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Translating Gene Therapy to the Clinic: Techniques and Approaches

Gene Therapy for the Prevention of Vein Graft Disease

Publication ,  Chapter
Mueller, SB; Kontos, CD
January 1, 2015

Despite advances in the medical management of atherosclerosis, surgical revascularization using autologous veins remains a mainstay of therapy for both coronary and peripheral artery disease. However, long-term outcomes following bypass surgery are limited by relatively high failure rates due to vein graft disease. Vein graft failure, together with the limited supply of native veins, has led to interest in gene therapy to prevent vein graft disease. Bypass grafting presents an ideal opportunity for gene therapy because vein grafts can be treated with gene delivery vectors ex vivo to maximize gene delivery, minimize systemic toxicity, and target the pathogenesis of vein graft disease at its onset. Here we discuss the pathogenesis of vein graft disease, vector delivery strategies, and potential molecular targets for preventing vein graft disease. We summarize the preclinical and clinical literature on gene therapy in vein grafting and discuss considerations for future therapies to prevent vein graft disease.

Duke Scholars

DOI

ISBN

9780128005637

Publication Date

January 1, 2015

Start / End Page

227 / 246
 

Citation

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Mueller, S. B., & Kontos, C. D. (2015). Gene Therapy for the Prevention of Vein Graft Disease. In Translating Gene Therapy to the Clinic: Techniques and Approaches (pp. 227–246). https://doi.org/10.1016/B978-0-12-800563-7.00015-4
Mueller, S. B., and C. D. Kontos. “Gene Therapy for the Prevention of Vein Graft Disease.” In Translating Gene Therapy to the Clinic: Techniques and Approaches, 227–46, 2015. https://doi.org/10.1016/B978-0-12-800563-7.00015-4.
Mueller SB, Kontos CD. Gene Therapy for the Prevention of Vein Graft Disease. In: Translating Gene Therapy to the Clinic: Techniques and Approaches. 2015. p. 227–46.
Mueller, S. B., and C. D. Kontos. “Gene Therapy for the Prevention of Vein Graft Disease.” Translating Gene Therapy to the Clinic: Techniques and Approaches, 2015, pp. 227–46. Scopus, doi:10.1016/B978-0-12-800563-7.00015-4.
Mueller SB, Kontos CD. Gene Therapy for the Prevention of Vein Graft Disease. Translating Gene Therapy to the Clinic: Techniques and Approaches. 2015. p. 227–246.
Journal cover image

DOI

ISBN

9780128005637

Publication Date

January 1, 2015

Start / End Page

227 / 246