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Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.

Publication ,  Journal Article
Feix, JA; Peery, CA; Gan, TJ; Warner, DS; James, ML; Zomorodi, A; McDonagh, DL
Published in: Springerplus
2015

BACKGROUND: Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation with hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined. METHODS: Using a retrospective cohort of neurosurgical patients at Duke University Medical Center between March 2005 and March 2012, patient characteristics were compared between those who developed post-craniotomy hemorrhage and those who did not. RESULTS: A total of 4,109 craniotomy procedures were analyzed with 61 patients having repeat craniotomy for post-operative hemorrhage (1.5%). The rate of reoperation in the group receiving 6% High Molecular Weight Hydroxyethyl Starch (Hextend(®)) was 2.6 vs. 1.3% for patients that did not receive hetastarch (P = 0.13). The reoperation rate for those receiving 6% hydroxyethyl Starch 130/0.4 (Voluven(®)) was 1.4 vs. 1.6% in patients not receiving Voluven (P = 0.85). CONCLUSIONS: In this retrospective cohort, intra-operative hydroxyethyl starch was not associated with an increased risk of post-craniotomy hemorrhage.

Duke Scholars

Published In

Springerplus

DOI

ISSN

2193-1801

Publication Date

2015

Volume

4

Start / End Page

350

Location

Switzerland
 

Citation

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Feix, J. A., Peery, C. A., Gan, T. J., Warner, D. S., James, M. L., Zomorodi, A., & McDonagh, D. L. (2015). Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage. Springerplus, 4, 350. https://doi.org/10.1186/s40064-015-1126-0
Feix, James A., C Andrew Peery, Tong J. Gan, David S. Warner, Michael L. James, Ali Zomorodi, and David L. McDonagh. “Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.Springerplus 4 (2015): 350. https://doi.org/10.1186/s40064-015-1126-0.
Feix JA, Peery CA, Gan TJ, Warner DS, James ML, Zomorodi A, et al. Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage. Springerplus. 2015;4:350.
Feix, James A., et al. “Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.Springerplus, vol. 4, 2015, p. 350. Pubmed, doi:10.1186/s40064-015-1126-0.
Feix JA, Peery CA, Gan TJ, Warner DS, James ML, Zomorodi A, McDonagh DL. Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage. Springerplus. 2015;4:350.
Journal cover image

Published In

Springerplus

DOI

ISSN

2193-1801

Publication Date

2015

Volume

4

Start / End Page

350

Location

Switzerland