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Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.

Publication ,  Journal Article
Younes, L; Ratnanather, JT; Brown, T; Aylward, E; Nopoulos, P; Johnson, H; Magnotta, VA; Paulsen, JS; Margolis, RL; Albin, RL; Miller, MI ...
Published in: Hum Brain Mapp
March 2014

Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

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Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

March 2014

Volume

35

Issue

3

Start / End Page

792 / 809

Location

United States

Related Subject Headings

  • Prodromal Symptoms
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Huntington Disease
  • Humans
  • Female
  • Experimental Psychology
  • Basal Ganglia
  • Atrophy
 

Citation

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Younes, L., Ratnanather, J. T., Brown, T., Aylward, E., Nopoulos, P., Johnson, H., … PREDICT-HD Investigators and Coordinators of the Huntington Study Group, . (2014). Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. Hum Brain Mapp, 35(3), 792–809. https://doi.org/10.1002/hbm.22214
Younes, Laurent, J Tilak Ratnanather, Timothy Brown, Elizabeth Aylward, Peg Nopoulos, Hans Johnson, Vincent A. Magnotta, et al. “Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.Hum Brain Mapp 35, no. 3 (March 2014): 792–809. https://doi.org/10.1002/hbm.22214.
Younes L, Ratnanather JT, Brown T, Aylward E, Nopoulos P, Johnson H, et al. Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. Hum Brain Mapp. 2014 Mar;35(3):792–809.
Younes, Laurent, et al. “Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.Hum Brain Mapp, vol. 35, no. 3, Mar. 2014, pp. 792–809. Pubmed, doi:10.1002/hbm.22214.
Younes L, Ratnanather JT, Brown T, Aylward E, Nopoulos P, Johnson H, Magnotta VA, Paulsen JS, Margolis RL, Albin RL, Miller MI, Ross CA, PREDICT-HD Investigators and Coordinators of the Huntington Study Group. Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. Hum Brain Mapp. 2014 Mar;35(3):792–809.
Journal cover image

Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

March 2014

Volume

35

Issue

3

Start / End Page

792 / 809

Location

United States

Related Subject Headings

  • Prodromal Symptoms
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Huntington Disease
  • Humans
  • Female
  • Experimental Psychology
  • Basal Ganglia
  • Atrophy