Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.
Publication
, Journal Article
Phua, KKL; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK
Published in: Adv Healthc Mater
June 2014
The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.
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Published In
Adv Healthc Mater
DOI
EISSN
2192-2659
Publication Date
June 2014
Volume
3
Issue
6
Start / End Page
837 / 842
Location
Germany
Related Subject Headings
- Survival Rate
- RNA, Messenger
- Mice, Inbred C57BL
- Mice
- Melanoma, Experimental
- Intramolecular Oxidoreductases
- Immunotherapy
- Female
- Electroporation
- Disease Models, Animal
Citation
APA
Chicago
ICMJE
MLA
NLM
Phua, K. K. L., Boczkowski, D., Dannull, J., Pruitt, S., Leong, K. W., & Nair, S. K. (2014). Whole blood cells loaded with messenger RNA as an anti-tumor vaccine. Adv Healthc Mater, 3(6), 837–842. https://doi.org/10.1002/adhm.201300512
Phua, Kyle K. L., David Boczkowski, Jens Dannull, Scott Pruitt, Kam W. Leong, and Smita K. Nair. “Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.” Adv Healthc Mater 3, no. 6 (June 2014): 837–42. https://doi.org/10.1002/adhm.201300512.
Phua KKL, Boczkowski D, Dannull J, Pruitt S, Leong KW, Nair SK. Whole blood cells loaded with messenger RNA as an anti-tumor vaccine. Adv Healthc Mater. 2014 Jun;3(6):837–42.
Phua, Kyle K. L., et al. “Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.” Adv Healthc Mater, vol. 3, no. 6, June 2014, pp. 837–42. Pubmed, doi:10.1002/adhm.201300512.
Phua KKL, Boczkowski D, Dannull J, Pruitt S, Leong KW, Nair SK. Whole blood cells loaded with messenger RNA as an anti-tumor vaccine. Adv Healthc Mater. 2014 Jun;3(6):837–842.
Published In
Adv Healthc Mater
DOI
EISSN
2192-2659
Publication Date
June 2014
Volume
3
Issue
6
Start / End Page
837 / 842
Location
Germany
Related Subject Headings
- Survival Rate
- RNA, Messenger
- Mice, Inbred C57BL
- Mice
- Melanoma, Experimental
- Intramolecular Oxidoreductases
- Immunotherapy
- Female
- Electroporation
- Disease Models, Animal