Michael William Lutz | Scholars@Duke

Michael William Lutz
Assistant Professor of Neurology

Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.

Current Appointments & Affiliations

Assistant Professor of Neurology, Neurology, Clinical Science Departments 2014

Contact Information

2200 West Main Street, Suite A-200, Durham, NC 27705
Box 3503, Durham, NC 27708-0344
michael.lutz@duke.edu (919) 660-7621

Background
Education, Training, & Certifications
- Ph.D., Duke University 1986
Research
Selected Grants
- Deciphering the regulation of gene expression in the etiology of LOAD awarded by National Institutes of Health 2017 - 2022
- Lewy body neuropathologies and SNCA gene: variants expression and splicing awarded by National Institutes of Health 2013 - 2019
- Alzheimer's Disease, Genes, and Pesticide Use in the Agricultural Health Study awarded by National Institutes of Health 2014 - 2019
- Role of the TOMM40 poly-T variant in the pathogenesis of Alzheimer's disease awarded by National Institutes of Health 2013 - 2019
- Genes, environments, interactions, and cognitive decline in the HRS awarded by Wake Forest University 2015 - 2018
- Sex and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2017 - 2018
- Genes, environments, interactions, and cognitive decline in the HRS awarded by National Institutes of Health 2014 - 2015
- Genetic Factors that Impact the Risk of Alzheimer's Disease awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Books
  - Lutz, M, and Kenakin, T. Quantitative Molecular Pharmacology and Informatics in Drug Discovery. John Wiley & Sons, 1999.
- Conference Papers
  - Wu, W, Daszykowski, M, Walczak, B, Sweatman, BC, Connor, SC, Haselden, JN, Crowther, DJ, Gill, RW, and Lutz, MW. "Peak alignment of urine NMR spectra using fuzzy warping." March 2006. Full Text
- Journal Articles
  - Khachaturian, AS, Hayden, KM, Mielke, MM, Tang, Y, Lutz, MW, Gold, M, Kukull, WA, Mohs, R, Gauthier, S, Molinuevo, JL, Zetterberg, H, and Khachaturian, ZS. "New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 14, no. 6 (June 2018): 703-706. Full Text
  - Zhao, X, Liu, X, Zhang, A, Chen, H, Huo, Q, Li, W, Ye, R, Chen, Z, Liang, L, Liu, QA, Shen, J, Jin, X, Li, W, Nygaard, M, Liu, X, Hou, Y, Ni, T, Bolund, L, Gottschalk, W, Tao, W, Gu, J, Tian, X-L, Yang, H, Wang, J, Xu, X, Lutz, MW, Min, J, Zeng, Y, and Nie, C. "The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese." Aging 10, no. 6 (June 2018): 1206-1222. Full Text
  - Chiba-Falek, O, Gottschalk, WK, and Lutz, MW. "The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 14, no. 5 (May 2018): 692-698. Full Text
  - Hunter, JC, Handing, EP, Casanova, R, Kuchibhatla, M, Lutz, MW, Saldana, S, Plassman, BL, and Hayden, KM. "Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 14, no. 4 (April 2018): 454-461. Full Text
  - Khachaturian, AS, Hayden, KM, Mielke, MM, Tang, Y, Lutz, MW, Gustafson, DR, Kukull, WA, Mohs, R, and Khachaturian, ZS. "Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 14, no. 4 (April 2018): 532-534. Full Text
  - Li, K, O'Brien, R, Lutz, M, Luo, S, and Alzheimer's Disease Neuroimaging Initiative, . "A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data." Alzheimer's & dementia : the journal of the Alzheimer's Association (January 3, 2018). Full Text
  - Yu, L, Lutz, MW, Farfel, JM, Wilson, RS, Burns, DK, Saunders, AM, De Jager, PL, Barnes, LL, Schneider, JA, and Bennett, DA. "Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 13, no. 12 (December 2017): 1380-1388. Full Text
  - Nishimura, A, Nonomura, H, Tanaka, S, Yoshida, M, Maruyama, Y, Aritomi, Y, Saunders, AM, Burns, DK, Lutz, MW, Runyan, G, Lai, E, Budur, K, and Roses, AD. "Characterization of APOE and TOMM40 allele frequencies in the Japanese population." Alzheimer'S & Dementia (New York, N. Y.) 3, no. 4 (November 2017): 524-530. Full Text
  - Tagliafierro, L, Glenn, O-C, Zamora, ME, Beach, TG, Woltjer, RL, Lutz, MW, and Chiba-Falek, O. "Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies." Alzheimer's & dementia : the journal of the Alzheimer's Association 13, no. 11 (November 2017): 1237-1250. Full Text
  - Willette, AA, Webb, JL, Lutz, MW, Bendlin, BB, Wennberg, AM, Oh, JM, Roses, A, Koscik, RL, Hermann, BP, Dowling, NM, Asthana, S, Johnson, SC, and Alzheimer's Disease Neuroimaging Initiative, . "Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 13, no. 11 (November 2017): 1217-1225. Full Text
  - Larsen, PA, Lutz, MW, Hunnicutt, KE, Mihovilovic, M, Saunders, AM, Yoder, AD, and Roses, AD. "The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 13, no. 7 (July 2017): 828-838. Full Text Open Access Copy
  - Yu, L, Lutz, MW, Wilson, RS, Burns, DK, Roses, AD, Saunders, AM, Gaiteri, C, De Jager, PL, Barnes, LL, and Bennett, DA. "TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype." Neurology 88, no. 7 (February 2017): 661-668. Full Text
  - Yu, L, Lutz, MW, Wilson, RS, Burns, DK, Roses, AD, Saunders, AM, Yang, J, Gaiteri, C, De Jager, PL, Barnes, LL, and Bennett, DA. "APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans." Plos One 12, no. 7 (January 2017): e0180356-null. Full Text
  - Saul, R, Lutz, MW, Burns, DK, Roses, AD, and Chiba-Falek, O. "The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants." Human Mutation 37, no. 9 (September 2016): 877-883. Full Text
  - Roses, A, Sundseth, S, Saunders, A, Gottschalk, W, Burns, D, and Lutz, M. "Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 12, no. 6 (June 2016): 687-694. (Review) Full Text
  - Wennberg, AMV, Spira, AP, Pettigrew, C, Soldan, A, Zipunnikov, V, Rebok, GW, Roses, AD, Lutz, MW, Miller, MM, Thambisetty, M, and Albert, MS. "Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults." Journal of the neurological sciences 365 (June 2016): 89-95. Full Text
  - Zeng, Y, Chen, H, Ni, T, Ruan, R, Nie, C, Liu, X, Feng, L, Zhang, F, Lu, J, Li, J, Li, Y, Tao, W, Gregory, SG, Gottschalk, W, Lutz, MW, Land, KC, Yashin, A, Tan, Q, Yang, Z, Bolund, L, Ming, Q, Yang, H, Min, J, Willcox, DC, Willcox, BJ, Gu, J, Hauser, E, Tian, X-L, and Vaupel, JW. "Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages." Rejuvenation research 19, no. 3 (June 2016): 195-203. Full Text Open Access Copy
  - Lutz, MW, Crenshaw, D, Welsh-Bohmer, KA, Burns, DK, and Roses, AD. "New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics." Current neurology and neuroscience reports 16, no. 5 (May 2016): 48-. (Review) Full Text
  - Zeng, Y, Nie, C, Min, J, Liu, X, Li, M, Chen, H, Xu, H, Wang, M, Ni, T, Li, Y, Yan, H, Zhang, J-P, Song, C, Chi, L-Q, Wang, H-M, Dong, J, Zheng, G-Y, Lin, L, Qian, F, Qi, Y, Liu, X, Cao, H, Wang, Y, Zhang, L, Li, Z, Zhou, Y, Wang, Y, Lu, J, Li, J, Qi, M, Bolund, L, Yashin, A, Land, KC, Gregory, S, Yang, Z, Gottschalk, W, Tao, W, Wang, J, Wang, J, Xu, X, Bae, H, Nygaard, M, Christiansen, L, Christensen, K, Franceschi, C, Lutz, MW, Gu, J, Tan, Q, Perls, T, Sebastiani, P, Deelen, J, Slagboom, E, Hauser, E, Xu, H, Tian, X-L, Yang, H, and Vaupel, JW. "Novel loci and pathways significantly associated with longevity." Scientific Reports 6 (February 25, 2016): 21243-null. Full Text Open Access Copy
  - Roses, AD, Akkari, PA, Chiba-Falek, O, Lutz, MW, Gottschalk, WK, Saunders, AM, Saul, B, Sundseth, S, and Burns, D. "Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing." Expert opinion on drug metabolism & toxicology 12, no. 2 (January 4, 2016): 135-147. (Review) Full Text
  - Lutz, MW, Sundseth, SS, Burns, DK, Saunders, AM, Hayden, KM, Burke, JR, Welsh-Bohmer, KA, and Roses, AD. "A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease." Alzheimer'S & Dementia (New York, N. Y.) 2, no. 1 (January 2016): 30-44. Full Text
  - Lyall, DM, Muñoz Maniega, S, Harris, SE, Bastin, ME, Murray, C, Lutz, MW, Saunders, AM, Roses, AD, Valdés Hernández, MDC, Royle, NA, Starr, JM, Porteous, DJ, Deary, IJ, and Wardlaw, JM. "APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds." International journal of stroke : official journal of the International Stroke Society 10, no. 8 (December 2015): 1297-1300. Full Text
  - Lutz, MW, Saul, R, Linnertz, C, Glenn, O-C, Roses, AD, and Chiba-Falek, O. "A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression." Alzheimer's & dementia : the journal of the Alzheimer's Association 11, no. 10 (October 2015): 1133-1143. Full Text
  - Hayden, KM, Lutz, MW, Kuchibhatla, M, Germain, C, and Plassman, BL. "Effect of APOE and CD33 on Cognitive Decline." PloS one 10, no. 6 (January 2015): e0130419-. Full Text
  - Hayden, KM, Lutz, MW, Kuchibhatla, M, Germain, C, and Plassman, BL. "Correction: Effect of APOE and CD33 on Cognitive Decline." PloS one 10, no. 7 (January 2015): e0134887-. Full Text
  - Gottschalk, WK, Lutz, MW, He, YT, Saunders, AM, Burns, DK, Roses, AD, and Chiba-Falek, O. "The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging." Journal of Parkinson'S Disease and Alzheimer'S Disease 1, no. 1 (November 2014). Full Text
  - Roses, AD, Lutz, MW, Saunders, AM, Goldgaber, D, Saul, R, Sundseth, SS, Akkari, PA, Roses, SM, Gottschalk, WK, Whitfield, KE, Vostrov, AA, Hauser, MA, Allingham, RR, Burns, DK, Chiba-Falek, O, and Welsh-Bohmer, KA. "African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles." Alzheimer's & dementia : the journal of the Alzheimer's Association 10, no. 6 (November 2014): 592-601.e2. Full Text
  - Lyall, DM, Harris, SE, Bastin, ME, Muñoz Maniega, S, Murray, C, Lutz, MW, Saunders, AM, Roses, AD, Valdés Hernández, MDC, Royle, NA, Starr, JM, Porteous, DJ, Wardlaw, JM, and Deary, IJ. "Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?." Translational Psychiatry 4 (September 23, 2014): e449-null. Full Text
  - Greenbaum, L, Springer, RR, Lutz, MW, Heymann, A, Lubitz, I, Cooper, I, Kravitz, E, Sano, M, Roses, AD, Silverman, JM, Saunders, AM, and Beeri, MS. "The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes." European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 24, no. 9 (September 2014): 1492-1499. Full Text
  - Linnertz, C, Anderson, L, Gottschalk, W, Crenshaw, D, Lutz, MW, Allen, J, Saith, S, Mihovilovic, M, Burke, JR, Welsh-Bohmer, KA, Roses, AD, and Chiba-Falek, O. "The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 10, no. 5 (September 2014): 541-551. Full Text
  - Linnertz, C, Lutz, MW, Ervin, JF, Allen, J, Miller, NR, Welsh-Bohmer, KA, Roses, AD, and Chiba-Falek, O. "The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease." Human Molecular Genetics 23, no. 18 (September 2014): 4814-4821. Full Text
  - Lyall, DM, Harris, SE, Bastin, ME, Muñoz Maniega, S, Murray, C, Lutz, MW, Saunders, AM, Roses, AD, Valdés Hernández, MDC, Royle, NA, Starr, JM, Porteous, DJ, Wardlaw, JM, and Deary, IJ. "Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936." Neurobiology of Aging 35, no. 6 (June 2014): 1513.e25-1513.e33. Full Text
  - Lyall, DM, Harris, SE, Bastin, ME, Muñoz Maniega, S, Murray, C, Lutz, MW, Saunders, AM, Roses, AD, Valdés Hernández, MDC, Royle, NA, Starr, JM, Porteous, DJ, Wardlaw, JM, and Deary, IJ. "Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936." Neurobiology of Aging 35, no. 6 (June 1, 2014). Full Text
  - Roses, AD, Saunders, AM, Lutz, MW, Zhang, N, Hariri, AR, Asin, KE, Crenshaw, DG, Budur, K, Burns, DK, and Brannan, SK. "New applications of disease genetics and pharmacogenetics to drug development." Current opinion in pharmacology 14 (February 2014): 81-89. (Review) Full Text
  - Davies, G, Harris, SE, Reynolds, CA, Payton, A, Knight, HM, Liewald, DC, Lopez, LM, Luciano, M, Gow, AJ, Corley, J, Henderson, R, Murray, C, Pattie, A, Fox, HC, Redmond, P, Lutz, MW, Chiba-Falek, O, Linnertz, C, Saith, S, Haggarty, P, McNeill, G, Ke, X, Ollier, W, Horan, M, Roses, AD, Ponting, CP, Porteous, DJ, Tenesa, A, Pickles, A, Starr, JM, Whalley, LJ, Pedersen, NL, Pendleton, N, Visscher, PM, and Deary, IJ. "A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing." Molecular Psychiatry 19, no. 1 (January 1, 2014): 76-87. Full Text
  - Davies, G, Harris, SE, Reynolds, CA, Payton, A, Knight, HM, Liewald, DC, Lopez, LM, Luciano, M, Gow, AJ, Corley, J, Henderson, R, Murray, C, Pattie, A, Fox, HC, Redmond, P, Lutz, MW, Chiba-Falek, O, Linnertz, C, Saith, S, Haggarty, P, McNeill, G, Ke, X, Ollier, W, Horan, M, Roses, AD, Ponting, CP, Porteous, DJ, Tenesa, A, Pickles, A, Starr, JM, Whalley, LJ, Pedersen, NL, Pendleton, N, Visscher, PM, and Deary, IJ. "A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing." Molecular Psychiatry 19, no. 1 (January 2014): 76-87. Full Text
  - Greenbaum, L, Springer, RR, Lutz, MW, Heymann, A, Lubitz, I, Cooper, I, Kravitz, E, Sano, M, Roses, AD, Silverman, JM, Saunders, AM, and Beeri, MS. "The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes." European Neuropsychopharmacology 24, no. 9 (January 1, 2014): 1492-1499. Full Text
  - Lyall, DM, Harris, SE, Bastin, ME, Muñoz Maniega, S, Murray, C, Lutz, MW, Saunders, AM, Roses, AD, Valdés Hernández, MDC, Royle, NA, Starr, JM, Porteous, DJ, Wardlaw, JM, and Deary, IJ. "Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936." Neurobiology of Aging 35, no. 6 (2014): 1513e25-1513e33.
  - Mastaglia, FL, Rojana-udomsart, A, James, I, Needham, M, Day, TJ, Kiers, L, Corbett, JA, Saunders, AM, Lutz, MW, Roses, AD, and Alzheimer’s Disease Neuroimaging Initiative, . "Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms." Neuromuscular disorders : NMD 23, no. 12 (December 2013): 969-974. Full Text
  - Mastaglia, FL, Rojana-udomsart, A, James, I, Needham, M, Day, TJ, Kiers, L, Corbett, JA, Saunders, AM, Lutz, MW, and Roses, AD. "Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms." Neuromuscular Disorders 23, no. 12 (December 1, 2013): 969-974. Full Text
  - Roses, AD, Lutz, MW, Crenshaw, DG, Grossman, I, Saunders, AM, and Gottschalk, WK. "TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial." Alzheimer's & dementia : the journal of the Alzheimer's Association 9, no. 2 (March 2013): 132-136. (Review) Full Text
  - Crenshaw, DG, Gottschalk, WK, Lutz, MW, Grossman, I, Saunders, AM, Burke, JR, Welsh-Bohmer, KA, Brannan, SK, Burns, DK, and Roses, AD. "Using genetics to enable studies on the prevention of Alzheimer's disease." Clinical Pharmacology and Therapeutics 93, no. 2 (February 2013): 177-185. Full Text
  - Lyall, DM, Royle, NA, Harris, SE, Bastin, ME, Maniega, SM, Murray, C, Lutz, MW, Saunders, AM, Roses, AD, del Valdés Hernández, MC, Starr, JM, Porteous, DJ, Wardlaw, JM, and Deary, IJ. "Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936." PloS one 8, no. 11 (January 2013): e80513-. Full Text
  - Caselli, RJ, Dueck, AC, Huentelman, MJ, Lutz, MW, Saunders, AM, Reiman, EM, and Roses, AD. "Longitudinal modeling of cognitive aging and the TOMM40 effect." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 8, no. 6 (November 2012): 490-495. Full Text
  - Hayden, KM, McEvoy, JM, Linnertz, C, Attix, D, Kuchibhatla, M, Saunders, AM, Lutz, MW, Welsh-Bohmer, KA, Roses, AD, and Chiba-Falek, O. "A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging." Alzheimers Dement 8, no. 5 (September 2012): 381-388. Full Text Link to Item
  - Bruno, D, Pomara, N, Nierenberg, J, Ritchie, JC, Lutz, MW, Zetterberg, H, and Blennow, K. "Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants." Experimental gerontology 47, no. 5 (May 2012): 347-352. Full Text
  - Bruno, D, Nierenberg, JJ, Ritchie, JC, Lutz, MW, and Pomara, N. "Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants." Psychoneuroendocrinology 37, no. 3 (March 2012): 366-371. Full Text
  - Linnertz, C, Saunders, AM, Lutz, MW, Crenshaw, DM, Grossman, I, Burns, DK, Whitfield, KE, Hauser, MA, McCarthy, JJ, Ulmer, M, Allingham, R, Welsh-Bohmer, KA, Roses, AD, and Chiba-Falek, O. "Characterization of the poly-T variant in the TOMM40 gene in diverse populations." PLoS One 7, no. 2 (2012): e30994-. Full Text Link to Item
  - Pomara, N, Bruno, D, Sidtis, JJ, Lutz, MW, Greenblatt, DJ, Saunders, AM, and Roses, AD. "Translocase of outer mitochondrial membrane 40 homolog (TOMM40) poly-T length modulates lorazepam-related cognitive toxicity in healthy APOE ε4-negative elderly." Journal of Clinical Psychopharmacology 31, no. 4 (August 2011): 544-546. (Letter) Full Text
  - Johnson, SC, La Rue, A, Hermann, BP, Xu, G, Koscik, RL, Jonaitis, EM, Bendlin, BB, Hogan, KJ, Roses, AD, Saunders, AM, Lutz, MW, Asthana, S, Green, RC, and Sager, MA. "The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 7, no. 4 (July 2011): 456-465. Full Text
  - Lutz, MW, Crenshaw, DG, Saunders, AM, and Roses, AD. "The importance of being connected." Journal of Alzheimer'S Disease : Jad 24, no. 2 (January 2011): 247-251. Full Text
  - Roses, AD, Lutz, MW, Amrine-Madsen, H, Saunders, AM, Crenshaw, DG, Sundseth, SS, Huentelman, MJ, Welsh-Bohmer, KA, and Reiman, EM. "A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease." The Pharmacogenomics Journal 10, no. 5 (October 2010): 375-384. Full Text
  - Grossman, I, Lutz, MW, Crenshaw, DG, Saunders, AM, Burns, DK, and Roses, AD. "Alzheimer's disease: diagnostics, prognostics and the road to prevention." The Epma Journal 1, no. 2 (June 29, 2010): 293-303. Full Text
  - Lutz, MW, Crenshaw, DG, Saunders, AM, and Roses, AD. "Genetic variation at a single locus and age of onset for Alzheimer's disease." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 6, no. 2 (March 2010): 125-131. Full Text
  - Lutz, MW, Warren, PV, Gill, RW, and Searls, DB. "Managing genomic and proteomic knowledge." Drug Discovery Today: Technologies 2, no. 3 (September 2005): 197-204. Full Text
  - Selleseth, DW, Talarico, CL, Miller, T, Lutz, MW, Biron, KK, and Harvey, RJ. "Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication." Antimicrobial Agents and Chemotherapy 47, no. 4 (April 2003): 1468-1471. Full Text
  - Lopez, VA, Bourne, EJ, Lutz, MW, and Condreay, LD. "Assessment of the COBAS Amplicor HBV Monitor Test for quantitation of serum hepatitis B virus DNA levels." Journal of Clinical Microbiology 40, no. 6 (June 2002): 1972-1976. Full Text
  - Gauthier, J, Bourne, EJ, Lutz, MW, Crowther, LM, Dienstag, JL, Brown, NA, and Condreay, LD. "Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine." The Journal of Infectious Diseases 180, no. 6 (December 1999): 1757-1762. Full Text
  - Allen, MI, Gauthier, J, DesLauriers, M, Bourne, EJ, Carrick, KM, Baldanti, F, Ross, LL, Lutz, MW, and Condreay, LD. "Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine." Journal of clinical microbiology 37, no. 10 (October 1999): 3338-3347.
  - Lutz, MW, Morgan, PH, Kenakin, TP, Goetz, A, Queen, K, Irving, P, Rose, D, Gill, JM, and Rimele, T. "A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle." Journal of pharmacological and toxicological methods 36, no. 3 (November 1996): 171-183. Full Text
  - Weiss, JM, Morgan, PH, Lutz, MW, and Kenakin, TP. "The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy." Journal of theoretical biology 181, no. 4 (August 1996): 381-397. Full Text
  - Lutz, MW, Menius, JA, Choi, TD, Gooding Laskody, R, Domanico, PL, Goetz, AS, and Saussy, DL. "Experimental design for high-throughput screening." Drug Discovery Today 1, no. 7 (July 1996): 277-286. Full Text
  - Saussy, DL, Goetz, AS, Queen, KL, King, HK, Lutz, MW, and Rimele, TJ. "Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype." The Journal of pharmacology and experimental therapeutics 278, no. 1 (July 1996): 136-144.
  - Weiss, JM, Morgan, PH, Lutz, MW, and Kenakin, TP. "The Cubic Ternary Complex Receptor–Occupancy Model II. Understanding Apparent Affinity." Journal of Theoretical Biology 178, no. 2 (January 1996): 169-182. Full Text
  - Weiss, JM, Morgan, PH, Lutz, MW, and Kenakin, TP. "The Cubic Ternary Complex Receptor–Occupancy Model I. Model Description." Journal of Theoretical Biology 178, no. 2 (January 1996): 151-167. Full Text
  - Lutz, MW, Kenakin, TP, Corsi, M, Menius, JA, Krishnamoorthy, C, Rimele, T, and Morgan, PH. "Use of resampling techniques to estimate the variance of parameters in pharmacological assays when experimental protocols preclude independent replication: an example using Schild regressions." Journal of Pharmacological and Toxicological Methods 34, no. 1 (September 1995): 37-46. Full Text
  - Kenakin, T, Morgan, P, and Lutz, M. "On the importance of the "antagonist assumption" to how receptors express themselves." Biochemical pharmacology 50, no. 1 (June 1995): 17-26. (Review) Full Text
  - Goetz, AS, Lutz, MW, Rimele, TJ, and Saussy, DL. "Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes." The Journal of pharmacology and experimental therapeutics 271, no. 3 (December 1994): 1228-1233.
  - Lutz, MW, Morgan, PH, James, MK, Feldman, PL, Brackeen, MF, Lahey, AP, James, SV, Bilotta, JM, and Pressley, JC. "A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics." The Journal of pharmacology and experimental therapeutics 271, no. 2 (November 1994): 795-803.
  - Feldman, PL, James, MK, Brackeen, MF, Bilotta, JM, Schuster, SV, Lahey, AP, Lutz, MW, Johnson, MR, and Leighton, HJ. "Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics." Journal of Medicinal Chemistry 34, no. 7 (July 1991): 2202-2208. Full Text
  - Kenakin, T, Morgan, PH, and Lutz, M. "Drug and tissue factors both confound KA measurements." Trends in pharmacological sciences 11, no. 7 (July 1990): 273-274. Full Text
  - Morgan, PH, Lutz, MW, and Kenakin, TP. "KRAX is important operational determinant of tissue response. KRAX as parameter for classification." Trends in pharmacological sciences 9, no. 10 (October 1988): 351-. (Letter) Full Text
  - Morgan, PH, Lutz, MW, and Kemakin, TP. "KRAXas parameter for classification." Trends in Pharmacological Sciences 9, no. 10 (January 1, 1988): 351-. (Letter) Full Text
  - Lutz, MW, Hammond, WE, Stead, WW, Blunden, PB, and Pryor, DB. "AUTOMATIC PROGRAMMING SYSTEM TO CREATE MEDICALLY-ORIENTED REPORT GENERATORS." Proceedings - Annual Symposium on Computer Applications in Medical Care (December 1, 1985): 422-426.
  - Hammond, WE, Straube, MJ, Stead, WW, and Lutz, M. "TMR--MEETING THE DEMAND FOR THE VARIETY OF REPORT MODALITIES." Proceedings - Annual Symposium on Computer Applications in Medical Care (December 1, 1984): 421-424.
Teaching & Mentoring
Recent Courses
- ECE 899: Special Readings in Electrical Engineering 2016

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Selected Grants

Selected Publications

Books

Conference Papers

Journal Articles

Recent Courses