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Comparison of electric field strength and spatial distribution of electroconvulsive therapy and magnetic seizure therapy in a realistic human head model.

Publication ,  Journal Article
Lee, WH; Lisanby, SH; Laine, AF; Peterchev, AV
Published in: Eur Psychiatry
August 2016

BACKGROUND: This study examines the strength and spatial distribution of the electric field induced in the brain by electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). METHODS: The electric field induced by standard (bilateral, right unilateral, and bifrontal) and experimental (focal electrically administered seizure therapy and frontomedial) ECT electrode configurations as well as a circular MST coil configuration was simulated in an anatomically realistic finite element model of the human head. Maps of the electric field strength relative to an estimated neural activation threshold were used to evaluate the stimulation strength and focality in specific brain regions of interest for these ECT and MST paradigms and various stimulus current amplitudes. RESULTS: The standard ECT configurations and current amplitude of 800-900mA produced the strongest overall stimulation with median of 1.8-2.9 times neural activation threshold and more than 94% of the brain volume stimulated at suprathreshold level. All standard ECT electrode placements exposed the hippocampi to suprathreshold electric field, although there were differences across modalities with bilateral and right unilateral producing respectively the strongest and weakest hippocampal stimulation. MST stimulation is up to 9 times weaker compared to conventional ECT, resulting in direct activation of only 21% of the brain. Reducing the stimulus current amplitude can make ECT as focal as MST. CONCLUSIONS: The relative differences in electric field strength may be a contributing factor for the cognitive sparing observed with right unilateral compared to bilateral ECT, and MST compared to right unilateral ECT. These simulations could help understand the mechanisms of seizure therapies and develop interventions with superior risk/benefit ratio.

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Published In

Eur Psychiatry

DOI

EISSN

1778-3585

Publication Date

August 2016

Volume

36

Start / End Page

55 / 64

Location

England

Related Subject Headings

  • Seizures
  • Psychiatry
  • Models, Anatomic
  • Male
  • Humans
  • Hippocampus
  • Head
  • Electrodes
  • Electroconvulsive Therapy
  • Electric Stimulation
 

Citation

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Lee, W. H., Lisanby, S. H., Laine, A. F., & Peterchev, A. V. (2016). Comparison of electric field strength and spatial distribution of electroconvulsive therapy and magnetic seizure therapy in a realistic human head model. Eur Psychiatry, 36, 55–64. https://doi.org/10.1016/j.eurpsy.2016.03.003
Lee, W. H., S. H. Lisanby, A. F. Laine, and A. V. Peterchev. “Comparison of electric field strength and spatial distribution of electroconvulsive therapy and magnetic seizure therapy in a realistic human head model.Eur Psychiatry 36 (August 2016): 55–64. https://doi.org/10.1016/j.eurpsy.2016.03.003.
Lee, W. H., et al. “Comparison of electric field strength and spatial distribution of electroconvulsive therapy and magnetic seizure therapy in a realistic human head model.Eur Psychiatry, vol. 36, Aug. 2016, pp. 55–64. Pubmed, doi:10.1016/j.eurpsy.2016.03.003.
Journal cover image

Published In

Eur Psychiatry

DOI

EISSN

1778-3585

Publication Date

August 2016

Volume

36

Start / End Page

55 / 64

Location

England

Related Subject Headings

  • Seizures
  • Psychiatry
  • Models, Anatomic
  • Male
  • Humans
  • Hippocampus
  • Head
  • Electrodes
  • Electroconvulsive Therapy
  • Electric Stimulation