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Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.

Publication ,  Journal Article
Oladosu, FA; Maixner, W; Nackley, AG
Published in: Mayo Clin Proc
August 2015

Drugs that target G protein-coupled receptors (GPCRs) represent the primary treatment strategy for patients with acute and chronic pain; however, there is substantial individual variability in both the efficacy and adverse effects associated with these drugs. Variability in drug responses is due, in part, to individuals' diversity in alternative splicing of pain-relevant GPCRs. G protein-coupled receptor alternative splice variants often exhibit distinct tissue distribution patterns, drug-binding properties, and signaling characteristics that may impact disease pathology as well as the extent and direction of analgesic effects. We review the importance of GPCRs and their known splice variants to the management of pain.

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Published In

Mayo Clin Proc

DOI

EISSN

1942-5546

Publication Date

August 2015

Volume

90

Issue

8

Start / End Page

1135 / 1151

Location

England

Related Subject Headings

  • Receptors, G-Protein-Coupled
  • Pain
  • Molecular Targeted Therapy
  • Humans
  • Analgesics
  • Alternative Splicing
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Oladosu, F. A., Maixner, W., & Nackley, A. G. (2015). Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. Mayo Clin Proc, 90(8), 1135–1151. https://doi.org/10.1016/j.mayocp.2015.06.010
Oladosu, Folabomi A., William Maixner, and Andrea G. Nackley. “Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.Mayo Clin Proc 90, no. 8 (August 2015): 1135–51. https://doi.org/10.1016/j.mayocp.2015.06.010.
Oladosu FA, Maixner W, Nackley AG. Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. Mayo Clin Proc. 2015 Aug;90(8):1135–51.
Oladosu, Folabomi A., et al. “Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.Mayo Clin Proc, vol. 90, no. 8, Aug. 2015, pp. 1135–51. Pubmed, doi:10.1016/j.mayocp.2015.06.010.
Oladosu FA, Maixner W, Nackley AG. Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. Mayo Clin Proc. 2015 Aug;90(8):1135–1151.
Journal cover image

Published In

Mayo Clin Proc

DOI

EISSN

1942-5546

Publication Date

August 2015

Volume

90

Issue

8

Start / End Page

1135 / 1151

Location

England

Related Subject Headings

  • Receptors, G-Protein-Coupled
  • Pain
  • Molecular Targeted Therapy
  • Humans
  • Analgesics
  • Alternative Splicing
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences