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Into new territory: improved microbial synthesis through engineering of the essential metabolic network.

Publication ,  Journal Article
Lynch, MD
Published in: Current opinion in biotechnology
April 2016

Advances in synthetic biology and metabolic engineering offer the promise of next generation bioprocesses to produce numerous products including specialty and bulk chemicals and even biofuels sustainably from renewable feedstocks. A primary challenge is the optimization of product flux, within a much larger and complex metabolic network. While simple gene deletion methods can be used in the case of non-essential byproduct pathways, more sophisticated approaches are required when competitive fluxes are essential to host cellular functions. Engineering essential metabolic networks has been traditionally off-limits to metabolic engineers. Newer approaches to be reviewed include the rebalancing or rewiring of the metabolic network by tuning the levels of essential enzymes and the use of dynamic metabolic control strategies to conditionally reduce essential competitive fluxes.

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Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

April 2016

Volume

38

Start / End Page

106 / 111

Related Subject Headings

  • Transcription, Genetic
  • Synthetic Biology
  • Metabolic Networks and Pathways
  • Metabolic Engineering
  • Biotechnology
  • Biofuels
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lynch, M. D. (2016). Into new territory: improved microbial synthesis through engineering of the essential metabolic network. Current Opinion in Biotechnology, 38, 106–111. https://doi.org/10.1016/j.copbio.2016.01.009
Lynch, Michael D. “Into new territory: improved microbial synthesis through engineering of the essential metabolic network.Current Opinion in Biotechnology 38 (April 2016): 106–11. https://doi.org/10.1016/j.copbio.2016.01.009.
Lynch, Michael D. “Into new territory: improved microbial synthesis through engineering of the essential metabolic network.Current Opinion in Biotechnology, vol. 38, Apr. 2016, pp. 106–11. Epmc, doi:10.1016/j.copbio.2016.01.009.
Journal cover image

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

April 2016

Volume

38

Start / End Page

106 / 111

Related Subject Headings

  • Transcription, Genetic
  • Synthetic Biology
  • Metabolic Networks and Pathways
  • Metabolic Engineering
  • Biotechnology
  • Biofuels
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology