Myeloid growth factors.

Journal Article (Journal Article)

Febrile neutropenia, a common side effect of myelosuppressive chemotherapy in patients with cancer, can result in prolonged hospitalization and broad-spectrum antibiotic use, often prompting treatment delays or dose reductions of drug regimens. Prophylactic use of myeloid growth factors (mainly the colony-stimulating factors filgrastim and pegfilgrastim) in patients of heightened risk can reduce the severity and duration of febrile neutropenia. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Myeloid Growth Factors provide recommendations on the use of these agents mainly in the oncology setting based on clinical evidence and expert consensus. This version includes revisions surrounding the issue of timing of pegfilgrastim administration. It also includes new sections on tbo-filgrastim, a recently approved agent that is biologically similar to filgrastim, and the role of myeloid growth factors in the hematopoietic cell transplant setting.

Full Text

Duke Authors

Cited Authors

  • Crawford, J; Armitage, J; Balducci, L; Becker, PS; Blayney, DW; Cataland, SR; Heaney, ML; Hudock, S; Kloth, DD; Kuter, DJ; Lyman, GH; McMahon, B; Rugo, HS; Saad, AA; Schwartzberg, LS; Shayani, S; Steensma, DP; Talbott, M; Vadhan-Raj, S; Westervelt, P; Westmoreland, M; Dwyer, M; Ho, M; National comprehensive cancer network,

Published Date

  • October 1, 2013

Published In

Volume / Issue

  • 11 / 10

Start / End Page

  • 1266 - 1290

PubMed ID

  • 24142827

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2013.0148


  • eng

Conference Location

  • United States