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Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.

Publication ,  Journal Article
Sasaki, T; Hoffmann, U; Kobayashi, M; Sheng, H; Ennaceur, A; Lombard, FW; Warner, DS
Published in: Neurocrit Care
October 2016

BACKGROUND: Cognitive dysfunction can be a long-term complication following subarachnoid hemorrhage (SAH). Preclinical models have been variously characterized to emulate this disorder. This study was designed to directly compare long-term cognitive deficits in the context of similar levels of insult severity in the cisterna magna double-blood (DB) injection versus prechiasmatic blood (PB) injection SAH models. METHODS: Pilot work identified blood injectate volumes necessary to provide similar mortality rates (20-25 %). Rats were then randomly assigned to DB or PB insults. Saline injection and naïve rats were used as controls. Functional and cognitive outcome was assessed over 35 days. RESULTS: DB and PB caused similar transient rotarod deficits. PB rats exhibited decreased anxiety behavior on the elevated plus maze, while anxiety was increased in DB. DB and PB caused differential deficits in the novel object recognition and novel object location tasks. Morris water maze performance was similarly altered in both models (decreased escape latency and increased swimming speed). SAH caused histologic damage in the medial prefrontal cortex, perirhinal cortex, and hippocampal CA1, although severity of injury in the respective regions differed between DB and PB. CONCLUSION: Both SAH models caused long-term cognitive deficits in the context of similar insult severity. Cognitive deficits differed between the two models, as did distribution of histologic injury. Each model offers unique properties and both models may be useful for study of SAH-induced cognitive deficits.

Duke Scholars

Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

October 2016

Volume

25

Issue

2

Start / End Page

293 / 305

Location

United States

Related Subject Headings

  • Subarachnoid Hemorrhage
  • Rats, Wistar
  • Rats
  • Neurology & Neurosurgery
  • Maze Learning
  • Male
  • Disease Models, Animal
  • Cognitive Dysfunction
  • Behavior, Animal
  • Animals
 

Citation

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MLA
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Sasaki, T., Hoffmann, U., Kobayashi, M., Sheng, H., Ennaceur, A., Lombard, F. W., & Warner, D. S. (2016). Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats. Neurocrit Care, 25(2), 293–305. https://doi.org/10.1007/s12028-016-0250-1
Sasaki, Toshihiro, Ulrike Hoffmann, Motomu Kobayashi, Huaxin Sheng, Abdelkader Ennaceur, Frederick W. Lombard, and David S. Warner. “Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.Neurocrit Care 25, no. 2 (October 2016): 293–305. https://doi.org/10.1007/s12028-016-0250-1.
Sasaki T, Hoffmann U, Kobayashi M, Sheng H, Ennaceur A, Lombard FW, et al. Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats. Neurocrit Care. 2016 Oct;25(2):293–305.
Sasaki, Toshihiro, et al. “Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.Neurocrit Care, vol. 25, no. 2, Oct. 2016, pp. 293–305. Pubmed, doi:10.1007/s12028-016-0250-1.
Sasaki T, Hoffmann U, Kobayashi M, Sheng H, Ennaceur A, Lombard FW, Warner DS. Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats. Neurocrit Care. 2016 Oct;25(2):293–305.
Journal cover image

Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

October 2016

Volume

25

Issue

2

Start / End Page

293 / 305

Location

United States

Related Subject Headings

  • Subarachnoid Hemorrhage
  • Rats, Wistar
  • Rats
  • Neurology & Neurosurgery
  • Maze Learning
  • Male
  • Disease Models, Animal
  • Cognitive Dysfunction
  • Behavior, Animal
  • Animals