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Applications of elastin-like polypeptides in drug delivery.

Publication ,  Journal Article
MacEwan, SR; Chilkoti, A
Published in: Journal of controlled release : official journal of the Controlled Release Society
September 2014

Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments. Due to their genetically encoded design and recombinant synthesis, the sequence and size of ELPs can be exactly defined. These design parameters control the structure and function of the ELP with a precision that is unmatched by synthetic polymers. Due to these attributes, ELPs have been used extensively for drug delivery in a variety of different embodiments-as soluble macromolecular carriers, self-assembled nanoparticles, cross-linked microparticles, or thermally coacervated depots. These ELP systems have been used to deliver biologic therapeutics, radionuclides, and small molecule drugs to a variety of anatomical sites for the treatment of diseases including cancer, type 2 diabetes, osteoarthritis, and neuroinflammation.

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Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

September 2014

Volume

190

Start / End Page

314 / 330

Related Subject Headings

  • Temperature
  • Pharmacology & Pharmacy
  • Peptides
  • Neoplasms
  • Nanoparticles
  • Humans
  • Elastin
  • Drug Carriers
  • Delayed-Action Preparations
  • 4003 Biomedical engineering
 

Citation

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MacEwan, S. R., & Chilkoti, A. (2014). Applications of elastin-like polypeptides in drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society, 190, 314–330. https://doi.org/10.1016/j.jconrel.2014.06.028
MacEwan, Sarah R., and Ashutosh Chilkoti. “Applications of elastin-like polypeptides in drug delivery.Journal of Controlled Release : Official Journal of the Controlled Release Society 190 (September 2014): 314–30. https://doi.org/10.1016/j.jconrel.2014.06.028.
MacEwan SR, Chilkoti A. Applications of elastin-like polypeptides in drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 2014 Sep;190:314–30.
MacEwan, Sarah R., and Ashutosh Chilkoti. “Applications of elastin-like polypeptides in drug delivery.Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 190, Sept. 2014, pp. 314–30. Epmc, doi:10.1016/j.jconrel.2014.06.028.
MacEwan SR, Chilkoti A. Applications of elastin-like polypeptides in drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 2014 Sep;190:314–330.
Journal cover image

Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

September 2014

Volume

190

Start / End Page

314 / 330

Related Subject Headings

  • Temperature
  • Pharmacology & Pharmacy
  • Peptides
  • Neoplasms
  • Nanoparticles
  • Humans
  • Elastin
  • Drug Carriers
  • Delayed-Action Preparations
  • 4003 Biomedical engineering