Overview
Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.
Current Appointments & Affiliations
Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Professor in Pathology
·
2024 - Present
Pathology,
Clinical Science Departments
Recent Publications
Basic Science and Pathogenesis
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Patients with Alzheimer's Disease (AD) frequently manifest comorbid neuropsychiatric symptoms (NPS) with depression and anxiety being most prevalent. Previously we identified shared genetic risk loci between AD and major depressive disorder (MD ... Full text CiteSingle-nucleus multi-omics of Parkinson's disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks.
Journal Article Acta Neuropathol Commun · July 2, 2024 The genetic architecture of Parkinson's disease (PD) is complex and multiple brain cell subtypes are involved in the neuropathological progression of the disease. Here we aimed to advance our understanding of PD genetic complexity at a cell subtype precisi ... Full text Link to item CiteFacilitation of motor evoked potentials after tetanic peripheral nerve stimulation.
Journal Article Clin Neurophysiol · June 2024 OBJECTIVE: Tetanic stimulation of a peripheral nerve prior to transcranial electrical stimulation (TES) may enhance motor evoked potential (MEP) amplitudes. The purpose of this study was to investigate the post-tetanic MEP (p-MEP) technique in improving ME ... Full text Link to item CiteRecent Grants
A spatially resolved joint cortical metabolome and proteome in aging and menopause for the rhesus macaque
ResearchCo Investigator · Awarded by National Institute on Aging · 2022 - 2027CSF Proteomic Studies of APOE4 copy number-dependent effects on the Complement Pathway
ResearchCo Investigator · Awarded by National Institute on Aging · 2022 - 2027Hypoperfusion, Hemodynamic Control Domains and Neurovascular Dysregulation in AD brain pathology
ResearchCo Investigator · Awarded by National Institute on Aging · 2023 - 2027View All Grants
Education, Training & Certifications
Duke University ·
1986
Ph.D.