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Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.

Publication ,  Journal Article
Phua, KKL; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK
Published in: Adv Healthc Mater
June 2014

The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.

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Published In

Adv Healthc Mater

DOI

EISSN

2192-2659

Publication Date

June 2014

Volume

3

Issue

6

Start / End Page

837 / 842

Location

Germany

Related Subject Headings

  • Survival Rate
  • RNA, Messenger
  • Mice, Inbred C57BL
  • Mice
  • Melanoma, Experimental
  • Intramolecular Oxidoreductases
  • Immunotherapy
  • Female
  • Electroporation
  • Disease Models, Animal
 

Citation

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Phua, K. K. L., Boczkowski, D., Dannull, J., Pruitt, S., Leong, K. W., & Nair, S. K. (2014). Whole blood cells loaded with messenger RNA as an anti-tumor vaccine. Adv Healthc Mater, 3(6), 837–842. https://doi.org/10.1002/adhm.201300512
Phua, Kyle K. L., David Boczkowski, Jens Dannull, Scott Pruitt, Kam W. Leong, and Smita K. Nair. “Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.Adv Healthc Mater 3, no. 6 (June 2014): 837–42. https://doi.org/10.1002/adhm.201300512.
Phua KKL, Boczkowski D, Dannull J, Pruitt S, Leong KW, Nair SK. Whole blood cells loaded with messenger RNA as an anti-tumor vaccine. Adv Healthc Mater. 2014 Jun;3(6):837–42.
Phua, Kyle K. L., et al. “Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.Adv Healthc Mater, vol. 3, no. 6, June 2014, pp. 837–42. Pubmed, doi:10.1002/adhm.201300512.
Phua KKL, Boczkowski D, Dannull J, Pruitt S, Leong KW, Nair SK. Whole blood cells loaded with messenger RNA as an anti-tumor vaccine. Adv Healthc Mater. 2014 Jun;3(6):837–842.
Journal cover image

Published In

Adv Healthc Mater

DOI

EISSN

2192-2659

Publication Date

June 2014

Volume

3

Issue

6

Start / End Page

837 / 842

Location

Germany

Related Subject Headings

  • Survival Rate
  • RNA, Messenger
  • Mice, Inbred C57BL
  • Mice
  • Melanoma, Experimental
  • Intramolecular Oxidoreductases
  • Immunotherapy
  • Female
  • Electroporation
  • Disease Models, Animal