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Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?

Publication ,  Journal Article
Bursac, N
Published in: The Journal of clinical investigation
July 2014

Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation after aortic banding in murine hearts arises almost exclusively from proliferation of resident fibroblasts originating from both the epicardium and a previously unrecognized source, the endocardium. Further characterization of fibroblast origin and function in different types and stages of heart disease could lead to development of improved fibroblast-targeted cardiac therapies.

Duke Scholars

Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

July 2014

Volume

124

Issue

7

Start / End Page

2850 / 2853

Related Subject Headings

  • Myocardium
  • Male
  • Immunology
  • Heart Failure
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bursac, N. (2014). Cardiac fibroblasts in pressure overload hypertrophy: the enemy within? The Journal of Clinical Investigation, 124(7), 2850–2853. https://doi.org/10.1172/jci76628
Bursac, Nenad. “Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?The Journal of Clinical Investigation 124, no. 7 (July 2014): 2850–53. https://doi.org/10.1172/jci76628.
Bursac N. Cardiac fibroblasts in pressure overload hypertrophy: the enemy within? The Journal of clinical investigation. 2014 Jul;124(7):2850–3.
Bursac, Nenad. “Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?The Journal of Clinical Investigation, vol. 124, no. 7, July 2014, pp. 2850–53. Epmc, doi:10.1172/jci76628.
Bursac N. Cardiac fibroblasts in pressure overload hypertrophy: the enemy within? The Journal of clinical investigation. 2014 Jul;124(7):2850–2853.

Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

July 2014

Volume

124

Issue

7

Start / End Page

2850 / 2853

Related Subject Headings

  • Myocardium
  • Male
  • Immunology
  • Heart Failure
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences