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Huaxin Sheng

Associate Professor in Anesthesiology
Anesthesiology
Box 3094 Med Ctr, Durham, NC 27710
138 Sands Bldg, Durham, NC 27710

Overview


We have successfully developed various rodent models of brain and spinal cord injuries in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma, subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia, and compression injury. We also established cardiac arrest and hemorrhagic shock models for studying multiple organ dysfunction.  Our current studies focus on two projects. One is to examine the efficacy of catalytic antioxidants in treating cerebral ischemia, and the other is to investigate the effectiveness of post-conditioning on the outcome of subarachnoid hemorrhage-induced cognitive dysfunction.

We are a part of the NIH Stroke Preclinical Assessment Network (SPAN).

Current Appointments & Affiliations


Associate Professor in Anesthesiology · 2021 - Present Anesthesiology, Clinical Science Departments

Recent Publications


Glucocorticoid signaling mediates lymphopoiesis impairment after cardiac arrest in mice.

Journal Article J Cereb Blood Flow Metab · June 2025 Cardiac arrest (CA) is a life-threatening condition that requires immediate medical attention. Considerable advances in resuscitation have led to an increasing number of patients who survive the initial arrest event. However, among this growing patient pop ... Full text Link to item Cite

Activation of ATF6 Signaling Confers Long-Term Beneficial Effects in Young and Aged Mice After Permanent Stroke.

Journal Article Transl Stroke Res · April 21, 2025 Ischemic stroke disrupts protein homeostasis in brain cells, causes endoplasmic reticulum (ER) stress, and consequently activates the unfolded protein response (UPR). The primary function of UPR activation is to help cells restore ER function, thereby prom ... Full text Link to item Cite

Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage.

Journal Article Pharmaceuticals (Basel) · April 8, 2025 Background: Manganese porphyrin, MnTnBuOE-2-PyP5+ (BMX-001), improves neurologic deficits in experimental ischemic stroke and has the potential to serve as an adjunct with thrombolysis or thrombectomy in stroke patients. In 10-30% of stroke patients follow ... Full text Link to item Cite
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Recent Grants


Impact of Autonomic Dysfunction on Multi-Organ Dysfunction following Severe TBI: The AUTO-BOOST Study

ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2028

The Unfolded Protein Response and Neuroprotection in Stroke

ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2016 - 2026

Novel mitochondrial protective properties of annexin A1

ResearchResearch Scientist · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2021 - 2026

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Education, Training & Certifications


Nantong Medical College (China) · 1984 M.D.