulicht, Sasha H. Bakhru, Maureane Hoffman, Solomon S. Steiner, and James C. Costin. “Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin.” Thromb Res 146 (October 2016): 113–18. https://doi.org/10.1016/j.thromres.2016.07.008.
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  - Guinn, Nicole R., Nathan H. Waldron, Mary L. Cooter, Corinne L. Goldberg, Miklos D. Kertai, Karthik Raghunathan, Nicholas Bandarenko, Maureane Hoffman, and Elliott Bennett-Guerrero. “No association between donor age and recipient outcomes: transfusion of plasma in patients undergoing coronary artery bypass grafting surgery.” Transfusion 56, no. 7 (July 2016): 1723–29. https://doi.org/10.1111/trf.13616.
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  - Hoffman, M., J. -. Y. Chang, M. Ezban, and D. M. Monroe. “An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model.” J Thromb Haemost 14, no. 6 (June 2016): 1249–54. https://doi.org/10.1111/jth.13311.
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  - Lastrapes, K. K., B. M. Mohammed, M. A. Mazepa, E. J. Martin, J. C. Barrett, G. V. Massey, J. G. Kuhn, et al. “Coated platelets and severe haemophilia A bleeding phenotype: Is there a connection?” Haemophilia 22, no. 1 (January 2016): 148–51. https://doi.org/10.1111/hae.12844.
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  - Mohammed, B. M., D. Contaifer, K. K. Lastrapes, E. J. Martin, M. A. Mazepa, M. Hoffman, D. M. Monroe, and D. F. Brophy. “Coated platelet assay: a feasible approach to a complicated science.” Haemophilia 22, no. 1 (January 2016): e67–70. https://doi.org/10.1111/hae.12845.
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  - Hoffman, Maureane. “Coagulation in Liver Disease.” Semin Thromb Hemost 41, no. 5 (July 2015): 447–54. https://doi.org/10.1055/s-0035-1550435.
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  - Hoffman, Maureane, Zoya Volovyk, and Dougald M. Monroe. “Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.” Anesthesiology 122, no. 2 (February 2015): 353–62. https://doi.org/10.1097/ALN.0000000000000540.
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  - Ahmadzia, Homa, Evelyn Lockhart, Chad Grotegut, Samantha Thomas, Ian Welsby, Maureane Hoffman, Amy Murtha, and Geeta Swamy. “161: Effect of antifibrinolytic drugs on in vitro clot formation among peripartum women.” American Journal of Obstetrics and Gynecology 212, no. 1 (January 2015): S96–S96. https://doi.org/10.1016/j.ajog.2014.10.207.
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  - Hoffman, Maureane, and Dougald M. Monroe. “Reversing targeted oral anticoagulants.” Hematology Am Soc Hematol Educ Program 2014, no. 1 (December 5, 2014): 518–23. https://doi.org/10.1182/asheducation-2014.1.518.
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  - Hoffman, Maureane. “Engineering a new generation of hemostatic agents: highlights of the Scientific Session on Hemostasis at the 2013 meeting of the American Society of Hematology.” Expert Rev Hematol 7, no. 3 (June 2014): 343–45. https://doi.org/10.1586/17474086.2014.903154.
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  - Hoffman, Maureane, and Rafal Pawlinski. “Hemostasis: old system, new players, new directions.” Thromb Res 133 Suppl 1 (May 2014): S1–2. https://doi.org/10.1016/j.thromres.2014.03.001.
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  - Monroe, Dougald M., and Maureane Hoffman. “A mouse bleeding model to study oral anticoagulants.” Thromb Res 133 Suppl 1 (May 2014): S6–8. https://doi.org/10.1016/j.thromres.2014.03.003.
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  - Dickneite, Gerhard, and Maureane Hoffman. “Reversing the new oral anticoagulants with prothrombin complex concentrates (PCCs): what is the evidence?” Thromb Haemost 111, no. 2 (February 2014): 189–98. https://doi.org/10.1160/TH13-05-0431.
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  - Monroe, D. M., M. Hoffman, H. R. Roberts, and U. Hedner. “Progressive improvement in wound healing with increased therapy in haemophilia B mice.” Haemophilia 19, no. 6 (November 2013): 926–32. https://doi.org/10.1111/hae.12220.
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  - Mazepa, Marshall, Maureane Hoffman, and Dougald Monroe. “Superactivated platelets: thrombus regulators, thrombin generators, and potential clinical targets.” Arterioscler Thromb Vasc Biol 33, no. 8 (August 2013): 1747–52. https://doi.org/10.1161/ATVBAHA.113.301790.
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  - Hoffman, Maureane, and Lisa J. H. Cichon. “Practical coagulation for the blood banker.” Transfusion 53, no. 7 (July 2013): 1594–1602. https://doi.org/10.1111/trf.12201.
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  - Dargaud, Y., M. Hoffman, L. Lefrapper, F. -. C. Lin, A. Genty, B. Chatard, S. Marin, C. Négrier, and D. M. Monroe. “Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels.” J Thromb Haemost 11, no. 6 (June 2013): 1043–52. https://doi.org/10.1111/jth.12244.
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  - Hoffman, Maureane, and Dougald M. Monroe. “Low intensity laser therapy speeds wound healing in hemophilia by enhancing platelet procoagulant activity.” Wound Repair Regen 20, no. 5 (September 2012): 770–77. https://doi.org/10.1111/j.1524-475X.2012.00828.x.
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  - Hoffman, M., and Y. Dargaud. “Mechanisms and monitoring of bypassing agent therapy.” J Thromb Haemost 10, no. 8 (August 2012): 1478–85. https://doi.org/10.1111/j.1538-7836.2012.04793.x.
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  - Forsyth, A. L., G. -. É. Rivard, L. A. Valentino, N. Zourikian, M. Hoffman, P. E. Monahan, M. E. R. Van Meegeren, and F. Forriol. “Consequences of intra-articular bleeding in haemophilia: science to clinical practice and beyond.” Haemophilia 18 Suppl 4 (July 2012): 112–19. https://doi.org/10.1111/j.1365-2516.2012.02835.x.
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  - Monroe, Dougald M., and Maureane Hoffman. “The clotting system - a major player in wound healing.” Haemophilia 18 Suppl 5 (July 2012): 11–16. https://doi.org/10.1111/j.1365-2516.2012.02889.x.
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  - Hoffman, Maureane. “Hemostatic properties of the FVIIa analog NN1731.” Thromb Res 129 Suppl 2 (May 2012): S49–50. https://doi.org/10.1016/j.thromres.2012.02.032.
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  - Hoffman, M., and D. M. Monroe. “The multiple roles of tissue factor in wound healing.” Frontiers in Bioscience Scholar 4 S, no. 2 (January 1, 2012): 713–21. https://doi.org/10.2741/s295.
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  - Hoffman, Maureane, and Dougald M. Monroe. “The multiple roles of tissue factor in wound healing.” Front Biosci (Schol Ed) 4 (January 1, 2012): 713–21. https://doi.org/10.2741/s295.
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  - Hoffman, Maureane. “Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress.” Med Hypotheses 77, no. 6 (December 2011): 1088–93. https://doi.org/10.1016/j.mehy.2011.09.009.
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  - Sauls, Derrick L., Maria Warren, and Maureane Hoffman. “Homocysteinylated fibrinogen forms disulfide-linked complexes with albumin.” Thromb Res 127, no. 6 (June 2011): 576–81. https://doi.org/10.1016/j.thromres.2011.01.009.
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  - Hoffman, M., Z. Volovyk, E. Persson, D. A. Gabriel, M. Ezban, and D. M. Monroe. “Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity.” J Thromb Haemost 9, no. 4 (April 2011): 759–66. https://doi.org/10.1111/j.1538-7836.2011.04223.x.
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  - Burchiel, Kim J. “International normalized ratio.” J Neurosurg 114, no. 1 (January 2011): 8. https://doi.org/10.3171/2010.3.JNS10155.
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  - West, Kelly L., Cory Adamson, and Maureane Hoffman. “International normalized ratio Response.” Journal of Neurosurgery 114, no. 1 (January 1, 2011): 8–8.
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  - West, Kelly L., Cory Adamson, and Maureane Hoffman. “Prophylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literature.” J Neurosurg 114, no. 1 (January 2011): 9–18. https://doi.org/10.3171/2010.7.JNS091857.
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  - “Regulation of Hemostasis and Thrombosis,” December 1, 2010, 87–95. https://doi.org/10.1016/B978-1-4160-3773-6.10009-6.
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  - Hoffman, M., and D. M. Monroe. “Inflammation does not predispose to bleeding in hemophilia.” J Thromb Haemost 8, no. 11 (November 2010): 2583–85. https://doi.org/10.1111/j.1538-7836.2010.04032.x.
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  - Hoffman, M. “Heparins: Clinical use and laboratory monitoring.” Laboratory Medicine 41, no. 10 (October 1, 2010): 621–26. https://doi.org/10.1309/LMSXWC3A4LBIJP2B.
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  - Hoffman, M., and D. M. Monroe. “Wound healing in haemophilia--breaking the vicious cycle.” Haemophilia 16 Suppl 3 (May 2010): 13–18. https://doi.org/10.1111/j.1365-2516.2010.02254.x.
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  - Hoffman, Maureane, and Dougald M. Monroe. “Platelet binding and activity of recombinant factor VIIa.” Thromb Res 125 Suppl 1 (April 2010): S16–18. https://doi.org/10.1016/j.thromres.2010.01.025.
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  - Monroe, Dougald M., Nigel Mackman, and Maureane Hoffman. “Wound healing in hemophilia B mice and low tissue factor mice.” Thromb Res 125 Suppl 1 (April 2010): S74–77. https://doi.org/10.1016/j.thromres.2010.01.043.
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  - Nimjee, Shahid M., Sabah Oney, Zoya Volovyk, Kristin M. Bompiani, Steve B. Long, Maureane Hoffman, and Bruce A. Sullenger. “Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.” Rna 15, no. 12 (December 2009): 2105–11. https://doi.org/10.1261/rna.1240109.
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  - Rau, Jill C., Carolyn Deans, Maureane R. Hoffman, David B. Thomas, Gray T. Malcom, Arthur W. Zieske, Jack P. Strong, Gary G. Koch, and Frank C. Church. “Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study.” Exp Mol Pathol 87, no. 3 (December 2009): 178–83. https://doi.org/10.1016/j.yexmp.2009.09.003.
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  - Smyth, S. S., R. P. McEver, A. S. Weyrich, C. N. Morrell, M. R. Hoffman, G. M. Arepally, P. A. French, H. L. Dauerman, R. C. Becker, and R. C. 2009 Platelet Colloquium Participants. “Platelet functions beyond hemostasis.” J Thromb Haemost 7, no. 11 (November 2009): 1759–66. https://doi.org/10.1111/j.1538-7836.2009.03586.x.
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  - Hoffman, Maureane, and Dougald M. Monroe. “Tissue factor in brain is not saturated with factor VIIa: implications for factor VIIa dosing in intracerebral hemorrhage.” Stroke 40, no. 8 (August 2009): 2882–84. https://doi.org/10.1161/STROKEAHA.109.555433.
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  - Volovyk, Zoya, Dougald M. Monroe, YiWei Qi, Richard Becker, and Maureane Hoffman. “A rationally designed heparin, M118, has anticoagulant activity similar to unfractionated heparin and different from Lovenox in a cell-based model of thrombin generation.” J Thromb Thrombolysis 28, no. 2 (August 2009): 132–39. https://doi.org/10.1007/s11239-009-0360-0.
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  - Hoffman, M., S. Pradhan, and D. M. Monroe. “Celecoxib does not delay cutaneous wound healing in haemophilia B mice.” Haemophilia 15, no. 2 (March 2009): 615–16. https://doi.org/10.1111/j.1365-2516.2008.01970.x.
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  - Monroe, Dougald M., and Maureane Hoffman. “The coagulation cascade in cirrhosis.” Clin Liver Dis 13, no. 1 (February 2009): 1–9. https://doi.org/10.1016/j.cld.2008.09.014.
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  - Monroe, Dougald M., and Maureane Hoffman. “Dysregulation of hemostasis by cancer.” Cancer Treat Res 148 (2009): 3–15. https://doi.org/10.1007/978-0-387-79962-9_1.
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  - Hoffman, Maureane. “FVIIa: you've come a long way, baby!.” Blood 112, no. 8 (October 15, 2008): 3002–3. https://doi.org/10.1182/blood-2008-08-171280.
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  - Hoffman, M. “Animal models of bleeding and tissue repair.” Haemophilia 14 Suppl 3 (July 2008): 62–67. https://doi.org/10.1111/j.1365-2516.2008.01729.x.
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  - Hoffman, M. “Alterations of fibrinogen structure in human disease.” Cardiovasc Hematol Agents Med Chem 6, no. 3 (July 2008): 206–11. https://doi.org/10.2174/187152508784871981.
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  - McDonald, Anna G., Katie Yang, Harold R. Roberts, Dougald M. Monroe, and Maureane Hoffman. “Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia.” Blood 111, no. 4 (February 15, 2008): 2046–48. https://doi.org/10.1182/blood-2007-05-092916.
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  - Hoffman, Maureane. “Some things I thought I knew about tissue factor that turn out to be wrong.” Thromb Res 122 Suppl 1 (2008): S73–77. https://doi.org/10.1016/S0049-3848(08)70024-0.
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  - Northup, P. G., V. Sundaram, M. B. Fallon, K. R. Reddy, R. A. Balogun, A. J. Sanyal, Q. M. Anstee, et al. “Hypercoagulation and thrombophilia in liver disease.” J Thromb Haemost 6, no. 1 (January 2008): 2–9. https://doi.org/10.1111/j.1538-7836.2007.02772.x.
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  - McDonald, A., M. Hoffman, U. Hedner, H. R. Roberts, and D. M. Monroe. “Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B.” J Thromb Haemost 5, no. 8 (August 2007): 1577–83. https://doi.org/10.1111/j.1538-7836.2007.02647.x.
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  - Tripodi, A., S. H. Caldwell, M. Hoffman, J. F. Trotter, and A. J. Sanyal. “Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease.” Aliment Pharmacol Ther 26, no. 2 (July 15, 2007): 141–48. https://doi.org/10.1111/j.1365-2036.2007.03369.x.
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  - Hoffman, M., C. M. Colina, A. G. McDonald, G. M. Arepally, L. Pedersen, and D. M. Monroe. “Tissue factor around dermal vessels has bound factor VII in the absence of injury.” J Thromb Haemost 5, no. 7 (July 2007): 1403–8. https://doi.org/10.1111/j.1538-7836.2007.02576.x.
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  - Monroe, Dougald M., Maureane Hoffman, and Harold R. Roberts. “Fathers of modern coagulation.” Thromb Haemost 98, no. 1 (July 2007): 3–5.
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  - Sauls, D. L., A. E. Banini, L. C. Boyd, and M. Hoffman. “Elevated prothrombin level and shortened clotting times in subjects with type 2 diabetes.” J Thromb Haemost 5, no. 3 (March 2007): 638–39. https://doi.org/10.1111/j.1538-7836.2007.02366.x.
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  - Hoffman, Maureane, and Dougald M. Monroe. “Coagulation 2006: a modern view of hemostasis.” Hematol Oncol Clin North Am 21, no. 1 (February 2007): 1–11. https://doi.org/10.1016/j.hoc.2006.11.004.
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  - Sauls, Derrick L., Erin K. Arnold, Charles W. Bell, Jonathan C. Allen, and Maureane Hoffman. “Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia.” Thromb Res 120, no. 1 (2007): 117–26. https://doi.org/10.1016/j.thromres.2006.08.001.
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  - Hoffman, Maureane, Anna Harger, Angela Lenkowski, Ulla Hedner, Harold R. Roberts, and Dougald M. Monroe. “Cutaneous wound healing is impaired in hemophilia B.” Blood 108, no. 9 (November 1, 2006): 3053–60. https://doi.org/10.1182/blood-2006-05-020495.
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  - Caldwell, Stephen H., Maureane Hoffman, Ton Lisman, B Gail Macik, Patrick G. Northup, K Rajender Reddy, Armando Tripodi, Arun J. Sanyal, and Arun J. Coagulation in Liver Disease Group. “Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management.” Hepatology 44, no. 4 (October 2006): 1039–46. https://doi.org/10.1002/hep.21303.
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  - Hoffman, M., H. C. Whinna, and D. M. Monroe. “Circulating tissue factor accumulates in thrombi, but not in hemostatic plugs.” J Thromb Haemost 4, no. 9 (September 2006): 2092–93. https://doi.org/10.1111/j.1538-7836.2006.02085.x.
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  - Allen, Geoffrey A., Maureane Hoffman, Harold R. Roberts, and Dougald M. Monroe. “Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia.” Br J Haematol 134, no. 3 (August 2006): 314–19. https://doi.org/10.1111/j.1365-2141.2006.06178.x.
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  - Roberts, Harold R., Maureane Hoffman, and Dougald M. Monroe. “A cell-based model of thrombin generation.” Semin Thromb Hemost 32 Suppl 1 (April 2006): 32–38. https://doi.org/10.1055/s-2006-939552.
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  - Sauls, Derrick L., Evelyn Lockhart, Maria Esteban Warren, Angela Lenkowski, Susan E. Wilhelm, and Maureane Hoffman. “Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia.” Biochemistry 45, no. 8 (February 28, 2006): 2480–87. https://doi.org/10.1021/bi052076j.
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  - Roberts, Susan T., and Barbara L. Kennedy. “Why are young college women not using condoms? Their perceived risk, drug use, and developmental vulnerability may provide important clues to sexual risk.” Arch Psychiatr Nurs 20, no. 1 (February 2006): 32–40. https://doi.org/10.1016/j.apnu.2005.08.008.
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  - Monroe, Dougald M., and Maureane Hoffman. “What does it take to make the perfect clot?” Arterioscler Thromb Vasc Biol 26, no. 1 (January 2006): 41–48. https://doi.org/10.1161/01.ATV.0000193624.28251.83.
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  - Wolberg, Alisa S., Geoffrey A. Allen, Dougald M. Monroe, Ulla Hedner, Harold R. Roberts, and Maureane Hoffman. “High dose factor VIIa improves clot structure and stability in a model of haemophilia B.” Br J Haematol 131, no. 5 (December 2005): 645–55. https://doi.org/10.1111/j.1365-2141.2005.05820.x.
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  - Hoffman, Maureane M., and Dougald M. Monroe. “Rethinking the coagulation cascade.” Curr Hematol Rep 4, no. 5 (September 2005): 391–96.
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  - Glasscock, Laura N., Sophie M. Réhault, Christopher W. Gregory, Scott T. Cooper, Tracy P. Jackson, Maureane Hoffman, and Frank C. Church. “Protein C inhibitor (plasminogen activator inhibitor-3) expression in the CWR22 prostate cancer xenograft.” Exp Mol Pathol 79, no. 1 (August 2005): 23–32. https://doi.org/10.1016/j.yexmp.2005.02.008.
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  - Hoffman, M., and R. S. Bobrow. “Excess factor VIII and hypercoagulability [3] (multiple letters).” Journal of the American Board of Family Practice 18, no. 4 (July 1, 2005): 328.
  - Hoffman, Maureane. “Excess factor VIII and hypercoagulability.” J Am Board Fam Pract 18, no. 4 (July 2005): 328. https://doi.org/10.3122/jabfm.18.4.328.
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  - Kempton, Christine L., Maureane Hoffman, Harold R. Roberts, and Dougald M. Monroe. “Platelet heterogeneity: variation in coagulation complexes on platelet subpopulations.” Arterioscler Thromb Vasc Biol 25, no. 4 (April 2005): 861–66. https://doi.org/10.1161/01.ATV.0000155987.26583.9b.
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  - Hoffman, M. “One more way that mice and men are different.” J Thromb Haemost 3, no. 3 (March 2005): 448–49. https://doi.org/10.1111/j.1538-7836.2005.01220.x.
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  - HOFFMAN, Maureane, Zhi Hong MENG, Harold R. ROBERTS, and Dougald M. MONROE. “Rethinking the Coagulation Cascade.” Japanese Journal of Thrombosis and Hemostasis 16, no. 1 (2005): 70–81. https://doi.org/10.2491/jjsth.16.70.
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  - Hoffman, Maureane. “The cellular basis of traumatic bleeding.” Mil Med 169, no. 12 Suppl (December 2004): 5–4. https://doi.org/10.7205/milmed.169.12s.5.
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  - Wolberg, Alisa S., Zhi Hong Meng, Dougald M. Monroe, and Maureane Hoffman. “A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function.” J Trauma 56, no. 6 (June 2004): 1221–28. https://doi.org/10.1097/01.ta.0000064328.97941.fc.
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  - Allen, G. A., A. S. Wolberg, J. A. Oliver, M. Hoffman, H. R. Roberts, and D. M. Monroe. “Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system.” J Thromb Haemost 2, no. 3 (March 2004): 402–13. https://doi.org/10.1111/j.1538-7933.2003.00617.x.
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  - Hoffman, Maureane. “UNDERSTANDING AND MANAGING COAGULOPATHIC BLEEDING.” Shock 21, no. Supplement (March 2004): 149–149. https://doi.org/10.1097/00024382-200403001-00593.
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  - Sauls, Derrick L., Leon C. Boyd, Jonathan C. Allen, and Maureane Hoffman. “Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits.” J Nutr Biochem 15, no. 2 (February 2004): 96–102. https://doi.org/10.1016/j.jnutbio.2003.09.010.
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  - Roberts, Harold R., Dougald M. Monroe, and Maureane Hoffman. “Safety profile of recombinant factor VIIa.” Semin Hematol 41, no. 1 Suppl 1 (January 2004): 101–8. https://doi.org/10.1053/j.seminhematol.2003.11.019.
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  - Hoffman, Maureane. “The Potential Role of Factor VIIa in Transfusion Medicine.” Transfusion Alternatives in Transfusion Medicine 5, no. s5 (December 2003): 20–22. https://doi.org/10.1111/j.1778-428x.2003.tb00096.x.
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  - Hoffman, Maureane. “Laboratory monitoring of high-dose factor VIIa therapy.” Ann Intern Med 139, no. 9 (November 4, 2003): 791. https://doi.org/10.7326/0003-4819-139-9-200311040-00020.
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  - Meng, Zhi Hong, Alisa S. Wolberg, Dougald M. Monroe, and Maureane Hoffman. “The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients.” J Trauma 55, no. 5 (November 2003): 886–91. https://doi.org/10.1097/01.TA.0000066184.20808.A5.
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  - Hoffman, Maureane, Kim L. M. Loh, Virginia K. Bond, Diane Palmieri, Julie L. Ryan, and Frank C. Church. “Localization of heparin cofactor II in injured human skin: a potential role in wound healing.” Exp Mol Pathol 75, no. 2 (October 2003): 109–18. https://doi.org/10.1016/s0014-4800(03)00073-x.
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  - Hoffman, Maureane. “A cell-based model of coagulation and the role of factor VIIa.” Blood Rev 17 Suppl 1 (September 2003): S1–5. https://doi.org/10.1016/s0268-960x(03)90000-2.
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  - Hoffman, Maureane. “Remodeling the blood coagulation cascade.” J Thromb Thrombolysis 16, no. 1–2 (August 2003): 17–20. https://doi.org/10.1023/B:THRO.0000014588.95061.28.
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  - Fields, Ryan C., Jonathan G. Schoenecker, Justin P. Hart, Maureane R. Hoffman, Salvatore V. Pizzo, and Jeffrey H. Lawson. “Protease-activated receptor-2 signaling triggers dendritic cell development.” Am J Pathol 162, no. 6 (June 2003): 1817–22. https://doi.org/10.1016/S0002-9440(10)64316-7.
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  - Veldman, Alex, Maureane Hoffman, and Silke Ehrenforth. “New insights into the coagulation system and implications for new therapeutic options with recombinant factor VIIa.” Curr Med Chem 10, no. 10 (May 2003): 797–811. https://doi.org/10.2174/0929867033457728.
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  - Wolberg, Alisa S., Dougald M. Monroe, Harold R. Roberts, and Maureane Hoffman. “Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk.” Blood 101, no. 8 (April 15, 2003): 3008–13. https://doi.org/10.1182/blood-2002-08-2527.
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  - Sauls, D. L., A. S. Wolberg, and M. Hoffman. “Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia.” J Thromb Haemost 1, no. 2 (February 2003): 300–306. https://doi.org/10.1046/j.1538-7836.2003.00053.x.
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  - Hoffman, Maureane, and Dougald M. Monroe. “The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis.” Disease a Month 49, no. 1 (January 2003): 14–21. https://doi.org/10.1053/shem.2001.29504.
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  - Hoffman, Maureane, and Dougald M. Monroe. “The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis.” Dis Mon 49, no. 1 (January 2003): 14–21. https://doi.org/10.1053/mda.2003.29504b.
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  - Allen, Geoffrey A., Maureane Hoffman, Harold R. Roberts, and Dougald M. Monroe. “Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage.” Can J Anaesth 49, no. 10 (December 2002): S7-14.
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  - Brown, Simon A., Louis M. Aledort, and Christine A. Lee. “Haemostasis: from bench to bedside.” Haemophilia 8, no. 5 (September 2002): 685–93. https://doi.org/10.1046/j.1365-2516.2002.00653.x.
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  - Monroe, Dougald M., Maureane Hoffman, and Harold R. Roberts. “Platelets and thrombin generation.” Arterioscler Thromb Vasc Biol 22, no. 9 (September 1, 2002): 1381–89. https://doi.org/10.1161/01.atv.0000031340.68494.34.
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  - Wolberg, A. S., D. A. Gabriel, and M. Hoffman. “Analyzing fibrin clot structure using a microplate reader.” Blood Coagul Fibrinolysis 13, no. 6 (September 2002): 533–39. https://doi.org/10.1097/00001721-200209000-00008.
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  - Monroe, Dougald M., and Maureane Hoffman. “Coagulation factor interaction with platelets.” Thromb Haemost 88, no. 2 (August 2002): 179.
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  - Oliver, Julie A., Dougald M. Monroe, Frank C. Church, Harold R. Roberts, and Maureane Hoffman. “Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces.” Blood 100, no. 2 (July 15, 2002): 539–46. https://doi.org/10.1182/blood.v100.2.539.
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  - Abu-Duhier, Faisal M., Anne C. Goodeve, Gill A. Wilson, Rory S. Carr, Ian R. Peake, and John T. Reilly. “FLT3 internal tandem duplication mutations are rare in agnogenic myeloid metaplasia.” Blood 100, no. 1 (July 1, 2002): 364. https://doi.org/10.1182/blood-2002-02-0536.
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  - Gui, Tong, Hui-Feng Lin, Da-Yun Jin, Maureane Hoffman, David L. Straight, Harold R. Roberts, and Darrel W. Stafford. “Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.” Blood 100, no. 1 (July 1, 2002): 153–58. https://doi.org/10.1182/blood.v100.1.153.
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  - Hoffman, Maureane, Douglas M. Monroe, and Harold R. Roberts. “Platelet-dependent action of high-dose factor VIIa.” Blood 100, no. 1 (July 1, 2002): 364–65. https://doi.org/10.1182/blood-2002-03-0736.
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  - White, R., C. Rusconi, E. Scardino, A. Wolberg, J. Lawson, M. Hoffman, and B. Sullenger. “Generation of species cross-reactive aptamers using "toggle" SELEX.” Mol Ther 4, no. 6 (December 2001): 567–73. https://doi.org/10.1006/mthe.2001.0495.
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  - Schoenecker, J. G., R. K. Johnson, A. P. Lesher, J. D. Day, S. D. Love, M. R. Hoffman, T. L. Ortel, W. Parker, and J. H. Lawson. “Exposure of mice to topical bovine thrombin induces systemic autoimmunity.” Am J Pathol 159, no. 5 (November 2001): 1957–69. https://doi.org/10.1016/S0002-9440(10)63043-X.
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  - Hoffman, M., and D. M. Monroe. “The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis.” Semin Hematol 38, no. 4 Suppl 12 (October 2001): 6–9. https://doi.org/10.1016/s0037-1963(01)90140-4.
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  - Kjalke, M., M. Ezban, D. M. Monroe, M. Hoffman, H. R. Roberts, and U. Hedner. “High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system.” Br J Haematol 114, no. 1 (July 2001): 114–20. https://doi.org/10.1046/j.1365-2141.2001.02870.x.
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  - Hoffman, M., and D. M. Monroe. “A cell-based model of hemostasis.” Thromb Haemost 85, no. 6 (June 2001): 958–65.
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  - Sindram, D., R. J. Porte, M. R. Hoffman, R. C. Bentley, and P. A. Clavien. “Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: a Kupffer cell-mediated injury.” Faseb J 15, no. 7 (May 2001): 1230–32. https://doi.org/10.1096/fj.00-0554fje.
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  - Gui, T., H. F. Lin, M. R. Hoffman, D. L. Straight, and D. W. Stafford. “In vivo behavior of factor ix and certain gla domain mutants evaluated in coagulation factor k-deficient mice.” Blood 96, no. 11 PART I (December 1, 2000).
  - Sauls, D. L., A. S. Wolberg, and M. Hoffman. “Hyperhomocysteenemia induces alterations in fffirinogen function and fibrin clot structure in a rabbit model.” Blood 96, no. 11 PART I (December 1, 2000).
  - Monroe, D. M., M. Hoffman, G. A. Allen, and H. R. Roberts. “The factor VII-platelet interplay: Effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia.” Seminars in Thrombosis and Hemostasis 26, no. 4 (November 25, 2000): 373–77.
  - Gui, T., H. F. Lin, M. R. Hoffman, D. L. Straight, and D. W. Stafford. “In vivo behavior of factor IX and certain GLA domain mutants evaluated in coagulation factor M-deficient mice.” Blood 96, no. 11 (November 16, 2000): 35A-35A.
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  - White, Rebekah, Chris Rusconi, Maureane Hoffman, Jeff Lawson, and Bruce Sullenger. “Inhibition of human and pig thrombin by a high-affinity nuclease-resistant RNA aptamer.” Journal of the American College of Surgeons 191, no. 4 (October 2000): S74–75. https://doi.org/10.1016/s1072-7515(00)00605-0.
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  - Brigden, M. L., A. Pattullo, and G. Brown. “Pneumococcal vaccine administration associated with splenectomy: the need for improved education, documentation, and the use of a practical checklist.” Am J Hematol 65, no. 1 (September 2000): 25–29. https://doi.org/10.1002/1096-8652(200009)65:1<25::aid-ajh4>3.0.co;2-8.
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  - Wolberg, A. S., R. H. Kon, D. M. Monroe, and M. Hoffman. “Coagulation factor XI is a contaminant in intravenous immunoglobulin preparations.” Am J Hematol 65, no. 1 (September 2000): 30–34. https://doi.org/10.1002/1096-8652(200009)65:1<30::aid-ajh5>3.0.co;2-j.
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  - Wolberg, Alisa S., Rachel H. Kon, Dougald M. Monroe, and Maureane Hoffman. “Coagulation factor XI is a contaminant in intravenous immunoglobulin preparations.” American Journal of Hematology 65, no. 1 (September 2000): 30–34. https://doi.org/10.1002/1096-8652(200009)65:1<30::aid-ajh5>3.3.co;2-a.
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  - Wolberg, A. S., R. H. Kon, D. M. Monroe, M. Ezban, H. R. Roberts, and M. Hoffman. “Deencryption of cellular tissue factor is independent of its cytoplasmic domain.” Biochem Biophys Res Commun 272, no. 2 (June 7, 2000): 332–36. https://doi.org/10.1006/bbrc.2000.2783.
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  - Allen, G. A., D. M. Monroe, H. R. Roberts, and M. Hoffman. “The effect of factor X level on thrombin generation and the procoagulant effect of activated factor VII in a cell-based model of coagulation.” Blood Coagul Fibrinolysis 11 Suppl 1 (April 2000): S3–7. https://doi.org/10.1097/00001721-200004001-00002.
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  - Hoffman, M., D. M. Monroe, and R. A. Roubey. “Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis?” Immunol Res 22, no. 2–3 (2000): 191–97. https://doi.org/10.1385/IR:22:2-3:191.
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  - Monroe, D. M., M. Hoffman, G. A. Allen, and H. R. Roberts. “The factor VII-platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia.” Semin Thromb Hemost 26, no. 4 (2000): 373–77. https://doi.org/10.1055/s-2000-8455.
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  - Sindram, D., R. J. Porte, M. R. Hoffman, R. C. Bentley, and P. A. Clavien. “Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver.” Gastroenterology 118, no. 1 (January 2000): 183–91. https://doi.org/10.1016/s0016-5085(00)70427-6.
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  - Hoffman, M. R., R. Kon, A. Wolberg, and D. M. Monroe. “Coagulation factor XI is present in intravenous immunoglobulin (IVIG) preparations.” Transfusion 39, no. 10 (October 1, 1999): 99S-99S.
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  - Russell, K. E., P. C. Perkins, M. R. Hoffman, R. T. Miller, K. M. Walker, F. J. Fuller, and D. C. Sellon. “Platelets from thrombocytopenic ponies acutely infected with equine infectious anemia virus are activated in vivo and hypofunctional.” Virology 259, no. 1 (June 20, 1999): 7–19. https://doi.org/10.1006/viro.1999.9737.
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  - Wolberg, A. S., D. M. Monroe, H. R. Roberts, and M. R. Hoffman. “Tissue factor de-encryption: ionophore treatment induces changes in tissue factor activity by phosphatidylserine-dependent and -independent mechanisms.” Blood Coagul Fibrinolysis 10, no. 4 (June 1999): 201–10.
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  - Soslau, Gerald. “Chemistry and Biology of Serpins Edited by Frank C. Church, Dennis D. Cunningham, David Ginsburg, Maureane Hoffman, Stuart R. Stone, and Douglas M. Tollefsen. Plenum Press: New York. 1997. xvii + 358 pp. $95.00. ISBN 0-306-45698-2.” Journal of the American Chemical Society 121, no. 20 (May 1999): 4931–32. https://doi.org/10.1021/ja9856497.
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  - Oliver, J. A., D. M. Monroe, H. R. Roberts, and M. Hoffman. “Thrombin activates factor XI on activated platelets in the absence of factor XII.” Arterioscler Thromb Vasc Biol 19, no. 1 (January 1999): 170–77. https://doi.org/10.1161/01.atv.19.1.170.
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  - Palmier, D., J. A. Underwood, M. Hoffman, and F. Church. “Protein C inhibitor in the human endometrium.” Faseb Journal 12, no. 8 (December 1, 1998).
  - Thomas, D. W., R. B. Mannon, P. J. Mannon, A. Latour, J. A. Oliver, M. Hoffman, O. Smithies, B. H. Koller, and T. M. Coffman. “Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.” J Clin Invest 102, no. 11 (December 1, 1998): 1994–2001. https://doi.org/10.1172/JCI5116.
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  - Kjalke, M., D. M. Monroe, M. Hoffman, J. A. Oliver, M. Ezban, and H. R. Roberts. “Active site-inactivated factors VIIa, Xa, and IXa inhibit individual steps in a cell-based model of tissue factor-initiated coagulation.” Thromb Haemost 80, no. 4 (October 1998): 578–84.
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  - Sindram, D., R. J. Porte, M. R. Hoffman, A. Florence, and P. A. Clavien. “Platelets cause sinusoidal endothelial cell apoptosis of the cold ischemic rat liver: A new target in liver transplantation.” Hepatology 28, no. 4 (October 1, 1998): 405A-405A.
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  - Roberts, H. R., D. M. Monroe, J. A. Oliver, J. Y. Chang, and M. Hoffman. “Newer concepts of blood coagulation.” Haemophilia 4, no. 4 (July 1998): 331–34. https://doi.org/10.1046/j.1365-2516.1998.440331.x.
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  - Hoffman, M., D. M. Monroe, and H. R. Roberts. “Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high-dose activated factor VII.” Blood Coagul Fibrinolysis 9 Suppl 1 (March 1998): S61–65.
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  - Kjalke, M., D. M. Monroe, M. Hoffman, J. A. Oliver, M. Ezban, U. Hedner, and H. R. Roberts. “The effects of activated factor VII in a cell-based model for tissue factor-initiated coagulation.” Blood Coagul Fibrinolysis 9 Suppl 1 (March 1998): S21–25.
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  - Monroe, D. M., M. Hoffman, J. A. Oliver, and H. R. Roberts. “A possible mechanism of action of activated factor VII independent of tissue factor.” Blood Coagul Fibrinolysis 9 Suppl 1 (March 1998): S15–20.
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  - Sindram, D., R. J. Porte, M. Hoffman, J. F. Madden, and P. A. Clavien. “Platelets induce endothelial cell apoptosis upon reperfusion following cold ischemia in rat liver.” European Journal of Gastroenterology and Hepatology 10, no. 12 (January 1, 1998): A56. https://doi.org/10.1097/00042737-199812000-00184.
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  - Vredenburgh, J. J., A. Hussein, D. Fisher, M. Hoffman, M. Elkordy, P. Rubin, C. Gilbert, et al. “A randomized trial of recombinant human interleukin-11 following autologous bone marrow transplantation with peripheral blood progenitor cell support in patients with breast cancer.” Biol Blood Marrow Transplant 4, no. 3 (1998): 134–41. https://doi.org/10.1053/bbmt.1998.v4.pm9923411.
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  - Monroe, D. M., M. Hoffman, J. A. Oliver, and H. R. Roberts. “Platelet activity of high-dose factor VIIa is independent of tissue factor.” Br J Haematol 99, no. 3 (December 1997): 542–47. https://doi.org/10.1046/j.1365-2141.1997.4463256.x.
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  - Neese, L., C. Gregory, F. French, M. Hoffman, and F. Church. “Protein C inhibitor biochemistry and pathology.” Faseb Journal 11, no. 3 (December 1, 1997).
  - Roubey, R. A., and M. Hoffman. “From antiphospholipid syndrome to antibody-mediated thrombosis.” Lancet 350, no. 9090 (November 22, 1997): 1491–93. https://doi.org/10.1016/S0140-6736(05)63936-0.
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  - Kjalke, M., J. A. Oliver, D. M. Monroe, M. Hoffman, M. Ezban, U. Hedner, and H. R. Roberts. “The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration.” Thromb Haemost 78, no. 4 (October 1997): 1202–8.
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  - Neese, L. L., S. T. Cooner, T. P. Jackson, M. N. DiCuccio, M. Hoffman, and E. C. Church. “Evidence of protein C inhibitor in prostatic carcinoma.” Faseb Journal 10, no. 6 (December 1, 1996).
  - DiCuccio, M. N., P. Shami, and M. Hoffman. “A functional tethered ligand thrombin receptor is present on human hematopoietic progenitor cells.” Exp Hematol 24, no. 8 (July 1996): 914–18.
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  - Monroe, D. M., M. Hoffman, and H. R. Roberts. “Transmission of a procoagulant signal from tissue factor-bearing cell to platelets.” Blood Coagul Fibrinolysis 7, no. 4 (June 1996): 459–64. https://doi.org/10.1097/00001721-199606000-00005.
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  - Sumner, W. T., D. M. Monroe, and M. Hoffman. “Variability in platelet procoagulant activity in healthy volunteers.” Thromb Res 81, no. 5 (March 1, 1996): 533–43. https://doi.org/10.1016/0049-3848(96)00028-x.
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  - Wortham, T. S., and M. Hoffman. “Culturing unactivated monocytes.” J Leukoc Biol 59, no. 2 (February 1996): 311–12. https://doi.org/10.1002/jlb.59.2.311a.
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  - Cooper, S. T., L. L. Neese, M. N. DiCuccio, D. K. Liles, M. Hoffman, and F. C. Church. “Vascular localization of the heparin-binding serpins antithrombin, heparin cofactor II, and protein C inhibitor.” Clinical and Applied Thrombosis/Hemostasis 2, no. 3 (January 1, 1996): 185–91. https://doi.org/10.1177/107602969600200307.
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  - Hoffman, M., D. M. Monroe, and H. R. Roberts. “Cellular interactions in hemostasis.” Haemostasis 26 Suppl 1 (1996): 12–16. https://doi.org/10.1159/000217233.
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  - Cooper, S. T., L. L. Neese, M. N. DiCuccio, D. K. Liles, M. R. Hoffman, and F. C. Church. “Vascular localization of the heparin-binding serpins antithrombin, heparin cofactor II and protein C inhibitor.” Blood 86, no. 10 (November 15, 1995): 1493–1493.
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  - Hoffman, M., D. M. Monroe, J. A. Oliver, and H. R. Roberts. “Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation.” Blood 86, no. 5 (September 1, 1995): 1794–1801.
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  - Crago, A. M., H. F. Wu, M. Hoffman, and F. C. Church. “Monocyte chemoattractant activity of Ser195-->Ala active site mutant recombinant alpha-thrombin.” Exp Cell Res 219, no. 2 (August 1995): 650–56. https://doi.org/10.1006/excr.1995.1275.
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  - Larson, P. J., J. M. Thorp, R. C. Miller, and M. Hoffman. “The monocyte monolayer assay: a noninvasive technique for predicting the severity of in utero hemolysis.” Am J Perinatol 12, no. 3 (May 1995): 157–60. https://doi.org/10.1055/s-2007-994440.
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  - Bonner, J. C., A. Badgett, M. Hoffman, and P. M. Lindroos. “Inhibition of platelet-derived growth factor-BB-induced fibroblast proliferation by plasmin-activated alpha 2-macroglobulin is mediated via an alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein-dependent mechanism.” J Biol Chem 270, no. 11 (March 17, 1995): 6389–95. https://doi.org/10.1074/jbc.270.11.6389.
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  - Hoffman, M., and S. T. Cooper. “Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms.” Blood Cells Mol Dis 21, no. 2 (1995): 156–67. https://doi.org/10.1006/bcmd.1995.0018.
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  - Monroe, D. M., H. R. Roberts, and M. Hoffman. “Platelet procoagulant complex assembly in a tissue factor-initiated system.” Br J Haematol 88, no. 2 (October 1994): 364–71. https://doi.org/10.1111/j.1365-2141.1994.tb05032.x.
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  - Hoffman, M., K. Romp, and D. Monroe. “Platelets contain releasable coagulation factor IX antigen: response.” Blood Coagul Fibrinolysis 5, no. 4 (August 1994): 657–58.
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  - Romp, K. G., W. P. Peters, and M. Hoffman. “Reticulated platelet counts in patients undergoing autologous bone marrow transplantation: an aid in assessing marrow recovery.” Am J Hematol 46, no. 4 (August 1994): 319–24. https://doi.org/10.1002/ajh.2830460411.
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  - MARTIN, D. M. A., and E. G. D. TUDDENHAM. “ACTIVATION OF FACTOR-X BY FACTOR VIIA ON MONOCYTE CELL-SURFACES.” Blood 83, no. 12 (June 15, 1994): 3828–3828.
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  - Martin, D. M., and E. G. Tuddenham. “Activation of factor X by factor VIIa on monocyte cell surfaces.” Blood 83, no. 12 (June 15, 1994): 3828–29.
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  - Church, F. C., and M. R. Hoffman. “Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation.” Trends Cardiovasc Med 4, no. 3 (May 1994): 140–46. https://doi.org/10.1016/1050-1738(94)90066-3.
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  - Hoffman, M., D. M. Monroe, and H. R. Roberts. “Human monocytes support factor X activation by factor VIIa, independent of tissue factor: implications for the therapeutic mechanism of high-dose factor VIIa in hemophilia.” Blood 83, no. 1 (January 1, 1994): 38–42.
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  - Romp, K. G., D. M. Monroe, and M. Hoffman. “Platelets contain releasable coagulation factor IX antigen.” Blood Coagul Fibrinolysis 4, no. 6 (December 1993): 905–10.
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  - CRAGO, A. M., H. F. WU, M. R. HOFFMAN, and F. C. CHURCH. “MONOCYTE CHEMOATTRACTANT ACTIVITY OF ACTIVE-SITE MUTANT RECOMBINANT THROMBIN AND THROMBIN RECEPTOR PEPTIDE SFLLRN.” Blood 82, no. 10 (November 15, 1993): A26–A26.
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  - Hoffman, M., and F. C. Church. “Response of blood leukocytes to thrombin receptor peptides.” J Leukoc Biol 54, no. 2 (August 1993): 145–51. https://doi.org/10.1002/jlb.54.2.145.
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  - HOFFMAN, M. R., and F. C. CHURCH. “RESPONSE OF BLOOD LEUKOCYTES TO THROMBIN RECEPTOR PEPTIDES.” Faseb Journal 7, no. 7 (April 20, 1993): A1191–A1191.
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  - BONNER, J. C., A. L. GOODELL, A. BADGETT, and M. R. HOFFMAN. “ALPHA(2)-MACROGLOBULIN (ALPHA(2)M)-PROTEASE COMPLEXES INHIBIT PLATELET-DERIVED GROWTH-FACTOR (PDGF)-INDUCED LUNG FIBROBLAST PROLIFERATION.” American Review of Respiratory Disease 147, no. 4 (April 1, 1993): A277–A277.
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  - Hoffman, M., D. M. Monroe, and H. R. Roberts. “Platelet activation in patients with thrombotic thrombocytopenic purpura.” Am J Hematol 42, no. 2 (February 1993): 182–85. https://doi.org/10.1002/ajh.2830420208.
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  - Hoffman, M., D. M. Monroe, and H. R. Roberts. “A rapid method to isolate platelets from human blood by density gradient centrifugation.” Am J Clin Pathol 98, no. 5 (November 1992): 531–33. https://doi.org/10.1093/ajcp/98.5.531.
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  - Hoffman, M., D. M. Monroe, and H. R. Roberts. “Coagulation factor IXa binding to activated platelets and platelet-derived microparticles: a flow cytometric study.” Thromb Haemost 68, no. 1 (July 6, 1992): 74–78.
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  - Bonner, J. C., A. L. Goodell, J. A. Lasky, and M. R. Hoffman. “Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the "slow" and "fast" conformations of alpha 2-macroglobulin.” J Biol Chem 267, no. 18 (June 25, 1992): 12837–44.
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  - Hoffman, M., K. A. Faulkner, M. A. Iannone, and F. C. Church. “The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels.” Biochim Biophys Acta 1095, no. 1 (October 16, 1991): 78–82. https://doi.org/10.1016/0167-4889(91)90047-2.
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  - DeStefano, A., and M. Hoffman. “The effect of alpha 2 macroglobulin-proteinase complexes on macrophage Ia expression in vivo.” Immunol Invest 20, no. 1 (February 1991): 33–43. https://doi.org/10.3109/08820139109054923.
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  - Church, F. C., C. W. Pratt, and M. Hoffman. “Leukocyte chemoattractant peptides from the serpin heparin cofactor II.” J Biol Chem 266, no. 2 (January 15, 1991): 704–9.
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  - Hoffman, M. “Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions.” Vox Sang 60, no. 3 (1991): 184–87. https://doi.org/10.1111/j.1423-0410.1991.tb00900.x.
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  - Bonner, J. C., A. Badgett, A. R. Osornio-Vargas, M. Hoffman, and A. R. Brody. “PDGF-stimulated fibroblast proliferation is enhanced synergistically by receptor-recognized alpha 2-macroglobulin.” J Cell Physiol 145, no. 1 (October 1990): 1–8. https://doi.org/10.1002/jcp.1041450102.
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  - Hoffman, M., C. W. Pratt, L. W. Corbin, and F. C. Church. “Characteristics of the chemotactic activity of heparin cofactor II proteolysis products.” J Leukoc Biol 48, no. 2 (August 1990): 156–62. https://doi.org/10.1002/jlb.48.2.156.
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  - Hoffman, M., and P. Jenner. “Variability in the fibrinogen and von Willebrand factor content of cryoprecipitate. Implications for reducing donor exposure.” Am J Clin Pathol 93, no. 5 (May 1990): 694–97. https://doi.org/10.1093/ajcp/93.5.694.
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  - Roche, P. A., M. R. Hoffman, and S. V. Pizzo. “Effect of interferon-gamma and human alpha 2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression.” Biochim Biophys Acta 1051, no. 2 (February 19, 1990): 166–73. https://doi.org/10.1016/0167-4889(90)90189-k.
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  - Corbin, L. W., F. C. Church, and M. Hoffman. “Production of chemotactic peptides by neutrophil degradation of heparin cofactor II.” Thromb Res 57, no. 1 (January 1, 1990): 77–85. https://doi.org/10.1016/0049-3848(90)90196-j.
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  - Kurlander, R. J., M. Hoffman, S. S. Kratz, and J. Gates. “Comparison of the effects of IL-1 alpha and TNF-alpha on phagocyte accumulation and murine antibacterial immunity.” Cell Immunol 123, no. 1 (October 1, 1989): 9–22. https://doi.org/10.1016/0008-8749(89)90264-5.
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  - Bonner, J. C., M. Hoffman, and A. R. Brody. “Alpha-macroglobulin secreted by alveolar macrophages serves as a binding protein for a macrophage-derived homologue of platelet-derived growth factor.” Am J Respir Cell Mol Biol 1, no. 3 (September 1989): 171–79. https://doi.org/10.1165/ajrcmb/1.3.171.
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  - Bonner, J. C., M. Hoffman, and A. R. Brody. “A platelet-derived growth factor homolog secreted by alveolar macrophages is complexed to an alpha-macroglobulin.” Transplant Proc 21, no. 4 (August 1989): 3704–5.
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  - Hoffman, M., C. W. Pratt, R. L. Brown, and F. C. Church. “Heparin cofactor II-proteinase reaction products exhibit neutrophil chemoattractant activity.” Blood 73, no. 6 (May 1, 1989): 1682–85.
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  - Hoffman, M., S. V. Pizzo, and J. B. Weinberg. “Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages.” Agents Actions 25, no. 3–4 (December 1988): 360–67. https://doi.org/10.1007/BF01965043.
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  - Cattaneo, M., J. F. Mustard, M. T. Canciani, M. Richardson, A. B. Federici, and P. M. Mannucci. “Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway.” Thromb Haemost 60, no. 2 (October 31, 1988): 280–88.
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  - Hoffman, M., A. F. Haney, and J. B. Weinberg. “Reduced trypsin-binding capacity of alpha 2-macroglobulin in the peritoneal fluid of women with endometriosis: possible relevance to alterations in macrophase function.” Fertil Steril 50, no. 1 (July 1988): 39–47. https://doi.org/10.1016/s0015-0282(16)60006-7.
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  - Gonias, S. L., S. V. Pizzo, and M. Hoffman. “Clearance and distribution of recombinant murine gamma-interferon in mice.” Cancer Res 48, no. 8 (April 15, 1988): 2021–24.
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  - HOFFMAN, M., S. CHITNENI, J. B. WEINBERG, and R. KURLANDER. “INVIVO EFFECTS OF TUMOR NECROSIS FACTOR (TNF), AND INTERLEUKIN-1 (IL1) ON MURINE PERITONEAL MACROPHAGE (MP) FUNCTIONS.” Faseb Journal 2, no. 6 (March 25, 1988): A1600–A1600.
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  - Hoffman, M., and J. B. Weinberg. “Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages.” J Leukoc Biol 42, no. 6 (December 1987): 704–7. https://doi.org/10.1002/jlb.42.6.704.
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  - HOFFMAN, M., and J. B. WEINBERG. “TUMOR-NECROSIS-FACTOR-ALPHA (TNF) STIMULATES PEROXIDE PRODUCTION AND EXPRESSION OF FC-RECEPTORS FOR IGG2B/1A (FCR), BUT DOES NOT INDUCE IA EXPRESSION ON MURINE PERITONEAL-MACROPHAGES (MP).” Journal of Leukocyte Biology 42, no. 5 (November 1, 1987): 609–609.
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  - Hoffman, M., and C. S. Greenberg. “The effect of fibrin polymerization inhibitors on quantitative measurements of plasma fibrinogen.” Am J Clin Pathol 88, no. 4 (October 1987): 490–93. https://doi.org/10.1093/ajcp/88.4.490.
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  - Hoffman, M. R., S. V. Pizzo, and J. B. Weinberg. “Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms.” J Immunol 139, no. 6 (September 15, 1987): 1885–90.
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  - Hoffman, M., J. A. Koepke, and F. K. Widmann. “Fibrinogen content of low-volume cryoprecipitate.” Transfusion 27, no. 4 (July 1987): 356–58. https://doi.org/10.1046/j.1537-2995.1987.27487264748.x.
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  - HOFFMAN, M. R., and C. S. GREENBERG. “THE EFFECT OF FIBRIN POLYMERIZATION INHIBITORS ON QUANTITATIVE MEASUREMENTS OF PLASMA-FIBRINOGEN.” American Journal of Clinical Pathology 87, no. 3 (March 1, 1987): 419–419.
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  - HOFFMAN, M., S. V. PIZZO, and J. B. WEINBERG. “MODULATION OF PERITONEAL MACROPHAGE (MP) MEMBRANE-ANTIGENS BY ALPHA2-MACROGLOBULIN TRYPSIN (A2M-T) COMPLEXES.” Proceedings of the American Association for Cancer Research 28 (March 1, 1987): 343–343.
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  - HOFFMAN, M., S. V. PIZZO, and J. B. WEINBERG. “ALPHA-2 MACROGLOBULIN-PROTEASE COMPLEXES (ALPHA-2-M-P) DECREASE PERITONEAL MACROPHAGE (MAC) IA EXPRESSION.” Journal of Leukocyte Biology 40, no. 3 (September 1, 1986): 291–291.
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  - Hoffman, M., H. E. Fuchs, and S. V. Pizzo. “The macrophage-mediated regulation of hepatocyte synthesis of antithrombin III and alpha 1-proteinase inhibitor.” Thromb Res 41, no. 5 (March 1, 1986): 707–15. https://doi.org/10.1016/0049-3848(86)90368-3.
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  - TUCKER, J. A., M. R. HOFFMAN, R. E. MCLENDON, P. INGRAM, and J. D. SHELBURNE. “ELECTRON-PROBE MICROANALYSIS OF HALLERVORDEN-SPATZ DISEASE.” American Journal of Clinical Pathology 85, no. 3 (March 1, 1986): 385–385.
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  - Bigner, S. H., P. D. Elmore, A. L. Dee, M. Hoffman, and W. W. Johnston. “Unusual presentations of inflammatory conditions in cerebrospinal fluid.” Acta Cytol 29, no. 3 (May 1985): 291–96.
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  - Hoffman, M., S. R. Feldman, and S. V. Pizzo. “Alpha 2-macroglobulin 'fast' forms inhibit superoxide production by activated macrophages.” Biochim Biophys Acta 760, no. 3 (November 8, 1983): 421–23. https://doi.org/10.1016/0304-4165(83)90384-7.
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  - Hoffman, M., S. R. Feldman, and S. V. Pizzo. “α₂-macroglobulin 'fast' forms inhibit superoxide production by activated macrophages.” Bba General Subjects 760, no. 3 (1983): 421–23.
  - Hoffman, M., and A. P. Autor. “Effect of cyclooxygenase inhibitors and protease inhibitors on phorbol-induced stimulation of oxygen consumption and superoxide production by rat pulmonary macrophages.” Biochem Pharmacol 31, no. 5 (March 1, 1982): 775–80. https://doi.org/10.1016/0006-2952(82)90462-2.
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  - Autor, A. P., and M. Hoffman. “NADPH-dependent oxygen reductase activity in pulmonary macrophages.” Bull Eur Physiopathol Respir 17 Suppl (1981): 153–66.
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  - Hoffman, M., and A. P. Autor. “Production of superoxide anion by an NADPH-oxidase from rat pulmonary macrophages.” Febs Lett 121, no. 2 (December 1, 1980): 352–54. https://doi.org/10.1016/0014-5793(80)80379-6.
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  - Hoffman, M., J. B. Stevens, and A. P. Autor. “Adaptation to hyperoxia in the neonatal rat: kinetic parameters of the oxygen-mediated induction of lung superoxide dismutases, catalase and glutathione peroxidase.” Toxicology 16, no. 3 (1980): 215–25. https://doi.org/10.1016/0300-483x(80)90118-3.
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  - Hoffman, M., and A. P. Autor. “Changes in oxygen consumption and phagocytosis in rat pulmonary macrophages related to animal maturation.” Experimental Lung Research 1, no. 4 (January 1, 1980): 313–22. https://doi.org/10.3109/01902148009069651.
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- Book Sections
  - Hoffman, M. “Regulation of hemostasis and thrombosis.” In Cardiac Intensive Care, 81-89.e2, 2018. https://doi.org/10.1016/B978-0-323-52993-8.00008-4.
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  - Hoffman, M. “Cell-mediated hemostasis.” In Trauma Induced Coagulopathy, 3–14, 2016. https://doi.org/10.1007/978-3-319-28308-1_1.
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- Other Articles
  - Sarich, Troy C., Jonathan H. Seltzer, Scott D. Berkowitz, James Costin’, John T. Curnutte, C Michael Gibson, Maureane Hoffman, et al. “Novel oral anticoagulants and reversal agents: Considerations for clinical development.” Am Heart J, June 2015. https://doi.org/10.1016/j.ahj.2015.03.010.
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- Conference Papers
  - Nandi, S., E. P. Sproul, L. Sommerville, D. M. Monroe, M. R. Hoffman, and A. C. Brown. “Platelet-Like-Particles Mediate Matrix Properties to Promote Cell Migration in a Hemophilia Wound Healing Model.” In Tissue Engineering Part A, 23:S11–S11. MARY ANN LIEBERT, INC, 2017.
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  - Sung, Anthony D., Richard Yen, Divino Deoliveira, Yiqun Jiao, Sadhna Piryani, Alyssa Bernanke, Sharon Hall, et al. “Fibrinogen-Coated Nanospheres Prevent Thrombocytopenia-Related Bleeding.” In Biology of Blood and Marrow Transplantation, 21:S111–13. Elsevier BV, 2015. https://doi.org/10.1016/j.bbmt.2014.11.140.
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  - Hoffman, Maureane R., Zoya Volovyk, and Dougald M. Monroe. “Partial Reversal of Dabigatran Effect by a Prothrombin Complex Concentrate in a Model of Thrombin Generation.” In Blood, 120:3420–3420. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.3420.3420.
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  - Dargaud, Yesim, Maureane Hoffman, Claude Negrier, Leana Lefrapper, and Dougald M. Monroe. “The Impact of Factor IX Level on Thrombin Generation and Bleeding During Warfarin Anticoagulation.” In Blood, 118:250–250. AMER SOC HEMATOLOGY, 2011.
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  - Hoffman, Maureane R., Egon Persson, Mirella Ezban, and Dougald M. Monroe. “Increased Platelet Binding of NN1731, a Factor VIIa Variant with Enhanced Tissue Factor-Independent Activity.” In Blood, 116:491–491. AMER SOC HEMATOLOGY, 2010.
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  - Hoffman, M., E. Persson, M. Ezban, and D. M. Monroe. “Platelet binding of NN1731, a factor VIIa variant with enhanced tissue factor-independent activity.” In Haemophilia, 16:68–68. WILEY-BLACKWELL PUBLISHING, INC, 2010.
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  - Hoffman, M., M. Ezban, and D. Monroe. “An analog of rFVIIa, NN1731, speeds wound healing in a mouse model of hemophilia B.” In Haemophilia, 16:73–74. WILEY-BLACKWELL PUBLISHING, INC, 2010.
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  - McDonald, Anna G., Katherine Yang, Harold R. Roberts, Dougald M. Monroe, and Maureane Hoffman. “Tissue Factor Is Absent from Sites of Cutaneous Wounds: Implications for Bleeding in Hemophilia.” In Blood, 108:1803–1803. American Society of Hematology, 2006. https://doi.org/10.1182/blood.v108.11.1803.1803.
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  - McDonald, Anna G., Maureane Hoffman, Ulla Hedner, Harold R. Roberts, and Dougald M. Monroe. “Restoring initial thrombin generation does not normalize cutaneous wound healingin hemophilia B.” In Blood, 108:306A-306A. AMER SOC HEMATOLOGY, 2006.
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  - Sauls, D. L., A. Lenkowski, and M. Hoffman. “Homocysteinylation of human fibrinogen leads to formation of complexes with albumin, which impairs fibrinolytic enzyme binding and activation.” In Arteriosclerosis Thrombosis and Vascular Biology, 26:E103–4. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - Hoffman, M., A. Lenkowski, J. Brock, U. Hedner, and D. M. Monroe. “Delayed wound healing in hemophilia B mice.” In Blood, 106:894A-894A. AMER SOC HEMATOLOGY, 2005.
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  - Sauls, D. L., E. Lockhart, and M. Hoffman. “Reaction of fibrinogen with homocysteine thiolactone mimics the dysfibrinogenemia produced by hyperhomocysteinemia.” In Blood, 106:44A-44A. AMER SOC HEMATOLOGY, 2005.
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  - Kempton, Christine L., Maureane Hoffman, Angie Lenkowski, Harold R. Roberts, and Dougald M. Monroe. “COAT Platelet Formation Is P2Y12-Dependent.” In Blood, 104:1569–1569. American Society of Hematology, 2004. https://doi.org/10.1182/blood.v104.11.1569.1569.
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  - Sauls, D. L., M. B. Dallas, H. G. Allen, M. Hoffman, and J. C. Allen. “Folate deficiency decreases insulin-receptor binding, prolongs fibrinolysis, and causes hyperhomocysteinemia in rabbits.” In Faseb Journal, 18:A137–A137. FEDERATION AMER SOC EXP BIOL, 2004.
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  - Kempton, C. L., M. Hoffman, Z. H. Meng, H. R. Roberts, and D. M. Monroe. “Platelets stimulated with convulxin plus thrombin develop platelet subpopulations with increased binding of factor VIII, factor IX, and factor X.” In Blood, 102:293A-293A. AMER SOC HEMATOLOGY, 2003.
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  - Kinlaw, L. M., D. L. Sauls, and M. Hoffman. “Hyperhomocysteinemia leads to elevated levels of plasminogen activator inhibitor-1.” In Arteriosclerosis Thrombosis and Vascular Biology, 23:A13–A13. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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  - Sauls, D. L., M. Hoffman, and J. C. Allen. “Diet induced hyperhomocysteinemia in rabbits impairs fibrinolysis.” In Faseb Journal, 17:A330–A330. FEDERATION AMER SOC EXP BIOL, 2003.
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  - Wolberg, A. S., D. M. Monroe, U. Hedner, H. R. Roberts, and M. Hoffman. “High dose factor VIIa enhances clot stability in a model of hemophilia.” In Blood, 98:826A-827A. AMER SOC HEMATOLOGY, 2001.
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  - Sauls, D. L., A. S. Wolberg, and M. Hoffman. “Hyperhomocysteinemia induces alterations in fibrinogen function and fibrin clot structure in a rabbit model.” In Blood, 96:39A-39A. AMER SOC HEMATOLOGY, 2000.
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  - Sauls, D. L., and M. Hoffman. “Hyperhomocysteinemia induces monocyte tissue factor (TF) expression in vivo.” In Blood, 96:32B-32B. AMER SOC HEMATOLOGY, 2000.
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  - Allen, G. A., D. M. Monroe, H. R. Roberts, and M. Hoffman. “Tissue factor independent effect of high dose factor VIIa directly correlates with factor X levels.” In Blood, 94:228A-228A. AMER SOC HEMATOLOGY, 1999.
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  - Oliver, J. A., D. M. Monroe, H. R. Roberts, F. C. Church, and M. Hoffman. “Activated protein C (APC) functions by inhibiting initiation of coagulation rather than by terminating a hemostatic response.” In Blood, 94:224A-224A. AMER SOC HEMATOLOGY, 1999.
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  - Wolberg, A. S., J. A. Oliver, P. A. McDowell, L. L. Phillips, M. E. Mohan, D. M. Monroe, H. R. Roberts, and M. Hoffman. “The initial rate, but not the total amount, of thrombin (IIa) generated determines fibrin clot structure in a cell-based model of coagulation.” In Blood, 94:230A-231A. AMER SOC HEMATOLOGY, 1999.
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  - Wolberg, A. S., R. H. Kon, D. M. Monroe, M. Ezban, H. R. Roberts, and M. Hoffman. “De-encryption of cellular tissue factor is independent of its cytoplasmic domain.” In Blood, 94:227A-227A. AMER SOC HEMATOLOGY, 1999.
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  - Allen, G. A., A. S. Wolberg, J. A. Oliver, M. Hoffman, H. R. Roberts, and D. M. Monroe. “Effect of varied procoagulant concentration on thrombin generation in a model system.” In Thrombosis and Haemostasis, 316–17. F K SCHATTAUER VERLAG GMBH, 1999.
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  - Kon, R. H., A. S. Wolberg, J. A. Oliver, D. M. Monroe, and M. Hoffman. “Factor XI is a contaminant in intravenous immunoglobulin (IVIG) preparations.” In Thrombosis and Haemostasis, 459–60. F K SCHATTAUER VERLAG GMBH, 1999.
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  - Monroe, D. M., M. Hoffman, H. R. Roberts, S. D. Holmes, and M. N. Blackburn. “Discordance between lipid-based and cell-based assays in assessing anti-factor IX antibodies.” In Thrombosis and Haemostasis, 476–476. F K SCHATTAUER VERLAG GMBH, 1999.
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  - Oliver, J. A., D. M. Monroe, H. R. Roberts, F. C. Church, and M. Hoffman. “Activated protein C cleaves factor Va more efficiently on endothelium than on platelets.” In Thrombosis and Haemostasis, 425–425. F K SCHATTAUER VERLAG GMBH, 1999.
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  - Palmieri, D., A. Underwood, M. Hoffman, and F. Church. “Protein C inhibitor in the human endometrium.” In Faseb Journal, 12:A1417–A1417. FEDERATION AMER SOC EXP BIOL, 1998.
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  - Hoffman, M., and D. W. Stafford. “Co-localization of factor IX and collagen type IV in human vascular tissues.” In Blood, 90:3045–3045. W B SAUNDERS CO, 1997.
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  - Oliver, J. A., D. M. Monroe, H. R. Roberts, and M. Hoffman. “Activated platelets provide a surface for the activation of factor XI by thrombin and factor Xa.” In Blood, 90:111–111. W B SAUNDERS CO, 1997.
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  - Wolberg, A. S., M. Hoffman, D. M. Monroe, and H. R. Roberts. “Competition between factors X and IX for activation by f.VIIa/tissue factor (TF): Effect on thrombin (IIa) production in a cell-based model.” In Blood, 90:1292–1292. W B SAUNDERS CO, 1997.
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  - Wolberg, A. S., M. Hoffman, D. M. Monroe, and H. R. Roberts. “De-encryption of cellular tissue factor (TF) activity increases activation of both factors IX & X.” In Blood, 90:1293–1293. W B SAUNDERS CO, 1997.
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  - Hoffman, M., D. M. Monroe, and R. A. S. Roubey. “Procoagulant activin of autoantibodies associated with the antiphospholipid syndrome in an in vitro cell-based model of coagulation.” In Arthritis and Rheumatism, 40:1603–1603. LIPPINCOTT-RAVEN PUBL, 1997.
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  - Kjalke, M., D. M. Monroe, M. Hoffman, J. A. Oliver, M. Ezban, and H. R. Roberts. “Comparison of the effects of active site-inhibited factors VIIa, Xa, and IXa in a cell-based model for tissue factor initiated coagulation.” In Thrombosis and Haemostasis, PS40–PS40. F K SCHATTAUER VERLAG GMBH, 1997.
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  - Kjalke, M., J. A. Oliver, D. M. Monroe, M. Hoffman, M. Ezban, U. Hedner, and H. R. Roberts. “The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin treatment.” In Thrombosis and Haemostasis, PS44–PS44. F K SCHATTAUER VERLAG GMBH, 1997.
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  - Monroe, D. M., M. Hoffman, J. A. Oliver, and H. R. Roberts. “High dose factor VIIa activates factor X on activated platelets in the absence of tissue factor.” In Thrombosis and Haemostasis, SC681–SC681. SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN, 1997.
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  - Kjalke, M., J. A. Oliver, D. M. Monroe, M. Hoffman, M. Ezban, H. R. Roberts, and U. Hedner. “The effect of active site-inhibited coagulation factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin treatment.” In Blood, 88:2996–2996. W B SAUNDERS CO, 1996.
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  - Monroe, D. M., M. Hoffman, and H. R. Roberts. “High dose factor VIIa promotes thrombin generation on activated platelets in the absence of tissue factor.” In Blood, 88:2071–2071. W B SAUNDERS CO, 1996.
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  - Neese, L. L., S. T. Cooper, T. P. Jackson, M. N. DiCuccio, M. Hoffman, and E. C. Church. “Evidence of protein C inhibitor in prostatic carcinoma.” In Faseb Journal, 10:1578–1578. FEDERATION AMER SOC EXP BIOL, 1996.
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  - Hoffman, M., K. L. M. Loh, J. M. Longchamps, and F. C. Church. “Heparin cofactor II (HCII) is associated with macrophages in healing skin: A potential role for HCII in controlling extravascular thrombin activity.” In Journal of Leukocyte Biology, 57–57. FEDERATION AMER SOC EXP BIOL, 1996.
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  - Oliver, J. A., D. M. Monroe, K. Gaud, H. R. Roberts, and M. Hoffman. “Coagulation factor XIa enhances the binding of both zymogen and activated factor IX to stimulated human platelets.” In Blood, 86:1786–1786. W B SAUNDERS CO, 1995.
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  - Oliver, J. A., M. Hoffman, D. M. Monroe, M. Ezban, U. Hedner, and H. R. Roberts. “Active site-inhibited coagulation factor VIIa blocks platelet activation, thrombin generation, and accumulation of platelet-bound factor X in a tissue factor-initiated system.” In Blood, 86:295–295. W B SAUNDERS CO, 1995.
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  - GAUD, K. G., D. M. MONROE, H. R. ROBERTS, and M. HOFFMAN. “COAGULATION FACTOR-XIA PROMOTES FACTOR-IX BINDING TO ACTIVATED PLATELETS.” In Thrombosis and Haemostasis, 73:1208–1208. F K SCHATTAUER VERLAG GMBH, 1995.
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  - HOFFMAN, M., D. M. MONROE, J. A. OLIVER, and H. R. ROBERTS. “FACTOR-IXA AND FACTOR-XA PLAY DISTINCT ROLES IN INITIATION OF COAGULATION BY TISSUE FACTOR.” In Thrombosis and Haemostasis, 73:1175–1175. F K SCHATTAUER VERLAG GMBH, 1995.
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  - GAUD, K., D. M. MONROE, and M. HOFFMAN. “COAGULATION-FACTOR XIA PROMOTES FACTOR-IX BINDING TO PLATELETS.” In Faseb Journal, 9:A838–A838. FEDERATION AMER SOC EXP BIOL, 1995.
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  - HOFFMAN, M., D. M. MONROE, and H. R. ROBERTS. “FACTOR IXA AND FACTOR XA PLAY DISTINCT ROLES IN TISSUE FACTOR-DEPENDENT INITIATION OF COAGULATION.” In Blood, 84:A190–A190. W B SAUNDERS CO, 1994.
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  - DOTY, K. G., D. M. MONROE, and M. HOFFMAN. “PLATELETS CONTAIN RELEASABLE COAGULATION FACTOR-IX.” In Thrombosis and Haemostasis, 69:1155–1155. F K SCHATTAUER VERLAG GMBH, 1993.
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  - HOFFMAN, M., D. M. MONROE, and H. R. ROBERTS. “THE EFFECT OF ANTITHROMBIN (AT) AND TISSUE FACTOR PATHWAY INHIBITOR (TFPI) IN A CELL-BASED MODEL OF COAGULATION.” In Thrombosis and Haemostasis, 69:1141–1141. F K SCHATTAUER VERLAG GMBH, 1993.
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  - HOFFMAN, M., D. M. MONROE, and H. R. ROBERTS. “THE INTERACTION OF MONOCYTES AND PLATELETS IN A CELL-BASED MODEL OF FACTOR-IX DEFICIENCY.” In Circulation, 86:408–408. AMER HEART ASSOC, 1992.
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  - HOFFMAN, M. R., H. E. FUCHS, and S. V. PIZZO. “SYNTHESIS OF ANTITHROMBIN-III BY CULTURED RAT HEPATOCYTES.” In Laboratory Investigation, 50:A26–A26. WILLIAMS & WILKINS, 1984.
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Teaching & Mentoring
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- 1992-present Director, Hematology and Flow Cytometry Laboratories, Durham VA Medical Center
  
  1998-present Director, Transfusion Service, Durham VA Medical Center

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