Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiology, Medicine, Duke University 1993 - 1997
  • M.D., Virginia Commonwealth University 1989
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2017
  • Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2017
  • Assistant Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2001 - 2008
  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2006 - 2008
  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2006
  • Associate in the Department of Medicine, Medicine, Cardiology, Medicine 1997 - 1999
  • Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 1997
• Recognition
• 

  In the News

  • NOV 24, 2015

    Seven Faculty Named AAAS Fellows
• Expertise
• 

  Global Scholarship

  • Teaching

    • South Korea (Country) 
• Research
• 

  Selected Grants

  • Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
  • Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
  • Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
  • Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
  • University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
  • Mitigators of Radiation-Induced Endovascular Injury: Targeting Tie2 and Thrombocytopenia awarded by National Institutes of Health 2017 - 2022
  • Genetic dissection of angiogenesis in the tuberculous granuloma awarded by National Institutes of Health 2017 - 2022
  • TIE2 Activation for the Treatment of Chemical-Induced Acute Lung Injury awarded by National Institutes of Health 2017 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
  • The role of muscle progenitor cells in muscle and vascular regeneration in PAD awarded by National Institutes of Health 2017 - 2020
  • Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
  • Gertrude B. Elion Mentored Medical Student Award awarded by Triangle Community Foundation 2018 - 2019
  • Gertrude Elion Mentored Medical Research Award awarded by Triangle Community Foundation 2018 - 2019
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Skeletal Muscle and Vascular Remodeling in Peripheral Artery Disease awarded by National Institutes of Health 2015 - 2018
  • A Novel Molecular Regulator of Vascular Homeostasis awarded by  American Heart Association 2016 - 2018
  • Seahorse XFe96 Extracellular Flux Analyzer awarded by North Carolina Biotechnology Center 2017 - 2018
  • Enhancing dendritic cell migration to drive potent anti-tumor immune responses awarded by National Institutes of Health 2013 - 2017
  • Skeletal Muscle and Vascular Remodeling in Peripheral Artery Disease awarded by National Institutes of Health 2014 - 2016
  • Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury awarded by National Institutes of Health 2013 - 2016
  • Muscle-Resident Stem Cells for Angiogenesis and Vascular Maturation in PAD awarded by National Institutes of Health 2013 - 2016
  • Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
  • Institutional Training Grant in Pediatric Cardiology awarded by National Institutes of Health 2009 - 2015
  • Novel pathways modulating Raf-mediated cardiac hypertrophy awarded by National Institutes of Health 2013 - 2015
  • The role of satellite cells in adult skeletal muscle growth and maintenance awarded by University of Kentucky 2013 - 2014
  • Peripheral endothelial and muscle cell pathology in cardiovascular disease awarded by National Institutes of Health 2010 - 2013
  • PTEN Gene Therapy for Vein Graft Disease awarded by National Institutes of Health 2009 - 2012
  • The Role of PTEN in Endothelial Biology awarded by National Institutes of Health 2008 - 2012
  • The Role of ADAM15 in sTie@ Shedding and Ischemic Angiogenesis awarded by National Institutes of Health 2009 - 2010
  • Systems Biology of Angiogenesis awarded by National Institutes of Health 2006 - 2009
  • Endothelial Cell Molecular Alterations in Cancer awarded by National Institutes of Health 2002 - 2008
  • Therapeutic Angiogenesis for Erectile Dysfunction awarded by National Institutes of Health 2004 - 2008
  • The Role of Tie2 and the Angiopoietins in EPC Biology awarded by National Institutes of Health 2005 - 2007
  • Downregulation of Tie2 awarded by National Institutes of Health 2004 - 2007
  • The Angiopoietins in Vascular Maintenance and Remodeling awarded by National Institutes of Health 2002 - 2007
  • TIE2-Associated Molecular Targets in Tumor Vasculature awarded by National Institutes of Health 2002 - 2005
  • Endothelial signal transduction by tek and tie awarded by National Institutes of Health 1997 - 2002
  • Role of TEK signaling in endothelial biology awarded by National Institutes of Health 1996 - 2002
  • Endothelial Signal Transduction By Tek And Tie awarded by National Institutes of Health 1997 - 1999
  • Tek Signaling And Endothelial Biology awarded by National Institutes of Health 1996 - 1999
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Mueller, SB, and Kontos, CD. "Gene Therapy for the Prevention of Vein Graft Disease." In Translating Gene Therapy to the Clinic: Techniques and Approaches, 227-246. November 17, 2014.  Full Text

  • Journal Articles

    • Myers, VD, Tomar, D, Madesh, M, Wang, J, Song, J, Zhang, X-Q, Gupta, MK, Tahrir, FG, Gordon, J, McClung, JM, Kontos, CD, Khalili, K, Cheung, JY, and Feldman, AM. "Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.(Accepted)" Journal of Cellular Physiology 233, no. 9 (September 2018): 6319-6326.  Full Text
    • Tahrir, FG, Shanmughapriya, S, Ahooyi, TM, Knezevic, T, Gupta, MK, Kontos, CD, McClung, JM, Madesh, M, Gordon, J, Feldman, AM, Cheung, JY, and Khalili, K. "Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes." Journal of Cellular Physiology 233, no. 2 (February 2018): 748-758.  Full Text
    • McClung, JM, McCord, TJ, Ryan, TE, Schmidt, CA, Green, TD, Southerland, KW, Reinardy, JL, Mueller, SB, Venkatraman, TN, Lascola, CD, Keum, S, Marchuk, DA, Spangenburg, EE, Dokun, A, Annex, BH, and Kontos, CD. "BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy." Circulation 136, no. 3 (July 2017): 281-296.  Full Text
    • Feldman, AM, Kontos, CD, McClung, JM, Gerhard, GS, Khalili, K, and Cheung, JY. "Precision Medicine for Heart Failure: Lessons From Oncology." Circulation. Heart Failure 10, no. 6 (June 2017).  Full Text
    • Oehlers, SH, Cronan, MR, Beerman, RW, Johnson, MG, Huang, J, Kontos, CD, Stout, JE, and Tobin, DM. "Infection-Induced Vascular Permeability Aids Mycobacterial Growth." The Journal of infectious diseases 215, no. 5 (March 2017): 813-817.  Full Text
    • Fujisawa, T, Wang, K, Niu, X-L, Egginton, S, Ahmad, S, Hewett, P, Kontos, CD, and Ahmed, A. "Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes." Cardiovascular Research 113, no. 1 (January 2017): 81-89.  Full Text
    • McClung, JM, McCord, TJ, Southerland, K, Schmidt, CA, Padgett, ME, Ryan, TE, and Kontos, CD. "Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density." Journal of Vascular Surgery 64, no. 4 (October 2016): 1101-1111.e2.  Full Text
    • Mueller, SB, and Kontos, CD. "Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling." The Journal of Clinical Investigation 126, no. 9 (September 2016): 3188-3191.  Full Text
    • Padgett, ME, McCord, TJ, McClung, JM, and Kontos, CD. "Methods for Acute and Subacute Murine Hindlimb Ischemia." Journal of visualized experiments : JoVE , no. 112 (June 21, 2016).  Full Text
    • Mofarrahi, M, McClung, JM, Kontos, CD, Davis, EC, Tappuni, B, Moroz, N, Pickett, AE, Huck, L, Harel, S, Danialou, G, and Hussain, SNA. "Angiopoietin-1 enhances skeletal muscle regeneration in mice." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 308, no. 7 (April 2015): R576-R589.  Full Text
    • McClung, JM, Reinardy, JL, Mueller, SB, McCord, TJ, Kontos, CD, Brown, DA, Hussain, SNA, Schmidt, CA, Ryan, TE, and Green, TD. "Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment." Frontiers in physiology 6 (January 2015): 161-.  Full Text
    • Reinardy, JL, Corey, DM, Golzio, C, Mueller, SB, Katsanis, N, and Kontos, CD. "Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway." PloS one 10, no. 10 (January 2015): e0139614-.  Full Text
    • Shen, J, Frye, M, Lee, BL, Reinardy, JL, McClung, JM, Ding, K, Kojima, M, Xia, H, Seidel, C, Lima e Silva, R, Dong, A, Hackett, SF, Wang, J, Howard, BW, Vestweber, D, Kontos, CD, Peters, KG, and Campochiaro, PA. "Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature." The Journal of clinical investigation 124, no. 10 (October 2014): 4564-4576.  Full Text
    • Kontos, CD. "More than skin deep: connecting melanocyte pigmentation and angiogenic diseases." The Journal of Clinical Investigation 124, no. 1 (January 2014): 76-79.  Full Text
    • Duscha, BD, Robbins, JL, Kontos, CD, Kraus, WE, and Annex, BH. "Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle." (December 1, 2013): 99-134. (Chapter)
    • Kontos, CD, and Willett, CG. "Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation." J Natl Cancer Inst 105, no. 16 (August 21, 2013): 1163-1165.  Full Text  Link to Item
    • Southerland, KW, Frazier, SB, Bowles, DE, Milano, CA, and Kontos, CD. "Gene therapy for the prevention of vein graft disease." Translational Research : the Journal of Laboratory and Clinical Medicine 161, no. 4 (April 2013): 321-338. (Review)  Full Text
    • Lee, C-L, Moding, EJ, Cuneo, KC, Li, Y, Sullivan, JM, Mao, L, Washington, I, Jeffords, LB, Rodrigues, RC, Ma, Y, Das, S, Kontos, CD, Kim, Y, Rockman, HA, and Kirsch, DG. "p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice." Science signaling 5, no. 234 (July 24, 2012): ra52-.  Full Text
    • McClung, JM, McCord, TJ, Keum, S, Johnson, S, Annex, BH, Marchuk, DA, and Kontos, CD. "Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice." The American Journal of Pathology 180, no. 5 (May 2012): 2156-2169.  Full Text
    • Simnick, AJ, Amiram, M, Liu, W, Hanna, G, Dewhirst, MW, Kontos, CD, and Chilkoti, A. "In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide." J Control Release 155, no. 2 (October 30, 2011): 144-151.  Full Text  Link to Item
    • Chen, L, Xu, B, Liu, L, Luo, Y, Zhou, H, Chen, W, Shen, T, Han, X, Kontos, CD, and Huang, S. "Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death." Free Radical Biology & Medicine 50, no. 5 (March 2011): 624-632.  Full Text
    • Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model." American Journal of Physiology. Heart and Circulatory Physiology 298, no. 6 (June 2010): H2174-H2191.  Full Text
    • Furgeson, SB, Simpson, PA, Park, I, Vanputten, V, Horita, H, Kontos, CD, Nemenoff, RA, and Weiser-Evans, MCM. "Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation." Cardiovasc Res 86, no. 2 (May 1, 2010): 274-282.  Full Text  Link to Item
    • Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use." Journal of Cellular and Molecular Medicine 14, no. 3 (March 2010): 528-552. (Review)  Full Text
    • Sagana, RL, Yan, M, Cornett, AM, Tsui, JL, Stephenson, DA, Huang, SK, Moore, BB, Ballinger, MN, Melonakos, J, Kontos, CD, Aronoff, DM, Peters-Golden, M, and White, ES. "Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression." The Journal of Biological Chemistry 284, no. 47 (November 2009): 32264-32271.  Full Text
    • Ahmed, A, Fujisawa, T, Niu, X-L, Ahmad, S, Al-Ani, B, Chudasama, K, Abbas, A, Potluri, R, Bhandari, V, Findley, CM, Lam, GKW, Huang, J, Hewett, PW, Cudmore, M, and Kontos, CD. "Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide." Circulation Research 104, no. 12 (June 2009): 1333-1336.  Full Text
    • Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport." Physiological Genomics 38, no. 1 (June 2009): 29-41.  Full Text
    • Lima, B, Lam, GKW, Xie, L, Diesen, DL, Villamizar, N, Nienaber, J, Messina, E, Bowles, D, Kontos, CD, Hare, JM, Stamler, JS, and Rockman, HA. "Endogenous S-nitrosothiols protect against myocardial injury." Proc Natl Acad Sci U S A 106, no. 15 (April 14, 2009): 6297-6302.  Full Text  Link to Item
    • Qiu, W, Federico, L, Naples, M, Avramoglu, RK, Meshkani, R, Zhang, J, Tsai, J, Hussain, M, Dai, K, Iqbal, J, Kontos, CD, Horie, Y, Suzuki, A, and Adeli, K. "Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins." Hepatology 48, no. 6 (December 2008): 1799-1809.  Full Text  Link to Item
    • Estrada, R, Zeng, Q, Lu, H, Sarojini, H, Lee, J-F, Mathis, SP, Sanchez, T, Wang, E, Kontos, CD, Lin, C-Y, Hla, T, Haribabu, B, and Lee, M-J. "Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells." The Journal of Biological Chemistry 283, no. 44 (October 2008): 30363-30375.  Full Text
    • Xie, D, Findley, CM, Greenfield, JM, Pippen, AM, Kontos, CD, Donatucci, CF, and Annex, BH. "A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits." J Sex Med 5, no. 9 (September 2008): 2069-2078.  Full Text  Link to Item
    • Findley, CM, Mitchell, RG, Duscha, BD, Annex, BH, and Kontos, CD. "Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease." J Am Coll Cardiol 52, no. 5 (July 29, 2008): 387-393.  Full Text  Link to Item
    • Sarraf-Yazdi, S, Mi, J, Moeller, BJ, Niu, X, White, RR, Kontos, CD, Sullenger, BA, Dewhirst, MW, and Clary, BM. "Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer." J Surg Res 146, no. 1 (May 1, 2008): 16-23.  Full Text  Link to Item
    • Xie, D, Hazarika, S, Andrich, AJ, Padgett, ME, Kontos, CD, Donatucci, CF, and Annex, BH. "High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue." J Sex Med 5, no. 5 (May 2008): 1137-1148.  Full Text  Link to Item
    • Mi, J, Zhang, X, Rabbani, ZN, Liu, Y, Reddy, SK, Su, Z, Salahuddin, FK, Viles, K, Giangrande, PH, Dewhirst, MW, Sullenger, BA, Kontos, CD, and Clary, BM. "RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin." Mol Ther 16, no. 1 (January 2008): 66-73.  Full Text  Link to Item
    • White, RR, Roy, JA, Viles, KD, Sullenger, BA, and Kontos, CD. "A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function." Angiogenesis 11, no. 4 (2008): 395-401.  Full Text  Link to Item
    • Findley, CM, Cudmore, MJ, Ahmed, A, and Kontos, CD. "VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling." Arterioscler Thromb Vasc Biol 27, no. 12 (December 2007): 2619-2626.  Full Text  Link to Item
    • Hazarika, S, Dokun, AO, Li, Y, Popel, AS, Kontos, CD, and Annex, BH. "Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1." Circ Res 101, no. 9 (October 26, 2007): 948-956.  Full Text  Link to Item
    • Cao, Y, Sonveaux, P, Liu, S, Zhao, Y, Mi, J, Clary, BM, Li, C-Y, Kontos, CD, and Dewhirst, MW. "Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth." Cancer Res 67, no. 8 (April 15, 2007): 3835-3844.  Full Text  Link to Item
    • Kontos, CD, and Annex, BH. "Engineered transcription factors for therapeutic angiogenesis." Curr Opin Mol Ther 9, no. 2 (April 2007): 145-152. (Review)  Link to Item
    • Li, Y, Hazarika, S, Xie, D, Pippen, AM, Kontos, CD, and Annex, BH. "In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia." Diabetes 56, no. 3 (March 2007): 656-665.  Full Text  Link to Item
    • DeKroon, R, Robinette, JB, Hjelmeland, AB, Wiggins, E, Blackwell, M, Mihovilovic, M, Fujii, M, York, J, Hart, J, Kontos, C, Rich, J, and Strittmatter, WJ. "APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2." Circ Res 99, no. 8 (October 13, 2006): 829-836.  Full Text  Link to Item
    • Huang, N, Khan, A, Ashrafpour, H, Neligan, PC, Forrest, CR, Kontos, CD, and Pang, CY. "Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability." American Journal of Physiology. Heart and Circulatory Physiology 291, no. 1 (July 2006): H127-H137.  Full Text
    • Xie, D, Li, Y, Reed, EA, Odronic, SI, Kontos, CD, and Annex, BH. "An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia." J Vasc Surg 44, no. 1 (July 2006): 166-175.  Full Text  Link to Item
    • Mi, J, Sarraf-Yazdi, S, Zhang, X, Cao, Y, Dewhirst, MW, Kontos, CD, Li, C-Y, and Clary, BM. "A comparison of antiangiogenic therapies for the prevention of liver metastases." J Surg Res 131, no. 1 (March 2006): 97-104.  Full Text  Link to Item
    • Mi, J, Zhang, X, Rabbani, ZN, Liu, Y, Su, Z, Vujaskovic, Z, Kontos, CD, Sullenger, BA, and Clary, BM. "H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity. (Published online)" Nucleic Acids Res 34, no. 12 (2006): 3577-3584.  Full Text  Link to Item
    • White, ES, Atrasz, RG, Hu, B, Phan, SH, Stambolic, V, Mak, TW, Hogaboam, CM, Flaherty, KR, Martinez, FJ, Kontos, CD, and Toews, GB. "Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)." American Journal of Respiratory and Critical Care Medicine 173, no. 1 (January 2006): 112-121.  Full Text
    • Hjelmeland, AB, Hjelmeland, MD, Shi, Q, Hart, JL, Bigner, DD, Wang, X-F, Kontos, CD, and Rich, JN. "Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity." Cancer Res 65, no. 24 (December 15, 2005): 11276-11281.  Full Text  Link to Item
    • Liu, S, Premont, RT, Kontos, CD, Zhu, S, and Rockey, DC. "A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension." Nature Medicine 11, no. 9 (September 4, 2005): 952-958.  Full Text
    • Xie, D, Kontos, CD, Donatucci, CF, and Annex, BH. "Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues." J Sex Med 2, no. 5 (September 2005): 634-640.  Full Text  Link to Item
    • Singh, N, Macnamara, E, Rashid, S, Ambati, J, Kontos, CD, Higgins, E, and Ambati, BK. "Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization." Biochem Biophys Res Commun 332, no. 1 (June 24, 2005): 194-199.  Full Text  Link to Item
    • Hata, JA, Petrofski, JA, Schroder, JN, Williams, ML, Timberlake, SH, Pippen, A, Corwin, MT, Solan, AK, Jakoi, A, Gehrig, TR, Kontos, CD, and Milano, CA. "Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts." J Thorac Cardiovasc Surg 129, no. 6 (June 2005): 1405-1413.  Full Text  Link to Item
    • Sanchez, T, Thangada, S, Wu, M-T, Kontos, CD, Wu, D, Wu, H, and Hla, T. "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor." Proceedings of the National Academy of Sciences of the United States of America 102, no. 12 (March 11, 2005): 4312-4317.  Full Text
    • Huang, J, Niu, X-L, Pippen, AM, Annex, BH, and Kontos, CD. "Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia." Arterioscler Thromb Vasc Biol 25, no. 2 (February 2005): 354-358.  Full Text  Link to Item
    • Xie, D, Kontos, CD, Donatucci, CF, and Annex, BH. "Erratum: Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues (Journal of Sexual Medicine (2005) 2 (634-640))." Journal of Sexual Medicine 2, no. 6 (2005): 876--.  Full Text
    • Khan, A, Ashrafpour, H, Huang, N, Neligan, PC, Kontos, C, Zhong, A, Forrest, CR, and Pang, CY. "Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 287, no. 5 (November 2004): R1219-R1229.  Full Text
    • Dai, Q, Huang, J, Klitzman, B, Dong, C, Goldschmidt-Clermont, PJ, March, KL, Rokovich, J, Johnstone, B, Rebar, EJ, Spratt, SK, Case, CC, Kontos, CD, and Annex, BH. "Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia." Circulation 110, no. 16 (October 19, 2004): 2467-2475.  Full Text  Link to Item
    • Yamaoka-Tojo, M, Ushio-Fukai, M, Hilenski, L, Dikalov, SI, Chen, YE, Tojo, T, Fukai, T, Fujimoto, M, Patrushev, NA, Wang, N, Kontos, CD, Bloom, GS, and Alexander, RW. "IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation." Circulation Research 95, no. 3 (August 2004): 276-283.  Full Text
    • Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." FASEB JOURNAL 18, no. 2 (February 2004): 326-328.  Full Text  Link to Item
    • Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 18, no. 2 (February 2004): 326-328.  Full Text
    • Zadeh, G, Qian, B, Okhowat, A, Sabha, N, Kontos, CD, and Guha, A. "Targeting the Tie2/Tek receptor in astrocytomas." The American Journal of Pathology 164, no. 2 (February 2004): 467-476.  Full Text
    • Peters, KG, Kontos, CD, Lin, PC, Wong, AL, Rao, P, Huang, L, Dewhirst, MW, and Sankar, S. "Functional significance of Tie2 signaling in the adult vasculature." Recent Progress in Hormone Research 59 (January 2004): 51-71. (Review)  Full Text
    • Liu, S, Premont, RT, Kontos, CD, Huang, J, and Rockey, DC. "Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt." J Biol Chem 278, no. 50 (December 12, 2003): 49929-49935.  Full Text  Link to Item
    • Cai, J, Ahmad, S, Jiang, WG, Huang, J, Kontos, CD, Boulton, M, and Ahmed, A. "Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells." Diabetes 52, no. 12 (December 2003): 2959-2968.  Full Text
    • White, RR, Shan, S, Rusconi, CP, Shetty, G, Dewhirst, MW, Kontos, CD, and Sullenger, BA. "Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2." Proc Natl Acad Sci U S A 100, no. 9 (April 29, 2003): 5028-5033.  Full Text  Link to Item
    • Niu, X-L, Peters, KG, and Kontos, CD. "Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism." J Biol Chem 277, no. 35 (August 30, 2002): 31768-31773.  Full Text  Link to Item
    • Huang, J, and Kontos, CD. "Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN." Arterioscler Thromb Vasc Biol 22, no. 5 (May 1, 2002): 745-751.  Link to Item
    • Huang, J, and Kontos, CD. "PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects." The Journal of Biological Chemistry 277, no. 13 (March 2002): 10760-10766.  Full Text
    • Kontos, CD, Cha, EH, York, JD, and Peters, KG. "The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis." Molecular and Cellular Biology 22, no. 6 (March 2002): 1704-1713.  Full Text
    • Bussolati, B, Dunk, C, Grohman, M, Kontos, CD, Mason, J, and Ahmed, A. "Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide." Am J Pathol 159, no. 3 (September 2001): 993-1008.  Full Text  Link to Item
    • Huang, L, Sankar, S, Lin, C, Kontos, CD, Schroff, AD, Cha, EH, Feng, SM, Li, SF, Yu, Z, Van Etten, RL, Blanar, MA, and Peters, KG. "HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity." J Biol Chem 274, no. 53 (December 31, 1999): 38183-38188.  Link to Item
    • Kontos, CD. "Inhibition of rat vascular smooth muscle cell proliferation in vitro and in vivo by recombinant replication-competent herpes simplex virus - Editorial Comment." STROKE 30, no. 11 (November 1999): 2438-2439.  Link to Item
    • Kontos, CD, and Annex, BH. "Angiogenesis." Curr Atheroscler Rep 1, no. 2 (September 1999): 165-171. (Review)  Link to Item
    • Calvert, JT, Riney, TJ, Kontos, CD, Cha, EH, Prieto, VG, Shea, CR, Berg, JN, Nevin, NC, Simpson, SA, Pasyk, KA, Speer, MC, Peters, KG, and Marchuk, DA. "Allelic and locus heterogeneity in inherited venous malformations." Hum Mol Genet 8, no. 7 (July 1999): 1279-1289.  Link to Item
    • Kontos, CD. "Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits - Comment." STROKE 30, no. 1 (January 1999): 125-125.  Link to Item
    • Kontos, CD. "Expression of nerve growth factor and trkA after transient focal cerebral ischemia in rats - Comment." STROKE 29, no. 8 (August 1998): 1697-1697.  Link to Item
    • Kontos, CD, Stauffer, TP, Yang, WP, York, JD, Huang, L, Blanar, MA, Meyer, T, and Peters, KG. "Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt." Molecular and Cellular Biology 18, no. 7 (July 1998): 4131-4140.  Full Text
    • Peters, KG, Coogan, A, Berry, D, Marks, J, Iglehart, JD, Kontos, CD, Rao, P, Sankar, S, and Trogan, E. "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." Br J Cancer 77, no. 1 (1998): 51-56.  Link to Item
    • Kontos, CD. "Intravenous basic fibroblast growth factor decreases brain injury resulting from focal ischemia in cats - Comment." STROKE 28, no. 3 (March 1997): 615-616.  Link to Item
    • Kontos, CD, Wei, EP, Williams, JI, Kontos, HA, and Povlishock, JT. "Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo." The American Journal of Physiology 263, no. 4 Pt 2 (October 1992): H1234-H1242.  Full Text
    • Kontos, CD, Wei, EP, Williams, JI, Kontos, HA, and Povlishock, JT. "Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo." American Journal of Physiology - Heart and Circulatory Physiology 263, no. 4 32-4 (1992): H1234-H1242.
• Teaching & Mentoring
• 

  Recent Courses

  • CRP 257: Proteomics and Protein Biology in Medicine 2018
  • PHARM 493: Research Independent Study 2018
  • PHARM 494: Research Independent Study 2016
  • PHARM 534: Interdisciplinary Approach to Pharmacology 2016

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