Jeffrey Melson Clarke
Assistant Professor of Medicine
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2017
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018
Contact Information
- Dept Of Medicine, Box_31379 Med Ctr, Durham, NC 27710
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jeffrey.clarke@duke.edu
(919) 684-8111
- Background
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Education, Training, & Certifications
- Hematology and Medical Oncology Fellowship, Medicine, Duke University School of Medicine 2011 - 2015
- Internal Medicine Chief Resident, Medicine, Duke University School of Medicine 2012 - 2013
- Categorical Internal Medicine Residency, Medicine, Duke University School of Medicine 2008 - 2011
- M.D., Indiana University School of Medicine 2008
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Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2015 - 2017
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2012 - 2013
- Research
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Selected Grants
- TOP 1705 awarded by Bristol-Myers Squibb Company 2018 - 2023
- SPI-POZ-202 awarded by Spectrum Pharmaceuticals, Inc 2017 - 2022
- M15-534 awarded by AbbVie Inc. 2017 - 2022
- Bayer 16044 awarded by Bayer HealthCare AG 2017 - 2021
- A screening protocol to determine tumor antigen expression and HLA sub-type ofr eligibility determination for clinical trials evaluating the safety and efficacy of Autologous T Cell expressing enhance awarded by Adaptimmune Limited 2016 - 2021
- Genentech GO29537 awarded by F. Hoffmann-La Roche Ltd 2015 - 2020
- mRNA-4157-P101 awarded by Moderna Therapeutics, Inc. 2017 - 2019
- Adaptimmune MAGE awarded by Adaptimmune Limited 2018 - 2019
- First-in-human dose escalation of TEW-7197 monotherapy in subjects with advanced stage solid tumors awarded by MedPacto, Inc 2014 - 2019
- Identification of Genetic Determinates for Disparities in African American Patients with Non-Small Cell Lung Cancer awarded by V Foundation for Cancer Research 2016 - 2018
- A phase Ib study of combination Regorafenib with PF-03446962 in patient with refactory metastatic colorectal cancer or G awarded by Pfizer, Inc. 2013 - 2018
- Evaluation of Tumor Infiltrating Lymphocytes in Resected Non Small Cell Lung Cancer awarded by Lung Cancer Initiative of North Carolina 2015 - 2018
- Lilly H9H-MC-JBEF awarded by Eli Lilly and Company 2016 - 2018
- Blood-based Biomarker Profiling for TEW-7197 awarded by MedPacto, Inc 2016 - 2018
- Publications & Artistic Works
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Selected Publications
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Journal Articles
- Clarke, JM, George, DJ, Lisi, S, and Salama, AKS. "Immune Checkpoint Blockade: The New Frontier in Cancer Treatment." Targeted oncology 13, no. 1 (February 13, 2018): 1-20. Full Text
- Yi, JS, Ready, N, Healy, P, Dumbauld, C, Osborne, R, Berry, M, Shoemaker, D, Clarke, J, Crawford, J, Tong, B, Harpole, D, D'Amico, TA, McSherry, F, Dunphy, F, McCall, SJ, Christensen, JD, Wang, X, and Weinhold, KJ. "Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 24 (December 2017): 7474-7482. Full Text
- Bedoya, A, Glisinski, K, Clarke, J, Lind, RN, Buckley, CE, and Shofer, S. "Systemic Bevacizumab for Recurrent Respiratory Papillomatosis: A Single Center Experience of Two Cases." The American Journal of Case Reports 18 (July 31, 2017): 842-846. Full Text
- Clarke, JM, Wang, X, and Ready, NE. "Surrogate clinical endpoints to predict overall survival in non-small cell lung cancer trials-are we in a new era?." Translational lung cancer research 4, no. 6 (December 2015): 804-808. Full Text
- Hatch, AJ, Clarke, JM, Nixon, AB, and Hurwitz, HI. "Identifying Blood-Based Protein Biomarkers for Antiangiogenic Agents in the Clinic: A Decade of Progress." Cancer journal (Sudbury, Mass.) 21, no. 4 (July 2015): 322-326. (Review) Full Text
- Lyman, GH, Bohlke, K, Khorana, AA, Kuderer, NM, Lee, AY, Arcelus, JI, Balaban, EP, Clarke, JM, Flowers, CR, Francis, CW, Gates, LE, Kakkar, AK, Key, NS, Levine, MN, Liebman, HA, Tempero, MA, Wong, SL, Somerfield, MR, Falanga, A, and American Society of Clinical Oncology, . "Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 33, no. 6 (February 2015): 654-656. Full Text
- Clarke, JM, Hurwitz, HI, and Rangwala, F. "Understanding the mechanisms of action of antiangiogenic agents in metastatic colorectal cancer: a clinician's perspective." Cancer treatment reviews 40, no. 9 (October 2014): 1065-1072. (Review) Full Text
- Clarke, JM, Hurwitz, HI, and Rangwala, F. "Understanding the mechanisms of action of antiangiogenic agents in metastatic colorectal cancer: A clinician's perspective." Cancer Treatment Reviews 40, no. 9 (2014): 1065-1072. Full Text
- Clarke, JM, and Hurwitz, HI. "Understanding and targeting resistance to anti-angiogenic therapies." J Gastrointest Oncol 4, no. 3 (September 2013): 253-263. Full Text Link to Item
- Clarke, JM, and Hurwitz, HI. "Targeted inhibition of VEGF receptor 2: an update on ramucirumab." Expert Opinion on Biological Therapy 13, no. 8 (August 2013): 1187-1196. (Review) Full Text
- Lyman, GH, Khorana, AA, Kuderer, NM, Lee, AY, Arcelus, JI, Balaban, EP, Clarke, JM, Flowers, CR, Francis, CW, Gates, LE, Kakkar, AK, Key, NS, Levine, MN, Liebman, HA, Tempero, MA, Wong, SL, Prestrud, AA, Falanga, A, and American Society of Clinical Oncology Clinical Practice, . "Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 31, no. 17 (June 2013): 2189-2204. (Review) Full Text
- Clarke, JM, and Armstrong, AJ. "Novel therapies for the treatment of advanced prostate cancer." Curr Treat Options Oncol 14, no. 1 (March 2013): 109-126. (Review) Full Text Link to Item
- Mis, L, and Clarke, JM. "Ipilimumab-Induced Pneumonitis: A Case Report." Journal of Pharmacy Technology 29, no. 2 (March 2013): 94-98. Full Text
- Clarke, JM, and Hurwitz, HI. "Ziv-aflibercept: binding to more than VEGF-A--does more matter?." Nature Reviews. Clinical Oncology 10, no. 1 (January 2013): 10-11. Full Text
- Clarke, JM, Morse, MA, Lyerly, HK, Clay, T, and Osada, T. "Adenovirus vaccine immunotherapy targeting WT1-expressing tumors." Expert Opin Biol Ther 10, no. 6 (June 2010): 875-883. (Review) Full Text Link to Item
- Clarke, JM, and Helft, P. "Long-term survival of a woman with well differentiated papillary mesothelioma of the peritoneum: A case report and review of the literature." Journal of Medical Case Reports 4 (2010). Full Text
- Struck, A, Howard, T, Chiorean, EG, Clarke, JM, Riffenburgh, R, and Cardenes, HR. "Non-ampullary duodenal adenocarcinoma: factors important for relapse and survival." Journal of Surgical Oncology 100, no. 2 (August 2009): 144-148. Full Text
- Struck, A, Howard, T, Chiorean, EG, Clarke, JM, Riffenburgh, R, and Cardenes, HR. "Non-ampullary duodenal adenocarcinoma: Factors important for relapse and survival (Journal of Surgical Oncology (2009) 100, 2, (144-148))." Journal of Surgical Oncology 100, no. 5 (2009): 434--. Full Text
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