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Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.

Publication ,  Journal Article
Liu, J; Pang, Y; Bhattacharyya, J; Liu, W; Weitzhandler, I; Li, X; Chilkoti, A
Published in: Advanced healthcare materials
August 2016

Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one-step ring-opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self-assembles into well-defined nanoparticles with tunable size.

Duke Scholars

Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

August 2016

Volume

5

Issue

15

Start / End Page

1868 / 1873

Related Subject Headings

  • Prodrugs
  • Particle Size
  • Paclitaxel
  • Nanoparticles
  • Humans
  • Female
  • Drug Carriers
  • Cell Line, Tumor
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, J., Pang, Y., Bhattacharyya, J., Liu, W., Weitzhandler, I., Li, X., & Chilkoti, A. (2016). Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug. Advanced Healthcare Materials, 5(15), 1868–1873. https://doi.org/10.1002/adhm.201600230
Liu, Jinyao, Yan Pang, Jayanta Bhattacharyya, Wenge Liu, Isaac Weitzhandler, Xinghai Li, and Ashutosh Chilkoti. “Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.Advanced Healthcare Materials 5, no. 15 (August 2016): 1868–73. https://doi.org/10.1002/adhm.201600230.
Liu J, Pang Y, Bhattacharyya J, Liu W, Weitzhandler I, Li X, et al. Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug. Advanced healthcare materials. 2016 Aug;5(15):1868–73.
Liu, Jinyao, et al. “Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.Advanced Healthcare Materials, vol. 5, no. 15, Aug. 2016, pp. 1868–73. Epmc, doi:10.1002/adhm.201600230.
Liu J, Pang Y, Bhattacharyya J, Liu W, Weitzhandler I, Li X, Chilkoti A. Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug. Advanced healthcare materials. 2016 Aug;5(15):1868–1873.
Journal cover image

Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

August 2016

Volume

5

Issue

15

Start / End Page

1868 / 1873

Related Subject Headings

  • Prodrugs
  • Particle Size
  • Paclitaxel
  • Nanoparticles
  • Humans
  • Female
  • Drug Carriers
  • Cell Line, Tumor
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology