Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.
Publication
, Journal Article
Oladosu, FA; Maixner, W; Nackley, AG
Published in: Mayo Clin Proc
August 2015
Drugs that target G protein-coupled receptors (GPCRs) represent the primary treatment strategy for patients with acute and chronic pain; however, there is substantial individual variability in both the efficacy and adverse effects associated with these drugs. Variability in drug responses is due, in part, to individuals' diversity in alternative splicing of pain-relevant GPCRs. G protein-coupled receptor alternative splice variants often exhibit distinct tissue distribution patterns, drug-binding properties, and signaling characteristics that may impact disease pathology as well as the extent and direction of analgesic effects. We review the importance of GPCRs and their known splice variants to the management of pain.
Duke Scholars
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Published In
Mayo Clin Proc
DOI
EISSN
1942-5546
Publication Date
August 2015
Volume
90
Issue
8
Start / End Page
1135 / 1151
Location
England
Related Subject Headings
- Receptors, G-Protein-Coupled
- Pain
- Molecular Targeted Therapy
- Humans
- Analgesics
- Alternative Splicing
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Oladosu, F. A., Maixner, W., & Nackley, A. G. (2015). Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. Mayo Clin Proc, 90(8), 1135–1151. https://doi.org/10.1016/j.mayocp.2015.06.010
Oladosu, Folabomi A., William Maixner, and Andrea G. Nackley. “Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.” Mayo Clin Proc 90, no. 8 (August 2015): 1135–51. https://doi.org/10.1016/j.mayocp.2015.06.010.
Oladosu FA, Maixner W, Nackley AG. Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. Mayo Clin Proc. 2015 Aug;90(8):1135–51.
Oladosu, Folabomi A., et al. “Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.” Mayo Clin Proc, vol. 90, no. 8, Aug. 2015, pp. 1135–51. Pubmed, doi:10.1016/j.mayocp.2015.06.010.
Oladosu FA, Maixner W, Nackley AG. Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. Mayo Clin Proc. 2015 Aug;90(8):1135–1151.
Published In
Mayo Clin Proc
DOI
EISSN
1942-5546
Publication Date
August 2015
Volume
90
Issue
8
Start / End Page
1135 / 1151
Location
England
Related Subject Headings
- Receptors, G-Protein-Coupled
- Pain
- Molecular Targeted Therapy
- Humans
- Analgesics
- Alternative Splicing
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences