Overview
Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Chemistry
·
2006 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor of Chemistry
·
2005 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor of Radiology
·
2005 - Present
Radiology,
Clinical Science Departments
Professor of Physics
·
2015 - Present
Physics,
Trinity College of Arts & Sciences
Member of the Duke Cancer Institute
·
2013 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Efficient 15N hyperpolarization of [15N3]metronidazole antibiotic via spin-relayed pulsed SABRE-SHEATH
Journal Article Journal of Magnetic Resonance Open · September 1, 2025 Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) is an NMR hyperpolarization technique that relies of the simultaneous exchange of parahydrogen and a to-be-hyperpolarized molecule on the metal ... Full text CiteInvestigation of <sup>15</sup>N-SABRE hyperpolarization at high pressures and in supercritical fluids.
Journal Article Journal of magnetic resonance (San Diego, Calif. : 1997) · June 2025 Signal Amplification By Reversible Exchange (SABRE) is a parahydrogen-based hyperpolarization technique that can generate orders-of-magnitude larger signals than thermal spin polarization within a minute. However, this method is limited by the availability ... Full text CiteExchange-selective excitation pulses for dynamic magnetic resonance.
Journal Article Science advances · February 2025 Coherent evolution is punctuated by dynamical processes such as chemical exchange, conformational transformation, or site hopping in many important problems ranging from biomolecular function to ion trap quantum computation. One well-explored example is nu ... Full text CiteRecent Grants
Novel Hyperpolarization Approaches for Magnetic Resonance Applications
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2025 - 2029From Molecules to Masterpieces: AI-Powered Insights into Cultural Heritage
ResearchCollaborator · Awarded by Schmidt Sciences, LLC · 2026 - 2027Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education, Training & Certifications
University of California, Berkeley ·
1980
Ph.D.
University of California, Berkeley ·
1979
M.S.