Kidney α-intercalated cells and lipocalin 2: defending the urinary tract.
A growing body of evidence indicates that the kidneys contribute substantially to immune defense against pathogens in the urinary tract. In this issue, Paragas et al. report that α-intercalated cells (A-ICs) within the nephron collecting duct sense infecting Gram-negative bacteria, resulting in simultaneously secretion of the iron chelating protein lipocalin 2 (LCN2) and protons, which acidify the urine. A-IC-specific LCN2 and proton secretion markedly reduced the ability of infecting uropathogenic E. coli (UPEC) to grow and sustain infection. The capacity of A-ICs to sense and actively promote clearance of infecting bacteria in the lower urinary tract represents a novel function for these specialized kidney cells, which are best known for their role in modulating acid-base homeostasis.
Duke Scholars
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- Uropathogenic Escherichia coli
- Urinary Tract Infections
- Proto-Oncogene Proteins
- Oncogene Proteins
- Lipocalins
- Lipocalin-2
- Kidney Tubules, Collecting
- Immunology
- Humans
- Female
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Uropathogenic Escherichia coli
- Urinary Tract Infections
- Proto-Oncogene Proteins
- Oncogene Proteins
- Lipocalins
- Lipocalin-2
- Kidney Tubules, Collecting
- Immunology
- Humans
- Female