Risk of type 2 diabetes and cumulative excess weight exposure in the Framingham Offspring Study.


Journal Article

AIM: Mid-life obesity is associated with T2D risk. However, less is known about the cumulative effect of obesity during adulthood. METHODS: Framingham Offspring Study participants who had an examination at 35±2 years and were initially free of T2D were included in this study (N=1026). A cumulative excess weight (CEW) score (year*kg/m²) was calculated until T2D diagnostic or the end of follow-up. RESULTS: Eighty-four individuals (8.2%) developed T2D over 20±6 years. Mean CEW scores were 118.0±114.6 year*kg/m² in individuals who developed T2D and 30.2±91.4 year*kg/m² in those who did not develop T2D (P<0.01). T2D risk was doubled for each standard deviation increase in the CEW score (OR=1.99 [1.64-2.40]; P<0.001). However, CEW score was only significantly associated with T2D incidence for participants with a baseline BMI <25 kg/m² (OR =2.13 [1.36-3.36]; P<0.001). CONCLUSIONS: Accumulating weight between the mid-thirties to the mid-fifties increases the risk of developing T2D. However, BMI in mid-thirties remains a stronger predictor of T2D risk.

Full Text

Duke Authors

Cited Authors

  • Bouchard, DR; Porneala, B; Janssen, I; Langlois, M-F; Baillargeon, J-P; Fox, CS; Meigs, JB; D'Agostino, RB; Pencina, M; Hivert, M-F

Published Date

  • May 2013

Published In

Volume / Issue

  • 27 / 3

Start / End Page

  • 214 - 218

PubMed ID

  • 23312789

Pubmed Central ID

  • 23312789

Electronic International Standard Serial Number (EISSN)

  • 1873-460X

Digital Object Identifier (DOI)

  • 10.1016/j.jdiacomp.2012.11.009


  • eng

Conference Location

  • United States