Overview
We have successfully developed various rodent models of brain and spinal cord injuries in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma, subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia, and compression injury. We also established cardiac arrest and hemorrhagic shock models for studying multiple organ dysfunction. Our current studies focus on two projects. One is to examine the efficacy of catalytic antioxidants in treating cerebral ischemia, and the other is to investigate the effectiveness of post-conditioning on the outcome of subarachnoid hemorrhage-induced cognitive dysfunction.
We are a part of the NIH Stroke Preclinical Assessment Network (SPAN).
We are a part of the NIH Stroke Preclinical Assessment Network (SPAN).
Current Appointments & Affiliations
Professor in Anesthesiology
·
2025 - Present
Anesthesiology,
Clinical Science Departments
Recent Publications
Feasibility of a Multi-Laboratory Model of Middle Cerebral Artery Thromboembolic Stroke with Thrombolysis: TE-MCAo.
Journal Article Transl Stroke Res · January 30, 2026 UNLABELLED: No single animal stroke model satisfies all needs of translational stroke investigation. While the nylon filament model is widely accepted in preclinical translational stroke research, thromboembolic models have more physiological relevance. Th ... Full text Link to item CiteActivation of Intestinal Mast Cells Contributes to Gut Damage After Cardiac Arrest in Mice.
Journal Article Shock · January 1, 2026 Sudden cardiac arrest (CA) is associated with high mortality and morbidity rates, largely due to detrimental effects of global ischemia on every organ. Notably, clinical evidence indicates that gastrointestinal tract damage is frequently observed in succes ... Full text Link to item CiteThe Stroke Preclinical Assessment Network Multi-laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo.
Journal Article J Vis Exp · December 19, 2025 Current translational rodent stroke models induce middle cerebral artery occlusion (MCAo) using nylon filaments, injected emboli, intraluminal thrombin, or perivascular endothelin-1 to simulate human stroke. Among these methods, thromboemboli injection fol ... Full text Link to item CiteRecent Grants
Impact of Autonomic Dysfunction on Multi-Organ Dysfunction following Severe TBI: The AUTO-BOOST Study
ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2028Integrated Training in Anesthesiology Research
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2027Duke Testing Site for Stroke Preclinical Assessment Network
ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2026View All Grants
Education
Nantong Medical College (China) ·
1984
M.D.