Overview
Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.
Current Appointments & Affiliations
Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Professor in Pathology
·
2024 - Present
Pathology,
Clinical Science Departments
Recent Publications
Public Health
Journal Article Alzheimer S Dementia the Journal of the Alzheimer S Association · December 1, 2025 BACKGROUND: Clinical and research experts often struggle to access and fully utilize the large amount of health parameters and biomarkers available in research and clinical databases. Moreover, the data analyzed by researchers frequently represent static s ... Full text CiteBasic Science and Pathogenesis
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Patients with Alzheimer's Disease (AD) frequently manifest comorbid neuropsychiatric symptoms (NPS) with depression and anxiety being most prevalent. Previously we identified shared genetic risk loci between AD and major depressive disorder (MD ... Full text CiteSingle-nucleus multi-omics of Parkinson's disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks.
Journal Article Acta Neuropathol Commun · July 2, 2024 The genetic architecture of Parkinson's disease (PD) is complex and multiple brain cell subtypes are involved in the neuropathological progression of the disease. Here we aimed to advance our understanding of PD genetic complexity at a cell subtype precisi ... Full text Open Access Link to item CiteRecent Grants
A spatially resolved joint cortical metabolome and proteome in aging and menopause for the rhesus macaque
ResearchCo Investigator · Awarded by National Institute on Aging · 2022 - 2027CSF Proteomic Studies of APOE4 copy number-dependent effects on the Complement Pathway
ResearchCo Investigator · Awarded by National Institute on Aging · 2022 - 2027Hypoperfusion, Hemodynamic Control Domains and Neurovascular Dysregulation in AD brain pathology
ResearchCo Investigator · Awarded by National Institute on Aging · 2023 - 2027View All Grants
Education, Training & Certifications
Duke University ·
1986
Ph.D.