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Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe.

Publication ,  Journal Article
Nankivil, D; Waterman, G; LaRocca, F; Keller, B; Kuo, AN; Izatt, JA
Published in: Biomed Opt Express
November 1, 2015

We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for both imaging modes, and the optical paths for each imaging mode were optimized for their respective application using a combination of commercial and custom optics. The system has a working distance of 26.1 mm and a measured axial resolution of 8 μm (in air). In posterior segment mode, the design has a lateral resolution of 9 μm, 7.4 mm imaging depth range (in air), 4.9 mm 6dB fall-off range (in air), and peak sensitivity of 103 dB over a 22° field of view (FOV). In anterior segment mode, the design has a lateral resolution of 24 μm, imaging depth range of 7.4 mm (in air), 6dB fall-off range of 4.5 mm (in air), depth-of-focus of 3.6 mm, and a peak sensitivity of 99 dB over a 17.5 mm FOV. In addition, the probe includes a wide-field iris imaging system to simplify alignment. A fold mirror assembly actuated by a bi-stable rotary solenoid was used to switch between anterior and posterior segment imaging modes, and a miniature motorized translation stage was used to adjust the objective lens position to correct for patient refraction between -12.6 and + 9.9 D. The entire probe weighs less than 630 g with a form factor of 20.3 x 9.5 x 8.8 cm. Healthy volunteers were imaged to illustrate imaging performance.

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Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

November 1, 2015

Volume

6

Issue

11

Start / End Page

4516 / 4528

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

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Nankivil, D., Waterman, G., LaRocca, F., Keller, B., Kuo, A. N., & Izatt, J. A. (2015). Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe. Biomed Opt Express, 6(11), 4516–4528. https://doi.org/10.1364/BOE.6.004516
Nankivil, Derek, Gar Waterman, Francesco LaRocca, Brenton Keller, Anthony N. Kuo, and Joseph A. Izatt. “Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe.Biomed Opt Express 6, no. 11 (November 1, 2015): 4516–28. https://doi.org/10.1364/BOE.6.004516.
Nankivil D, Waterman G, LaRocca F, Keller B, Kuo AN, Izatt JA. Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe. Biomed Opt Express. 2015 Nov 1;6(11):4516–28.
Nankivil, Derek, et al. “Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe.Biomed Opt Express, vol. 6, no. 11, Nov. 2015, pp. 4516–28. Pubmed, doi:10.1364/BOE.6.004516.
Nankivil D, Waterman G, LaRocca F, Keller B, Kuo AN, Izatt JA. Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe. Biomed Opt Express. 2015 Nov 1;6(11):4516–4528.
Journal cover image

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

November 1, 2015

Volume

6

Issue

11

Start / End Page

4516 / 4528

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics