Lee Zou

Journal Article Nat Cell Biol · June 2025 DNA double-strand breaks (DSB) are among the most deleterious forms of DNA damage and, if unresolved, result in DNA mutations and chromosomal aberrations that can cause disease, including cancer. Repair of DSBs by homologous recombination requires extensiv ... Full text Link to item Cite

Gap resection matters in BRCA mutant cancer.

Journal Article Genes Dev · May 2, 2025 Cancer cells deficient in BRCA1/2 have impaired DNA repair, making them sensitive to PARP inhibitors (PARPis). In this issue of Genes & Development, Seppa and colleagues (doi:10.1101/gad.352421.124) investigated how BRCA1 protects single-stranded DNA gaps ... Full text Link to item Cite

A Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors.

Journal Article Clin Cancer Res · January 6, 2025 PURPOSE: Preclinical studies have identified molecular correlates of sensitivity to ATR inhibition. This translational study was designed to test the ATR inhibitor berzosertib in patients with advanced solid tumors carrying alterations in ATRX, ataxia-tela ... Full text Link to item Cite

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Education, Training & Certifications

Stony Brook University · 1999 Ph.D.

Lee Zou

Current Appointments & Affiliations

In the News

Recent Publications

ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome.

Gap resection matters in BRCA mutant cancer.

A Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors.

Recent Grants

Pharmacological Sciences Training Program

Mechanisms of replication fork protection and recovery

Mechanisms of APOBEC3A-induced cancer evolution and cancer vulnerability

Education, Training & Certifications