Skip to main content

Low central venous pressure versus acute normovolemic hemodilution versus conventional fluid management for reducing blood loss in radical retropubic prostatectomy: a randomized controlled trial.

Publication ,  Journal Article
Habib, AS; Moul, JW; Polascik, TJ; Robertson, CN; Roche, AM; White, WD; Hill, SE; Nosnick, I; Gan, TJ; Duke Perioperative Outcome Study Group,
Published in: Curr Med Res Opin
May 2014

OBJECTIVE: To compare acute normovolemic hemodilution versus low central venous pressure strategy versus conventional fluid management in reducing intraoperative estimated blood loss, hematocrit drop and need for blood transfusion in patients undergoing radical retropubic prostatectomy under general anesthesia. RESEARCH DESIGN AND METHODS: Patients undergoing radical retropubic prostatectomy under general anesthesia were randomized to conventional fluid management, acute normovolemic hemodilution or low central venous pressure (≤5 mmHg). Treatment effects on estimated blood loss and hematocrit change were tested in multivariable regression models accounting for surgeon, prostate size, and all two-way interactions. RESULTS: Ninety-two patients completed the study. Estimated blood loss (mean ± SD) was significantly lower with low central venous pressure (706 ± 362 ml) compared to acute normovolemic hemodilution (1103 ± 635 ml) and conventional (1051 ± 714 ml) groups (p = 0.0134). There was no difference between the groups in need for blood transfusion, or hematocrit drop from preoperative values. The multivariate model predicting estimated blood loss showed a significant effect of treatment (p = 0.0028) and prostate size (p = 0.0323), accounting for surgeon (p = 0.0013). In the model predicting hematocrit change, accounting for surgeon difference (p = 0.0037), the treatment effect depended on prostate size (p = 0.0007) with the slope of low central venous pressure differing from the other two groups. Hematocrit was predicted to drop more with increased prostate size in acute normovolemic hemodilution and conventional groups but not with low central venous pressure. KEY LIMITATIONS: Limitations include the inability to blind providers to group assignment, possible variability between providers in estimation of blood loss, and the relatively small sample size that was not powered to detect differences between the groups in need for blood transfusion. CONCLUSIONS: Maintaining low central venous pressure reduced estimated blood loss compared to conventional fluid management and acute normovolemic hemodilution in patients undergoing radical retropubic prostatectomy but there was no difference in allogeneic blood transfusion between the groups.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Curr Med Res Opin

DOI

EISSN

1473-4877

Publication Date

May 2014

Volume

30

Issue

5

Start / End Page

937 / 943

Location

England

Related Subject Headings

  • Prostatectomy
  • Middle Aged
  • Male
  • Humans
  • Hemodilution
  • General & Internal Medicine
  • Fluid Therapy
  • Central Venous Pressure
  • Blood Loss, Surgical
  • Anesthesia, General
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Habib, A. S., Moul, J. W., Polascik, T. J., Robertson, C. N., Roche, A. M., White, W. D., … Duke Perioperative Outcome Study Group, . (2014). Low central venous pressure versus acute normovolemic hemodilution versus conventional fluid management for reducing blood loss in radical retropubic prostatectomy: a randomized controlled trial. Curr Med Res Opin, 30(5), 937–943. https://doi.org/10.1185/03007995.2013.877436
Habib, Ashraf S., Judd W. Moul, Thomas J. Polascik, Cary N. Robertson, Anthony M. Roche, William D. White, Stephen E. Hill, Israel Nosnick, Tong J. Gan, and Tong J. Duke Perioperative Outcome Study Group. “Low central venous pressure versus acute normovolemic hemodilution versus conventional fluid management for reducing blood loss in radical retropubic prostatectomy: a randomized controlled trial.Curr Med Res Opin 30, no. 5 (May 2014): 937–43. https://doi.org/10.1185/03007995.2013.877436.
Habib, Ashraf S., et al. “Low central venous pressure versus acute normovolemic hemodilution versus conventional fluid management for reducing blood loss in radical retropubic prostatectomy: a randomized controlled trial.Curr Med Res Opin, vol. 30, no. 5, May 2014, pp. 937–43. Pubmed, doi:10.1185/03007995.2013.877436.
Habib AS, Moul JW, Polascik TJ, Robertson CN, Roche AM, White WD, Hill SE, Nosnick I, Gan TJ, Duke Perioperative Outcome Study Group. Low central venous pressure versus acute normovolemic hemodilution versus conventional fluid management for reducing blood loss in radical retropubic prostatectomy: a randomized controlled trial. Curr Med Res Opin. 2014 May;30(5):937–943.

Published In

Curr Med Res Opin

DOI

EISSN

1473-4877

Publication Date

May 2014

Volume

30

Issue

5

Start / End Page

937 / 943

Location

England

Related Subject Headings

  • Prostatectomy
  • Middle Aged
  • Male
  • Humans
  • Hemodilution
  • General & Internal Medicine
  • Fluid Therapy
  • Central Venous Pressure
  • Blood Loss, Surgical
  • Anesthesia, General