Overview
I am a Surgical Oncologist with clinical and research training in pancreatic and hepatobiliary malignancy. In 2018, I joined Duke University as the Chief of Surgical Oncology, and the Chief of Surgery in the Duke Cancer Institute. Previously, I led the clinical and research efforts regarding pancreatic neoplasia within the Department of Surgery at Memorial Sloan Kettering Cancer Center, and served as the Associate Director for Clinical Programs within the David Rubenstein Center for Pancreatic Cancer Research. I also held the Murray F. Brennan endowed Chair in Surgery.
Over the previous ten years, I have been interested in the progression of pancreatic precursor lesions called intraductal papillary mucinous neoplasms (IPMN). These cystic precursor lesions of the pancreas present an opportunity for to both study cancer progression, and potentially prevent the development of this lethal malignancy. My research has focused on biomarker development to identify high-risk IPMN as well as studies evaluating the cause of this disease process. I have successfully completed phase II and phase III clinical trials in patients with pancreatic cancer and IPMN, and am currently the PI of a first-in-human multi-center randomized chemoprevention trial for pancreatic cancer that is targeting patients with high-risk IPMN.
My laboratory includes both pre and postdoctoral trainees, and they play a critical role in the development of our pancreatic cancer prevention program.
Current Appointments & Affiliations
Recent Publications
Social Vulnerability as a Neighborhood-Level Determinant of Pancreatic Cancer Survivorship: A National Analysis of Veterans Affairs Patients.
Conference Ann Surg Oncol · February 2026 BACKGROUND: Veterans Affairs (VA) patients participate within the largest USA equal-access healthcare system, though still experience cancer mortality disparities by social determinants. The Social Vulnerability Index (SVI)-measuring community poverty, min ... Full text Link to item CiteUse of Virtual Oncology in Hepatopancreatobiliary Cancers: A Scoping Review.
Journal Article Ann Surg Oncol · January 2026 BACKGROUND: Telehealth has emerged as a promising solution to address access gaps in cancer care, particularly for complex conditions such as hepatopancreatobiliary (HPB) cancers. Despite the broader adoption of telemedicine in oncology, HPB cancers remain ... Full text Link to item CiteComprehensive Assessment of the Intrinsic Pancreatic Microbiome.
Journal Article Ann Surg · December 1, 2025 OBJECTIVE: To sought comprehensively profile tissue and cyst fluid in patients with benign, precancerous, and cancerous conditions of the pancreas to characterize the intrinsic pancreatic microbiome. BACKGROUND: Small studies in pancreatic ductal adenocarc ... Full text Link to item CiteRecent Grants
Duke Research Training Program in Surgical Oncology
Inst. Training Prgm or CMECo-Principal Investigator · Awarded by National Cancer Institute · 2024 - 2029Advanced Immunobiology Traning Program for Surgeons
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Allergy and Infectious Diseases · 2019 - 2029Disparate Survival, Disparate Workforce: An Integrated Approach to Improving Head and Neck Cancer Outcomes and Diversity in the Oncology Workforce
ResearchCo Investigator · Awarded by National Institute of Dental and Craniofacial Research · 2024 - 2029View All Grants