Overview
Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.
Current Appointments & Affiliations
Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Professor in Pathology
·
2024 - Present
Pathology,
Clinical Science Departments
Recent Publications
Evaluating the Duke Iterative Cognitive Examination Against the Montreal Cognitive Assessment: Validity and Clinical Utility.
Journal Article Neurol Clin Pract · June 2026 BACKGROUND AND OBJECTIVES: Rapid and valid cognitive screening tools are a mainstay of clinical practice in the assessment of mild cognitive impairment and dementia. Although there are several available tools, there is concern for reduced sensitivity over ... Full text Link to item CiteA diagnostic plasma omics-biomarker for Alzheimer's disease informed by microglial single-cell transcriptomics: A pilot study.
Preprint · May 5, 2026 Full text Link to item CiteThe Duke MG Patient Registry III. Comparative Effectiveness of Azathioprine and Mycophenolate Mofetil in Generalized Myasthenia Gravis, a Retrospective Single Center Review.
Conference Muscle Nerve · May 2026 INTRODUCTION/AIMS: Azathioprine (AZA) and mycophenolate mofetil (MMF) are the most commonly used non-steroidal immunosuppressants in patients with generalized myasthenia gravis (gMG) in North America but their relative effectiveness among disease subgroups ... Full text Link to item CiteRecent Grants
LRRK2 signaling in the progression of Parkinson¿s disease and dementia
ResearchBiostatistician III · Awarded by National Institutes of Health · 2026 - 2029A spatially resolved joint cortical metabolome and proteome in aging and menopause for the rhesus macaque
ResearchCo Investigator · Awarded by National Institute on Aging · 2022 - 2027Integrative modeling and dynamic prediction of Alzheimer's disease
ResearchCo Investigator · Awarded by National Institute on Aging · 2020 - 2027View All Grants
Education
Duke University ·
1986
Ph.D.