Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?
Publication
, Journal Article
Bursac, N
Published in: The Journal of clinical investigation
July 2014
Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation after aortic banding in murine hearts arises almost exclusively from proliferation of resident fibroblasts originating from both the epicardium and a previously unrecognized source, the endocardium. Further characterization of fibroblast origin and function in different types and stages of heart disease could lead to development of improved fibroblast-targeted cardiac therapies.
Duke Scholars
Published In
The Journal of clinical investigation
DOI
EISSN
1558-8238
ISSN
0021-9738
Publication Date
July 2014
Volume
124
Issue
7
Start / End Page
2850 / 2853
Related Subject Headings
- Myocardium
- Male
- Immunology
- Heart Failure
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Bursac, N. (2014). Cardiac fibroblasts in pressure overload hypertrophy: the enemy within? The Journal of Clinical Investigation, 124(7), 2850–2853. https://doi.org/10.1172/jci76628
Bursac, Nenad. “Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?” The Journal of Clinical Investigation 124, no. 7 (July 2014): 2850–53. https://doi.org/10.1172/jci76628.
Bursac N. Cardiac fibroblasts in pressure overload hypertrophy: the enemy within? The Journal of clinical investigation. 2014 Jul;124(7):2850–3.
Bursac, Nenad. “Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?” The Journal of Clinical Investigation, vol. 124, no. 7, July 2014, pp. 2850–53. Epmc, doi:10.1172/jci76628.
Bursac N. Cardiac fibroblasts in pressure overload hypertrophy: the enemy within? The Journal of clinical investigation. 2014 Jul;124(7):2850–2853.
Published In
The Journal of clinical investigation
DOI
EISSN
1558-8238
ISSN
0021-9738
Publication Date
July 2014
Volume
124
Issue
7
Start / End Page
2850 / 2853
Related Subject Headings
- Myocardium
- Male
- Immunology
- Heart Failure
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences