Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.
Publication
, Journal Article
Choi, BD; Gedeon, PC; Sanchez-Perez, L; Bigner, DD; Sampson, JH
Published in: Oncoimmunology
December 1, 2013
Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway.
Duke Scholars
Published In
Oncoimmunology
DOI
ISSN
2162-4011
Publication Date
December 1, 2013
Volume
2
Issue
12
Start / End Page
e26757
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3204 Immunology
- 1112 Oncology and Carcinogenesis
- 1107 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Choi, B. D., Gedeon, P. C., Sanchez-Perez, L., Bigner, D. D., & Sampson, J. H. (2013). Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. Oncoimmunology, 2(12), e26757. https://doi.org/10.4161/onci.26757
Choi, Bryan D., Patrick C. Gedeon, Luis Sanchez-Perez, Darell D. Bigner, and John H. Sampson. “Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.” Oncoimmunology 2, no. 12 (December 1, 2013): e26757. https://doi.org/10.4161/onci.26757.
Choi BD, Gedeon PC, Sanchez-Perez L, Bigner DD, Sampson JH. Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. Oncoimmunology. 2013 Dec 1;2(12):e26757.
Choi, Bryan D., et al. “Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.” Oncoimmunology, vol. 2, no. 12, Dec. 2013, p. e26757. Pubmed, doi:10.4161/onci.26757.
Choi BD, Gedeon PC, Sanchez-Perez L, Bigner DD, Sampson JH. Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. Oncoimmunology. 2013 Dec 1;2(12):e26757.
Published In
Oncoimmunology
DOI
ISSN
2162-4011
Publication Date
December 1, 2013
Volume
2
Issue
12
Start / End Page
e26757
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3204 Immunology
- 1112 Oncology and Carcinogenesis
- 1107 Immunology