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Jeffrey Melson Clarke

Associate Professor of Medicine
Medicine, Medical Oncology
Dept of Medicine, BOX_31379 Med Ctr, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor of Medicine · 2023 - Present Medicine, Medical Oncology, Medicine
Member of the Duke Cancer Institute · 2018 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Updated Overall Survival Analysis From the Phase II PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic Non-Small Cell Lung Cancer.

Journal Article J Clin Oncol · December 10, 2025 The phase II PHAROS study previously showed that encorafenib plus binimetinib has antitumor activity in patients with BRAF V600E-mutant metastatic non-small cell lung cancer (mNSCLC). In PHAROS, 98 patients (59 treatment-naïve; 39 previously treated) recei ... Full text Link to item Cite

A Phase II study of GT103 in combination with pembrolizumab in refractory, metastatic non-small cell lung cancer.

Journal Article Cancer · November 1, 2025 BACKGROUND: Treatment options for patients with advanced non-small cell lung cancer (NSCLC) with disease progression following immune checkpoint inhibitor (ICI) and platinum-based chemotherapy are limited. GT103 is a fully human immunoglobulin G3 monoclona ... Full text Link to item Cite

Updated Efficacy and Safety From the Phase 2 PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic NSCLC-A Brief Report.

Journal Article J Thorac Oncol · October 2025 INTRODUCTION: The PHAROS primary analysis revealed robust antitumor activity and acceptable safety with encorafenib plus binimetinib in patients with BRAF V600E-mutant metastatic NSCLC (mNSCLC). We report results after 18 months of additional follow-up. ME ... Full text Link to item Cite
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Education, Training & Certifications


Indiana University, School of Medicine · 2008 M.D.