Huaxin Sheng | Scholars@Duke

Huaxin Sheng
Associate Professor in Anesthesiology

We have successfully developed various rodent models of brain and spinal cord injuries in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma, subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia and compression injury. We also established cardiac arrest and hemorrhagic shock models for studying multiple organ dysfunction. Our current studies focus on two projects. One is to examine the efficacy of catalytic antioxidant in treating cerebral ischemia and the other is to examine the efficacy of post-conditioning on outcome of subarachnoid hemorrhage induced cognitive dysfunction.

Current Appointments & Affiliations

Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2011

Contact Information

138 Sands Bldg, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
sheng001@mc.duke.edu (919) 684-6319

Background
Education, Training, & Certifications
- Attending Neurosurgeon, Lecturer, Vice-Chairman, Neurosurgery, China Medical University (China) 1989 - 1995
- Instructor of Neuroanatomy, Anatomy, China Medical University (China) 1984 - 1986
- M.D., Nantong Medical College (China) 1984
Duke Appointment History
- Associate Professor in Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2008 - 2011
- Assistant Professor in Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2006 - 2008
- Assistant Research Professor in Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 1999 - 2006
Research
Selected Grants
- The Unfolded Protein Response and Neuroprotection in Stroke awarded by National Institutes of Health 2016 - 2021
- Effect of Aging on Brain Ischemia/Stroke Outcome; Pathways, Mechanisms, and Rescue awarded by National Institutes of Health 2016 - 2020
- Validation of a Novel Fungicidal Approach for Cryptococcal Meningitis 2018 - 2020
- Translating Endogenous Vascular Protective Cascades into Therapy for Aneurysmal Subarachnoid Hemorrhage awarded by Washington University in St. Louis 2015 - 2019
- Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage awarded by National Institutes of Health 2015 - 2018
- STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health 2015 - 2017
- Role of SUMO Conjugation in Ischemia: Significance, Mechanisms and Pathways awarded by National Institutes of Health 2012 - 2017
- Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant awarded by University of Alabama at Birmingham 2013 - 2016
- Restoration of Endoplasmic Reticulum Function in Experimental Stroke awarded by National Institutes of Health 2012 - 2015
- Fe porphyrin-based Redox Modulator in Experimental Stroke Outcome awarded by National Institutes of Health 2013 - 2015
- S-Nitrosylated Hemoglobin and Ischemic Brain Injury awarded by National Institutes of Health 2009 - 2012
- Ethyl Nitrite and Subarachnoid Hemorrhage awarded by National Institutes of Health 2008 - 2011
- Biomedical and Biological Research Applications of a Storage-Ring Free-Electron Laser awarded by Air Force Office of Scientific Research 2000 - 2008
- Anesthetics, GABA and the Injured Brain awarded by National Institutes of Health 2003 - 2008
- Extracellular Oxygen Radicals and Ischemic Brain Injury awarded by National Institutes of Health 2000 - 2003
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lan, Bangxin, Wei Liu, Ya-Chao Wang, Junhui Shi, Yang Li, Song Xu, Huaxin Sheng, et al. “High-speed widefield photoacoustic microscopy of small-animal hemodynamics..” Biomed Opt Express 9, no. 10 (October 1, 2018): 4689–4701. https://doi.org/10.1364/BOE.9.004689.
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  - Shen, Yuntian, Baihui Yan, Qiang Zhao, Zhuoran Wang, Jiangbo Wu, Jiafa Ren, Wei Wang, et al. “Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice..” J Am Heart Assoc 7, no. 17 (September 4, 2018). https://doi.org/10.1161/JAHA.118.009634.
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  - Smilnak, Gordon J., Lefko T. Charalambous, Drew Cutshaw, Alykhan M. Premji, Charles D. Giamberardino, Christi G. Ballard, Andrew P. Bartuska, et al. “Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy..” J Infect Dis 218, no. 7 (August 24, 2018): 1147–54. https://doi.org/10.1093/infdis/jiy286.
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  - Karhausen, Jörn, Joshua D. Bernstock, Kory R. Johnson, Huaxin Sheng, Qing Ma, Yuntian Shen, Wei Yang, John M. Hallenbeck, and Wulf Paschen. “Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion..” Lab Invest 98, no. 6 (June 2018): 799–813. https://doi.org/10.1038/s41374-018-0035-6.
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  - Liu, Huaqin, Zhui Yu, Ying Li, Bin Xu, Baihui Yan, Wulf Paschen, David S. Warner, Wei Yang, and Huaxin Sheng. “Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice..” Aging Dis 9, no. 1 (February 2018): 31–39. https://doi.org/10.14336/AD.2017.0221.
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  - Jiang, Meng, Shu Yu, Zhui Yu, Huaxin Sheng, Ying Li, Shuai Liu, David S. Warner, Wulf Paschen, and Wei Yang. “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G..” Stroke 48, no. 6 (June 2017): 1646–54. https://doi.org/10.1161/STROKEAHA.117.016579.
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  - Warner, David S., and Huaxin Sheng. “Anesthetic Neuroprotection? It's Complicated..” Anesthesiology 126, no. 4 (April 2017): 579–81. https://doi.org/10.1097/ALN.0000000000001535.
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  - Yu, Zhui, Huaxin Sheng, Shuai Liu, Shengli Zhao, Christopher C. Glembotski, David S. Warner, Wulf Paschen, and Wei Yang. “Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome..” J Cereb Blood Flow Metab 37, no. 3 (March 2017): 1069–79. https://doi.org/10.1177/0271678X16650218.
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  - Zhang, Lin, Xiaozhi Liu, Huaxin Sheng, Shuai Liu, Ying Li, Julia Q. Zhao, David S. Warner, Wulf Paschen, and Wei Yang. “Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice..” Neuroscience 343 (February 20, 2017): 190–212. https://doi.org/10.1016/j.neuroscience.2016.11.036.
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  - Cui, Jianzhong, Changmeng Cui, Ying Cui, Ran Li, Huaxin Sheng, Xiaohua Jiang, Yanxia Tian, Kaijie Wang, and Junling Gao. “Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage..” Cell Physiol Biochem 42, no. 1 (2017): 137–44. https://doi.org/10.1159/000477122.
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  - Taninishi, Hideki, Molly Pearlstein, Huaxin Sheng, Miwa Izutsu, Rafael E. Chaparro, Larry B. Goldstein, and David S. Warner. “Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat..” J Cereb Blood Flow Metab 36, no. 12 (December 2016): 2203–10. https://doi.org/10.1177/0271678X15616980.
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  - Hoffmann, Ulrike, Huaxin Sheng, Cenk Ayata, and David S. Warner. “Anesthesia in Experimental Stroke Research..” Transl Stroke Res 7, no. 5 (October 2016): 358–67. https://doi.org/10.1007/s12975-016-0491-5.
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  - Sasaki, Toshihiro, Ulrike Hoffmann, Motomu Kobayashi, Huaxin Sheng, Abdelkader Ennaceur, Frederick W. Lombard, and David S. Warner. “Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats..” Neurocrit Care 25, no. 2 (October 2016): 293–305. https://doi.org/10.1007/s12028-016-0250-1.
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  - Yang, Wei, Huaxin Sheng, and Haichen Wang. “Targeting the SUMO pathway for neuroprotection in brain ischaemia..” Stroke Vasc Neurol 1, no. 3 (September 2016): 101–7. https://doi.org/10.1136/svn-2016-000031.
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  - Lee, Han Kyu, Sehoon Keum, Huaxin Sheng, David S. Warner, Donald C. Lo, and Douglas A. Marchuk. “Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume..” J Clin Invest 126, no. 8 (August 1, 2016): 2827–38. https://doi.org/10.1172/JCI84491.
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  - Liu, Shuai, Huaxin Sheng, Zhui Yu, Wulf Paschen, and Wei Yang. “O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress..” J Cereb Blood Flow Metab 36, no. 2 (February 2016): 393–98. https://doi.org/10.1177/0271678X15608393.
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  - Hsieh, Justin T., Beilei Lei, Huaxin Sheng, Talagnair Venkatraman, Christopher D. Lascola, David S. Warner, and Michael L. James. “Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage..” Neuroendocrinology 103, no. 5 (2016): 518–30. https://doi.org/10.1159/000440883.
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  - Ashcraft, Kathleen A., Mary-Keara Boss, Artak Tovmasyan, Kingshuk Roy Choudhury, Andrew N. Fontanella, Kenneth H. Young, Gregory M. Palmer, et al. “Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model..” Int J Radiat Oncol Biol Phys 93, no. 4 (November 15, 2015): 892–900. https://doi.org/10.1016/j.ijrobp.2015.07.2283.
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  - Hong, Jun, Vijaya Nandiwada, Victoria Jones, Miaomiao Lu, David S. Warner, Somnath Mukhopadhyay, and Huaxin Sheng. “CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery..” Neurosci Lett 597 (June 15, 2015): 19–24. https://doi.org/10.1016/j.neulet.2015.04.016.
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  - Chaparro, Rafael E., Miwa Izutsu, Toshihiro Sasaki, Huaxin Sheng, Yi Zheng, Homa Sadeghian, Tao Qin, et al. “Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice..” J Cereb Blood Flow Metab 35, no. 6 (June 2015): 1044–53. https://doi.org/10.1038/jcbfm.2015.23.
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  - Taninishi, Hideki, Jin Yong Jung, Miwa Izutsu, Zhengfeng Wang, Huaxin Sheng, and David S. Warner. “A blinded randomized assessment of laser Doppler flowmetry efficacy in standardizing outcome from intraluminal filament MCAO in the rat..” J Neurosci Methods 241 (February 15, 2015): 111–20. https://doi.org/10.1016/j.jneumeth.2014.12.006.
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  - Lei, Beilei, Huaxin Sheng, Haichen Wang, Christopher D. Lascola, David S. Warner, Daniel T. Laskowitz, and Michael L. James. “Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage..” J Vis Exp, no. 89 (July 3, 2014). https://doi.org/10.3791/51439.
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  - Wang, Liangli, Ramona M. Rodriguiz, William C. Wetsel, Huaxin Sheng, Shengli Zhao, Xiaozhi Liu, Wulf Paschen, and Wei Yang. “Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories..” J Psychiatry Neurosci 39, no. 4 (July 2014): 259–66.
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  - Wang, Ruihua, Jun Hong, Miaomiao Lu, Jessica E. Neil, Michael P. Vitek, Xiaozhi Liu, David S. Warner, Fengqiao Li, and Huaxin Sheng. “ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury..” J Neurosci Res 92, no. 7 (July 2014): 884–92. https://doi.org/10.1002/jnr.23371.
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  - Sheng, Huaxin, Raphael E. Chaparro, Toshihiro Sasaki, Miwa Izutsu, Robert D. Pearlstein, Artak Tovmasyan, and David S. Warner. “Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders..” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2437–64. https://doi.org/10.1089/ars.2013.5413.
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  - Yang, Wei, Huaxin Sheng, J Will Thompson, Shengli Zhao, Liangli Wang, Pei Miao, Xiaozhi Liu, M Arthur Moseley, and Wulf Paschen. “Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways..” Stroke 45, no. 4 (April 2014): 1115–22. https://doi.org/10.1161/STROKEAHA.113.004315.
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  - Iwabuchi, Masahiro, Huaxin Sheng, J Will Thompson, Liangli Wang, Laura G. Dubois, David Gooden, Marthur Moseley, Wulf Paschen, and Wei Yang. “Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia..” J Cereb Blood Flow Metab 34, no. 3 (March 2014): 425–32. https://doi.org/10.1038/jcbfm.2013.210.
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  - Spasojevic, Ivan, Tin Weitner, Artak Tovmasyan, Huaxin Sheng, Sumitra Miriyala, David Leu, Zrinka Rajic, et al. “Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.” Free Radical Biology and Medicine 65 (November 2013): S132–S132. https://doi.org/10.1016/j.freeradbiomed.2013.10.728.
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  - Tovmasyan, Artak, Tin Weitner, Huaxin Sheng, MiaoMiao Lu, Zrinka Rajic, David S. Warner, Ivan Spasojevic, Julio S. Reboucas, Ludmil Benov, and Ines Batinic-Haberle. “Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology..” Inorg Chem 52, no. 10 (May 20, 2013): 5677–91. https://doi.org/10.1021/ic3012519.
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  - Benner, Eric J., Dominic Luciano, Rebecca Jo, Khadar Abdi, Patricia Paez-Gonzalez, Huaxin Sheng, David S. Warner, Chunlei Liu, Cagla Eroglu, and Chay T. Kuo. “Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4..” Nature 497, no. 7449 (May 16, 2013): 369–73. https://doi.org/10.1038/nature12069.
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  - Weitner, Tin, Ivan Kos, Huaxin Sheng, Artak Tovmasyan, Julio S. Reboucas, Ping Fan, David S. Warner, Zeljko Vujaskovic, Ines Batinic-Haberle, and Ivan Spasojevic. “Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+..” Free Radic Biol Med 58 (May 2013): 73–80. https://doi.org/10.1016/j.freeradbiomed.2013.01.006.
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  - Wang, Z., R. Wang, H. Sheng, S. P. Sheng, W. Paschen, and W. Yang. “Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons..” Spinal Cord 51, no. 2 (February 2013): 139–43. https://doi.org/10.1038/sc.2012.100.
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  - Yates, Robert B., Huaxin Sheng, Hiroaki Sakai, Daniel T. Kleven, Noelle A. DeSimone, Mark Stafford-Smith, and David S. Warner. “Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat..” Journal of Cardiothoracic and Vascular Anesthesia 27, no. 1 (February 2013): 71–78. https://doi.org/10.1053/j.jvca.2012.06.012.
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  - Benner, E. J., D. Luciano, R. Jo, K. Abdi, P. Paez-Gonzalez, H. Sheng, D. S. Warner, C. Liu, C. Eroglu, and C. T. Kuo. “Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.” Nature 497, no. 7449 (2013): 369–73. https://doi.org/10.1038/nature12069.
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  - Tovmasyan, Artak, Huaxin Sheng, Tin Weitner, Amanda Arulpragasam, Miaomiao Lu, David S. Warner, Zeljko Vujaskovic, Ivan Spasojevic, and Ines Batinic-Haberle. “Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators..” Med Princ Pract 22, no. 2 (2013): 103–30. https://doi.org/10.1159/000341715.
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  - Sheng, Siyuan P., Beilei Lei, Michael L. James, Christopher D. Lascola, Talaignair N. Venkatraman, Jin Yong Jung, Mervyn Maze, et al. “Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage..” Anesthesiology 117, no. 6 (December 2012): 1262–75. https://doi.org/10.1097/aln.0b013e3182746b81.
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  - Rajic, Zrinka, Artak Tovmasyan, Ivan Spasojevic, Huaxin Sheng, Miaomiao Lu, Alice M. Li, Edith B. Gralla, David S. Warner, Ludmil Benov, and Ines Batinic-Haberle. “A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity..” Free Radic Biol Med 52, no. 9 (May 1, 2012): 1828–34. https://doi.org/10.1016/j.freeradbiomed.2012.02.006.
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  - Yang, Wei, J Will Thompson, Zhengfeng Wang, Liangli Wang, Huaxin Sheng, Matthew W. Foster, M Arthur Moseley, and Wulf Paschen. “Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics..” J Proteome Res 11, no. 2 (February 3, 2012): 1108–17. https://doi.org/10.1021/pr200834f.
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  - Sheng, Huaxin, Ivan Spasojevic, Hubert M. Tse, Jin Yong Jung, Jun Hong, Zhiquan Zhang, Jon D. Piganelli, Ines Batinic-Haberle, and David S. Warner. “Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage..” J Pharmacol Exp Ther 338, no. 3 (September 2011): 906–16. https://doi.org/10.1124/jpet.110.176701.
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  - Qing, Ma, Jae-Kwang Shim, Hilary P. Grocott, Huaxin Sheng, Joseph P. Mathew, and G Burkhard Mackensen. “The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass..” The Journal of Thoracic and Cardiovascular Surgery 142, no. 2 (August 2011): 424–29. https://doi.org/10.1016/j.jtcvs.2010.11.036.
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  - Tovmasyan, Artak G., Zrinka Rajic, Ivan Spasojevic, Julio S. Reboucas, Xin Chen, Daniela Salvemini, Huaxin Sheng, David S. Warner, Ludmil Benov, and Ines Batinic-Haberle. “Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins..” Dalton Trans 40, no. 16 (April 28, 2011): 4111–21. https://doi.org/10.1039/c0dt01321h.
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  - Sheng, Huaxin, James D. Reynolds, Richard L. Auten, Ivan T. Demchenko, Claude A. Piantadosi, Jonathan S. Stamler, and David S. Warner. “Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage..” Stroke 42, no. 2 (February 2011): 471–76. https://doi.org/10.1161/STROKEAHA.110.600569.
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  - Homi, H Mayumi, Huaxin Sheng, Gowthami M. Arepally, G Burkhard Mackensen, and Hilary P. Grocott. “Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass..” Anesth Analg 111, no. 1 (July 2010): 38–45. https://doi.org/10.1213/ANE.0b013e3181e0549f.
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  - Wang, Zhengfeng, Wei Yang, Gavin W. Britz, Frederick W. Lombard, David S. Warner, and Huaxin Sheng. “Development of a simplified spinal cord ischemia model in mice..” J Neurosci Methods 189, no. 2 (June 15, 2010): 246–51. https://doi.org/10.1016/j.jneumeth.2010.04.003.
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  - Sheng, Huaxin, Wei Yang, Shiro Fukuda, Hubert M. Tse, Wulf Paschen, Kwame Johnson, Ines Batinic-Haberle, et al. “Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat..” Free Radical Biology & Medicine 47, no. 7 (October 2009): 917–23. https://doi.org/10.1016/j.freeradbiomed.2009.05.039.
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  - Takata, Ken, Huaxin Sheng, Cecil O. Borel, Daniel T. Laskowitz, David S. Warner, and Frederick W. Lombard. “Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage..” J Neurosurg Anesthesiol 21, no. 4 (October 2009): 326–33. https://doi.org/10.1097/ANA.0b013e3181acfde7.
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  - Paschen, W., W. Yang, and H. Sheng. “TRANSIENT CEREBRAL ISCHEMIA AND PROTEIN SUMOYLATION.” Journal of Neurochemistry 108 (March 1, 2009): 59–59.
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  - Takata, Ken, Huaxin Sheng, Cecil O. Borel, Daniel T. Laskowitz, David S. Warner, and Frederick W. Lombard. “Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives..” Exp Neurol 213, no. 2 (October 2008): 336–44. https://doi.org/10.1016/j.expneurol.2008.06.009.
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  - Yang, Wei, Huaxin Sheng, H Mayumi Homi, David S. Warner, and Wulf Paschen. “Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?.” J Neurochem 106, no. 3 (August 2008): 989–99. https://doi.org/10.1111/j.1471-4159.2008.05404.x.
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  - Yang, Wei, Huaxin Sheng, David S. Warner, and Wulf Paschen. “Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation..” J Cereb Blood Flow Metab 28, no. 5 (May 2008): 892–96. https://doi.org/10.1038/sj.jcbfm.9600601.
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  - Yang, Wei, Huaxin Sheng, David S. Warner, and Wulf Paschen. “Transient global cerebral ischemia induces a massive increase in protein sumoylation..” J Cereb Blood Flow Metab 28, no. 2 (February 2008): 269–79. https://doi.org/10.1038/sj.jcbfm.9600523.
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  - Rice, Henry E., Edward W. Hsu, Huaxin Sheng, Debra A. Evenson, Alex J. Freemerman, Kristine M. Safford, James M. Provenzale, David S. Warner, and G Allan Johnson. “Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice..” Ajr Am J Roentgenol 188, no. 4 (April 2007): 1101–8. https://doi.org/10.2214/AJR.06.0663.
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  - Sakai, Hiroaki, Huaxin Sheng, Robert B. Yates, Kazuyoshi Ishida, Robert D. Pearlstein, and David S. Warner. “Isoflurane provides long-term protection against focal cerebral ischemia in the rat..” Anesthesiology 106, no. 1 (January 2007): 92–99. https://doi.org/10.1097/00000542-200701000-00017.
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  - Elsersy, Hazem, Javier Mixco, Huaxin Sheng, Robert D. Pearlstein, and David S. Warner. “Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection..” Anesthesiology 105, no. 1 (July 2006): 81–90. https://doi.org/10.1097/00000542-200607000-00016.
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  - Freiberger, John J., Hagir B. Suliman, Huaxin Sheng, Jessica McAdoo, Claude A. Piantadosi, and David S. Warner. “A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats..” Brain Res 1075, no. 1 (February 23, 2006): 213–22. https://doi.org/10.1016/j.brainres.2005.12.088.
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  - Leinenweber, Stephen B., Huaxin Sheng, John R. Lynch, Haichen Wang, Ines Batinić-Haberle, Daniel T. Laskowitz, James D. Crapo, Robert D. Pearlstein, and David S. Warner. “Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model..” Eur J Pharmacol 531, no. 1–3 (February 15, 2006): 126–32. https://doi.org/10.1016/j.ejphar.2005.12.031.
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  - Gao, Junling, Haichen Wang, Huaxin Sheng, John R. Lynch, David S. Warner, Lori Durham, Michael P. Vitek, and Daniel T. Laskowitz. “A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage..” Neurocrit Care 4, no. 1 (2006): 25–31. https://doi.org/10.1385/NCC:4:1:025.
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  - Ma, Q., H. P. Grocott, C. Sulzer, K. Yoshitani, H. Sheng, and G. B. Mackensen. “Effect of mean arterial pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass.” Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006).
  - Sakai, H., R. Yates, H. Sheng, R. Pearlstein, and D. S. Warner. “Isoflurane provides sustained neuroprotection in rats subjected to focal ischemia.” Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006). https://doi.org/10.1097/00008506-200610000-00030.
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  - Takata, K., F. W. Lombard, H. Sheng, D. Laskowitz, C. O. Borel, and D. S. Warner. “A rat model of cerebral vasospasm resulting in chronic motor and neurocognitive deficits following experimental sah.” Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006). https://doi.org/10.1097/00008506-200610000-00059.
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  - Wang, Haichen, Junling Gao, Timothy F. Lassiter, David L. McDonagh, Huaxin Sheng, David S. Warner, John R. Lynch, and Daniel T. Laskowitz. “Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage..” Neurocrit Care 5, no. 1 (2006): 71–78. https://doi.org/10.1385/NCC:5:1:71.
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  - Yokoo, Noriko, Huaxin Sheng, Javier Mixco, H Mayumi Homi, Robert D. Pearlstein, and David S. Warner. “Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine..” Anesth Analg 99, no. 3 (September 2004): 896–903. https://doi.org/10.1213/01.ANE.0000132973.32387.8B.
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  - Sheng, Huaxin, Ivan Spasojevic, David S. Warner, and Ines Batinic-Haberle. “Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy..” Neurosci Lett 366, no. 2 (August 12, 2004): 220–25. https://doi.org/10.1016/j.neulet.2004.05.050.
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  - Warner, David S., Huaxin Sheng, and Ines Batinić-Haberle. “Oxidants, antioxidants and the ischemic brain..” J Exp Biol 207, no. Pt 18 (August 2004): 3221–31. https://doi.org/10.1242/jeb.01022.
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  - Elsersy, Hazem, Huaxin Sheng, John R. Lynch, Maria Moldovan, Robert D. Pearlstein, and David S. Warner. “Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat..” Anesthesiology 100, no. 5 (May 2004): 1160–66. https://doi.org/10.1097/00000542-200405000-00018.
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  - Sheng, Huaxin, Haichen Wang, Hercilia M. Homi, Ivan Spasojevic, Ines Batinic-Haberle, Robert D. Pearlstein, and David S. Warner. “A no-laminectomy spinal cord compression injury model in mice..” J Neurotrauma 21, no. 5 (May 2004): 595–603. https://doi.org/10.1089/089771504774129928.
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  - Homi, H Mayumi, Javier M. Mixco, Huaxin Sheng, Hilary P. Grocott, Robert D. Pearlstein, and David S. Warner. “Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice..” Anesthesiology 99, no. 5 (November 2003): 1145–51. https://doi.org/10.1097/00000542-200311000-00022.
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  - Borel, Cecil O., Andy McKee, Augusto Parra, Michael M. Haglund, Amy Solan, Vikas Prabhakar, Huaxin Sheng, David S. Warner, and Laura Niklason. “Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage..” Stroke 34, no. 2 (February 2003): 427–33.
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  - Ross, Aron D., Huaxin Sheng, David S. Warner, Claude A. Piantadosi, Ines Batinic-Haberle, Brian J. Day, and James D. Crapo. “Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity..” Free Radic Biol Med 33, no. 12 (December 15, 2002): 1657–69.
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  - McGirt, Matthew J., John R. Lynch, Augusto Parra, Huaxin Sheng, Robert D. Pearlstein, Daniel T. Laskowitz, Dale A. Pelligrino, and David S. Warner. “Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage..” Stroke 33, no. 12 (December 2002): 2950–56.
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  - Sheng, Huaxin, Ines Batinc-Haberle, and David S. Warner. “Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury..” Drug News Perspect 15, no. 10 (December 2002): 654–65.
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  - Bowler, Russell P., Huaxin Sheng, Jan J. Enghild, Robert D. Pearlstein, David S. Warner, and James D. Crapo. “A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke..” Free Radic Biol Med 33, no. 8 (October 15, 2002): 1141–52.
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  - Sheng, Huaxin, Jan J. Enghild, Russell Bowler, Manisha Patel, Ines Batinić-Haberle, Carla L. Calvi, Brian J. Day, Robert D. Pearlstein, James D. Crapo, and David S. Warner. “Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia..” Free Radic Biol Med 33, no. 7 (October 1, 2002): 947–61.
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  - McGirt, Matthew J., Augusto Parra, Huaxin Sheng, Yoshinori Higuchi, Tim D. Oury, Daniel T. Laskowitz, Robert D. Pearlstein, and David S. Warner. “Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase..” Stroke 33, no. 9 (September 2002): 2317–23.
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  - McGirt, M. J., J. R. Lynch, H. X. Sheng, R. Pearlstein, D. T. Laskowitz, D. A. Pelligrino, and D. S. Warner. “Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates cerebral vasospasm after subarachnoid hemorrhage in the mouse via augmentation of endothelial nitric oxide synthase.” Neurosurgery 51, no. 2 (August 1, 2002): 580–580.
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  - Parra, Augusto, Matthew J. McGirt, Huaxin Sheng, Daniel T. Laskowitz, Robert D. Pearlstein, and David S. Warner. “Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis..” Neurol Res 24, no. 5 (July 2002): 510–16. https://doi.org/10.1179/016164102101200276.
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  - Wainwright, M. S., H. Sheng, Y. Sato, G. Burkhard Mackensen, R. P. Steffen, R. D. Pearlstein, and D. S. Warner. “Pharmacological correction of hypothermic P50 shift does not alter outcome from focal cerebral ischemia in rats.” American Journal of Physiology Heart and Circulatory Physiology 282, no. 5 51-5 (June 29, 2002).
  - Wainwright, Mark S., Huaxin Sheng, Yukie Sato, G Burkhard Mackensen, Robert P. Steffen, Robert D. Pearlstein, and David S. Warner. “Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats..” Am J Physiol Heart Circ Physiol 282, no. 5 (May 2002): H1863–70. https://doi.org/10.1152/ajpheart.00863.2001.
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  - Lynch, J. R., M. J. McGirt, D. A. Pelligrino, D. T. Laskowitz, H. X. Sheng, and D. S. Warner. “Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage in mice.” Neurology 58, no. 7 (April 9, 2002): A367–A367.
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  - Leinenweber, S. B., H. X. Sheng, J. Lynch, I. Batinic-Haberle, D. Laskowitz, and D. S. Warner. “Effects of a metalloporphyrin catalytic antioxidant in a murine model of closed head injury.” Pediatric Research 51, no. 4 (April 1, 2002): 48A-48A.
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  - Batinic-Haberle, I., I. Spasojevic, H. X. Sheng, D. S. Warner, and I. Fridovich. “Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/traumatic injuries of central nervous system..” Free Radical Biology and Medicine 33 (January 1, 2002): S236–37.
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  - Batinic-Haberle, I., I. Spasojevic, H. X. Sheng, D. S. Warner, and I. Fridovich. “Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/raumatic injuries of central nervous system..” Free Radical Biology and Medicine 33 (January 1, 2002): S125–26.
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  - McGirt, M. J., A. Parra, H. X. Sheng, D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Attenuation of cerebral vasospasm following subarachnoid hemorrhage in mice over-expressing extracellular superoxide dismutase.” Stroke 33, no. 1 (January 1, 2002): 380–380.
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  - Warner, D. S., H. X. Sheng, R. D. Pearlstein, C. Calvi, and J. D. Crapo. “AEOL 10150, a metalloporphyrin catalytic antioxidant, reduces injury from focal ischemia in the rat and mouse.” Free Radical Biology and Medicine 33 (January 1, 2002): S126–27.
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  - McDaniel, B., H. Sheng, D. S. Warner, L. W. Hedlund, and H. Benveniste. “Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study..” Neuroimage 14, no. 6 (December 2001): 1244–55. https://doi.org/10.1006/nimg.2001.0934.
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  - Mackensen, G. B., M. Patel, H. Sheng, C. L. Calvi, I. Batinic-Haberle, B. J. Day, L. P. Liang, et al. “Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant..” J Neurosci 21, no. 13 (July 1, 2001): 4582–92.
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  - Pineda, J. A., M. Aono, H. Sheng, J. Lynch, J. C. Wellons, D. T. Laskowitz, R. D. Pearlstein, R. Bowler, J. Crapo, and D. S. Warner. “Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse..” J Neurotrauma 18, no. 6 (June 2001): 625–34. https://doi.org/10.1089/089771501750291864.
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  - Enghild, J. J., H. Christiansen, H. Sheng, R. Bowler, I. B. Thorgersen, J. Crapo, D. Warner, and P. Hojrup. “Changes in protein expression after a superoxide dismutase mimetic in stroke..” Free Radical Biology and Medicine 31 (January 1, 2001): S132–S132.
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  - Parra, A., M. J. McGirt, H. X. Sheng, R. D. Pearlstein, D. T. Laskowitz, and D. S. Warner. “Effects of extracellular superoxide dismutase on arterial vascular structural changes after acute subarachnoid hemorrhage in the mouse.” Stroke 32, no. 1 (January 1, 2001): 359–359.
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  - Ross, A. D., D. S. Warner, H. X. Sheng, C. A. Piantadosi, B. J. Day, and J. D. Crapo. “Species-specific hemodynamic effects of metalloporphyrin SOD mimetics.” Free Radical Biology and Medicine 31 (January 1, 2001): S96–S96.
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  - Warner, D. S., H. X. Sheng, R. Bowler, J. Enghild, M. Patel, and J. D. Crapo. “Effects of metalloporphyrin catalytic antioxidants on rodent focal ischemic brain damage.” Free Radical Biology and Medicine 31 (January 1, 2001): S134–S134.
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  - Mackensen, G. B., B. Nellgârd, M. Kudo, H. Sheng, R. D. Pearlstein, and D. S. Warner. “Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats..” Anesthesiology 93, no. 4 (October 2000): 1102–6. https://doi.org/10.1097/00000542-200010000-00035.
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  - Wellons, John C., Huaxin Sheng, Jose Pineda, Gary W. Massey, Robert D. Pearlstein, David S. Warner, and Daniel T. Laskowitz. “813 Intracerebral Infusion of Human Recombinant Apolipoprotein E3 Reduces Global Ischemic Brain Injury in Apolipoprotein E Deficient Mice..” Neurosurgery 47, no. 2 (August 1, 2000). https://doi.org/10.1097/00006123-200008000-00161.
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  - Wellons, John C., Huaxin Sheng, Jose Pineda, Gary W. Massey, Robert D. Pearlstein, David S. Warner, and Daniel T. Laskowitz. “813 Intracerebral Infusion of Human Recombinant Apolipoprotein E3 Reduces Global Ischemic Brain Injury in Apolipoprotein E Deficient Mice..” Neurosurgery 47, no. 2 (August 1, 2000). https://doi.org/10.1097/0006123-200008000-00161.
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  - Wellons, J. C., H. Sheng, D. T. Laskowitz, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia..” Brain Res 868, no. 1 (June 16, 2000): 14–21. https://doi.org/10.1016/s0006-8993(00)02216-2.
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  - Sheng, H., M. Kudo, G. B. Mackensen, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia..” Exp Neurol 163, no. 2 (June 2000): 392–98. https://doi.org/10.1006/exnr.2000.7363.
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  - Sheng, H., T. C. Brady, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse..” Neurosci Lett 267, no. 1 (May 21, 1999): 13–16. https://doi.org/10.1016/s0304-3940(99)00316-x.
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  - Sarraf-Yazdi, S., H. Sheng, H. P. Grocott, R. D. Bart, R. D. Pearlstein, R. P. Steffen, and D. S. Warner. “Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat..” Brain Res 826, no. 2 (May 1, 1999): 172–80. https://doi.org/10.1016/s0006-8993(99)01233-0.
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  - Sheng, H., D. T. Laskowitz, G. B. Mackensen, M. Kudo, R. D. Pearlstein, and D. S. Warner. “Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse..” Stroke 30, no. 5 (May 1999): 1118–24.
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  - Sheng, H., D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Characterization of a recovery global cerebral ischemia model in the mouse..” J Neurosci Methods 88, no. 1 (April 1, 1999): 103–9.
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  - Grocott, H. P., H. Sheng, Y. Miura, S. Sarraf-Yazdi, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “The effects of aprotinin on outcome from cerebral ischemia in the rat..” Anesth Analg 88, no. 1 (January 1999): 1–7. https://doi.org/10.1097/00000539-199901000-00001.
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  - Sarraf-Yazdi, S., H. Sheng, A. D. Brinkhous, R. D. Pearlstein, and D. S. Warner. “Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat..” J Neurosurg Anesthesiol 11, no. 1 (January 1999): 31–36.
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  - Sheng, H., R. D. Bart, T. D. Oury, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia..” Neuroscience 88, no. 1 (January 1999): 185–91.
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  - Bart, R., H. Sheng, T. Oury, J. Crapo, R. Pearlstein, and D. Warner. “Modulation of cerebral blood flow is not the mechanism of neuroprotection in transgenic mice over expressing human extracellular superoxide dismutase (EC-SOD).” Critical Care Medicine 26, no. 1 SUPPL. (December 1, 1998).
  - Sarraf-Yazdi, S., H. Sheng, H. P. Grocott, R. D. Pearlstein, R. P. Steffen, and D. S. Warner. “Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine (MK-801) on infarct size following focal cerebral ischemia in conscious rats.” Anesthesiology 89, no. 3A (September 1, 1998): U747–U747.
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  - Bart, R. D., H. Sheng, D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia..” Neuroreport 9, no. 11 (August 3, 1998): 2615–20.
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  - Grocott, H. P., R. D. Bart, H. Sheng, Y. Miura, R. Steffen, R. D. Pearlstein, and D. S. Warner. “Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat..” Stroke 29, no. 8 (August 1998): 1650–55.
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  - Sarraf-Yazdi, S., H. Sheng, Y. Miura, C. McFarlane, F. Dexter, R. Pearlstein, and D. S. Warner. “Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat..” Anesth Analg 87, no. 1 (July 1998): 72–78. https://doi.org/10.1097/00000539-199807000-00016.
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  - Sheng, H., D. T. Laskowitz, E. Bennett, D. E. Schmechel, R. D. Bart, A. M. Saunders, R. D. Pearlstein, A. D. Roses, and D. S. Warner. “Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice..” J Cereb Blood Flow Metab 18, no. 4 (April 1998): 361–66. https://doi.org/10.1097/00004647-199804000-00003.
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  - Pittman, J. E., H. Sheng, R. Pearlstein, A. Brinkhous, F. Dexter, and D. S. Warner. “Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat..” Anesthesiology 87, no. 5 (November 1997): 1139–44.
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  - Grocott, H. P., N. A. Bart, Y. Muira, H. Sheng, N. A. Pearlstein, and D. S. Warner. “A680 NEUROPROTECTION FROM RSR 13 IN A RAT MODEL OF INCOMPLETE FOREBRAIN ISCHEMIA.” Anesthesiology 87, no. Supplement (September 1997): 680A-680A. https://doi.org/10.1097/00000542-199709001-00680.
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  - Laskowitz, D. T., H. Sheng, R. D. Bart, K. A. Joyner, A. D. Roses, and D. S. Warner. “Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia..” J Cereb Blood Flow Metab 17, no. 7 (July 1997): 753–58. https://doi.org/10.1097/00004647-199707000-00005.
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  - Gillespie, J. S., and H. Sheng. “The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915..” Br J Pharmacol 94, no. 4 (August 1988): 1189–97. https://doi.org/10.1111/j.1476-5381.1988.tb11638.x.
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- Conference Papers
  - Lei, Beilei, Haichen Wang, Seongtae Jeong, Justin T. Hsieh, Mohammed Majeed, Hana Dawson, Huaxin Sheng, David S. Warner, and Michael L. James. “Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage..” In Neuroendocrinology, 103:665–77, 2016. https://doi.org/10.1159/000442204.
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