Overview
Research in the Franz group is involved in elucidating the structural and functional consequences of metal ion coordination in biological systems. We are particularly interested in understanding the coordination chemistry utilized by biology to manage essential yet toxic species like copper and iron. Understanding these principles further guides our development of new chemical tools to manipulate biological metal ion location, speciation, and reactivity for potential therapeutic benefit. We use a combination of synthesis, spectroscopy, and biochemistry in our work. Please visit our group website to learn more about our research.
Current Duke Appointments & Affiliations
James B. Duke Distinguished Professor of Chemistry
·
2025 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor of Chemistry
·
2015 - Present
Chemistry,
Trinity College of Arts & Sciences
Member of the Duke Cancer Institute
·
2003 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
A cysteine-rich domain of the Cryptococcus neoformans Cuf1 transcription factor is required for high copper stress sensing and fungal virulence.
Journal article mBio · July 8, 2026 UNLABELLED: The ability to sense, import, and detoxify copper (Cu) has been shown to be crucial for microbial pathogens to survive within an infected host. Previous studies conducted with the opportunistic human fungal pathogen Cryptococcus neoformans (Cn) ... Full text Link to item CiteProchelators modulate azole activity against <i>Candida albicans</i> in a metal-dependent manner.
Journal article RSC chemical biology · June 2026 Candida albicans is an opportunstic fungal pathogen of growing clinical concern, in part due to antifungal drug tolerance. Here we report a thiol-activated prochelation strategy that modulates the activity of azole antifungals against C. albicans ... Full text CiteLeveraging Vulnerabilities in Copper Trafficking for Synergistic Antifungal Activity.
Journal article ACS chemical biology · November 2025 Candida albicans is an opportunistic fungal pathogen that causes millions of infections per year, for which more efficacious treatments are needed. Observations that azole antifungals incite C. albicans to adjust a variety of metal-dependent ... Full text CiteRecent Grants
Pharmacological Sciences Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Developing Prodrugs to Selectively Suppress Beta-lactam Resistant Bacteria
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2029View All Grants
Education
Massachusetts Institute of Technology ·
2000
Ph.D.
Wellesley College ·
1995
B.A.