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Matilda Wray Nicholas

Professor of Dermatology
Dermatology
234 Crooked Creek Parkway, Durham, NC 27713
234 Crooked Creek Parkway, Durham, NC 27713

Overview


I have a wide array of research interests reflecting my many roles at Duke. I am interested in clinical trials and clinical pilot studies to better understand and treat inflammatory diseases of the skin. I am also interested in quality assurance and improvement studies to better care for our patients, our collogues and ourselves, as well as to target non evidence based overutilization of limited health care resources (such as unneeded lab monitoring). Finally, I am interested in alternative care delivery models, especially in measuring their quality and their impact on patients and physicians.

Current Appointments & Affiliations


Professor of Dermatology · 2023 - Present Dermatology, Clinical Science Departments
Professor in Medicine · 2023 - Present Medicine, Rheumatology and Immunology, Medicine

In the News


Published January 29, 2018
Physicians Overwhelmed by Messaging From Electronic Medical Records
Published August 11, 2017
How Safe and Effective is Your Sunscreen?
Published July 26, 2017
Don’t forget your sunscreen! Tips on keeping yourself safe from UV rays

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Recent Publications


Lymphoproliferative Disorders Mimicking Rheumatologic Disease: A Clinical Reasoning Perspective.

Journal Article Curr Allergy Asthma Rep · September 16, 2025 PURPOSE OF REVIEW: Lymphoproliferative disorders encompass a variety of hematologic diseases that are increasingly recognized. Patients with these conditions may present to rheumatologists or other specialists prior to a hematologist-oncologist. This revie ... Full text Open Access Link to item Cite

Mastocytosis: Part I: Pathogenesis, Clinical Presentation and Classification.

Journal Article J Am Acad Dermatol · June 19, 2025 Mast cells are tissue-resident immune cells which secrete numerous and varied immune mediators in response to a myriad of activation pathways and play an important physiological function in immunity, homeostasis, tissue repair, and nervous system regulatio ... Full text Link to item Cite

Mastocytosis: Part II: Diagnosis and Management of Mastocytosis through a Multidisciplinary Lens.

Journal Article J Am Acad Dermatol · June 19, 2025 Mastocytosis is a heterogeneous disorder marked by mast cell accumulation in various organs, presenting differently in children and adults. Red or brown maculopapular lesions on the skin should raise suspicion for mastocytosis. In children, presentations i ... Full text Link to item Cite
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Recent Grants


ACE Covid 19 Admin. Supplement: Molecular Regulation of B cells and T cells in Human SLE - Cost Reimbursable

Clinical TrialCo Investigator · Awarded by Emory University · 2021 - 2024

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2009 M.D.
University of North Carolina, Chapel Hill · 2007 Ph.D.
University of California, Davis · 1997 B.S.