Michael William Lutz | Scholars@Duke

Michael William Lutz
Associate Professor in Neurology

Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.

Current Appointments & Affiliations

Associate Professor in Neurology, Neurology, Behavioral Neurology, Neurology 2020
Assistant Professor in Pathology, Pathology, Clinical Science Departments 2020

Contact Information

311 Research Drive, Room 201-D, Durham, NC 27710
Box 2900, Durham, NC 27710
michael.lutz@duke.edu (919) 660-7621

Background
Education, Training, & Certifications
- Ph.D., Duke University 1986
Previous Appointments & Affiliations
- Assistant Professor of Neurology, Neurology, Clinical Science Departments 2014 - 2020
Research
Selected Grants
- A spatially resolved joint cortical metabolome and proteome in aging and menopause for the rhesus macaque awarded by National Institutes of Health 2022 - 2027
- CSF Proteomic Studies of APOE4 copy number-dependent effects on the Complement Pathway awarded by National Institutes of Health 2022 - 2027
- Integrative modeling and dynamic prediction of Alzheimer's disease awarded by National Institutes of Health 2020 - 2025
- Lewy body neuropathologies and SNCA gene: variants expression and splicing awarded by National Institutes of Health 2020 - 2025
- Brain networks in mouse models of aging awarded by National Institutes of Health 2019 - 2024
- Gender and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2019 - 2024
- Nerve Ultrasound for Diagnosis and Prognosis of GBS awarded by GBS/CIDP Foundation International 2020 - 2023
- Neuromuscular ultrasound and electric impedance myography in CMT type 1A: a prospective longitudinal study awarded by American Neuromuscular Foundation 2021 - 2023
- NACC UDS Subaward awarded by University of Washington 2021 - 2023
- Deciphering the regulation of gene expression in the etiology of LOAD awarded by National Institutes of Health 2017 - 2023
- Proteomic Determination of APOE4-induced Neuroinflammation in the Pathogenesis of Alzheimer's Disease awarded by Ruth K. Broad Biomedical Research Foundation 2020 - 2022
- Alzheimer's Disease, Genes, and Pesticide Use in the Agricultural Health Study awarded by National Institutes of Health 2014 - 2021
- Integrative modeling and dynamic prediction of Alzheimer's disease awarded by National Institutes of Health 2019 - 2020
- Shared genetic, epigenetic, and transcriptomic profiles between AD and PTSD: molecular insights into the heterogeneity of neuropsychiatric symptoms in Alzheimers Disease awarded by National Institutes of Health 2018 - 2020
- Role of the TOMM40 poly-T variant in the pathogenesis of Alzheimer's disease awarded by National Institutes of Health 2013 - 2020
- Lewy body neuropathologies and SNCA gene: variants expression and splicing awarded by National Institutes of Health 2013 - 2020
- Gender and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2017 - 2019
- Genes, environments, interactions, and cognitive decline in the HRS awarded by Wake Forest University 2015 - 2018
- Genes, environments, interactions, and cognitive decline in the HRS awarded by National Institutes of Health 2014 - 2015
- Identification of Genetic Factors that Impact the Risk of Alzheimer's Disease with Age awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Books
  - Grossman, I., M. W. Lutz, D. G. Crenshaw, A. M. Saunders, O. Chiba-Falek, W. K. Gottschalk, and A. D. Roses. Clinical Trials of AD Delay of Onset: Enrichment by a Prognostic Genetic Biomarker. Vol. 3, 2013. https://doi.org/10.1007/978-94-007-5866-7_7.
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  - Lutz, Michael, and Terry Kenakin. Quantitative Molecular Pharmacology and Informatics in Drug Discovery. John Wiley & Sons, 1999.
- Academic Articles
  - Crayle, J., M. Lutz, J. Raymond, P. Mehta, and R. Bedlack. “Study of "ALS reversals": LifeTime environmental exposures (StARLiTE).” Amyotroph Lateral Scler Frontotemporal Degener 24, no. 1–2 (February 2023): 54–62. https://doi.org/10.1080/21678421.2022.2090846.
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  - Bukhari-Parlakturk, Noreen, Michael W. Lutz, Hussein R. Al-Khalidi, Shakthi Unnithan, Joyce En-Hua Wang, Burton Scott, Pichet Termsarasab, Lawrence G. Appelbaum, and Nicole Calakos. “Suitability of Automated Writing Measures for Clinical Trial Outcome in Writer's Cramp.” Mov Disord 38, no. 1 (January 2023): 123–32. https://doi.org/10.1002/mds.29237.
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  - Sutton, Paige, Michael W. Lutz, F Lee Hartsell, Dorlan Kimbrough, N Troy Tagg, Mark Skeen, Nicholas M. Hudak, Christopher Eckstein, and Suma Shah. “Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: Presentation and outcomes of adults at a single center.” J Neuroimmunol 373 (December 15, 2022): 577987. https://doi.org/10.1016/j.jneuroim.2022.577987.
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  - Masha, Nidhila, Dorlan J. Kimbrough, Christopher P. Eckstein, Nicholas M. Hudak, Mark B. Skeen, F Lee Hartsell, Michael W. Lutz, and Suma Shah. “Neuromyelitis optica: Clinical course and potential prognostic indicators.” Mult Scler Relat Disord 69 (November 19, 2022): 104414. https://doi.org/10.1016/j.msard.2022.104414.
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  - Upadhya, Suraj, Daniel Gingerich, Michael William Lutz, and Ornit Chiba-Falek. “Differential Gene Expression and DNA Methylation in the Risk of Depression in LOAD Patients.” Biomolecules 12, no. 11 (November 12, 2022). https://doi.org/10.3390/biom12111679.
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  - Boccardi, Marina, Ron Handels, Michael Gold, Alice Grazia, Michael W. Lutz, Mike Martin, Rachel Nosheny, et al. “Clinical research in dementia: A perspective on implementing innovation.” Alzheimers Dement 18, no. 11 (November 2022): 2352–67. https://doi.org/10.1002/alz.12622.
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  - Temp, Anna G. M., Alexander Ly, Johnny van Doorn, Eric-Jan Wagenmakers, Yi Tang, Michael W. Lutz, and Stefan Teipel. “A Bayesian perspective on Biogen's aducanumab trial.” Alzheimers Dement 18, no. 11 (November 2022): 2341–51. https://doi.org/10.1002/alz.12615.
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  - Liu, Hongliang, Michael Lutz, Sheng Luo, and Sheng Alzheimer’s Disease Neuroimaging Initiative. “Genetic Association Between Epigenetic Aging-Acceleration and the Progression of Mild Cognitive Impairment to Alzheimer's Disease.” J Gerontol a Biol Sci Med Sci 77, no. 9 (September 1, 2022): 1734–42. https://doi.org/10.1093/gerona/glac138.
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  - Lutz, Michael W., Ara S. Khachaturian, Henrik Zetterberg, Kaj Blennow, Auriel A. Willette, Michelle M. Mielke, Kathleen M. Hayden, et al. “Biomarkers of Alzheimer syndrome and related dementias: A&D author's guide.” Alzheimers Dement 18, no. 9 (September 2022): 1595–1601. https://doi.org/10.1002/alz.12772.
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  - Kale, Emily B., Michael W. Lutz, and Aatif M. Husain. “Motor Evoked Potentials Double Train Stimulation: Optimal Number of Pulses per Train.” J Clin Neurophysiol 39, no. 5 (July 1, 2022): 401–5. https://doi.org/10.1097/WNP.0000000000000793.
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  - Li, Tianqi, Colleen Pappas, Scott T. Le, Qian Wang, Brandon S. Klinedinst, Brittany A. Larsen, Amy Pollpeter, et al. “APOE, TOMM40, and sex interactions on neural network connectivity.” Neurobiol Aging 109 (January 2022): 158–65. https://doi.org/10.1016/j.neurobiolaging.2021.09.020.
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  - Upadhya, Suraj, Hongliang Liu, Sheng Luo, Michael W. Lutz, and Ornit Chiba-Falek. “Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer's Disease Based on Major Depressive Disorder Risk Variants.” Front Neurosci 16 (2022): 827447. https://doi.org/10.3389/fnins.2022.827447.
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  - Chiba-Falek, O., and M. W. Lutz. “Bioinformatics pipeline to advance the identification of transcription regulatory variants in LOAD noncoding regions.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association 17 (December 1, 2021): e050665. https://doi.org/10.1002/alz.050665.
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  - Li, Tianqi, Colleen Pappas, Scott T. Le, Qian Wang, Brandon S. Klinedinst, Brittany A. Larsen, Amy Pollpeter, et al. “APOE, TOMM40, and Sex Interactions on Neural Network Connectivity.” Alzheimers Dement 17 Suppl 12 (December 2021): e058171. https://doi.org/10.1002/alz.058171.
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  - Lutz, M. W., M. M. Brown, M. Kucgibhatla, B. L. Plassman, S. Saldana, B. M. Snively, J. C. Chen, et al. “Analysis of pleiotropic genetic effects on cognitive decline and systemic inflammation in the Women's Health Initiative Memory Study.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association 17 (December 1, 2021): e050784. https://doi.org/10.1002/alz.050784.
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  - Ehrlich, Matthew E., Bin Han, Michael Lutz, Mohsen Ghiasi Ghorveh, Yasmin Ali Okeefe, Shreyansh Shah, Brad J. Kolls, and Carmelo Graffagnino. “Socioeconomic Influence on Emergency Medical Services Utilization for Acute Stroke: Think Nationally, Act Locally.” Neurohospitalist 11, no. 4 (October 2021): 317–25. https://doi.org/10.1177/19418744211010049.
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  - Kang, J. H., M. L. James, A. Gibson, O. Inamullah, G. C. Sherrill, M. W. Lutz, and C. B. Swisher. “Anticoagulation after Spontaneous Intraparenchymal Hemorrhage in Patients with Mechanical Heart Valves and Concomitant Atrial Fibrillation.” Journal of Neuroanaesthesiology and Critical Care 8, no. 3 (September 1, 2021): 203–7. https://doi.org/10.1055/s-0041-1735653.
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  - Deters, Kacie D., Elizabeth C. Mormino, Lei Yu, Michael W. Lutz, David A. Bennett, and Lisa L. Barnes. “TOMM40-APOE haplotypes are associated with cognitive decline in non-demented Blacks.” Alzheimers Dement 17, no. 8 (August 2021): 1287–96. https://doi.org/10.1002/alz.12295.
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  - Burns, Daniel K., Robert C. Alexander, Kathleen A. Welsh-Bohmer, Meredith Culp, Carl Chiang, Janet O’Neil, Rebecca M. Evans, et al. “Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.” Lancet Neurol 20, no. 7 (July 2021): 537–47. https://doi.org/10.1016/S1474-4422(21)00043-0.
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  - Temp, Anna G. M., Michael W. Lutz, Dominic Trepel, Yi Tang, Eric-Jan Wagenmakers, Ara S. Khachaturian, and Stefan Teipel. “How Bayesian statistics may help answer some of the controversial questions in clinical research on Alzheimer's disease.” Alzheimers Dement 17, no. 6 (June 2021): 917–19. https://doi.org/10.1002/alz.12374.
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  - Zhang, Yun, Xurui Jin, Michael W. Lutz, Sang-Yhun Ju, Keyang Liu, Guang Guo, Yi Zeng, and Yao Yao. “Interaction between APOE ε4 and dietary protein intake on cognitive decline: A longitudinal cohort study.” Clin Nutr 40, no. 5 (May 2021): 2716–25. https://doi.org/10.1016/j.clnu.2021.03.004.
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  - Kaleem, Safa, Michael W. Lutz, Christian E. Hernandez, Jennifer H. Kang, Michael L. James, Keith E. Dombrowski, Christa B. Swisher, and Joshua D. VanDerWerf. “A Triage Model for Interhospital Transfers of Low Risk Intracerebral Hemorrhage Patients.” J Stroke Cerebrovasc Dis 30, no. 4 (April 2021): 105616. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105616.
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  - Bryan, Jordan, Arpita Mandan, Gauri Kamat, W Kirby Gottschalk, Alexandra Badea, Kendra J. Adams, J Will Thompson, et al. “Likelihood ratio statistics for gene set enrichment in Alzheimer's disease pathways.” Alzheimers Dement 17, no. 4 (April 2021): 561–73. https://doi.org/10.1002/alz.12223.
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  - Inamullah, Ovais, Yuting P. Chiang, Muath Bishawi, Martin Weiss, Michael W. Lutz, Laura J. Blue, Wayne Feng, Carmelo A. Milano, Matthew Luedke, and Nada El Husseini. “Characteristics of strokes associated with centrifugal flow left ventricular assist devices.” Sci Rep 11, no. 1 (January 18, 2021): 1645. https://doi.org/10.1038/s41598-021-81445-8.
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  - Berger, Miles, Mary Cooter, Alexander S. Roesler, Stacey Chung, John Park, Jennifer L. Modliszewski, Keith W. VanDusen, et al. “APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.” J Alzheimers Dis 79, no. 2 (2021): 511–30. https://doi.org/10.3233/JAD-200747.
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  - Liu, Hongliang, Michael Lutz, Sheng Luo, and Sheng Alzheimer’s Disease Neuroimaging Initiative. “Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease.” J Alzheimers Dis 84, no. 3 (2021): 1323–35. https://doi.org/10.3233/JAD-210700.
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  - Zhang, Yun, Shihui Fu, Ding Ding, Michael W. Lutz, Yi Zeng, and Yao Yao. “Leisure Activities, APOE ε4, and Cognitive Decline: A Longitudinal Cohort Study.” Front Aging Neurosci 13 (2021): 736201. https://doi.org/10.3389/fnagi.2021.736201.
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  - Han, Bin, Huashuai Chen, Yao Yao, Xiaomin Liu, Chao Nie, Junxia Min, Yi Zeng, and Michael W. Lutz. “Genetic and non-genetic factors associated with the phenotype of exceptional longevity & normal cognition.” Sci Rep 10, no. 1 (November 5, 2020): 19140. https://doi.org/10.1038/s41598-020-75446-2.
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  - Kuchibhatla, Maragatha, Jaimie C. Hunter, Brenda L. Plassman, Michael W. Lutz, Ramon Casanova, Santiago Saldana, and Kathleen M. Hayden. “The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS).” Aging Ment Health 24, no. 9 (September 2020): 1479–86. https://doi.org/10.1080/13607863.2019.1594169.
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  - Lutz, Michael W., Sheng Luo, Douglas E. Williamson, and Ornit Chiba-Falek. “Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.” Alzheimers Dement 16, no. 9 (September 2020): 1280–92. https://doi.org/10.1002/alz.12128.
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  - Pytte, Julia, Loren L. Flynn, Ryan S. Anderton, Frank L. Mastaglia, Frances Theunissen, Ian James, Abigail Pfaff, et al. “Disease-modifying effects of an SCAF4 structural variant in a predominantly SOD1 ALS cohort.” Neurol Genet 6, no. 4 (August 2020): e470. https://doi.org/10.1212/NXG.0000000000000470.
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  - “New Thinking About Thinking, Part 3. Advice on preparing a successful manuscript for Alzheimer's & Dementia.” Alzheimers Dement 16, no. 7 (July 2020): 949–52. https://doi.org/10.1002/alz.12141.
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  - Lutz, Michael W., Daniel Sprague, Julio Barrera, and Ornit Chiba-Falek. “Shared genetic etiology underlying Alzheimer's disease and major depressive disorder.” Transl Psychiatry 10, no. 1 (March 9, 2020): 88. https://doi.org/10.1038/s41398-020-0769-y.
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  - Casanova, Ramon, Santiago Saldana, Michael W. Lutz, Brenda L. Plassman, Maragatha Kuchibhatla, and Kathleen M. Hayden. “Investigating Predictors of Cognitive Decline Using Machine Learning.” J Gerontol B Psychol Sci Soc Sci 75, no. 4 (March 9, 2020): 733–42. https://doi.org/10.1093/geronb/gby054.
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  - Lutz, Michael W., Daniel Sprague, and Ornit Chiba-Falek. “Bioinformatics strategy to advance the interpretation of Alzheimer's disease GWAS discoveries: The roads from association to causation.” Alzheimers Dement 15, no. 8 (August 2019): 1048–58. https://doi.org/10.1016/j.jalz.2019.04.014.
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  - Lutz, Michael W., Ramon Casanova, Santiago Saldana, Maragatha Kuchibhatla, Brenda L. Plassman, and Kathleen M. Hayden. “Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study.” Neurobiol Aging 80 (August 2019): 173–86. https://doi.org/10.1016/j.neurobiolaging.2018.10.028.
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  - Tang, Yi, Michael W. Lutz, and Yi Xing. “A systems-based model of Alzheimer's disease.” Alzheimers Dement 15, no. 1 (January 2019): 168–71. https://doi.org/10.1016/j.jalz.2018.06.3058.
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  - Burns, Daniel K., Carl Chiang, Kathleen A. Welsh-Bohmer, Stephen K. Brannan, Meredith Culp, Janet O’Neil, Grant Runyan, et al. “The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial.” Alzheimers Dement (N Y) 5 (2019): 661–70. https://doi.org/10.1016/j.trci.2019.09.010.
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  - Zeng, Yi, Chao Nie, Junxia Min, Huashuai Chen, Xiaomin Liu, Rui Ye, Zhihua Chen, et al. “Sex Differences in Genetic Associations With Longevity.” Jama Netw Open 1, no. 4 (August 2018): e181670. https://doi.org/10.1001/jamanetworkopen.2018.1670.
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  - Zhao, Xin, Xiaomin Liu, Aiping Zhang, Huashuai Chen, Qing Huo, Weiyang Li, Rui Ye, et al. “The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.” Aging (Albany Ny) 10, no. 6 (June 5, 2018): 1206–22. https://doi.org/10.18632/aging.101461.
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  - Khachaturian, Ara S., Kathleen M. Hayden, Michelle M. Mielke, Yi Tang, Michael W. Lutz, Michael Gold, Walter A. Kukull, et al. “New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia.” Alzheimers Dement 14, no. 6 (June 2018): 703–6. https://doi.org/10.1016/j.jalz.2018.05.002.
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  - Li, Kan, Richard O’Brien, Michael Lutz, Sheng Luo, and Sheng Alzheimer’s Disease Neuroimaging Initiative. “A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data.” Alzheimers Dement 14, no. 5 (May 2018): 644–51. https://doi.org/10.1016/j.jalz.2017.11.004.
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  - Chiba-Falek, Ornit, William K. Gottschalk, and Michael W. Lutz. “The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.” Alzheimers Dement 14, no. 5 (May 2018): 692–98. https://doi.org/10.1016/j.jalz.2018.01.015.
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  - Hunter, Jaimie C., Elizabeth P. Handing, Ramon Casanova, Maragatha Kuchibhatla, Michael W. Lutz, Santiago Saldana, Brenda L. Plassman, and Kathleen M. Hayden. “Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?” Alzheimers Dement 14, no. 4 (April 2018): 454–61. https://doi.org/10.1016/j.jalz.2017.10.007.
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  - Khachaturian, Ara S., Kathleen M. Hayden, Michelle M. Mielke, Yi Tang, Michael W. Lutz, Deborah R. Gustafson, Walter A. Kukull, Richard Mohs, and Zaven S. Khachaturian. “Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework.” Alzheimers Dement 14, no. 4 (April 2018): 532–34. https://doi.org/10.1016/j.jalz.2018.03.003.
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  - Yu, Lei, Michael W. Lutz, Jose M. Farfel, Robert S. Wilson, Daniel K. Burns, Ann M. Saunders, Philip L. De Jager, Lisa L. Barnes, Julie A. Schneider, and David A. Bennett. “Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.” Alzheimers Dement 13, no. 12 (December 2017): 1380–88. https://doi.org/10.1016/j.jalz.2017.05.002.
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  - Nishimura, Akira, Hidenori Nonomura, Shingo Tanaka, Michihiro Yoshida, Yuka Maruyama, Yutaka Aritomi, Ann M. Saunders, et al. “Characterization of APOE and TOMM40 allele frequencies in the Japanese population.” Alzheimers Dement (N Y) 3, no. 4 (November 2017): 524–30. https://doi.org/10.1016/j.trci.2017.07.003.
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  - Tagliafierro, Lidia, Omolara-Chinue Glenn, Madison E. Zamora, Thomas G. Beach, Randy L. Woltjer, Michael W. Lutz, and Ornit Chiba-Falek. “Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.” Alzheimers Dement 13, no. 11 (November 2017): 1237–50. https://doi.org/10.1016/j.jalz.2017.03.001.
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  - Willette, Auriel A., Joseph L. Webb, Michael W. Lutz, Barbara B. Bendlin, Alexandra M. Wennberg, Jennifer M. Oh, Allen Roses, et al. “Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts.” Alzheimers Dement 13, no. 11 (November 2017): 1217–25. https://doi.org/10.1016/j.jalz.2017.03.009.
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  - Larsen, Peter A., Michael W. Lutz, Kelsie E. Hunnicutt, Mirta Mihovilovic, Ann M. Saunders, Anne D. Yoder, and Allen D. Roses. “The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease.” Alzheimers Dement 13, no. 7 (July 2017): 828–38. https://doi.org/10.1016/j.jalz.2017.01.017.
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  - Yu, Lei, Michael W. Lutz, Robert S. Wilson, Daniel K. Burns, Allen D. Roses, Ann M. Saunders, Chris Gaiteri, Philip L. De Jager, Lisa L. Barnes, and David A. Bennett. “TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.” Neurology 88, no. 7 (February 14, 2017): 661–68. https://doi.org/10.1212/WNL.0000000000003614.
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  - Chiba-Falek, Ornit, and Michael W. Lutz. “Towards precision medicine in Alzheimer's disease: deciphering genetic data to establish informative biomarkers.” Expert Rev Precis Med Drug Dev 2, no. 1 (2017): 47–55. https://doi.org/10.1080/23808993.2017.1286227.
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  - Yu, Lei, Michael W. Lutz, Robert S. Wilson, Daniel K. Burns, Allen D. Roses, Ann M. Saunders, Jingyun Yang, et al. “APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.” Plos One 12, no. 7 (2017): e0180356. https://doi.org/10.1371/journal.pone.0180356.
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  - Saul, Robert, Michael W. Lutz, Daniel K. Burns, Allen D. Roses, and Ornit Chiba-Falek. “The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants.” Hum Mutat 37, no. 9 (September 2016): 877–83. https://doi.org/10.1002/humu.23023.
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  - Wennberg, Alexandra M. V., Adam P. Spira, Corinne Pettigrew, Anja Soldan, Vadim Zipunnikov, George W. Rebok, Allen D. Roses, et al. “Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults.” J Neurol Sci 365 (June 15, 2016): 89–95. https://doi.org/10.1016/j.jns.2016.04.017.
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  - Roses, Allen, Scott Sundseth, Ann Saunders, William Gottschalk, Dan Burns, and Michael Lutz. “Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.” Alzheimers Dement 12, no. 6 (June 2016): 687–94. https://doi.org/10.1016/j.jalz.2016.03.015.
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  - Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Chao Nie, Xiaomin Liu, Lei Feng, et al. “Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.” Rejuvenation Res 19, no. 3 (June 2016): 195–203. https://doi.org/10.1089/rej.2015.1737.
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  - Lutz, Michael W., Donna Crenshaw, Kathleen A. Welsh-Bohmer, Daniel K. Burns, and Allen D. Roses. “New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.” Curr Neurol Neurosci Rep 16, no. 5 (May 2016): 48. https://doi.org/10.1007/s11910-016-0643-8.
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  - Zeng, Yi, Chao Nie, Junxia Min, Xiaomin Liu, Mengmeng Li, Huashuai Chen, Hanshi Xu, et al. “Novel loci and pathways significantly associated with longevity.” Sci Rep 6 (February 25, 2016): 21243. https://doi.org/10.1038/srep21243.
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  - Lutz, Michael W., Scott S. Sundseth, Daniel K. Burns, Ann M. Saunders, Kathleen M. Hayden, James R. Burke, Kathleen A. Welsh-Bohmer, and Allen D. Roses. “A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease.” Alzheimers Dement (N Y) 2, no. 1 (January 1, 2016): 30–44. https://doi.org/10.1016/j.trci.2015.12.002.
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  - Roses, Allen D., P Anthony Akkari, Ornit Chiba-Falek, Michael W. Lutz, William Kirby Gottschalk, Ann Marie Saunders, Bob Saul, Scott Sundseth, and Daniel Burns. “Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing.” Expert Opin Drug Metab Toxicol 12, no. 2 (2016): 135–47. https://doi.org/10.1517/17425255.2016.1133586.
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  - Lyall, Donald M., Susana Muñoz Maniega, Sarah E. Harris, Mark E. Bastin, Catherine Murray, Michael W. Lutz, Ann M. Saunders, et al. “APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds.” Int J Stroke 10, no. 8 (December 2015): 1297–1300. https://doi.org/10.1111/ijs.12615.
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  - Lutz, Michael W., Robert Saul, Colton Linnertz, Omolara-Chinue Glenn, Allen D. Roses, and Ornit Chiba-Falek. “A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.” Alzheimers Dement 11, no. 10 (October 2015): 1133–43. https://doi.org/10.1016/j.jalz.2015.05.011.
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  - Hayden, Kathleen M., Michael W. Lutz, Maragatha Kuchibhatla, Cassandra Germain, and Brenda L. Plassman. “Correction: Effect of APOE and CD33 on Cognitive Decline.” Plos One 10, no. 7 (2015): e0134887. https://doi.org/10.1371/journal.pone.0134887.
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  - Hayden, Kathleen M., Michael W. Lutz, Maragatha Kuchibhatla, Cassandra Germain, and Brenda L. Plassman. “Effect of APOE and CD33 on Cognitive Decline.” Plos One 10, no. 6 (2015): e0130419. https://doi.org/10.1371/journal.pone.0130419.
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  - Gottschalk, William K., Michael W. Lutz, Yu Ting He, Ann M. Saunders, Daniel K. Burns, Allen D. Roses, and Ornit Chiba-Falek. “The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging.” J Parkinsons Dis Alzheimers Dis 1, no. 1 (November 2014). https://doi.org/10.13188/2376-922X.1000003.
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  - Roses, Allen D., Michael W. Lutz, Ann M. Saunders, Dmitry Goldgaber, Robert Saul, Scott S. Sundseth, P Anthony Akkari, et al. “African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.” Alzheimers Dement 10, no. 6 (November 2014): 592-601.e2. https://doi.org/10.1016/j.jalz.2014.06.009.
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  - Lyall, D. M., S. E. Harris, M. E. Bastin, S. Muñoz Maniega, C. Murray, M. W. Lutz, A. M. Saunders, et al. “Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?” Transl Psychiatry 4, no. 9 (September 23, 2014): e449. https://doi.org/10.1038/tp.2014.89.
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  - Linnertz, Colton, Michael W. Lutz, John F. Ervin, Jawara Allen, Natalie R. Miller, Kathleen A. Welsh-Bohmer, Allen D. Roses, and Ornit Chiba-Falek. “The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.” Hum Mol Genet 23, no. 18 (September 15, 2014): 4814–21. https://doi.org/10.1093/hmg/ddu196.
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  - Greenbaum, Lior, Ramit Ravona Springer, Michael W. Lutz, Anthony Heymann, Irit Lubitz, Itzik Cooper, Efrat Kravitz, et al. “The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.” Eur Neuropsychopharmacol 24, no. 9 (September 2014): 1492–99. https://doi.org/10.1016/j.euroneuro.2014.06.002.
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  - Linnertz, Colton, Lauren Anderson, William Gottschalk, Donna Crenshaw, Michael W. Lutz, Jawara Allen, Sunita Saith, et al. “The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.” Alzheimers Dement 10, no. 5 (September 2014): 541–51. https://doi.org/10.1016/j.jalz.2013.08.280.
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  - Lyall, Donald M., Sarah E. Harris, Mark E. Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W. Lutz, Ann M. Saunders, et al. “Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.” Neurobiol Aging 35, no. 6 (June 2014): 1513.e25-1513.e33. https://doi.org/10.1016/j.neurobiolaging.2014.01.006.
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  - Roses, Allen D., Ann M. Saunders, Michael W. Lutz, Nanyin Zhang, Ahmad R. Hariri, Karen E. Asin, Donna G. Crenshaw, Kumar Budur, Daniel K. Burns, and Stephen K. Brannan. “New applications of disease genetics and pharmacogenetics to drug development.” Curr Opin Pharmacol 14 (February 2014): 81–89. https://doi.org/10.1016/j.coph.2013.12.002.
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  - Lyall, D. M., S. E. Harris, M. E. Bastin, S. Muñoz Maniega, C. Murray, M. W. Lutz, A. M. Saunders, et al. “Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.” Neurobiology of Aging 35, no. 6 (2014): 1513e25–33.
  - Davies, G., S. E. Harris, C. A. Reynolds, A. Payton, H. M. Knight, D. C. Liewald, L. M. Lopez, et al. “A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.” Mol Psychiatry 19, no. 1 (January 2014): 76–87. https://doi.org/10.1038/mp.2012.159.
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  - Mastaglia, F. L., A. Rojana-udomsart, I. James, M. Needham, T. J. Day, L. Kiers, J. A. Corbett, et al. “Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms.” Neuromuscul Disord 23, no. 12 (December 2013): 969–74. https://doi.org/10.1016/j.nmd.2013.09.008.
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  - Roses, Allen D., Michael W. Lutz, Donna G. Crenshaw, Iris Grossman, Ann M. Saunders, and W Kirby Gottschalk. “TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.” Alzheimers Dement 9, no. 2 (March 2013): 132–36. https://doi.org/10.1016/j.jalz.2012.10.009.
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  - Crenshaw, D. G., W. K. Gottschalk, M. W. Lutz, I. Grossman, A. M. Saunders, J. R. Burke, K. A. Welsh-Bohmer, S. K. Brannan, D. K. Burns, and A. D. Roses. “Using genetics to enable studies on the prevention of Alzheimer's disease.” Clin Pharmacol Ther 93, no. 2 (February 2013): 177–85. https://doi.org/10.1038/clpt.2012.222.
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  - Lyall, Donald M., Natalie A. Royle, Sarah E. Harris, Mark E. Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W. Lutz, et al. “Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936.” Plos One 8, no. 11 (2013): e80513. https://doi.org/10.1371/journal.pone.0080513.
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  - Caselli, Richard J., Amylou C. Dueck, Matthew J. Huentelman, Michael W. Lutz, Ann M. Saunders, Eric M. Reiman, and Allen D. Roses. “Longitudinal modeling of cognitive aging and the TOMM40 effect.” Alzheimers Dement 8, no. 6 (November 2012): 490–95. https://doi.org/10.1016/j.jalz.2011.11.006.
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  - Hayden, Kathleen M., Jill M. McEvoy, Colton Linnertz, Deborah Attix, Maragatha Kuchibhatla, Ann M. Saunders, Michael W. Lutz, Kathleen A. Welsh-Bohmer, Allen D. Roses, and Ornit Chiba-Falek. “A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.” Alzheimers Dement 8, no. 5 (September 2012): 381–88. https://doi.org/10.1016/j.jalz.2011.10.005.
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  - Bruno, Davide, Nunzio Pomara, Jay Nierenberg, James C. Ritchie, Michael W. Lutz, Henrik Zetterberg, and Kaj Blennow. “Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.” Exp Gerontol 47, no. 5 (May 2012): 347–52. https://doi.org/10.1016/j.exger.2011.09.008.
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  - Bruno, Davide, Jay J. Nierenberg, James C. Ritchie, Michael W. Lutz, and Nunzio Pomara. “Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants.” Psychoneuroendocrinology 37, no. 3 (March 2012): 366–71. https://doi.org/10.1016/j.psyneuen.2011.07.006.
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  - Linnertz, Colton, Ann M. Saunders, Michael W. Lutz, Donna M. Crenshaw, Iris Grossman, Daniel K. Burns, Keith E. Whitfield, et al. “Characterization of the poly-T variant in the TOMM40 gene in diverse populations.” Plos One 7, no. 2 (2012): e30994. https://doi.org/10.1371/journal.pone.0030994.
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  - Pomara, Nunzio, Davide Bruno, John J. Sidtis, Michael W. Lutz, David J. Greenblatt, Ann M. Saunders, and Allen D. Roses. “Translocase of outer mitochondrial membrane 40 homolog (TOMM40) poly-T length modulates lorazepam-related cognitive toxicity in healthy APOE ε4-negative elderly.” J Clin Psychopharmacol 31, no. 4 (August 2011): 544–46. https://doi.org/10.1097/JCP.0b013e318222810e.
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  - Johnson, Sterling C., Asenath La Rue, Bruce P. Hermann, Guofan Xu, Rebecca L. Koscik, Erin M. Jonaitis, Barbara B. Bendlin, et al. “The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.” Alzheimers Dement 7, no. 4 (July 2011): 456–65. https://doi.org/10.1016/j.jalz.2010.11.012.
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  - Lutz, Michael W., Donna G. Crenshaw, Ann M. Saunders, and Allen D. Roses. “The importance of being connected.” J Alzheimers Dis 24, no. 2 (2011): 247–51. https://doi.org/10.3233/JAD-2010-101765.
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  - Roses, A. D., M. W. Lutz, H. Amrine-Madsen, A. M. Saunders, D. G. Crenshaw, S. S. Sundseth, M. J. Huentelman, K. A. Welsh-Bohmer, and E. M. Reiman. “A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.” Pharmacogenomics J 10, no. 5 (October 2010): 375–84. https://doi.org/10.1038/tpj.2009.69.
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  - Grossman, Iris, Michael W. Lutz, Donna G. Crenshaw, Ann M. Saunders, Daniel K. Burns, and Allen D. Roses. “Alzheimer's disease: diagnostics, prognostics and the road to prevention.” Epma J 1, no. 2 (June 2010): 293–303. https://doi.org/10.1007/s13167-010-0024-3.
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  - Lutz, Michael W., Donna G. Crenshaw, Ann M. Saunders, and Allen D. Roses. “Genetic variation at a single locus and age of onset for Alzheimer's disease.” Alzheimers Dement 6, no. 2 (March 2010): 125–31. https://doi.org/10.1016/j.jalz.2010.01.011.
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  - Lutz, M. W., P. V. Warren, R. W. Gill, and D. B. Searls. “Managing genomic and proteomic knowledge.” Drug Discovery Today: Technologies 2, no. 3 (November 3, 2005): 197–204. https://doi.org/10.1016/j.ddtec.2005.08.001.
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  - Selleseth, Dean W., Christine L. Talarico, Teresa Miller, Michael W. Lutz, Karen K. Biron, and Robert J. Harvey. “Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication.” Antimicrob Agents Chemother 47, no. 4 (April 2003): 1468–71. https://doi.org/10.1128/AAC.47.4.1468-1471.2003.
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  - Lopez, Vincent A., Eric J. Bourne, Michael W. Lutz, and Lynn D. Condreay. “Assessment of the COBAS Amplicor HBV Monitor Test for quantitation of serum hepatitis B virus DNA levels.” J Clin Microbiol 40, no. 6 (June 2002): 1972–76. https://doi.org/10.1128/JCM.40.6.1972-1976.2002.
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  - Gauthier, J., E. J. Bourne, M. W. Lutz, L. M. Crowther, J. L. Dienstag, N. A. Brown, and L. D. Condreay. “Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine.” J Infect Dis 180, no. 6 (December 1999): 1757–62. https://doi.org/10.1086/315147.
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  - Allen, M. I., J. Gauthier, M. DesLauriers, E. J. Bourne, K. M. Carrick, F. Baldanti, L. L. Ross, M. W. Lutz, and L. D. Condreay. “Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine.” J Clin Microbiol 37, no. 10 (October 1999): 3338–47. https://doi.org/10.1128/JCM.37.10.3338-3347.1999.
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  - Lutz, M. W., P. H. Morgan, T. P. Kenakin, A. Goetz, K. Queen, P. Irving, D. Rose, J. M. Gill, and T. Rimele. “A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle.” J Pharmacol Toxicol Methods 36, no. 3 (November 1996): 171–83. https://doi.org/10.1016/s1056-8719(96)00114-1.
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  - Weiss, J. M., P. H. Morgan, M. W. Lutz, and T. P. Kenakin. “The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy.” J Theor Biol 181, no. 4 (August 21, 1996): 381–97. https://doi.org/10.1006/jtbi.1996.0139.
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  - Saussy, D. L., A. S. Goetz, K. L. Queen, H. K. King, M. W. Lutz, and T. J. Rimele. “Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype.” J Pharmacol Exp Ther 278, no. 1 (July 1996): 136–44.
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  - Weiss, J. M., P. H. Morgan, M. W. Lutz, and T. P. Kenakin. “The cubic ternary complex receptor-occupancy model II. Understanding apparent affinity.” Journal of Theoretical Biology 178, no. 2 (January 21, 1996): 169–82. https://doi.org/10.1006/jtbi.1996.0015.
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  - Weiss, J. M., P. H. Morgan, M. W. Lutz, and T. P. Kenakin. “The cubic ternary complex receptor-occupancy model I. Model description.” Journal of Theoretical Biology 178, no. 2 (January 21, 1996): 151–67. https://doi.org/10.1006/jtbi.1996.0014.
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  - Lutz, M. W., J. A. Menius, T. D. Choi, R. G. Laskody, P. L. Domanico, A. S. Goetz, and D. L. Saussy. “Experimental design for high-throughput screening.” Drug Discovery Today 1, no. 7 (January 1, 1996): 277–86. https://doi.org/10.1016/1359-6446(96)10025-8.
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  - Lutz, M. W., T. P. Kenakin, M. Corsi, J. A. Menius, C. Krishnamoorthy, T. Rimele, and P. H. Morgan. “Use of resampling techniques to estimate the variance of parameters in pharmacological assays when experimental protocols preclude independent replication: an example using Schild regressions.” J Pharmacol Toxicol Methods 34, no. 1 (September 1995): 37–46. https://doi.org/10.1016/1056-8719(95)00024-c.
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  - Kenakin, T., P. Morgan, and M. Lutz. “On the importance of the "antagonist assumption" to how receptors express themselves.” Biochem Pharmacol 50, no. 1 (June 29, 1995): 17–26. https://doi.org/10.1016/0006-2952(95)00137-o.
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  - Goetz, A. S., M. W. Lutz, T. J. Rimele, and D. L. Saussy. “Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes.” J Pharmacol Exp Ther 271, no. 3 (December 1994): 1228–33.
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  - Lutz, M. W., P. H. Morgan, M. K. James, P. L. Feldman, M. F. Brackeen, A. P. Lahey, S. V. James, J. M. Bilotta, and J. C. Pressley. “A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics.” J Pharmacol Exp Ther 271, no. 2 (November 1994): 795–803.
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  - Feldman, P. L., M. K. James, M. F. Brackeen, J. M. Bilotta, S. V. Schuster, A. P. Lahey, M. W. Lutz, M. R. Johnson, and H. J. Leighton. “Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics.” J Med Chem 34, no. 7 (July 1991): 2202–8. https://doi.org/10.1021/jm00111a041.
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  - Kenakin, T., P. H. Morgan, and M. Lutz. “Drug and tissue factors both confound KA measurements.” Trends Pharmacol Sci 11, no. 7 (July 1990): 273–74. https://doi.org/10.1016/0165-6147(90)90005-s.
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  - Morgan, P. H., M. W. Lutz, and T. P. Kenakin. “KRAX is important operational determinant of tissue response. KRAX as parameter for classification.” Trends Pharmacol Sci 9, no. 10 (October 1988): 351. https://doi.org/10.1016/0165-6147(88)90250-7.
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  - Lutz, M. W., W. E. Hammond, W. W. Stead, P. B. Blunden, and D. B. Pryor. “AUTOMATIC PROGRAMMING SYSTEM TO CREATE MEDICALLY-ORIENTED REPORT GENERATORS.” Proceedings Annual Symposium on Computer Applications in Medical Care, December 1, 1985, 422–26.
  - Hammond, W. E., M. J. Straube, W. W. Stead, and M. Lutz. “TMR--MEETING THE DEMAND FOR THE VARIETY OF REPORT MODALITIES.” Proceedings Annual Symposium on Computer Applications in Medical Care, December 1, 1984, 421–24.
- Book Sections
  - Lutz, M. W. “Linking bioinformatics and cheminformatics: From genes to structure-activity relationships.” In Biomedical Applications of Computer Modeling, 135–70, 2000. https://doi.org/10.1201/9781420041873.
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- Conference Papers
  - Sanders, Donald B., Michael W. Lutz, Shruti M. Raja, Vern C. Juel, Jeffrey T. Guptill, Lisa D. Hobson-Webb, and Janice M. Massey. “THE DUKE MYASTHENIA GRAVIS CLINIC REGISTRY: ANALYSIS OF OUTCOMES.” In Muscle & Nerve, 65:S23–24, 2022.
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  - Wu, Wen, Michal Daszykowski, Beata Walczak, Brian C. Sweatman, Susan C. Connor, John N. Haselden, Daniel J. Crowther, Rob W. Gill, and Michael W. Lutz. “Peak alignment of urine NMR spectra using fuzzy warping.” In J Chem Inf Model, 46:863–75, 2006. https://doi.org/10.1021/ci050316w.
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