A survival guide to early T cell development.

Journal Article (Journal Article;Review)

The survival of immature T cell precursors is dependent on both thymus-derived extrinsic signals and self-autonomous pre-TCR-mediated signals. While the role of cytokines and the pre-TCR in promoting thymocyte survival has been well established, the relationship between pro- and anti-apoptotic signaling cascades remains poorly defined. Recent studies have established a link between cell survival and growth factor-mediated maintenance of cellular metabolism. In this regard, the Notch signaling pathway has emerged as more than an inducer of T lineage commitment and differentiation, but also as a potent trophic factor, promoting the survival and metabolic state of pre-T cells. In this review, we describe current concepts of the intracellular signaling pathways downstream of cell intrinsic and extrinsic factors that dictate survival versus death outcomes during early T cell development.

Full Text

Duke Authors

Cited Authors

  • Ciofani, M; Zúñiga-Pflücker, JC

Published Date

  • 2006

Published In

Volume / Issue

  • 34 / 2

Start / End Page

  • 117 - 132

PubMed ID

  • 16760572

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1385/IR:34:2:117


  • eng

Conference Location

  • United States