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Pharmacological activity of metal binding agents that alter copper bioavailability.

Publication ,  Journal Article
Helsel, ME; Franz, KJ
Published in: Dalton transactions (Cambridge, England : 2003)
May 2015

Iron, copper and zinc are required nutrients for many organisms but also potent toxins if misappropriated. An overload of any of these metals can be cytotoxic and ultimately lead to organ failure, whereas deficiencies can result in anemia, weakened immune system function, and other medical conditions. Cellular metal imbalances have been implicated in neurodegenerative diseases, cancer and infection. It is therefore critical for living organisms to maintain careful control of both the total levels and subcellular distributions of these metals to maintain healthy function. This perspective explores several strategies envisioned to alter the bioavailability of metal ions by using synthetic metal-binding agents targeted for diseases where misappropriated metal ions are suspected of exacerbating cellular damage. Specifically, we discuss chemical properties that influence the pharmacological outcome of a subset of metal-binding agents known as ionophores, and review several examples that have shown multiple pharmacological activities in metal-related diseases, with a specific focus on copper.

Duke Scholars

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Published In

Dalton transactions (Cambridge, England : 2003)

DOI

EISSN

1477-9234

ISSN

1477-9226

Publication Date

May 2015

Volume

44

Issue

19

Start / End Page

8760 / 8770

Related Subject Headings

  • Inorganic & Nuclear Chemistry
  • Humans
  • Disease
  • Copper
  • Chelating Agents
  • Biological Availability
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0307 Theoretical and Computational Chemistry
  • 0302 Inorganic Chemistry
 

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Helsel, M. E., & Franz, K. J. (2015). Pharmacological activity of metal binding agents that alter copper bioavailability. Dalton Transactions (Cambridge, England : 2003), 44(19), 8760–8770. https://doi.org/10.1039/c5dt00634a
Helsel, Marian E., and Katherine J. Franz. “Pharmacological activity of metal binding agents that alter copper bioavailability.Dalton Transactions (Cambridge, England : 2003) 44, no. 19 (May 2015): 8760–70. https://doi.org/10.1039/c5dt00634a.
Helsel ME, Franz KJ. Pharmacological activity of metal binding agents that alter copper bioavailability. Dalton transactions (Cambridge, England : 2003). 2015 May;44(19):8760–70.
Helsel, Marian E., and Katherine J. Franz. “Pharmacological activity of metal binding agents that alter copper bioavailability.Dalton Transactions (Cambridge, England : 2003), vol. 44, no. 19, May 2015, pp. 8760–70. Epmc, doi:10.1039/c5dt00634a.
Helsel ME, Franz KJ. Pharmacological activity of metal binding agents that alter copper bioavailability. Dalton transactions (Cambridge, England : 2003). 2015 May;44(19):8760–8770.
Journal cover image

Published In

Dalton transactions (Cambridge, England : 2003)

DOI

EISSN

1477-9234

ISSN

1477-9226

Publication Date

May 2015

Volume

44

Issue

19

Start / End Page

8760 / 8770

Related Subject Headings

  • Inorganic & Nuclear Chemistry
  • Humans
  • Disease
  • Copper
  • Chelating Agents
  • Biological Availability
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0307 Theoretical and Computational Chemistry
  • 0302 Inorganic Chemistry