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Therapeutic Efficacy of Antiglioma Mesenchymal Extracellular Matrix 131I-Radiolabeled Murine Monoclonal Antibody in a Human Glioma Xenograft Model

Publication ,  Journal Article
Lee, YS; Bullard, DE; Zalutsky, MR; Coleman, RE; Wikstrand, CJ; Friedman, HS; Colapinto, EV; Bigner, D
Published in: Cancer Research
January 1, 1988

The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6 an IgG2b immunoglobulin, which defines an epitope of the 000 μC i (P = 0.01). The percentage of anhnals with tumor regression progressively increased with increasing doses of isotope. For radiolabeled 45.6, there were 0 of 10 re seen underestimated the dose observed in a directly measured therapeutic trial by 35-52%. In this xenograft model, a radiolabeled antiglioma Mab against the extracelluhir matrix protein temiscin demonstrated therapeutic efficacy. The promising results obtained in this animal model suggest a potential value for this form of therapy against human malignant gliomas. © 1988, American Association for Cancer Research. All rights reserved.

Duke Scholars

Published In

Cancer Research

EISSN

1538-7445

ISSN

0008-5472

Publication Date

January 1, 1988

Volume

48

Issue

3

Start / End Page

584 / 588

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

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Lee, Y. S., Bullard, D. E., Zalutsky, M. R., Coleman, R. E., Wikstrand, C. J., Friedman, H. S., … Bigner, D. (1988). Therapeutic Efficacy of Antiglioma Mesenchymal Extracellular Matrix 131I-Radiolabeled Murine Monoclonal Antibody in a Human Glioma Xenograft Model. Cancer Research, 48(3), 584–588.
Lee, Y. S., D. E. Bullard, M. R. Zalutsky, R. E. Coleman, C. J. Wikstrand, H. S. Friedman, E. V. Colapinto, and D. Bigner. “Therapeutic Efficacy of Antiglioma Mesenchymal Extracellular Matrix 131I-Radiolabeled Murine Monoclonal Antibody in a Human Glioma Xenograft Model.” Cancer Research 48, no. 3 (January 1, 1988): 584–88.
Lee YS, Bullard DE, Zalutsky MR, Coleman RE, Wikstrand CJ, Friedman HS, et al. Therapeutic Efficacy of Antiglioma Mesenchymal Extracellular Matrix 131I-Radiolabeled Murine Monoclonal Antibody in a Human Glioma Xenograft Model. Cancer Research. 1988 Jan 1;48(3):584–8.
Lee YS, Bullard DE, Zalutsky MR, Coleman RE, Wikstrand CJ, Friedman HS, Colapinto EV, Bigner D. Therapeutic Efficacy of Antiglioma Mesenchymal Extracellular Matrix 131I-Radiolabeled Murine Monoclonal Antibody in a Human Glioma Xenograft Model. Cancer Research. 1988 Jan 1;48(3):584–588.

Published In

Cancer Research

EISSN

1538-7445

ISSN

0008-5472

Publication Date

January 1, 1988

Volume

48

Issue

3

Start / End Page

584 / 588

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis