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Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.

Publication ,  Journal Article
Choi, BD; Gedeon, PC; Sanchez-Perez, L; Bigner, DD; Sampson, JH
Published in: Oncoimmunology
December 1, 2013

Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway.

Duke Scholars

Published In

Oncoimmunology

DOI

ISSN

2162-4011

Publication Date

December 1, 2013

Volume

2

Issue

12

Start / End Page

e26757

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3204 Immunology
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Choi, B. D., Gedeon, P. C., Sanchez-Perez, L., Bigner, D. D., & Sampson, J. H. (2013). Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. Oncoimmunology, 2(12), e26757. https://doi.org/10.4161/onci.26757
Choi, Bryan D., Patrick C. Gedeon, Luis Sanchez-Perez, Darell D. Bigner, and John H. Sampson. “Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.Oncoimmunology 2, no. 12 (December 1, 2013): e26757. https://doi.org/10.4161/onci.26757.
Choi BD, Gedeon PC, Sanchez-Perez L, Bigner DD, Sampson JH. Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. Oncoimmunology. 2013 Dec 1;2(12):e26757.
Choi, Bryan D., et al. “Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.Oncoimmunology, vol. 2, no. 12, Dec. 2013, p. e26757. Pubmed, doi:10.4161/onci.26757.
Choi BD, Gedeon PC, Sanchez-Perez L, Bigner DD, Sampson JH. Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. Oncoimmunology. 2013 Dec 1;2(12):e26757.

Published In

Oncoimmunology

DOI

ISSN

2162-4011

Publication Date

December 1, 2013

Volume

2

Issue

12

Start / End Page

e26757

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3204 Immunology
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology