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DNA Repair Inhibitors: Potential Targets and Partners for Targeted Radionuclide Therapy.

Publication ,  Journal Article
Obata, H; Ogawa, M; Zalutsky, MR
Published in: Pharmaceutics
July 11, 2023

The present review aims to explore the potential targets/partners for future targeted radionuclide therapy (TRT) strategies, wherein cancer cells often are not killed effectively, despite receiving a high average tumor radiation dose. Here, we shall discuss the key factors in the cancer genome, especially those related to DNA damage response/repair and maintenance systems for escaping cell death in cancer cells. To overcome the current limitations of TRT effectiveness due to radiation/drug-tolerant cells and tumor heterogeneity, and to make TRT more effective, we propose that a promising strategy would be to target the DNA maintenance factors that are crucial for cancer survival. Considering their cancer-specific DNA damage response/repair ability and dysregulated transcription/epigenetic system, key factors such as PARP, ATM/ATR, amplified/overexpressed transcription factors, and DNA methyltransferases have the potential to be molecular targets for Auger electron therapy; moreover, their inhibition by non-radioactive molecules could be a partnering component for enhancing the therapeutic response of TRT.

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Published In

Pharmaceutics

DOI

ISSN

1999-4923

Publication Date

July 11, 2023

Volume

15

Issue

7

Location

Switzerland

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Obata, H., Ogawa, M., & Zalutsky, M. R. (2023). DNA Repair Inhibitors: Potential Targets and Partners for Targeted Radionuclide Therapy. Pharmaceutics, 15(7). https://doi.org/10.3390/pharmaceutics15071926
Obata, Honoka, Mikako Ogawa, and Michael R. Zalutsky. “DNA Repair Inhibitors: Potential Targets and Partners for Targeted Radionuclide Therapy.Pharmaceutics 15, no. 7 (July 11, 2023). https://doi.org/10.3390/pharmaceutics15071926.
Obata H, Ogawa M, Zalutsky MR. DNA Repair Inhibitors: Potential Targets and Partners for Targeted Radionuclide Therapy. Pharmaceutics. 2023 Jul 11;15(7).
Obata, Honoka, et al. “DNA Repair Inhibitors: Potential Targets and Partners for Targeted Radionuclide Therapy.Pharmaceutics, vol. 15, no. 7, July 2023. Pubmed, doi:10.3390/pharmaceutics15071926.
Obata H, Ogawa M, Zalutsky MR. DNA Repair Inhibitors: Potential Targets and Partners for Targeted Radionuclide Therapy. Pharmaceutics. 2023 Jul 11;15(7).

Published In

Pharmaceutics

DOI

ISSN

1999-4923

Publication Date

July 11, 2023

Volume

15

Issue

7

Location

Switzerland

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences