development of reagents for protein and peptide radioiodination that decrease deiodination in vivo by up to 100-fold, b) demonstration that At-211 labeled monoclonal antibodies are effective in the treatment of a rat model of neoplastic meningitis, c) synthesis of a thymidine analogue labeled with At-211 and the demonstration that this molecule is taken up in cellular DNA with highly cytotoxicity even at levels of only one atom bound per cell and d) development of
radiohalobenzylguanidines which are specifically cytotoxic for human neuroblastoma cells.
Current Appointments & Affiliations
Jonathan Spicehandler, M.D. Distinguished Professor of Neuro Oncology, in the School of Medicine · 2008 - Present Radiology, Clinical Science Departments
Education, Training & Certifications
Washington University in St. Louis · 1974 Ph.D.
Washington University in St. Louis · 1972 M.A.