Michael William Lutz | Scholars@Duke

Michael William Lutz
Assistant Professor of Neurology

Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.

Current Appointments & Affiliations

Assistant Professor of Neurology, Neurology, Clinical Science Departments 2014

Contact Information

311 Research Drive, Room 201-D, Durham, NC 27710
Box 2900, Durham, NC 27710
michael.lutz@duke.edu (919) 660-7621

Background
Education, Training, & Certifications
- Ph.D., Duke University 1986
Research
Selected Grants
- Brain networks in mouse models of aging awarded by National Institutes of Health 2019 - 2024
- Sex and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2019 - 2024
- Deciphering the regulation of gene expression in the etiology of LOAD awarded by National Institutes of Health 2017 - 2022
- Integrative modeling and dynamic prediction of Alzheimer's disease awarded by National Institutes of Health 2019 - 2020
- Shared genetic, epigenetic, and transcriptomic profiles between AD and PTSD: molecular insights into the heterogeneity of neuropsychiatric symptoms in Alzheimers Disease awarded by National Institutes of Health 2018 - 2020
- Alzheimer's Disease, Genes, and Pesticide Use in the Agricultural Health Study awarded by National Institutes of Health 2014 - 2020
- Role of the TOMM40 poly-T variant in the pathogenesis of Alzheimer's disease awarded by National Institutes of Health 2013 - 2020
- Lewy body neuropathologies and SNCA gene: variants expression and splicing awarded by National Institutes of Health 2013 - 2019
- Sex and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2017 - 2019
- Genes, environments, interactions, and cognitive decline in the HRS awarded by Wake Forest University 2015 - 2018
- Genes, environments, interactions, and cognitive decline in the HRS awarded by National Institutes of Health 2014 - 2015
- Genetic Factors that Impact the Risk of Alzheimer's Disease awarded by National Institutes of Health 2009 - 2012
Industry Relationships
- Zinfandel Pharmaceuticals
Publications & Artistic Works
Selected Publications
- Books
  - Lutz, Michael, and Terry Kenakin. Quantitative Molecular Pharmacology and Informatics in Drug Discovery. John Wiley & Sons, 1999.
- Academic Articles
  - Lutz, Michael W., Daniel Sprague, and Ornit Chiba-Falek. “Bioinformatics strategy to advance the interpretation of Alzheimer's disease GWAS discoveries: The roads from association to causation..” Alzheimers Dement 15, no. 8 (August 2019): 1048–58. https://doi.org/10.1016/j.jalz.2019.04.014.
    Full Text Link to Item
  - Lutz, Michael W., Ramon Casanova, Santiago Saldana, Maragatha Kuchibhatla, Brenda L. Plassman, and Kathleen M. Hayden. “Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study..” Neurobiol Aging 80 (August 2019): 173–86. https://doi.org/10.1016/j.neurobiolaging.2018.10.028.
    Full Text Link to Item
  - Kuchibhatla, Maragatha, Jaimie C. Hunter, Brenda L. Plassman, Michael W. Lutz, Ramon Casanova, Santiago Saldana, and Kathleen M. Hayden. “The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS)..” Aging Ment Health, April 25, 2019, 1–8. https://doi.org/10.1080/13607863.2019.1594169.
    Full Text Link to Item
  - Tang, Yi, Michael W. Lutz, and Yi Xing. “A systems-based model of Alzheimer's disease..” Alzheimers Dement 15, no. 1 (January 2019): 168–71. https://doi.org/10.1016/j.jalz.2018.06.3058.
    Full Text Link to Item
  - Zeng, Yi, Chao Nie, Junxia Min, Huashuai Chen, Xiaomin Liu, Rui Ye, Zhihua Chen, et al. “Sex Differences in Genetic Associations With Longevity..” Jama Netw Open 1, no. 4 (August 2018). https://doi.org/10.1001/jamanetworkopen.2018.1670.
    Full Text Link to Item
  - Zhao, Xin, Xiaomin Liu, Aiping Zhang, Huashuai Chen, Qing Huo, Weiyang Li, Rui Ye, et al. “The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese..” Aging (Albany Ny) 10, no. 6 (June 5, 2018): 1206–22. https://doi.org/10.18632/aging.101461.
    Full Text Link to Item
  - Khachaturian, Ara S., Kathleen M. Hayden, Michelle M. Mielke, Yi Tang, Michael W. Lutz, Michael Gold, Walter A. Kukull, et al. “New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia..” Alzheimers Dement 14, no. 6 (June 2018): 703–6. https://doi.org/10.1016/j.jalz.2018.05.002.
    Full Text Link to Item
  - Chiba-Falek, Ornit, William K. Gottschalk, and Michael W. Lutz. “The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes..” Alzheimers Dement 14, no. 5 (May 2018): 692–98. https://doi.org/10.1016/j.jalz.2018.01.015.
    Full Text Link to Item
  - Li, Kan, Richard O’Brien, Michael Lutz, Sheng Luo, and Sheng Alzheimer’s Disease Neuroimaging Initiative. “A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data..” Alzheimers Dement 14, no. 5 (May 2018): 644–51. https://doi.org/10.1016/j.jalz.2017.11.004.
    Full Text Open Access Copy Link to Item
  - Hunter, Jaimie C., Elizabeth P. Handing, Ramon Casanova, Maragatha Kuchibhatla, Michael W. Lutz, Santiago Saldana, Brenda L. Plassman, and Kathleen M. Hayden. “Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?.” Alzheimers Dement 14, no. 4 (April 2018): 454–61. https://doi.org/10.1016/j.jalz.2017.10.007.
    Full Text Link to Item
  - Khachaturian, Ara S., Kathleen M. Hayden, Michelle M. Mielke, Yi Tang, Michael W. Lutz, Deborah R. Gustafson, Walter A. Kukull, Richard Mohs, and Zaven S. Khachaturian. “Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework..” Alzheimers Dement 14, no. 4 (April 2018): 532–34. https://doi.org/10.1016/j.jalz.2018.03.003.
    Full Text Link to Item
  - Yu, Lei, Michael W. Lutz, Jose M. Farfel, Robert S. Wilson, Daniel K. Burns, Ann M. Saunders, Philip L. De Jager, Lisa L. Barnes, Julie A. Schneider, and David A. Bennett. “Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline..” Alzheimers Dement 13, no. 12 (December 2017): 1380–88. https://doi.org/10.1016/j.jalz.2017.05.002.
    Full Text Link to Item
  - Nishimura, Akira, Hidenori Nonomura, Shingo Tanaka, Michihiro Yoshida, Yuka Maruyama, Yutaka Aritomi, Ann M. Saunders, et al. “Characterization of APOE and TOMM40 allele frequencies in the Japanese population..” Alzheimers Dement (N Y) 3, no. 4 (November 2017): 524–30. https://doi.org/10.1016/j.trci.2017.07.003.
    Full Text Link to Item
  - Tagliafierro, Lidia, Omolara-Chinue Glenn, Madison E. Zamora, Thomas G. Beach, Randy L. Woltjer, Michael W. Lutz, and Ornit Chiba-Falek. “Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies..” Alzheimers Dement 13, no. 11 (November 2017): 1237–50. https://doi.org/10.1016/j.jalz.2017.03.001.
    Full Text Link to Item
  - Willette, Auriel A., Joseph L. Webb, Michael W. Lutz, Barbara B. Bendlin, Alexandra M. Wennberg, Jennifer M. Oh, Allen Roses, et al. “Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts..” Alzheimers Dement 13, no. 11 (November 2017): 1217–25. https://doi.org/10.1016/j.jalz.2017.03.009.
    Full Text Link to Item
  - Larsen, Peter A., Michael W. Lutz, Kelsie E. Hunnicutt, Mirta Mihovilovic, Ann M. Saunders, Anne D. Yoder, and Allen D. Roses. “The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease..” Alzheimers Dement 13, no. 7 (July 2017): 828–38. https://doi.org/10.1016/j.jalz.2017.01.017.
    Full Text Open Access Copy Link to Item
  - Yu, Lei, Michael W. Lutz, Robert S. Wilson, Daniel K. Burns, Allen D. Roses, Ann M. Saunders, Chris Gaiteri, Philip L. De Jager, Lisa L. Barnes, and David A. Bennett. “TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype..” Neurology 88, no. 7 (February 14, 2017): 661–68. https://doi.org/10.1212/WNL.0000000000003614.
    Full Text Link to Item
  - Chiba-Falek, Ornit, and Michael W. Lutz. “Towards precision medicine in Alzheimer's disease: deciphering genetic data to establish informative biomarkers..” Expert Rev Precis Med Drug Dev 2, no. 1 (2017): 47–55. https://doi.org/10.1080/23808993.2017.1286227.
    Full Text Link to Item
  - Yu, Lei, Michael W. Lutz, Robert S. Wilson, Daniel K. Burns, Allen D. Roses, Ann M. Saunders, Jingyun Yang, et al. “APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans..” Plos One 12, no. 7 (2017). https://doi.org/10.1371/journal.pone.0180356.
    Full Text Link to Item
  - Saul, Robert, Michael W. Lutz, Daniel K. Burns, Allen D. Roses, and Ornit Chiba-Falek. “The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants..” Hum Mutat 37, no. 9 (September 2016): 877–83. https://doi.org/10.1002/humu.23023.
    Full Text Link to Item
  - Wennberg, Alexandra M. V., Adam P. Spira, Corinne Pettigrew, Anja Soldan, Vadim Zipunnikov, George W. Rebok, Allen D. Roses, et al. “Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults..” J Neurol Sci 365 (June 15, 2016): 89–95. https://doi.org/10.1016/j.jns.2016.04.017.
    Full Text Link to Item
  - Roses, Allen, Scott Sundseth, Ann Saunders, William Gottschalk, Dan Burns, and Michael Lutz. “Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease..” Alzheimers Dement 12, no. 6 (June 2016): 687–94. https://doi.org/10.1016/j.jalz.2016.03.015.
    Full Text Link to Item
  - Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Chao Nie, Xiaomin Liu, Lei Feng, et al. “Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages..” Rejuvenation Res 19, no. 3 (June 2016): 195–203. https://doi.org/10.1089/rej.2015.1737.
    Full Text Open Access Copy Link to Item
  - Lutz, Michael W., Donna Crenshaw, Kathleen A. Welsh-Bohmer, Daniel K. Burns, and Allen D. Roses. “New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics..” Curr Neurol Neurosci Rep 16, no. 5 (May 2016). https://doi.org/10.1007/s11910-016-0643-8.
    Full Text Link to Item
  - Zeng, Yi, Chao Nie, Junxia Min, Xiaomin Liu, Mengmeng Li, Huashuai Chen, Hanshi Xu, et al. “Novel loci and pathways significantly associated with longevity..” Sci Rep 6 (February 25, 2016). https://doi.org/10.1038/srep21243.
    Full Text Open Access Copy Link to Item
  - Lutz, Michael W., Scott S. Sundseth, Daniel K. Burns, Ann M. Saunders, Kathleen M. Hayden, James R. Burke, Kathleen A. Welsh-Bohmer, and Allen D. Roses. “A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease..” Alzheimers Dement (N Y) 2, no. 1 (January 1, 2016): 30–44. https://doi.org/10.1016/j.trci.2015.12.002.
    Full Text Link to Item
  - Roses, Allen D., P Anthony Akkari, Ornit Chiba-Falek, Michael W. Lutz, William Kirby Gottschalk, Ann Marie Saunders, Bob Saul, Scott Sundseth, and Daniel Burns. “Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing..” Expert Opin Drug Metab Toxicol 12, no. 2 (2016): 135–47. https://doi.org/10.1517/17425255.2016.1133586.
    Full Text Link to Item
  - Lyall, Donald M., Susana Muñoz Maniega, Sarah E. Harris, Mark E. Bastin, Catherine Murray, Michael W. Lutz, Ann M. Saunders, et al. “APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds..” Int J Stroke 10, no. 8 (December 2015): 1297–1300. https://doi.org/10.1111/ijs.12615.
    Full Text Link to Item
  - Lutz, Michael W., Robert Saul, Colton Linnertz, Omolara-Chinue Glenn, Allen D. Roses, and Ornit Chiba-Falek. “A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression..” Alzheimers Dement 11, no. 10 (October 2015): 1133–43. https://doi.org/10.1016/j.jalz.2015.05.011.
    Full Text Link to Item
  - Hayden, Kathleen M., Michael W. Lutz, Maragatha Kuchibhatla, Cassandra Germain, and Brenda L. Plassman. “Effect of APOE and CD33 on Cognitive Decline..” Plos One 10, no. 6 (2015). https://doi.org/10.1371/journal.pone.0130419.
    Full Text Link to Item
  - Hayden, Kathleen M., Michael W. Lutz, Maragatha Kuchibhatla, Cassandra Germain, and Brenda L. Plassman. “Correction: Effect of APOE and CD33 on Cognitive Decline..” Plos One 10, no. 7 (2015). https://doi.org/10.1371/journal.pone.0134887.
    Full Text Link to Item
  - Gottschalk, William K., Michael W. Lutz, Yu Ting He, Ann M. Saunders, Daniel K. Burns, Allen D. Roses, and Ornit Chiba-Falek. “The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging..” J Parkinsons Dis Alzheimers Dis 1, no. 1 (November 2014). https://doi.org/10.13188/2376-922X.1000003.
    Full Text Link to Item
  - Roses, Allen D., Michael W. Lutz, Ann M. Saunders, Dmitry Goldgaber, Robert Saul, Scott S. Sundseth, P Anthony Akkari, et al. “African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles..” Alzheimers Dement 10, no. 6 (November 2014): 592-601.e2. https://doi.org/10.1016/j.jalz.2014.06.009.
    Full Text Link to Item
  - Lyall, D. M., S. E. Harris, M. E. Bastin, S. Muñoz Maniega, C. Murray, M. W. Lutz, A. M. Saunders, et al. “Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?.” Transl Psychiatry 4 (September 23, 2014). https://doi.org/10.1038/tp.2014.89.
    Full Text Link to Item
  - Linnertz, Colton, Michael W. Lutz, John F. Ervin, Jawara Allen, Natalie R. Miller, Kathleen A. Welsh-Bohmer, Allen D. Roses, and Ornit Chiba-Falek. “The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease..” Hum Mol Genet 23, no. 18 (September 15, 2014): 4814–21. https://doi.org/10.1093/hmg/ddu196.
    Full Text Link to Item
  - Greenbaum, Lior, Ramit Ravona Springer, Michael W. Lutz, Anthony Heymann, Irit Lubitz, Itzik Cooper, Efrat Kravitz, et al. “The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes..” Eur Neuropsychopharmacol 24, no. 9 (September 2014): 1492–99. https://doi.org/10.1016/j.euroneuro.2014.06.002.
    Full Text Link to Item
  - Linnertz, Colton, Lauren Anderson, William Gottschalk, Donna Crenshaw, Michael W. Lutz, Jawara Allen, Sunita Saith, et al. “The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes..” Alzheimers Dement 10, no. 5 (September 2014): 541–51. https://doi.org/10.1016/j.jalz.2013.08.280.
    Full Text Link to Item
  - Lyall, Donald M., Sarah E. Harris, Mark E. Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W. Lutz, Ann M. Saunders, et al. “Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936..” Neurobiol Aging 35, no. 6 (June 2014): 1513.e25-1513.e33. https://doi.org/10.1016/j.neurobiolaging.2014.01.006.
    Full Text Link to Item
  - Roses, Allen D., Ann M. Saunders, Michael W. Lutz, Nanyin Zhang, Ahmad R. Hariri, Karen E. Asin, Donna G. Crenshaw, Kumar Budur, Daniel K. Burns, and Stephen K. Brannan. “New applications of disease genetics and pharmacogenetics to drug development..” Current Opinion in Pharmacology 14 (February 2014): 81–89. https://doi.org/10.1016/j.coph.2013.12.002.
    Full Text
  - Davies, G., S. E. Harris, C. A. Reynolds, A. Payton, H. M. Knight, D. C. Liewald, L. M. Lopez, et al. “A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing..” Mol Psychiatry 19, no. 1 (January 2014): 76–87. https://doi.org/10.1038/mp.2012.159.
    Full Text Link to Item
  - Lyall, D. M., S. E. Harris, M. E. Bastin, S. Muñoz Maniega, C. Murray, M. W. Lutz, A. M. Saunders, et al. “Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.” Neurobiology of Aging 35, no. 6 (2014): 1513e25–33.
  - Mastaglia, F. L., A. Rojana-udomsart, I. James, M. Needham, T. J. Day, L. Kiers, J. A. Corbett, et al. “Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms..” Neuromuscul Disord 23, no. 12 (December 2013): 969–74. https://doi.org/10.1016/j.nmd.2013.09.008.
    Full Text Link to Item
  - Roses, Allen D., Michael W. Lutz, Donna G. Crenshaw, Iris Grossman, Ann M. Saunders, and W Kirby Gottschalk. “TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial..” Alzheimers Dement 9, no. 2 (March 2013): 132–36. https://doi.org/10.1016/j.jalz.2012.10.009.
    Full Text Link to Item
  - Crenshaw, D. G., W. K. Gottschalk, M. W. Lutz, I. Grossman, A. M. Saunders, J. R. Burke, K. A. Welsh-Bohmer, S. K. Brannan, D. K. Burns, and A. D. Roses. “Using genetics to enable studies on the prevention of Alzheimer's disease..” Clin Pharmacol Ther 93, no. 2 (February 2013): 177–85. https://doi.org/10.1038/clpt.2012.222.
    Full Text Link to Item
  - Lyall, Donald M., Natalie A. Royle, Sarah E. Harris, Mark E. Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W. Lutz, et al. “Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936..” Plos One 8, no. 11 (2013). https://doi.org/10.1371/journal.pone.0080513.
    Full Text Link to Item
  - Caselli, Richard J., Amylou C. Dueck, Matthew J. Huentelman, Michael W. Lutz, Ann M. Saunders, Eric M. Reiman, and Allen D. Roses. “Longitudinal modeling of cognitive aging and the TOMM40 effect..” Alzheimers Dement 8, no. 6 (November 2012): 490–95. https://doi.org/10.1016/j.jalz.2011.11.006.
    Full Text Link to Item
  - Hayden, Kathleen M., Jill M. McEvoy, Colton Linnertz, Deborah Attix, Maragatha Kuchibhatla, Ann M. Saunders, Michael W. Lutz, Kathleen A. Welsh-Bohmer, Allen D. Roses, and Ornit Chiba-Falek. “A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging..” Alzheimers Dement 8, no. 5 (September 2012): 381–88. https://doi.org/10.1016/j.jalz.2011.10.005.
    Full Text Link to Item
  - Bruno, Davide, Nunzio Pomara, Jay Nierenberg, James C. Ritchie, Michael W. Lutz, Henrik Zetterberg, and Kaj Blennow. “Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants..” Exp Gerontol 47, no. 5 (May 2012): 347–52. https://doi.org/10.1016/j.exger.2011.09.008.
    Full Text Link to Item
  - Bruno, Davide, Jay J. Nierenberg, James C. Ritchie, Michael W. Lutz, and Nunzio Pomara. “Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants..” Psychoneuroendocrinology 37, no. 3 (March 2012): 366–71. https://doi.org/10.1016/j.psyneuen.2011.07.006.
    Full Text Link to Item
  - Linnertz, Colton, Ann M. Saunders, Michael W. Lutz, Donna M. Crenshaw, Iris Grossman, Daniel K. Burns, Keith E. Whitfield, et al. “Characterization of the poly-T variant in the TOMM40 gene in diverse populations..” Plos One 7, no. 2 (2012). https://doi.org/10.1371/journal.pone.0030994.
    Full Text Link to Item
  - Pomara, Nunzio, Davide Bruno, John J. Sidtis, Michael W. Lutz, David J. Greenblatt, Ann M. Saunders, and Allen D. Roses. “Translocase of outer mitochondrial membrane 40 homolog (TOMM40) poly-T length modulates lorazepam-related cognitive toxicity in healthy APOE ε4-negative elderly..” J Clin Psychopharmacol 31, no. 4 (August 2011): 544–46. https://doi.org/10.1097/JCP.0b013e318222810e.
    Full Text Link to Item
  - Johnson, Sterling C., Asenath La Rue, Bruce P. Hermann, Guofan Xu, Rebecca L. Koscik, Erin M. Jonaitis, Barbara B. Bendlin, et al. “The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype..” Alzheimers Dement 7, no. 4 (July 2011): 456–65. https://doi.org/10.1016/j.jalz.2010.11.012.
    Full Text Link to Item
  - Lutz, Michael W., Donna G. Crenshaw, Ann M. Saunders, and Allen D. Roses. “The importance of being connected..” J Alzheimers Dis 24, no. 2 (2011): 247–51. https://doi.org/10.3233/JAD-2010-101765.
    Full Text Link to Item
  - Roses, A. D., M. W. Lutz, H. Amrine-Madsen, A. M. Saunders, D. G. Crenshaw, S. S. Sundseth, M. J. Huentelman, K. A. Welsh-Bohmer, and E. M. Reiman. “A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease..” Pharmacogenomics J 10, no. 5 (October 2010): 375–84. https://doi.org/10.1038/tpj.2009.69.
    Full Text Link to Item
  - Grossman, Iris, Michael W. Lutz, Donna G. Crenshaw, Ann M. Saunders, Daniel K. Burns, and Allen D. Roses. “Alzheimer's disease: diagnostics, prognostics and the road to prevention..” Epma J 1, no. 2 (June 2010): 293–303. https://doi.org/10.1007/s13167-010-0024-3.
    Full Text Link to Item
  - Lutz, Michael W., Donna G. Crenshaw, Ann M. Saunders, and Allen D. Roses. “Genetic variation at a single locus and age of onset for Alzheimer's disease..” Alzheimers Dement 6, no. 2 (March 2010): 125–31. https://doi.org/10.1016/j.jalz.2010.01.011.
    Full Text Link to Item
  - Lutz, M. W., P. V. Warren, R. W. Gill, and D. B. Searls. “Managing genomic and proteomic knowledge.” Drug Discovery Today: Technologies 2, no. 3 (November 3, 2005): 197–204. https://doi.org/10.1016/j.ddtec.2005.08.001.
    Full Text
  - Selleseth, Dean W., Christine L. Talarico, Teresa Miller, Michael W. Lutz, Karen K. Biron, and Robert J. Harvey. “Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication..” Antimicrob Agents Chemother 47, no. 4 (April 2003): 1468–71. https://doi.org/10.1128/aac.47.4.1468-1471.2003.
    Full Text Link to Item
  - Lopez, Vincent A., Eric J. Bourne, Michael W. Lutz, and Lynn D. Condreay. “Assessment of the COBAS Amplicor HBV Monitor Test for quantitation of serum hepatitis B virus DNA levels..” J Clin Microbiol 40, no. 6 (June 2002): 1972–76. https://doi.org/10.1128/jcm.40.6.1972-1976.2002.
    Full Text Link to Item
  - Gauthier, J., E. J. Bourne, M. W. Lutz, L. M. Crowther, J. L. Dienstag, N. A. Brown, and L. D. Condreay. “Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine..” J Infect Dis 180, no. 6 (December 1999): 1757–62. https://doi.org/10.1086/315147.
    Full Text Link to Item
  - Allen, M. I., J. Gauthier, M. DesLauriers, E. J. Bourne, K. M. Carrick, F. Baldanti, L. L. Ross, M. W. Lutz, and L. D. Condreay. “Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine..” J Clin Microbiol 37, no. 10 (October 1999): 3338–47.
    Link to Item
  - Lutz, M. W., P. H. Morgan, T. P. Kenakin, A. Goetz, K. Queen, P. Irving, D. Rose, J. M. Gill, and T. Rimele. “A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle..” J Pharmacol Toxicol Methods 36, no. 3 (November 1996): 171–83.
    Link to Item
  - Weiss, J. M., P. H. Morgan, M. W. Lutz, and T. P. Kenakin. “The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy..” J Theor Biol 181, no. 4 (August 21, 1996): 381–97. https://doi.org/10.1006/jtbi.1996.0139.
    Full Text Link to Item
  - Saussy, D. L., A. S. Goetz, K. L. Queen, H. K. King, M. W. Lutz, and T. J. Rimele. “Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype..” J Pharmacol Exp Ther 278, no. 1 (July 1996): 136–44.
    Link to Item
  - Weiss, J. M., P. H. Morgan, M. W. Lutz, and T. P. Kenakin. “The cubic ternary complex receptor-occupancy model II. Understanding apparent affinity.” Journal of Theoretical Biology 178, no. 2 (January 21, 1996): 169–82. https://doi.org/10.1006/jtbi.1996.0015.
    Full Text
  - Weiss, J. M., P. H. Morgan, M. W. Lutz, and T. P. Kenakin. “The cubic ternary complex receptor-occupancy model I. Model description.” Journal of Theoretical Biology 178, no. 2 (January 21, 1996): 151–67. https://doi.org/10.1006/jtbi.1996.0014.
    Full Text
  - Lutz, M. W., J. A. Menius, T. D. Choi, R. G. Laskody, P. L. Domanico, A. S. Goetz, and D. L. Saussy. “Experimental design for high-throughput screening.” Drug Discovery Today 1, no. 7 (January 1, 1996): 277–86. https://doi.org/10.1016/1359-6446(96)10025-8.
    Full Text
  - Lutz, M. W., T. P. Kenakin, M. Corsi, J. A. Menius, C. Krishnamoorthy, T. Rimele, and P. H. Morgan. “Use of resampling techniques to estimate the variance of parameters in pharmacological assays when experimental protocols preclude independent replication: an example using Schild regressions..” J Pharmacol Toxicol Methods 34, no. 1 (September 1995): 37–46.
    Link to Item
  - Kenakin, T., P. Morgan, and M. Lutz. “On the importance of the "antagonist assumption" to how receptors express themselves..” Biochem Pharmacol 50, no. 1 (June 29, 1995): 17–26. https://doi.org/10.1016/0006-2952(95)00137-o.
    Full Text Link to Item
  - Goetz, A. S., M. W. Lutz, T. J. Rimele, and D. L. Saussy. “Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes..” J Pharmacol Exp Ther 271, no. 3 (December 1994): 1228–33.
    Link to Item
  - Lutz, M. W., P. H. Morgan, M. K. James, P. L. Feldman, M. F. Brackeen, A. P. Lahey, S. V. James, J. M. Bilotta, and J. C. Pressley. “A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics..” J Pharmacol Exp Ther 271, no. 2 (November 1994): 795–803.
    Link to Item
  - Feldman, P. L., M. K. James, M. F. Brackeen, J. M. Bilotta, S. V. Schuster, A. P. Lahey, M. W. Lutz, M. R. Johnson, and H. J. Leighton. “Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics..” J Med Chem 34, no. 7 (July 1991): 2202–8. https://doi.org/10.1021/jm00111a041.
    Full Text Link to Item
  - Kenakin, T., P. H. Morgan, and M. Lutz. “Drug and tissue factors both confound KA measurements..” Trends Pharmacol Sci 11, no. 7 (July 1990): 273–74. https://doi.org/10.1016/0165-6147(90)90005-s.
    Full Text Link to Item
  - Morgan, P. H., M. W. Lutz, and T. P. Kenakin. “KRAX is important operational determinant of tissue response. KRAX as parameter for classification..” Trends Pharmacol Sci 9, no. 10 (October 1988). https://doi.org/10.1016/0165-6147(88)90250-7.
    Full Text Link to Item
  - Lutz, M. W., W. E. Hammond, W. W. Stead, P. B. Blunden, and D. B. Pryor. “AUTOMATIC PROGRAMMING SYSTEM TO CREATE MEDICALLY-ORIENTED REPORT GENERATORS..” Proceedings Annual Symposium on Computer Applications in Medical Care, December 1, 1985, 422–26.
  - Hammond, W. E., M. J. Straube, W. W. Stead, and M. Lutz. “TMR--MEETING THE DEMAND FOR THE VARIETY OF REPORT MODALITIES..” Proceedings Annual Symposium on Computer Applications in Medical Care, December 1, 1984, 421–24.
- Book Sections
  - Lutz, M. W. “Linking bioinformatics and cheminformatics: From genes to structure-activity relationships.” In Biomedical Applications of Computer Modeling, 135–70, 2000. https://doi.org/10.1201/9781420041873.
    Full Text
- Conference Papers
  - Wu, Wen, Michal Daszykowski, Beata Walczak, Brian C. Sweatman, Susan C. Connor, John N. Haselden, Daniel J. Crowther, Rob W. Gill, and Michael W. Lutz. “Peak alignment of urine NMR spectra using fuzzy warping..” In J Chem Inf Model, 46:863–75, 2006. https://doi.org/10.1021/ci050316w.
    Full Text Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Selected Grants

Industry Relationships

Selected Publications

Books

Academic Articles

Book Sections

Conference Papers