Christopher Dale Kontos | Scholars@Duke

Christopher Dale Kontos
Professor of Medicine

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Current Appointments & Affiliations

Professor of Medicine, Medicine, Cardiology, Medicine 2017
Director, Medical Scientist Training Program, Medicine, Cardiology, Medicine 2009
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1993

Contact Information

435 Sands Bldg, Durham, NC 27710
Duke Box 3629, Durham, NC 27710
cdkontos@duke.edu (919) 684-2119

Background
Education, Training, & Certifications
- Fellow in Cardiology, Medicine, Duke University 1993 - 1997
- M.D., Virginia Commonwealth University 1989
Duke Appointment History
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2017
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2017
- Assistant Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2001 - 2008
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2006 - 2008
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2006
- Associate in the Department of Medicine, Medicine, Cardiology, Medicine 1997 - 1999
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 1997
Recognition
In the News
- NOV 24, 2015
  
  Seven Faculty Named AAAS Fellows
Expertise
Global Scholarship
- Teaching
  - South Korea (Country)
Research
Selected Grants
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- Mitigators of Radiation-Induced Endovascular Injury: Targeting Tie2 and Thrombocytopenia awarded by National Institutes of Health 2017 - 2022
- A fully biological platform for monitoring mesoscale neural activity awarded by National Institutes of Health 2018 - 2020
- TIE2 Activation for the Treatment of Chemical-Induced Acute Lung Injury awarded by National Institutes of Health 2017 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- The role of muscle progenitor cells in muscle and vascular regeneration in PAD awarded by National Institutes of Health 2017 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- A Novel Molecular Regulator of Vascular Homeostasis awarded by American Heart Association 2016 - 2019
- Gertrude B. Elion Mentored Medical Student Award awarded by Triangle Community Foundation 2018 - 2019
- Gertrude Elion Mentored Medical Research Award awarded by Triangle Community Foundation 2018 - 2019
- Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
- Skeletal Muscle and Vascular Remodeling in Peripheral Artery Disease awarded by National Institutes of Health 2015 - 2018
- Seahorse XFe96 Extracellular Flux Analyzer awarded by North Carolina Biotechnology Center 2017 - 2018
- Enhancing dendritic cell migration to drive potent anti-tumor immune responses awarded by National Institutes of Health 2013 - 2017
- Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury awarded by National Institutes of Health 2013 - 2016
- Muscle-Resident Stem Cells for Angiogenesis and Vascular Maturation in PAD awarded by National Institutes of Health 2013 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Institutional Training Grant in Pediatric Cardiology awarded by National Institutes of Health 2009 - 2015
- Novel pathways modulating Raf-mediated cardiac hypertrophy awarded by National Institutes of Health 2013 - 2015
- The role of satellite cells in adult skeletal muscle growth and maintenance awarded by University of Kentucky 2013 - 2014
- Peripheral endothelial and muscle cell pathology in cardiovascular disease awarded by National Institutes of Health 2010 - 2013
- PTEN Gene Therapy for Vein Graft Disease awarded by National Institutes of Health 2009 - 2012
- The Role of PTEN in Endothelial Biology awarded by National Institutes of Health 2008 - 2012
- The Role of ADAM15 in sTie@ Shedding and Ischemic Angiogenesis awarded by National Institutes of Health 2009 - 2010
- Systems Biology of Angiogenesis awarded by National Institutes of Health 2006 - 2009
- Endothelial Cell Molecular Alterations in Cancer awarded by National Institutes of Health 2002 - 2008
- Therapeutic Angiogenesis for Erectile Dysfunction awarded by National Institutes of Health 2004 - 2008
- The Role of Tie2 and the Angiopoietins in EPC Biology awarded by National Institutes of Health 2005 - 2007
- Downregulation of Tie2 awarded by National Institutes of Health 2004 - 2007
- The Angiopoietins in Vascular Maintenance and Remodeling awarded by National Institutes of Health 2002 - 2007
- TIE2-Associated Molecular Targets in Tumor Vasculature awarded by National Institutes of Health 2002 - 2005
- Endothelial signal transduction by tek and tie awarded by National Institutes of Health 1997 - 2002
- Role of TEK signaling in endothelial biology awarded by National Institutes of Health 1996 - 2002
- Endothelial Signal Transduction By Tek And Tie awarded by National Institutes of Health 1997 - 1999
- Tek Signaling And Endothelial Biology awarded by National Institutes of Health 1996 - 1999
- missing activity
- missing activity
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Myers, VD, Tomar, D, Madesh, M, Wang, J, Song, J, Zhang, X-Q, Gupta, MK, Tahrir, FG, Gordon, J, McClung, JM, Kontos, CD, Khalili, K, Cheung, JY, and Feldman, AM. "Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis." Journal of Cellular Physiology 233, no. 9 (September 2018): 6319-6326. Full Text
  - Tahrir, FG, Shanmughapriya, S, Ahooyi, TM, Knezevic, T, Gupta, MK, Kontos, CD, McClung, JM, Madesh, M, Gordon, J, Feldman, AM, Cheung, JY, and Khalili, K. "Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes." Journal of Cellular Physiology 233, no. 2 (February 2018): 748-758. Full Text
  - McClung, JM, McCord, TJ, Ryan, TE, Schmidt, CA, Green, TD, Southerland, KW, Reinardy, JL, Mueller, SB, Venkatraman, TN, Lascola, CD, Keum, S, Marchuk, DA, Spangenburg, EE, Dokun, A, Annex, BH, and Kontos, CD. "BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy." Circulation 136, no. 3 (July 2017): 281-296. Full Text
  - Feldman, AM, Kontos, CD, McClung, JM, Gerhard, GS, Khalili, K, and Cheung, JY. "Precision Medicine for Heart Failure: Lessons From Oncology." Circulation. Heart Failure 10, no. 6 (June 2017). Full Text
  - Oehlers, SH, Cronan, MR, Beerman, RW, Johnson, MG, Huang, J, Kontos, CD, Stout, JE, and Tobin, DM. "Infection-Induced Vascular Permeability Aids Mycobacterial Growth." The Journal of Infectious Diseases 215, no. 5 (March 2017): 813-817. Full Text
  - Fujisawa, T, Wang, K, Niu, X-L, Egginton, S, Ahmad, S, Hewett, P, Kontos, CD, and Ahmed, A. "Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes." Cardiovascular Research 113, no. 1 (January 2017): 81-89. Full Text
  - McClung, JM, McCord, TJ, Southerland, K, Schmidt, CA, Padgett, ME, Ryan, TE, and Kontos, CD. "Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density." Journal of Vascular Surgery 64, no. 4 (October 2016): 1101-1111.e2. Full Text
  - Mueller, SB, and Kontos, CD. "Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling." The Journal of Clinical Investigation 126, no. 9 (September 2016): 3188-3191. Full Text
  - Padgett, ME, McCord, TJ, McClung, JM, and Kontos, CD. "Methods for Acute and Subacute Murine Hindlimb Ischemia." Journal of Visualized Experiments : Jove , no. 112 (June 21, 2016). Full Text
  - Mofarrahi, M, McClung, JM, Kontos, CD, Davis, EC, Tappuni, B, Moroz, N, Pickett, AE, Huck, L, Harel, S, Danialou, G, and Hussain, SNA. "Angiopoietin-1 enhances skeletal muscle regeneration in mice." American Journal of Physiology Regulatory, Integrative and Comparative Physiology 308, no. 7 (April 2015): R576-R589. Full Text
  - McClung, JM, Reinardy, JL, Mueller, SB, McCord, TJ, Kontos, CD, Brown, DA, Hussain, SNA, Schmidt, CA, Ryan, TE, and Green, TD. "Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment." Frontiers in Physiology 6 (January 2015): 161-null. Full Text
  - Reinardy, JL, Corey, DM, Golzio, C, Mueller, SB, Katsanis, N, and Kontos, CD. "Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway." PloS one 10, no. 10 (January 2015): e0139614-. Full Text
  - Shen, J, Frye, M, Lee, BL, Reinardy, JL, McClung, JM, Ding, K, Kojima, M, Xia, H, Seidel, C, Lima e Silva, R, Dong, A, Hackett, SF, Wang, J, Howard, BW, Vestweber, D, Kontos, CD, Peters, KG, and Campochiaro, PA. "Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature." The Journal of Clinical Investigation 124, no. 10 (October 2014): 4564-4576. Full Text
  - Kontos, CD. "More than skin deep: connecting melanocyte pigmentation and angiogenic diseases." The Journal of Clinical Investigation 124, no. 1 (January 2014): 76-79. Full Text
  - "Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle." (December 1, 2013): 99-134. (Chapter)
  - Kontos, CD, and Willett, CG. "Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation." J Natl Cancer Inst 105, no. 16 (August 21, 2013): 1163-1165. Full Text Link to Item
  - Southerland, KW, Frazier, SB, Bowles, DE, Milano, CA, and Kontos, CD. "Gene therapy for the prevention of vein graft disease." Translational Research : the Journal of Laboratory and Clinical Medicine 161, no. 4 (April 2013): 321-338. (Review) Full Text
  - Lee, C-L, Moding, EJ, Cuneo, KC, Li, Y, Sullivan, JM, Mao, L, Washington, I, Jeffords, LB, Rodrigues, RC, Ma, Y, Das, S, Kontos, CD, Kim, Y, Rockman, HA, and Kirsch, DG. "p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice." Science Signaling 5, no. 234 (July 24, 2012): ra52-null. Full Text
  - McClung, JM, McCord, TJ, Keum, S, Johnson, S, Annex, BH, Marchuk, DA, and Kontos, CD. "Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice." The American Journal of Pathology 180, no. 5 (May 2012): 2156-2169. Full Text
  - Simnick, AJ, Amiram, M, Liu, W, Hanna, G, Dewhirst, MW, Kontos, CD, and Chilkoti, A. "In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide." Journal of Controlled Release : Official Journal of the Controlled Release Society 155, no. 2 (October 2011): 144-151. Full Text
  - Chen, L, Xu, B, Liu, L, Luo, Y, Zhou, H, Chen, W, Shen, T, Han, X, Kontos, CD, and Huang, S. "Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death." Free Radical Biology & Medicine 50, no. 5 (March 2011): 624-632. Full Text
  - Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model." American Journal of Physiology. Heart and Circulatory Physiology 298, no. 6 (June 2010): H2174-H2191. Full Text
  - Furgeson, SB, Simpson, PA, Park, I, Vanputten, V, Horita, H, Kontos, CD, Nemenoff, RA, and Weiser-Evans, MCM. "Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation." Cardiovascular Research 86, no. 2 (May 2010): 274-282. Full Text
  - Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use." Journal of Cellular and Molecular Medicine 14, no. 3 (March 2010): 528-552. (Review) Full Text
  - Sagana, RL, Yan, M, Cornett, AM, Tsui, JL, Stephenson, DA, Huang, SK, Moore, BB, Ballinger, MN, Melonakos, J, Kontos, CD, Aronoff, DM, Peters-Golden, M, and White, ES. "Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression." The Journal of Biological Chemistry 284, no. 47 (November 2009): 32264-32271. Full Text
  - Ahmed, A, Fujisawa, T, Niu, X-L, Ahmad, S, Al-Ani, B, Chudasama, K, Abbas, A, Potluri, R, Bhandari, V, Findley, CM, Lam, GKW, Huang, J, Hewett, PW, Cudmore, M, and Kontos, CD. "Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide." Circulation Research 104, no. 12 (June 2009): 1333-1336. Full Text
  - Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport." Physiological Genomics 38, no. 1 (June 2009): 29-41. Full Text
  - Lima, B, Lam, GKW, Xie, L, Diesen, DL, Villamizar, N, Nienaber, J, Messina, E, Bowles, D, Kontos, CD, Hare, JM, Stamler, JS, and Rockman, HA. "Endogenous S-nitrosothiols protect against myocardial injury." Proceedings of the National Academy of Sciences of the United States of America 106, no. 15 (April 2009): 6297-6302. Full Text
  - Qiu, W, Federico, L, Naples, M, Avramoglu, RK, Meshkani, R, Zhang, J, Tsai, J, Hussain, M, Dai, K, Iqbal, J, Kontos, CD, Horie, Y, Suzuki, A, and Adeli, K. "Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins." Hepatology 48, no. 6 (December 2008): 1799-1809. Full Text Link to Item
  - Estrada, R, Zeng, Q, Lu, H, Sarojini, H, Lee, J-F, Mathis, SP, Sanchez, T, Wang, E, Kontos, CD, Lin, C-Y, Hla, T, Haribabu, B, and Lee, M-J. "Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells." The Journal of Biological Chemistry 283, no. 44 (October 2008): 30363-30375. Full Text
  - Xie, D, Findley, CM, Greenfield, JM, Pippen, AM, Kontos, CD, Donatucci, CF, and Annex, BH. "A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits." J Sex Med 5, no. 9 (September 2008): 2069-2078. Full Text Link to Item
  - Findley, CM, Mitchell, RG, Duscha, BD, Annex, BH, and Kontos, CD. "Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease." Journal of the American College of Cardiology 52, no. 5 (July 2008): 387-393. Full Text
  - Sarraf-Yazdi, S, Mi, J, Moeller, BJ, Niu, X, White, RR, Kontos, CD, Sullenger, BA, Dewhirst, MW, and Clary, BM. "Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer." J Surg Res 146, no. 1 (May 1, 2008): 16-23. Full Text Link to Item
  - Xie, D, Hazarika, S, Andrich, AJ, Padgett, ME, Kontos, CD, Donatucci, CF, and Annex, BH. "High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue." J Sex Med 5, no. 5 (May 2008): 1137-1148. Full Text Link to Item
  - Mi, J, Zhang, X, Rabbani, ZN, Liu, Y, Reddy, SK, Su, Z, Salahuddin, FK, Viles, K, Giangrande, PH, Dewhirst, MW, Sullenger, BA, Kontos, CD, and Clary, BM. "RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin." Mol Ther 16, no. 1 (January 2008): 66-73. Full Text Link to Item
  - White, RR, Roy, JA, Viles, KD, Sullenger, BA, and Kontos, CD. "A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function." Angiogenesis 11, no. 4 (2008): 395-401. Full Text Link to Item
  - Findley, CM, Cudmore, MJ, Ahmed, A, and Kontos, CD. "VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling." Arteriosclerosis, Thrombosis, and Vascular Biology 27, no. 12 (December 2007): 2619-2626. Full Text
  - Hazarika, S, Dokun, AO, Li, Y, Popel, AS, Kontos, CD, and Annex, BH. "Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1." Circulation Research 101, no. 9 (October 2007): 948-956. Full Text
  - Cao, Y, Sonveaux, P, Liu, S, Zhao, Y, Mi, J, Clary, BM, Li, C-Y, Kontos, CD, and Dewhirst, MW. "Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth." Cancer Res 67, no. 8 (April 15, 2007): 3835-3844. Full Text Link to Item
  - Kontos, CD, and Annex, BH. "Engineered transcription factors for therapeutic angiogenesis." Curr Opin Mol Ther 9, no. 2 (April 2007): 145-152. (Review) Link to Item
  - Li, Y, Hazarika, S, Xie, D, Pippen, AM, Kontos, CD, and Annex, BH. "In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia." Diabetes 56, no. 3 (March 2007): 656-665. Full Text
  - DeKroon, R, Robinette, JB, Hjelmeland, AB, Wiggins, E, Blackwell, M, Mihovilovic, M, Fujii, M, York, J, Hart, J, Kontos, C, Rich, J, and Strittmatter, WJ. "APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2." Circ Res 99, no. 8 (October 13, 2006): 829-836. Full Text Link to Item
  - Huang, N, Khan, A, Ashrafpour, H, Neligan, PC, Forrest, CR, Kontos, CD, and Pang, CY. "Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability." American Journal of Physiology. Heart and Circulatory Physiology 291, no. 1 (July 2006): H127-H137. Full Text
  - Xie, D, Li, Y, Reed, EA, Odronic, SI, Kontos, CD, and Annex, BH. "An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia." Journal of Vascular Surgery 44, no. 1 (July 2006): 166-175. Full Text
  - Mi, J, Sarraf-Yazdi, S, Zhang, X, Cao, Y, Dewhirst, MW, Kontos, CD, Li, C-Y, and Clary, BM. "A comparison of antiangiogenic therapies for the prevention of liver metastases." J Surg Res 131, no. 1 (March 2006): 97-104. Full Text Link to Item
  - Mi, J, Zhang, X, Rabbani, ZN, Liu, Y, Su, Z, Vujaskovic, Z, Kontos, CD, Sullenger, BA, and Clary, BM. "H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity. (Published online)" Nucleic Acids Res 34, no. 12 (2006): 3577-3584. Full Text Link to Item
  - White, ES, Atrasz, RG, Hu, B, Phan, SH, Stambolic, V, Mak, TW, Hogaboam, CM, Flaherty, KR, Martinez, FJ, Kontos, CD, and Toews, GB. "Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)." American Journal of Respiratory and Critical Care Medicine 173, no. 1 (January 2006): 112-121. Full Text
  - Hjelmeland, AB, Hjelmeland, MD, Shi, Q, Hart, JL, Bigner, DD, Wang, X-F, Kontos, CD, and Rich, JN. "Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity." Cancer Research 65, no. 24 (December 2005): 11276-11281. Full Text
  - "Erratum: Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues (Journal of Sexual Medicine (2005) 2 (634-640))." Journal of Sexual Medicine 2, no. 6 (November 1, 2005): 876-null. Full Text
  - Liu, S, Premont, RT, Kontos, CD, Zhu, S, and Rockey, DC. "A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension." Nature Medicine 11, no. 9 (September 4, 2005): 952-958. Full Text
  - Xie, D, Kontos, CD, Donatucci, CF, and Annex, BH. "Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues." The Journal of Sexual Medicine 2, no. 5 (September 2005): 634-640. Full Text
  - Singh, N, Macnamara, E, Rashid, S, Ambati, J, Kontos, CD, Higgins, E, and Ambati, BK. "Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization." Biochem Biophys Res Commun 332, no. 1 (June 24, 2005): 194-199. Full Text Link to Item
  - Hata, JA, Petrofski, JA, Schroder, JN, Williams, ML, Timberlake, SH, Pippen, A, Corwin, MT, Solan, AK, Jakoi, A, Gehrig, TR, Kontos, CD, and Milano, CA. "Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts." The Journal of Thoracic and Cardiovascular Surgery 129, no. 6 (June 2005): 1405-1413. Full Text
  - Sanchez, T, Thangada, S, Wu, M-T, Kontos, CD, Wu, D, Wu, H, and Hla, T. "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor." Proceedings of the National Academy of Sciences of the United States of America 102, no. 12 (March 11, 2005): 4312-4317. Full Text
  - Huang, J, Niu, X-L, Pippen, AM, Annex, BH, and Kontos, CD. "Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia." Arterioscler Thromb Vasc Biol 25, no. 2 (February 2005): 354-358. Full Text Link to Item
  - Khan, A, Ashrafpour, H, Huang, N, Neligan, PC, Kontos, C, Zhong, A, Forrest, CR, and Pang, CY. "Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism." American Journal of Physiology Regulatory, Integrative and Comparative Physiology 287, no. 5 (November 2004): R1219-R1229. Full Text
  - Dai, Q, Huang, J, Klitzman, B, Dong, C, Goldschmidt-Clermont, PJ, March, KL, Rokovich, J, Johnstone, B, Rebar, EJ, Spratt, SK, Case, CC, Kontos, CD, and Annex, BH. "Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia." Circulation 110, no. 16 (October 19, 2004): 2467-2475. Full Text Link to Item
  - Yamaoka-Tojo, M, Ushio-Fukai, M, Hilenski, L, Dikalov, SI, Chen, YE, Tojo, T, Fukai, T, Fujimoto, M, Patrushev, NA, Wang, N, Kontos, CD, Bloom, GS, and Alexander, RW. "IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation." Circulation Research 95, no. 3 (August 2004): 276-283. Full Text
  - Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." FASEB JOURNAL 18, no. 2 (February 2004): 326-328. Full Text Link to Item
  - Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 18, no. 2 (February 2004): 326-328. Full Text
  - Zadeh, G, Qian, B, Okhowat, A, Sabha, N, Kontos, CD, and Guha, A. "Targeting the Tie2/Tek receptor in astrocytomas." The American Journal of Pathology 164, no. 2 (February 2004): 467-476. Full Text
  - Peters, KG, Kontos, CD, Lin, PC, Wong, AL, Rao, P, Huang, L, Dewhirst, MW, and Sankar, S. "Functional significance of Tie2 signaling in the adult vasculature." Recent Progress in Hormone Research 59 (January 2004): 51-71. (Review) Full Text
  - Cai, J, Ahmad, S, Jiang, WG, Huang, J, Kontos, CD, Boulton, M, and Ahmed, A. "Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells." Diabetes 52, no. 12 (December 2003): 2959-2968. Full Text
  - Liu, S, Premont, RT, Kontos, CD, Huang, J, and Rockey, DC. "Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt." The Journal of Biological Chemistry 278, no. 50 (December 2003): 49929-49935. Full Text
  - White, RR, Shan, S, Rusconi, CP, Shetty, G, Dewhirst, MW, Kontos, CD, and Sullenger, BA. "Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2." Proceedings of the National Academy of Sciences of the United States of America 100, no. 9 (April 11, 2003): 5028-5033. Full Text
  - Niu, X-L, Peters, KG, and Kontos, CD. "Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism." The Journal of Biological Chemistry 277, no. 35 (August 2002): 31768-31773. Full Text
  - Huang, J, and Kontos, CD. "Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN." Arterioscler Thromb Vasc Biol 22, no. 5 (May 1, 2002): 745-751. Link to Item
  - Huang, J, and Kontos, CD. "PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects." The Journal of Biological Chemistry 277, no. 13 (March 2002): 10760-10766. Full Text
  - Kontos, CD, Cha, EH, York, JD, and Peters, KG. "The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis." Molecular and Cellular Biology 22, no. 6 (March 2002): 1704-1713. Full Text
  - Bussolati, B, Dunk, C, Grohman, M, Kontos, CD, Mason, J, and Ahmed, A. "Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide." The American Journal of Pathology 159, no. 3 (September 2001): 993-1008. Full Text
  - Huang, L, Sankar, S, Lin, C, Kontos, CD, Schroff, AD, Cha, EH, Feng, SM, Li, SF, Yu, Z, Van Etten, RL, Blanar, MA, and Peters, KG. "HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity." J Biol Chem 274, no. 53 (December 31, 1999): 38183-38188. Link to Item
  - Kontos, CD. "Inhibition of rat vascular smooth muscle cell proliferation in vitro and in vivo by recombinant replication-competent herpes simplex virus - Editorial Comment." STROKE 30, no. 11 (November 1999): 2438-2439. Link to Item
  - Kontos, CD, and Annex, BH. "Angiogenesis." Curr Atheroscler Rep 1, no. 2 (September 1999): 165-171. (Review) Link to Item
  - Calvert, JT, Riney, TJ, Kontos, CD, Cha, EH, Prieto, VG, Shea, CR, Berg, JN, Nevin, NC, Simpson, SA, Pasyk, KA, Speer, MC, Peters, KG, and Marchuk, DA. "Allelic and locus heterogeneity in inherited venous malformations." Human Molecular Genetics 8, no. 7 (July 1999): 1279-1289. Full Text
  - Kontos, CD. "Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits - Comment." STROKE 30, no. 1 (January 1999): 125-125. Link to Item
  - Kontos, CD. "Expression of nerve growth factor and trkA after transient focal cerebral ischemia in rats - Comment." STROKE 29, no. 8 (August 1998): 1697-1697. Link to Item
  - Kontos, CD, Stauffer, TP, Yang, WP, York, JD, Huang, L, Blanar, MA, Meyer, T, and Peters, KG. "Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt." Molecular and Cellular Biology 18, no. 7 (July 1998): 4131-4140. Full Text
  - Peters, KG, Coogan, A, Berry, D, Marks, J, Iglehart, JD, Kontos, CD, Rao, P, Sankar, S, and Trogan, E. "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." British Journal of Cancer 77, no. 1 (January 1998): 51-56. Full Text
  - Kontos, CD. "Intravenous basic fibroblast growth factor decreases brain injury resulting from focal ischemia in cats - Comment." STROKE 28, no. 3 (March 1997): 615-616. Link to Item
  - Kontos, CD, Wei, EP, Williams, JI, Kontos, HA, and Povlishock, JT. "Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo." The American Journal of Physiology 263, no. 4 Pt 2 (October 1992): H1234-H1242. Full Text
  - "Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo." American Journal of Physiology Heart and Circulatory Physiology 263, no. 4 32-4 (January 1, 1992).
- Book Sections
  - Mueller, SB, and Kontos, CD. "Gene Therapy for the Prevention of Vein Graft Disease." In Translating Gene Therapy to the Clinic, 227-246.: Elsevier, 2015. Full Text
Teaching & Mentoring
Recent Courses
- CRP 257: Proteomics and Protein Biology in Medicine 2018
- PHARM 493: Research Independent Study 2018

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