Huaxin Sheng | Scholars@Duke

Huaxin Sheng
Associate Professor in Anesthesiology

We have successfully developed various mouse models of brain and spinal cord injuries in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma, subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia and compression injury. Our current interests focus on two projects. One is to examine the efficacy of xenon in treating cerebral ischemia and the other is to define the role of NO donor in subarachnoid hemorrhage induced vasospasm.

Current Appointments & Affiliations

Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2011

Contact Information

138 Sands Bldg, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
sheng001@mc.duke.edu (919) 684-6319

Background
Education, Training, & Certifications
- Attending Neurosurgeon, Lecturer, Vice-Chairman, Neurosurgery, China Medical University (China) 1989 - 1995
- Instructor of Neuroanatomy, Anatomy, China Medical University (China) 1984 - 1986
- M.D., Nantong Medical College (China) 1984
Duke Appointment History
- Associate Professor in Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2008 - 2011
- Assistant Professor in Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2006 - 2008
- Assistant Research Professor in Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 1999 - 2006
Research
Selected Grants
- The Unfolded Protein Response and Neuroprotection in Stroke awarded by National Institutes of Health 2016 - 2021
- Translating Endogenous Vascular Protective Cascades into Therapy for Aneurysmal Subarachnoid Hemorrhage awarded by Washington University in St. Louis 2015 - 2019
- Effect of Aging on Brain Ischemia/Stroke Outcome; Pathways, Mechanisms, and Rescue awarded by National Institutes of Health 2016 - 2019
- Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage awarded by National Institutes of Health 2015 - 2018
- STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health 2015 - 2017
- Role of SUMO Conjugation in Ischemia: Significance, Mechanisms and Pathways awarded by National Institutes of Health 2012 - 2017
- Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant awarded by University of Alabama at Birmingham 2013 - 2016
- Restoration of Endoplasmic Reticulum Function in Experimental Stroke awarded by National Institutes of Health 2012 - 2015
- Fe porphyrin-based Redox Modulator in Experimental Stroke Outcome awarded by National Institutes of Health 2013 - 2015
- S-Nitrosylated Hemoglobin and Ischemic Brain Injury awarded by National Institutes of Health 2009 - 2012
- Ethyl Nitrite and Subarachnoid Hemorrhage awarded by National Institutes of Health 2008 - 2011
- Biomedical and Biological Research Applications of a Storage-Ring Free-Electron Laser awarded by Air Force Office of Scientific Research 2000 - 2008
- Anesthetics, GABA and the Injured Brain awarded by National Institutes of Health 2003 - 2008
- Extracellular Oxygen Radicals and Ischemic Brain Injury awarded by National Institutes of Health 2000 - 2003
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lan, B, Liu, W, Wang, Y-C, Shi, J, Li, Y, Xu, S, Sheng, H, Zhou, Q, Zou, J, Hoffmann, U, Yang, W, and Yao, J. "High-speed widefield photoacoustic microscopy of small-animal hemodynamics." Biomedical Optics Express 9, no. 10 (October 2018): 4689-4701. Full Text
  - Shen, Y, Yan, B, Zhao, Q, Wang, Z, Wu, J, Ren, J, Wang, W, Yu, S, Sheng, H, Crowley, SD, Ding, F, Paschen, W, and Yang, W. "Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice." Journal of the American Heart Association 7, no. 17 (September 2018): e009634-null. Full Text
  - Smilnak, GJ, Charalambous, LT, Cutshaw, D, Premji, AM, Giamberardino, CD, Ballard, CG, Bartuska, AP, Ejikeme, TU, Sheng, H, Verbick, LZ, Hedstrom, BA, Pagadala, PC, McCabe, AR, Perfect, JR, and Lad, SP. "Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy." The Journal of Infectious Diseases 218, no. 7 (August 2018): 1147-1154. Full Text
  - Karhausen, J, Bernstock, JD, Johnson, KR, Sheng, H, Ma, Q, Shen, Y, Yang, W, Hallenbeck, JM, and Paschen, W. "Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion." Laboratory Investigation; a Journal of Technical Methods and Pathology 98, no. 6 (June 2018): 799-813. Full Text
  - Liu, H, Yu, Z, Li, Y, Xu, B, Yan, B, Paschen, W, Warner, DS, Yang, W, and Sheng, H. "Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice." Aging and Disease 9, no. 1 (February 2018): 31-39. Full Text
  - Jiang, M, Yu, S, Yu, Z, Sheng, H, Li, Y, Liu, S, Warner, DS, Paschen, W, and Yang, W. "XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G." Stroke 48, no. 6 (June 2017): 1646-1654. Full Text
  - Warner, DS, and Sheng, H. "Anesthetic Neuroprotection? It's Complicated." Anesthesiology 126, no. 4 (April 2017): 579-581. Full Text
  - Yu, Z, Sheng, H, Liu, S, Zhao, S, Glembotski, CC, Warner, DS, Paschen, W, and Yang, W. "Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 37, no. 3 (March 2017): 1069-1079. Full Text
  - Zhang, L, Liu, X, Sheng, H, Liu, S, Li, Y, Zhao, JQ, Warner, DS, Paschen, W, and Yang, W. "Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice." Neuroscience 343 (February 2017): 190-212. Full Text
  - Cui, J, Cui, C, Cui, Y, Li, R, Sheng, H, Jiang, X, Tian, Y, Wang, K, and Gao, J. "Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage." Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 42, no. 1 (January 2017): 137-144. Full Text
  - Taninishi, H, Pearlstein, M, Sheng, H, Izutsu, M, Chaparro, RE, Goldstein, LB, and Warner, DS. "Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 36, no. 12 (December 2016): 2203-2210. Full Text
  - Hoffmann, U, Sheng, H, Ayata, C, and Warner, DS. "Anesthesia in Experimental Stroke Research." Translational Stroke Research 7, no. 5 (October 2016): 358-367. (Review) Full Text
  - Sasaki, T, Hoffmann, U, Kobayashi, M, Sheng, H, Ennaceur, A, Lombard, FW, and Warner, DS. "Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats." Neurocritical care 25, no. 2 (October 2016): 293-305. Full Text
  - Yang, W, Sheng, H, and Wang, H. "Targeting the SUMO pathway for neuroprotection in brain ischaemia." Stroke and Vascular Neurology 1, no. 3 (September 2016): 101-107. (Review) Full Text
  - Lee, HK, Keum, S, Sheng, H, Warner, DS, Lo, DC, and Marchuk, DA. "Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume." The Journal of Clinical Investigation 126, no. 8 (August 2016): 2827-2838. Full Text
  - Liu, S, Sheng, H, Yu, Z, Paschen, W, and Yang, W. "O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 36, no. 2 (February 2016): 393-398. Full Text
  - Hsieh, JT, Lei, B, Sheng, H, Venkatraman, T, Lascola, CD, Warner, DS, and James, ML. "Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage." Neuroendocrinology 103, no. 5 (January 2016): 518-530. Full Text
  - Lei, B, Wang, H, Jeong, S, Hsieh, JT, Majeed, M, Dawson, H, Sheng, H, Warner, DS, and James, ML. "Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage." NEUROENDOCRINOLOGY 103, no. 6 (2016): 665-677. Full Text Link to Item
  - Ashcraft, KA, Boss, M-K, Tovmasyan, A, Roy Choudhury, K, Fontanella, AN, Young, KH, Palmer, GM, Birer, SR, Landon, CD, Park, W, Das, SK, Weitner, T, Sheng, H, Warner, DS, Brizel, DM, Spasojevic, I, Batinic-Haberle, I, and Dewhirst, MW. "Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model." International Journal of Radiation Oncology, Biology, Physics 93, no. 4 (November 2015): 892-900. Full Text
  - Chaparro, RE, Izutsu, M, Sasaki, T, Sheng, H, Zheng, Y, Sadeghian, H, Qin, T, von Bornstadt, D, Herisson, F, Duan, B, Li, J-S, Jiang, K, Pearlstein, M, Pearlstein, RD, Smith, DE, Goldberg, ID, Ayata, C, and Warner, DS. "Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 35, no. 6 (June 2015): 1044-1053. Full Text
  - Hong, J, Nandiwada, V, Jones, V, Lu, M, Warner, DS, Mukhopadhyay, S, and Sheng, H. "CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery." Neuroscience letters 597 (June 2015): 19-24. Full Text
  - Taninishi, H, Jung, JY, Izutsu, M, Wang, Z, Sheng, H, and Warner, DS. "A blinded randomized assessment of laser Doppler flowmetry efficacy in standardizing outcome from intraluminal filament MCAO in the rat." Journal of neuroscience methods 241 (February 2015): 111-120. Full Text
  - Wang, L, Rodriguiz, RM, Wetsel, WC, Sheng, H, Zhao, S, Liu, X, Paschen, W, and Yang, W. "Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories." Journal of Psychiatry & Neuroscience : Jpn 39, no. 4 (July 2014): 259-266. Full Text
  - Wang, R, Hong, J, Lu, M, Neil, JE, Vitek, MP, Liu, X, Warner, DS, Li, F, and Sheng, H. "ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury." Journal of neuroscience research 92, no. 7 (July 2014): 884-892. Full Text
  - Sheng, H, Chaparro, RE, Sasaki, T, Izutsu, M, Pearlstein, RD, Tovmasyan, A, and Warner, DS. "Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders." Antioxidants & Redox Signaling 20, no. 15 (May 2014): 2437-2464. (Review) Full Text
  - Yang, W, Sheng, H, Thompson, JW, Zhao, S, Wang, L, Miao, P, Liu, X, Moseley, MA, and Paschen, W. "Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways." Stroke 45, no. 4 (April 2014): 1115-1122. Full Text
  - Iwabuchi, M, Sheng, H, Thompson, J, Wang, L, Dubois, LG, Gooden, D, Moseley, M, Paschen, W, and Yang, W. "Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia." Journal of Cerebral Blood Flow and Metabolism 34, no. 3 (March 1, 2014): 425-432. Full Text
  - Iwabuchi, M, Sheng, H, Thompson, JW, Wang, L, Dubois, LG, Gooden, D, Moseley, M, Paschen, W, and Yang, W. "Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 34, no. 3 (March 2014): 425-432. Full Text
  - Lei, B, Sheng, H, Wang, H, Lascola, CD, Warner, DS, Laskowitz, DT, and James, ML. "Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage." Journal of visualized experiments : JoVE , no. 89 (January 2014). Full Text
  - Wang, R, Hong, J, Lu, M, Neil, JE, Vitek, MP, Liu, X, Warner, DS, Li, F, and Sheng, H. "ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury." Journal of Neuroscience Research 92, no. 7 (January 1, 2014): 884-892. Full Text
  - Yang, W, Sheng, H, Thompson, JW, Zhao, S, Wang, L, Miao, P, Liu, X, Moseley, MA, and Paschen, W. "Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: Putative protective proteins/pathways." Stroke 45, no. 4 (January 1, 2014): 1115-1122. Full Text
  - Spasojevic, I, Weitner, T, Tovmasyan, A, Sheng, H, Miriyala, S, Leu, D, Rajic, Z, Warner, DS, Clair, DS, Huang, T-T, and Batinic-Haberle, I. "Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-PyP5+." Free Radical Biology and Medicine 65 (November 2013): S132-S132. Full Text
  - Tovmasyan, A, Weitner, T, Sheng, H, Lu, M, Rajic, Z, Warner, DS, Spasojevic, I, Reboucas, JS, Benov, L, and Batinic-Haberle, I. "Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology." Inorganic Chemistry 52, no. 10 (May 6, 2013): 5677-5691. Full Text
  - Benner, EJ, Luciano, D, Jo, R, Abdi, K, Paez-Gonzalez, P, Sheng, H, Warner, DS, Liu, C, Eroglu, C, and Kuo, CT. "Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4." Nature 497, no. 7449 (May 2013): 369-373. Full Text
  - Weitner, T, Kos, I, Sheng, H, Tovmasyan, A, Reboucas, JS, Fan, P, Warner, DS, Vujaskovic, Z, Batinic-Haberle, I, and Spasojevic, I. "Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+." Free Radical Biology & Medicine 58 (May 2013): 73-80. Full Text
  - Wang, Z, Wang, R, Sheng, H, Sheng, SP, Paschen, W, and Yang, W. "Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons." Spinal Cord 51, no. 2 (February 2013): 139-143. Full Text Link to Item
  - Yates, RB, Sheng, H, Sakai, H, Kleven, DT, DeSimone, NA, Stafford-Smith, M, and Warner, DS. "Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat." J Cardiothorac Vasc Anesth 27, no. 1 (February 2013): 71-78. Full Text Link to Item
  - Benner, EJ, Luciano, D, Jo, R, Abdi, K, Paez-Gonzalez, P, Sheng, H, Warner, DS, Liu, C, Eroglu, C, and Kuo, CT. "Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4." Nature 497, no. 7449 (2013): 369-373. Full Text
  - Tovmasyan, A, Sheng, H, Weitner, T, Arulpragasam, A, Lu, M, Warner, DS, Vujaskovic, Z, Spasojevic, I, and Batinic-Haberle, I. "Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators." Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre 22, no. 2 (January 2013): 103-130. (Review) Full Text
  - Yates, RB, Sheng, H, Sakai, H, Kleven, DT, Desimone, NA, Stafford-Smith, M, and Warner, DS. "Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat." Journal of Cardiothoracic and Vascular Anesthesia 27, no. 1 (2013): 71-78. Full Text
  - Sheng, SP, Lei, B, James, ML, Lascola, CD, Venkatraman, TN, Jung, JY, Maze, M, Franks, NP, Pearlstein, RD, Sheng, H, and Warner, DS. "Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage." Anesthesiology 117, no. 6 (December 2012): 1262-1275. Full Text Link to Item
  - Rajic, Z, Tovmasyan, A, Spasojevic, I, Sheng, H, Lu, M, Li, AM, Gralla, EB, Warner, DS, Benov, L, and Batinic-Haberle, I. "A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity." Free Radical Biology & Medicine 52, no. 9 (May 2012): 1828-1834. Full Text
  - Yang, W, Thompson, JW, Wang, Z, Wang, L, Sheng, H, Foster, MW, Moseley, MA, and Paschen, W. "Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics." Journal of Proteome Research 11, no. 2 (February 2012): 1108-1117. Full Text
  - Sheng, H, Spasojevic, I, Tse, HM, Jung, JY, Hong, J, Zhang, Z, Piganelli, JD, Batinic-Haberle, I, and Warner, DS. "Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage." The Journal of Pharmacology and Experimental Therapeutics 338, no. 3 (September 2011): 906-916. Full Text
  - Qing, M, Shim, J-K, Grocott, HP, Sheng, H, Mathew, JP, and Mackensen, GB. "The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass." J Thorac Cardiovasc Surg 142, no. 2 (August 2011): 424-429. Full Text Link to Item
  - Tovmasyan, AG, Rajic, Z, Spasojevic, I, Reboucas, JS, Chen, X, Salvemini, D, Sheng, H, Warner, DS, Benov, L, and Batinic-Haberle, I. "Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins." Dalton Transactions (Cambridge, England : 2003) 40, no. 16 (April 2011): 4111-4121. Full Text
  - Sheng, H, Reynolds, JD, Auten, RL, Demchenko, IT, Piantadosi, CA, Stamler, JS, and Warner, DS. "Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage." Stroke 42, no. 2 (February 2011): 471-476. Full Text
  - Homi, HM, Sheng, H, Arepally, GM, Mackensen, GB, and Grocott, HP. "Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass." Anesth Analg 111, no. 1 (July 2010): 38-45. Full Text Link to Item
  - Wang, Z, Yang, W, Britz, GW, Lombard, FW, Warner, DS, and Sheng, H. "Development of a simplified spinal cord ischemia model in mice." Journal of Neuroscience Methods 189, no. 2 (June 2010): 246-251. Full Text
  - Sheng, H, Yang, W, Fukuda, S, Tse, HM, Paschen, W, Johnson, K, Batinic-Haberle, I, Crapo, JD, Pearlstein, RD, Piganelli, J, and Warner, DS. "Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat." Free Radic Biol Med 47, no. 7 (October 1, 2009): 917-923. Full Text Link to Item
  - Takata, K, Sheng, H, Borel, CO, Laskowitz, DT, Warner, DS, and Lombard, FW. "Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage." J Neurosurg Anesthesiol 21, no. 4 (October 2009): 326-333. Full Text Link to Item
  - Paschen, W, Yang, W, and Sheng, H. "TRANSIENT CEREBRAL ISCHEMIA AND PROTEIN SUMOYLATION." JOURNAL OF NEUROCHEMISTRY 108 (March 2009): 59-59. Link to Item
  - Takata, K, Sheng, H, Borel, CO, Laskowitz, DT, Warner, DS, and Lombard, FW. "Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives." Exp Neurol 213, no. 2 (October 2008): 336-344. Full Text Link to Item
  - Yang, W, Sheng, H, Homi, HM, Warner, DS, and Paschen, W. "Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?." J Neurochem 106, no. 3 (August 2008): 989-999. (Review) Full Text Link to Item
  - Yang, W, Sheng, H, Warner, DS, and Paschen, W. "Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation." J Cereb Blood Flow Metab 28, no. 5 (May 2008): 892-896. Full Text Link to Item
  - Yang, W, Sheng, H, Warner, DS, and Paschen, W. "Transient global cerebral ischemia induces a massive increase in protein sumoylation." J Cereb Blood Flow Metab 28, no. 2 (February 2008): 269-279. Full Text Link to Item
  - Rice, HE, Hsu, EW, Sheng, H, Evenson, DA, Freemerman, AJ, Safford, KM, Provenzale, JM, Warner, DS, and Johnson, GA. "Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice." Ajr. American Journal of Roentgenology 188, no. 4 (April 2007): 1101-1108. Full Text
  - Sakai, H, Sheng, H, Yates, RB, Ishida, K, Pearlstein, RD, and Warner, DS. "Isoflurane provides long-term protection against focal cerebral ischemia in the rat." Anesthesiology 106, no. 1 (January 2007): 92-99. Link to Item
  - Elsersy, H, Mixco, J, Sheng, H, Pearlstein, RD, and Warner, DS. "Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection." Anesthesiology 105, no. 1 (July 2006): 81-90. Link to Item
  - Leinenweber, SB, Sheng, H, Lynch, JR, Wang, H, Batinić-Haberle, I, Laskowitz, DT, Crapo, JD, Pearlstein, RD, and Warner, DS. "Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model." Eur J Pharmacol 531, no. 1-3 (February 15, 2006): 126-132. Full Text Link to Item
  - Freiberger, JJ, Suliman, HB, Sheng, H, McAdoo, J, Piantadosi, CA, and Warner, DS. "A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats." Brain Research 1075, no. 1 (February 3, 2006): 213-222. Full Text
  - Gao, J, Wang, H, Sheng, H, Lynch, JR, Warner, DS, Durham, L, Vitek, MP, and Laskowitz, DT. "A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage." Neurocritical Care 4, no. 1 (January 2006): 25-31. Full Text
  - Ma, Q, Grocott, HP, Sulzer, C, Yoshitani, K, Sheng, H, and Mackensen, GB. "Effect of mean arterial pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass." Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 1-null.
  - Sakai, H, Yates, R, Sheng, H, Pearlstein, R, and Warner, DS. "Isoflurane provides sustained neuroprotection in rats subjected to focal ischemia." Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 281-null. Full Text
  - Takata, K, Lombard, FW, Sheng, H, Laskowitz, D, Borel, CO, and Warner, DS. "A rat model of cerebral vasospasm resulting in chronic motor and neurocognitive deficits following experimental sah." Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 295-null. Full Text
  - Wang, H, Gao, J, Lassiter, TF, McDonagh, DL, Sheng, H, Warner, DS, Lynch, JR, and Laskowitz, DT. "Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage." Neurocritical Care 5, no. 1 (January 2006): 71-78. Full Text
  - Yokoo, N, Sheng, H, Mixco, J, Homi, HM, Pearlstein, RD, and Warner, DS. "Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine." Anesth Analg 99, no. 3 (September 2004): 896-903. Full Text Link to Item
  - Sheng, H, Spasojevic, I, Warner, DS, and Batinic-Haberle, I. "Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy." Neuroscience Letters 366, no. 2 (August 2004): 220-225. Full Text
  - Warner, DS, Sheng, H, and Batinić-Haberle, I. "Oxidants, antioxidants and the ischemic brain." J Exp Biol 207, no. Pt 18 (August 2004): 3221-3231. (Review) Full Text Link to Item
  - Elsersy, H, Sheng, H, Lynch, JR, Moldovan, M, Pearlstein, RD, and Warner, DS. "Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat." Anesthesiology 100, no. 5 (May 2004): 1160-1166. Link to Item
  - Sheng, H, Wang, H, Homi, HM, Spasojevic, I, Batinic-Haberle, I, Pearlstein, RD, and Warner, DS. "A no-laminectomy spinal cord compression injury model in mice." Journal of Neurotrauma 21, no. 5 (May 2004): 595-603. Full Text
  - Homi, HM, Mixco, JM, Sheng, H, Grocott, HP, Pearlstein, RD, and Warner, DS. "Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice." Anesthesiology 99, no. 5 (November 2003): 1145-1151. Link to Item
  - Borel, CO, McKee, A, Parra, A, Haglund, MM, Solan, A, Prabhakar, V, Sheng, H, Warner, DS, and Niklason, L. "Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage." Stroke 34, no. 2 (February 2003): 427-433. Full Text
  - Ross, AD, Sheng, H, Warner, DS, Piantadosi, CA, Batinic-Haberle, I, Day, BJ, and Crapo, JD. "Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity." Free Radic Biol Med 33, no. 12 (December 15, 2002): 1657-1669. Link to Item
  - McGirt, MJ, Lynch, JR, Parra, A, Sheng, H, Pearlstein, RD, Laskowitz, DT, Pelligrino, DA, and Warner, DS. "Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage." Stroke 33, no. 12 (December 2002): 2950-2956. Full Text
  - Sheng, H, Batinc-Haberle, I, and Warner, DS. "Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury." Drug News Perspect 15, no. 10 (December 2002): 654-665. Link to Item
  - Bowler, RP, Sheng, H, Enghild, JJ, Pearlstein, RD, Warner, DS, and Crapo, JD. "A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke." Free Radical Biology & Medicine 33, no. 8 (October 2002): 1141-1152. Full Text
  - Sheng, H, Enghild, JJ, Bowler, R, Patel, M, Batinić-Haberle, I, Calvi, CL, Day, BJ, Pearlstein, RD, Crapo, JD, and Warner, DS. "Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia." Free Radical Biology & Medicine 33, no. 7 (October 2002): 947-961. Full Text
  - McGirt, MJ, Parra, A, Sheng, H, Higuchi, Y, Oury, TD, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase." Stroke 33, no. 9 (September 2002): 2317-2323. Full Text
  - McGirt, MJ, Lynch, JR, Sheng, HX, Pearlstein, R, Laskowitz, DT, Pelligrino, DA, and Warner, DS. "Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates cerebral vasospasm after subarachnoid hemorrhage in the mouse via augmentation of endothelial nitric oxide synthase." NEUROSURGERY 51, no. 2 (August 2002): 580-580. Link to Item
  - Parra, A, McGirt, MJ, Sheng, H, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis." Neurological Research 24, no. 5 (July 2002): 510-516. Full Text
  - Wainwright, MS, Sheng, H, Sato, Y, Mackensen, GB, Steffen, RP, Pearlstein, RD, and Warner, DS. "Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats." American Journal of Physiology. Heart and Circulatory Physiology 282, no. 5 (May 2002): H1863-H1870. Full Text
  - Lynch, JR, McGirt, MJ, Pelligrino, DA, Laskowitz, DT, Sheng, HX, and Warner, DS. "Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage in mice." NEUROLOGY 58, no. 7 (April 9, 2002): A367-A367. Link to Item
  - Leinenweber, SB, Sheng, HX, Lynch, J, Batinic-Haberle, I, Laskowitz, D, and Warner, DS. "Effects of a metalloporphyrin catalytic antioxidant in a murine model of closed head injury." PEDIATRIC RESEARCH 51, no. 4 (April 2002): 48A-48A. Link to Item
  - Batinic-Haberle, I, Spasojevic, I, Sheng, HX, Warner, DS, and Fridovich, I. "Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/traumatic injuries of central nervous system." FREE RADICAL BIOLOGY AND MEDICINE 33 (2002): S236-S237. Link to Item
  - Batinic-Haberle, I, Spasojevic, I, Sheng, HX, Warner, DS, and Fridovich, I. "Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/raumatic injuries of central nervous system." FREE RADICAL BIOLOGY AND MEDICINE 33 (2002): S125-S126. Link to Item
  - McGirt, MJ, Parra, A, Sheng, HX, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Attenuation of cerebral vasospasm following subarachnoid hemorrhage in mice over-expressing extracellular superoxide dismutase." STROKE 33, no. 1 (January 2002): 380-380. Link to Item
  - Warner, DS, Sheng, HX, Pearlstein, RD, Calvi, C, and Crapo, JD. "AEOL 10150, a metalloporphyrin catalytic antioxidant, reduces injury from focal ischemia in the rat and mouse." FREE RADICAL BIOLOGY AND MEDICINE 33 (2002): S126-S127. Link to Item
  - McDaniel, B, Sheng, H, Warner, DS, Hedlund, LW, and Benveniste, H. "Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study." Neuroimage 14, no. 6 (December 2001): 1244-1255. Full Text Link to Item
  - Mackensen, GB, Patel, M, Sheng, H, Calvi, CL, Batinic-Haberle, I, Day, BJ, Liang, LP, Fridovich, I, Crapo, JD, Pearlstein, RD, and Warner, DS. "Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 21, no. 13 (July 2001): 4582-4592. Full Text
  - Pineda, JA, Aono, M, Sheng, H, Lynch, J, Wellons, JC, Laskowitz, DT, Pearlstein, RD, Bowler, R, Crapo, J, and Warner, DS. "Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse." J Neurotrauma 18, no. 6 (June 2001): 625-634. Full Text Link to Item
  - Enghild, JJ, Christiansen, H, Sheng, H, Bowler, R, Thorgersen, IB, Crapo, J, Warner, D, and Hojrup, P. "Changes in protein expression after a superoxide dismutase mimetic in stroke." FREE RADICAL BIOLOGY AND MEDICINE 31 (2001): S132-S132. Link to Item
  - Parra, A, McGirt, MJ, Sheng, HX, Pearlstein, RD, Laskowitz, DT, and Warner, DS. "Effects of extracellular superoxide dismutase on arterial vascular structural changes after acute subarachnoid hemorrhage in the mouse." STROKE 32, no. 1 (January 2001): 359-359. Link to Item
  - Ross, AD, Warner, DS, Sheng, HX, Piantadosi, CA, Day, BJ, and Crapo, JD. "Species-specific hemodynamic effects of metalloporphyrin SOD mimetics." FREE RADICAL BIOLOGY AND MEDICINE 31 (2001): S96-S96. Link to Item
  - Warner, DS, Sheng, HX, Bowler, R, Enghild, J, Patel, M, and Crapo, JD. "Effects of metalloporphyrin catalytic antioxidants on rodent focal ischemic brain damage." FREE RADICAL BIOLOGY AND MEDICINE 31 (2001): S134-S134. Link to Item
  - Mackensen, GB, Nellgârd, B, Kudo, M, Sheng, H, Pearlstein, RD, and Warner, DS. "Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats." Anesthesiology 93, no. 4 (October 2000): 1102-1106. Link to Item
  - Wellons, JC, Sheng, H, Pineda, J, Massey, GW, Pearlstein, RD, Warner, DS, and Laskowitz, DT. "813 Intracerebral Infusion of Human Recombinant Apolipoprotein E3 Reduces Global Ischemic Brain Injury in Apolipoprotein E Deficient Mice." Neurosurgery 47, no. 2 (August 2000): 532-. Full Text
  - Wellons, JC, Sheng, H, Pineda, J, Massey, GW, Pearlstein, RD, Warner, DS, and Laskowitz, DT. "813 Intracerebral Infusion of Human Recombinant Apolipoprotein E3 Reduces Global Ischemic Brain Injury in Apolipoprotein E Deficient Mice." Neurosurgery 47, no. 2 (August 2000): 532-. Full Text
  - Wellons, JC, Sheng, H, Laskowitz, DT, Mackensen, GB, Pearlstein, RD, and Warner, DS. "A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia." Brain Res 868, no. 1 (June 16, 2000): 14-21. Link to Item
  - Sheng, H, Kudo, M, Mackensen, GB, Pearlstein, RD, Crapo, JD, and Warner, DS. "Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia." Exp Neurol 163, no. 2 (June 2000): 392-398. Full Text Link to Item
  - Sheng, H, Brady, TC, Pearlstein, RD, Crapo, JD, and Warner, DS. "Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse." Neurosci Lett 267, no. 1 (May 21, 1999): 13-16. Link to Item
  - Sarraf-Yazdi, S, Sheng, H, Grocott, HP, Bart, RD, Pearlstein, RD, Steffen, RP, and Warner, DS. "Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat." Brain Research 826, no. 2 (May 1999): 172-180. Full Text
  - Sheng, H, Laskowitz, DT, Mackensen, GB, Kudo, M, Pearlstein, RD, and Warner, DS. "Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse." Stroke 30, no. 5 (May 1999): 1118-1124. Link to Item
  - Sheng, H, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Characterization of a recovery global cerebral ischemia model in the mouse." J Neurosci Methods 88, no. 1 (April 1, 1999): 103-109. Link to Item
  - Grocott, HP, Sheng, H, Miura, Y, Sarraf-Yazdi, S, Mackensen, GB, Pearlstein, RD, and Warner, DS. "The effects of aprotinin on outcome from cerebral ischemia in the rat." Anesth Analg 88, no. 1 (January 1999): 1-7. Link to Item
  - Sarraf-Yazdi, S, Sheng, H, Brinkhous, AD, Pearlstein, RD, and Warner, DS. "Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat." J Neurosurg Anesthesiol 11, no. 1 (January 1999): 31-36. Link to Item
  - Sheng, H, Bart, RD, Oury, TD, Pearlstein, RD, Crapo, JD, and Warner, DS. "Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia." Neuroscience 88, no. 1 (January 1999): 185-191. Link to Item
  - Bart, R, Sheng, H, Oury, T, Crapo, J, Pearlstein, R, and Warner, D. "Modulation of cerebral blood flow is not the mechanism of neuroprotection in transgenic mice over expressing human extracellular superoxide dismutase (EC-SOD)." Critical Care Medicine 26, no. 1 SUPPL. (December 1, 1998).
  - Sarraf-Yazdi, S, Sheng, H, Grocott, HP, Pearlstein, RD, Steffen, RP, and Warner, DS. "Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine (MK-801) on infarct size following focal cerebral ischemia in conscious rats." ANESTHESIOLOGY 89, no. 3A (September 1998): U747-U747. Link to Item
  - Bart, RD, Sheng, H, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia." Neuroreport 9, no. 11 (August 1998): 2615-2620. Full Text
  - Grocott, HP, Bart, RD, Sheng, H, Miura, Y, Steffen, R, Pearlstein, RD, and Warner, DS. "Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat." Stroke 29, no. 8 (August 1998): 1650-1655. Full Text
  - Sarraf-Yazdi, S, Sheng, H, Miura, Y, McFarlane, C, Dexter, F, Pearlstein, R, and Warner, DS. "Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat." Anesth Analg 87, no. 1 (July 1998): 72-78. Link to Item
  - Sheng, H, Laskowitz, DT, Bennett, E, Schmechel, DE, Bart, RD, Saunders, AM, Pearlstein, RD, Roses, AD, and Warner, DS. "Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 18, no. 4 (April 1998): 361-366. Full Text
  - Pittman, JE, Sheng, H, Pearlstein, R, Brinkhous, A, Dexter, F, and Warner, DS. "Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat." Anesthesiology 87, no. 5 (November 1997): 1139-1144. Full Text
  - Grocott, HP, Bart, NA, Muira, Y, Sheng, H, Pearlstein, NA, and Warner, DS. "A680 NEUROPROTECTION FROM RSR 13 IN A RAT MODEL OF INCOMPLETE FOREBRAIN ISCHEMIA." Anesthesiology 87, no. Supplement (September 1997): 680A-680A. Full Text
  - Laskowitz, DT, Sheng, H, Bart, RD, Joyner, KA, Roses, AD, and Warner, DS. "Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 17, no. 7 (July 1997): 753-758. Full Text
  - Gillespie, JS, and Sheng, H. "The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915." Br J Pharmacol 94, no. 4 (August 1988): 1189-1197. Link to Item
  - Wainwright, MS, Sheng, H, Sato, Y, Burkhard Mackensen, G, Steffen, RP, Pearlstein, RD, and Warner, DS. "Pharmacological correction of hypothermic P50 shift does not alter outcome from focal cerebral ischemia in rats." American Journal of Physiology Heart and Circulatory Physiology 282, no. 5 51-5 (June 29, 2002).
- Conference Papers
  - Lei, B, Wang, H, Jeong, S, Hsieh, JT, Majeed, M, Dawson, H, Sheng, H, Warner, DS, and James, ML. "Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage." January 2016. Full Text

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