Overview
Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.
Current Duke Appointments & Affiliations
Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Professor in Pathology
·
2024 - Present
Pathology,
Clinical Science Departments
Recent Scholarly Works
Corrigendum to "Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: presentation and outcomes of adults at a single center" [J. Neuroimmunol. 2022, Article 577987].
Journal article J Neuroimmunol · September 6, 2026 Full text Link to item CiteClinical Practice Outcomes With Lecanemab for Alzheimer Disease.
Journal article Neurol Open Access · September 2026 BACKGROUND AND OBJECTIVES: Lecanemab, an antiamyloid monoclonal antibody, received US Food and Drug Administration approval in July 2023 to treat amyloid-positive early stages of Alzheimer disease (AD) and has since been adopted in many countries. The prim ... Full text Link to item CiteCellular transcriptomic signatures underpinning the heterogeneity of depression in Alzheimer's disease.
Journal article Alzheimers Dement · September 2026 INTRODUCTION: Late-onset Alzheimer's disease (LOAD) and major depressive disorder (MDD) share genetic etiologies. Here, we investigated brain transcriptomic landscapes to gain insights into shared and divergent molecular and biological etiologies across LO ... Full text Link to item CiteRecent Grants
Multiorgan Photon Counting CT and Machine Learning to Elucidate Aging Mechanisms and Interventions
ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2031Role of aging and APOE in the development of Alzheimer's disease and other neurodegenerative diseases
ResearchCo Investigator · Awarded by A. J. Fletcher Foundation · 2027 - 2030LRRK2 signaling in the progression of Parkinson¿s disease and dementia
ResearchBiostatistician III · Awarded by National Institutes of Health · 2026 - 2029View All Grants
Education
Duke University ·
1986
Ph.D.