A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.

Published

Journal Article

We previously reported that some systemic lupus erythematosus (SLE) patients have a population of circulating memory B cells with >2-fold higher levels of CD19. We show here that the presence of CD19(hi) B cells correlates with long-term adverse outcomes. These B cells do not appear anergic, as they exhibit high basal levels of phosphorylated Syk and ERK1/2, signal transduce in response to BCR crosslinking, and can become plasma cells (PCs) in vitro. Autoreactive anti-Smith (Sm) B cells are enriched in this population and the degree of enrichment correlates with the log of the serum anti-Sm titer, arguing that they undergo clonal expansion before PC differentiation. PC differentiation may occur at sites of inflammation, as CD19(hi) B cells have elevated CXCR3 levels and chemotax in response to its ligand CXCL9. Thus, CD19(hi) B cells are precursors to anti-self PCs, and identify an SLE patient subset likely to experience poor clinical outcomes.

Full Text

Duke Authors

Cited Authors

  • Nicholas, MW; Dooley, MA; Hogan, SL; Anolik, J; Looney, J; Sanz, I; Clarke, SH

Published Date

  • February 2008

Published In

Volume / Issue

  • 126 / 2

Start / End Page

  • 189 - 201

PubMed ID

  • 18077220

Pubmed Central ID

  • 18077220

International Standard Serial Number (ISSN)

  • 1521-6616

Digital Object Identifier (DOI)

  • 10.1016/j.clim.2007.10.004

Language

  • eng

Conference Location

  • United States