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Neural Control of Inflammation: Implications for Perioperative and Critical Care.

Publication ,  Journal Article
Steinberg, BE; Sundman, E; Terrando, N; Eriksson, LI; Olofsson, PS
Published in: Anesthesiology
May 2016

Inflammation and immunity are regulated by neural reflexes. Recent basic science research has demonstrated that a neural reflex, termed the inflammatory reflex, modulates systemic and regional inflammation in a multiplicity of clinical conditions encountered in perioperative medicine and critical care. In this review, the authors describe the anatomic and physiologic basis of the inflammatory reflex and review the evidence implicating this pathway in the modulation of sepsis, ventilator-induced lung injury, postoperative cognitive dysfunction, myocardial ischemia-reperfusion injury, and traumatic hemorrhage. The authors conclude with a discussion of how these new insights might spawn novel therapeutic strategies for the treatment of inflammatory diseases in the context of perioperative and critical care medicine.

Duke Scholars

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Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

May 2016

Volume

124

Issue

5

Start / End Page

1174 / 1189

Location

United States

Related Subject Headings

  • Reflex
  • Perioperative Care
  • Nervous System
  • Inflammation
  • Humans
  • Critical Care
  • Animals
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Steinberg, B. E., Sundman, E., Terrando, N., Eriksson, L. I., & Olofsson, P. S. (2016). Neural Control of Inflammation: Implications for Perioperative and Critical Care. Anesthesiology, 124(5), 1174–1189. https://doi.org/10.1097/ALN.0000000000001083
Steinberg, Benjamin E., Eva Sundman, Niccolo Terrando, Lars I. Eriksson, and Peder S. Olofsson. “Neural Control of Inflammation: Implications for Perioperative and Critical Care.Anesthesiology 124, no. 5 (May 2016): 1174–89. https://doi.org/10.1097/ALN.0000000000001083.
Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS. Neural Control of Inflammation: Implications for Perioperative and Critical Care. Anesthesiology. 2016 May;124(5):1174–89.
Steinberg, Benjamin E., et al. “Neural Control of Inflammation: Implications for Perioperative and Critical Care.Anesthesiology, vol. 124, no. 5, May 2016, pp. 1174–89. Pubmed, doi:10.1097/ALN.0000000000001083.
Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS. Neural Control of Inflammation: Implications for Perioperative and Critical Care. Anesthesiology. 2016 May;124(5):1174–1189.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

May 2016

Volume

124

Issue

5

Start / End Page

1174 / 1189

Location

United States

Related Subject Headings

  • Reflex
  • Perioperative Care
  • Nervous System
  • Inflammation
  • Humans
  • Critical Care
  • Animals
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences