Scholars@Duke
Matilda Wray Nicholas

Matilda Wray Nicholas

Professor of Dermatology
Dermatology
234 Crooked Creek Parkway Ste 300, Durham, NC 27713

Selected Publications

Image Quality Assessment Using Convolutional Neural Network in Clinical Skin Images.

Journal Article JID Innov · July 2024 The image quality received for clinical evaluation is often suboptimal. The goal is to develop an image quality analysis tool to assess patient- and primary care physician-derived images using deep learning model. Dataset included patient- and primary care ... Full text Link to item Cite

Contraceptive counseling for iPLEDGE and its burden on dermatologists.

Journal Article Arch Dermatol Res · May 28, 2024 Since 2006, iPLEDGE, a risk evaluation and mitigation strategy (REMS), has attempted to prevent fetal exposures in people taking isotretinoin through contraceptive requirements and regular pregnancy testing. There has been criticism of iPLEDGE's requiremen ... Full text Link to item Cite

Topical Prescription Management.

Journal Article Adv Exp Med Biol · 2024 With recent advances in topical therapies for atopic dermatitis (AD), steroid-sparing options like calcineurin inhibitors, Janus kinase (JAK) inhibitors, and phosphodiesterase-4 (PDE-4) inhibitors are becoming mainstays in therapy, underscoring the importa ... Full text Link to item Cite

A practical guide to clinical photography prior to skin biopsy: key tips and proposed workflow.

Journal Article Arch Dermatol Res · November 2023 High-quality clinical photography has become an integral part of dermatology in the context of patient evaluation and monitoring, clinical teaching, and research. Technological advancements in smartphones have allowed dermatologists to incorporate photogra ... Full text Link to item Cite

Implementation evaluation of a teledermatology virtual clinic at an academic medical center.

Journal Article Implement Sci Commun · October 27, 2023 BACKGROUND: Teledermatology (TD) is an evidence-based practice that may increase access to dermatologic care. We sought to use the Exploration, Preparation, Implementation, and Sustainment (EPIS) and the Reach, Efficacy, Adoption, Implementation, and Maint ... Full text Link to item Cite

The Impact of Air Pollution on Atopic Dermatitis.

Journal Article Curr Allergy Asthma Rep · August 2023 PURPOSE OF REVIEW: Atopic dermatitis (AD) remains a dermatological disease that imposes a significant burden on society. Air pollution has previously been linked to both the onset and severity of atopic dermatitis. As air pollution remains a critical envir ... Full text Link to item Cite

Halo Nevi After Covid-19 Vaccination: Molecular Mimicry Attributed Cutaneous Side-Effect?

Journal Article SKIN: Journal of Cutaneous Medicine · July 17, 2023 Covid-19 vaccination is a crucial component of the public health response to reduce the spread of Covid-19. Although well-tolerated, Covid-19 vaccination is associated with several cutaneous adverse reactions. Here, we document a case of a young man who de ... Full text Cite

The Cost Utility of Nonpregnancy Laboratory Monitoring for Persons on Isotretinoin Acne Therapy.

Journal Article JID Innov · May 2023 We sought to project the 1-year cost utility of nonpregnancy laboratory monitoring cessation among patients initiating isotretinoin. We conducted a model-based cost utility analysis comparing (i) current practice (CP) and (ii) cessation of nonpregnancy lab ... Full text Link to item Cite

Implementation Evaluation of a Teledermatology Virtual Clinic at an Academic Medical Center.

Journal Article Res Sq · February 28, 2023 BACKGROUND: Teledermatology (TD) is an evidence-based practice that may increase access to dermatologic care. We sought to evaluate implementation of TD at four Duke primary care practices. METHODS: We implemented a hybrid TD program where trained primary ... Full text Link to item Cite

Unsolicited patient images and burnout in dermatology.

Journal Article Clin Exp Dermatol · February 2, 2023 Full text Link to item Cite

Quality and Perceived Usefulness of Patient-Submitted Store-and-Forward Teledermatology Images.

Journal Article JAMA Dermatol · October 1, 2022 IMPORTANCE: Patient-submitted images vary considerably in quality and usefulness. Studies that characterize patient-submitted images in a real-life setting are lacking. OBJECTIVE: To evaluate the quality and perceived usefulness of patient-submitted images ... Full text Link to item Cite

Innate Immunity in Calcinosis Cutis

Journal Article Immuno · September 1, 2022 Calcinosis cutis is the deposition of calcium salts in the skin and subcutaneous tissue, manifesting as variably shaped papules, nodules, and plaques that can substantially impair quality of life. The pathophysiology of calcinosis cutis involves dysregulat ... Full text Cite

Store-and-Forward Images in Teledermatology: Narrative Literature Review.

Journal Article JMIR Dermatol · 2022 BACKGROUND: Store-and-forward (SAF) teledermatology uses electronically stored information, including patient photographs and demographic information, for clinical decision-making asynchronous to the patient encounter. The integration of SAF teledermatolog ... Full text Open Access Link to item Cite

Game-changer or flop: Teprotumumab may not provide lasting improvement of pretibial myxedema

Conference JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY · 2022 Cite

Early Implementation and Evaluation of a Teledermatology Virtual Clinic Within an Academic Medical Center

Journal Article Iproceedings · December 20, 2021 BackgroundTeledermatology can increase patient access; however, its optimal implementation remains unknown.Obj ... Full text Cite

Early Implementation and Evaluation of a Teledermatology Virtual Clinic Within an Academic Medical Center (Preprint)

Journal Article · December 3, 2021 BACKGROUNDTeledermatology can increase patient access; however, its optimal implementation remains unknown. ... Full text Cite

Cutaneous Lupus Erythematosus: Progress and Challenges.

Journal Article Curr Allergy Asthma Rep · April 4, 2020 PURPOSE OF REVIEW: The review provides an update on the diagnosis, pathogenesis, and treatment of cutaneous lupus erythematosus (CLE). RECENT FINDINGS: Diagnostic challenges exist in better defining CLE as an independent disease distinct from systemic lupu ... Full text Link to item Cite

A case of periostomy intestinal metaplasia without adenomatous or dysplastic changes in an ulcerative colitis patient.

Journal Article Clin Case Rep · March 2020 We strive to educate medical providers of the possibility of cellular transformation occurring as a parastomal complication and to emphasize the importance of close monitoring, as there is a risk, although low, of subsequent malignant transformation. ... Full text Link to item Cite

A comparison of knowledge acquisition and perceived efficacy of a traditional vs flipped classroom-based dermatology residency curriculum.

Journal Article Cutis · January 2020 Flipped and traditional classroom models were compared in the Duke University Medical Center (Durham, North Carolina) dermatology residency program for the 2014-2015 academic year. The residents participated in 12 lectures-6 traditional and 6 flipped-that ... Link to item Cite

Chapter 61: Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood

Chapter · 2019 "Important general basic science concepts are extensively covered in dedicated chapters appearing in an early section of the book, allowing subsequent clinical chapters to focus on relevant disease-specific pathophysiology in addition to ... ... Cite

Skin Disease and Neurological Conditions of the Elderly

Journal Article Current Geriatrics Reports · December 1, 2018 Purpose of Review: Summarize and review the body of literature associating neurological diseases of the elderly with cutaneous disease. Recent Findings: A growing body of evidence supports a close association between Parkinson’s disease and seborrheic derm ... Full text Cite

Prescription Treatment Options.

Chapter · 2017 Atopic dermatitis frequently requires the use of over-the-counter and prescription medications for effective management. Emollients and topical corticosteroids are effective for most patients and are the most commonly utilized agents by experienced dermato ... Full text Link to item Cite

North, south, or east? Blotting techniques.

Journal Article J Invest Dermatol · July 2013 Full text Link to item Cite

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.

Journal Article Clin Immunol · February 2008 We previously reported that some systemic lupus erythematosus (SLE) patients have a population of circulating memory B cells with >2-fold higher levels of CD19. We show here that the presence of CD19(hi) B cells correlates with long-term adverse outcomes. ... Full text Link to item Cite

In vitro pharmacology of clinically used central nervous system-active drugs as inverse H(1) receptor agonists.

Journal Article J Pharmacol Exp Ther · July 2007 The human histamine H(1) receptor (H(1)R) is a prototypical G protein-coupled receptor and an important, well characterized target for the development of antagonists to treat allergic conditions. Many neuropsychiatric drugs are also known to potently antag ... Full text Link to item Cite

Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss.

Journal Article J Clin Immunol · January 2007 : We report here that dysregulation of CD19, a coreceptor that augments B-cell receptor (BCR) signaling, occurs at two B-cell differentiative stages in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic autoantibody (ANCA) asso ... Full text Link to item Cite

EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity.

Journal Article J Immunol · September 1, 2006 EBV is associated with systemic lupus erythematosus (SLE), but how it might contribute to the etiology is not clear. Since EBV-encoded latent membrane protein 2A (LMP2A) interferes with normal B cell differentiation and function, we sought to determine its ... Full text Link to item Cite