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Gary Herbert Lyman

Adjunct Professor in the Department of Medicine
Medicine, Medical Oncology
Duke Box 2736, 2424 Erwin Road, Durham, NC 27705
2424 Erwin Road, Suite 205, Durham, NC 27705


Dr. Gary Lyman is Professor of Medicine in the Division of Medical Oncology, Department of Internal Medicine at Duke University School of Medicine and the Duke Cancer Institute. He serves as Director of the Comparative Effectiveness and Outcomes Research Program in Oncology. Dr Lyman is also Senior Fellow in the Duke Center for Clinical Health Policy Research. He is a nationally and internationally recognized authority on comparative effectiveness and health services and outcomes research. Lyman research is funded by the National Cancer Institute, the National Heart Lung and Blood Institute, the American Society of Clinical Oncology along with industry grants related to supportive cancer care. Dr Lyman has published some 400 research articles in in the professional medical literature. Direct funding from all sources supports an annual Comparative Effectiveness and Outcomes Research budget of over $5 million.

Dr Lyman’s research interests include:
Personalized Medicine and Cancer Supportive Care: In addition to the conduct of randomized controlled trials of new cancer diagnostic, prognostic, treatment and supportive care approaches, Dr Lyman’s research interests include the personalized management of early-stage breast cancer and supportive care of patients receiving cancer chemotherapy, most notably those at risk for febrile neutropenia and venous thromboembolism. Based on clinical trial results, Dr Lyman is actively involved in the development and validation of clinical risk models for patient selection and targeted intervention and preventive strategies. Dr Lyman is co-PI on an NCI on comparative effectiveness of cancer pharmacogenomics grant to discover and validate new genomic tools for guiding more personalized cancer treatments and on an NHLBI trial of thromboprophylaxis in high risk ambulatory patients receiving cancer chemotherapy.

Evidence synthesis, clinical practice guidelines and health policy: Dr Lyman conducts systematic reviews and meta-analyses of major clinical issues in support of clinical practice guidelines. Dr Lyman chairs several guidelines for the American Society of Clinical Oncology including those on antiemetics, venous thromboembolism, sentinel node biopsy in patients with breast cancer and cutaneous melanoma and on weight based dosing of chemotherapy. Dr Lyman also conducts analyses of large population studies of clinical outcomes associated with of current cancer patient management in a real world setting with a particular focus on cancer management in the elderly patient with cancer. Dr Lyman leads several decision simulation studies for improved clinical decision making and cost-effectiveness analysis of new and novel therapies based on results of clinical trials, systematic reviews and population studies. He serves as an advisor on new oncologic agents to the US FDA. Dr Lyman also serves as Editor-in-Chief of Cancer Investigation and on the editorial boards of several prestigious research journals.

Current Appointments & Affiliations

Adjunct Professor in the Department of Medicine · 2014 - Present Medicine, Medical Oncology, Medicine

Education, Training & Certifications

State University of New York, Buffalo · 1972 M.D.