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Actions of thrombin in the interstitium.

Publication ,  Journal Article
de Ridder, GG; Lundblad, RL; Pizzo, SV
Published in: J Thromb Haemost
January 2016

Thrombin is a pleiotropic enzyme best known for its contribution to fibrin formation and platelet aggregation during vascular hemostasis. There is increasing evidence to suggest a role for thrombin in the development of interstitial fibrosis, but interstitial thrombin has not been demonstrated by the direct determination of activity. Rather its presence is inferred by products of thrombin action such as fibrin and activated fibroblasts. This review will focus on possible mechanisms of thrombin formation in the interstitial space, the possible actions of thrombin, processes regulating thrombin activity in the interstitial space, and evidence supporting a role for thrombin in fibrosis.

Duke Scholars

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Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

January 2016

Volume

14

Issue

1

Start / End Page

40 / 47

Location

England

Related Subject Headings

  • Thrombin
  • Signal Transduction
  • Pulmonary Fibrosis
  • Prothrombin
  • Platelet Aggregation
  • Mice
  • Liver Cirrhosis
  • Humans
  • Hemostasis
  • Fibrosis
 

Citation

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de Ridder, G. G., Lundblad, R. L., & Pizzo, S. V. (2016). Actions of thrombin in the interstitium. J Thromb Haemost, 14(1), 40–47. https://doi.org/10.1111/jth.13191
Ridder, G. G. de, R. L. Lundblad, and S. V. Pizzo. “Actions of thrombin in the interstitium.J Thromb Haemost 14, no. 1 (January 2016): 40–47. https://doi.org/10.1111/jth.13191.
de Ridder GG, Lundblad RL, Pizzo SV. Actions of thrombin in the interstitium. J Thromb Haemost. 2016 Jan;14(1):40–7.
de Ridder, G. G., et al. “Actions of thrombin in the interstitium.J Thromb Haemost, vol. 14, no. 1, Jan. 2016, pp. 40–47. Pubmed, doi:10.1111/jth.13191.
de Ridder GG, Lundblad RL, Pizzo SV. Actions of thrombin in the interstitium. J Thromb Haemost. 2016 Jan;14(1):40–47.
Journal cover image

Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

January 2016

Volume

14

Issue

1

Start / End Page

40 / 47

Location

England

Related Subject Headings

  • Thrombin
  • Signal Transduction
  • Pulmonary Fibrosis
  • Prothrombin
  • Platelet Aggregation
  • Mice
  • Liver Cirrhosis
  • Humans
  • Hemostasis
  • Fibrosis