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Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.

Publication ,  Journal Article
Konjar, S; Yin, F; Bogyo, M; Turk, B; Kopitar-Jerala, N
Published in: FEBS Lett
June 3, 2010

Macrophages play a key role in innate immune response to pathogens and in tissue homeostasis, inflammation and repair. A serpin A3G (SpiA3G) is highly induced in classically activated macrophages. We show increased localization of SpiA3G in the nucleolus and co-localization with cathepsin L, upon classical, but not alternative activation of macrophages. Despite the increased expression of cathepsin L in the nuclei of classically activated macrophages, no cathepsin activity was detected. Since only pro-inflammatory, but not anti-inflammatory stimuli induce increased nucleolar localization of SpiA3G, we propose that SpiA3g translocation into the nucleolus is important in host defense against pathogens.

Duke Scholars

Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

June 3, 2010

Volume

584

Issue

11

Start / End Page

2201 / 2206

Location

England

Related Subject Headings

  • Serpins
  • Mice
  • Macrophages
  • Inflammation
  • Cell Nucleolus
  • Cell Line
  • Cathepsins
  • Cathepsin L
  • Biochemistry & Molecular Biology
  • Anti-Inflammatory Agents
 

Citation

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Konjar, S., Yin, F., Bogyo, M., Turk, B., & Kopitar-Jerala, N. (2010). Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. FEBS Lett, 584(11), 2201–2206. https://doi.org/10.1016/j.febslet.2010.03.031
Konjar, Spela, Fangfang Yin, Matthew Bogyo, Boris Turk, and Natasa Kopitar-Jerala. “Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.FEBS Lett 584, no. 11 (June 3, 2010): 2201–6. https://doi.org/10.1016/j.febslet.2010.03.031.
Konjar S, Yin F, Bogyo M, Turk B, Kopitar-Jerala N. Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. FEBS Lett. 2010 Jun 3;584(11):2201–6.
Konjar, Spela, et al. “Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.FEBS Lett, vol. 584, no. 11, June 2010, pp. 2201–06. Pubmed, doi:10.1016/j.febslet.2010.03.031.
Konjar S, Yin F, Bogyo M, Turk B, Kopitar-Jerala N. Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. FEBS Lett. 2010 Jun 3;584(11):2201–2206.
Journal cover image

Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

June 3, 2010

Volume

584

Issue

11

Start / End Page

2201 / 2206

Location

England

Related Subject Headings

  • Serpins
  • Mice
  • Macrophages
  • Inflammation
  • Cell Nucleolus
  • Cell Line
  • Cathepsins
  • Cathepsin L
  • Biochemistry & Molecular Biology
  • Anti-Inflammatory Agents