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Michael D Lynch

W. H. Gardner, Jr. Associate Professor of Biomedical Engineering
Biomedical Engineering

Current Appointments & Affiliations


W. H. Gardner, Jr. Associate Professor of Biomedical Engineering · 2023 - Present Biomedical Engineering, Pratt School of Engineering
Associate Professor in the Department of Biomedical Engineering · 2022 - Present Biomedical Engineering, Pratt School of Engineering
Associate Professor in Chemistry · 2022 - Present Chemistry, Trinity College of Arts & Sciences
Associate of the Duke Initiative for Science & Society · 2017 - Present Duke Science & Society, University Initiatives & Academic Support Units

Recent Publications


Scalable, robust, high-throughput expression & purification of nanobodies enabled by 2-stage dynamic control.

Journal Article Metabolic engineering · September 2024 Nanobodies are single-domain antibody fragments that have garnered considerable use as diagnostic and therapeutic agents as well as research tools. However, obtaining pure VHHs, like many proteins, can be laborious and inconsistent. High level cytoplasmic ... Full text Cite

2-Stage microfermentations.

Journal Article Metabolic engineering communications · June 2024 Cell based factories can be engineered to produce a wide variety of products. Advances in DNA synthesis and genome editing have greatly simplified the design and construction of these factories. It has never been easier to generate hundreds or even thousan ... Full text Cite

Phase separation methods for protein purification: A meta-analysis of purification performance and cost-effectiveness.

Journal Article Biotechnology journal · April 2024 Protein purifications based on phase separations (e.g., precipitation and liquid-liquid extraction) have seen little adoption in commercial protein drug production. To identify barriers, we analyzed the purification performance and economics of 290 phase s ... Full text Cite
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Recent Grants


University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Sustainable, Low Cost Production of Biosynthetic 1,2,4-Butanetriol and Butanetriol Trinitrate

ResearchPrincipal Investigator · Awarded by Naval Air Warfare Center · 2021 - 2024

Automated CRISPR Enabled DNA Synthesis (CEDS)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024

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Education, Training & Certifications


University of Colorado, School of Medicine · 2007 M.D.
University of Colorado, Boulder · 2005 Ph.D.