Skip to main content

Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.

Publication ,  Journal Article
Schmeling, H; Mahler, M; Levy, DM; Moore, K; Stevens, AM; Wick, J; McMillan, JD; Horneff, G; Assassi, S; Charles, J; Salazar, G; Mayes, MD ...
Published in: J Rheumatol
December 2015

OBJECTIVE: Autoantibodies to the dense fine speckled 70 kDa antigen (DFS70) are reported to be more common in individuals who do not have an antinuclear antibody (ANA)-associated rheumatic disease (AARD) than in patients with AARD. The frequency of anti-DFS70 antibodies has been thoroughly studied in adult but not in pediatric populations. The primary objective of this observational study was to determine the frequency of anti-DFS70 in pediatric AARD and reference cohorts. METHODS: Sera from 743 children with AARD and related conditions, and 345 samples from reference cohorts (healthy children and those being investigated for AARD) were studied for anti-DFS70 autoantibodies as measured by a chemiluminescence immunoassay. A de-identified administrative database was used to retrieve demographic, serologic, and clinical data. RESULTS: Anti-DFS70 antibodies were seen in 2.1% of healthy children and in 4.5% of sera from pediatric individuals referred for ANA testing. The frequency of anti-DFS70 was highest in juvenile localized scleroderma (LS; 4/29, 13.8%), juvenile dermatomyositis (JDM; 2/11, 18.2%), childhood systemic lupus erythematosus (cSLE; 19/331, 5.7%), diffuse cutaneous systemic sclerosis (1/22, 4.5%), celiac disease (2/49, 4.1%), and juvenile idiopathic arthritis (JIA; 5/202, 2.5%). Of note, anti-DFS70 antibodies were observed in 3/26 children (11.5%) with uveitis and JIA-associated uveitis. CONCLUSION: The frequency of anti-DFS70 autoantibodies in healthy pediatric subjects is within the lower range of that reported in adults. Anti-DFS70 antibodies can be found in childhood SSc and cSLE, but has a remarkably high frequency in children with LS, JDM, and uveitis.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

December 2015

Volume

42

Issue

12

Start / End Page

2419 / 2426

Location

Canada

Related Subject Headings

  • Transcription Factors
  • Sex Factors
  • Risk Assessment
  • Rheumatic Diseases
  • Reference Values
  • Male
  • Likelihood Functions
  • Humans
  • Follow-Up Studies
  • Fluorescent Antibody Technique, Indirect
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schmeling, H., Mahler, M., Levy, D. M., Moore, K., Stevens, A. M., Wick, J., … Fritzler, M. J. (2015). Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls. J Rheumatol, 42(12), 2419–2426. https://doi.org/10.3899/jrheum.150567
Schmeling, Heinrike, Michael Mahler, Deborah M. Levy, Katharine Moore, Anne M. Stevens, James Wick, Jacob D. McMillan, et al. “Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.J Rheumatol 42, no. 12 (December 2015): 2419–26. https://doi.org/10.3899/jrheum.150567.
Schmeling H, Mahler M, Levy DM, Moore K, Stevens AM, Wick J, et al. Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls. J Rheumatol. 2015 Dec;42(12):2419–26.
Schmeling, Heinrike, et al. “Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.J Rheumatol, vol. 42, no. 12, Dec. 2015, pp. 2419–26. Pubmed, doi:10.3899/jrheum.150567.
Schmeling H, Mahler M, Levy DM, Moore K, Stevens AM, Wick J, McMillan JD, Horneff G, Assassi S, Charles J, Salazar G, Mayes MD, Silverman ED, Klien-Gitelman M, Lee T, Brunner HI, Reed AM, Fritzler MJ. Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls. J Rheumatol. 2015 Dec;42(12):2419–2426.

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

December 2015

Volume

42

Issue

12

Start / End Page

2419 / 2426

Location

Canada

Related Subject Headings

  • Transcription Factors
  • Sex Factors
  • Risk Assessment
  • Rheumatic Diseases
  • Reference Values
  • Male
  • Likelihood Functions
  • Humans
  • Follow-Up Studies
  • Fluorescent Antibody Technique, Indirect