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Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders.

Publication ,  Journal Article
Harmon, JB; Sanders, AE; Wilder, RS; Essick, GK; Slade, GD; Hartung, JE; Nackley, AG
Published in: J Oral Facial Pain Headache
2016

AIMS: To investigate the relationship between omentin-1 levels and painful temporomandibular disorders (TMD). METHODS: In a case-control design, chronic painful TMD cases (n = 90) and TMD-free controls (n = 54) were selected from participants in the multisite OPPERA study (Orofacial Pain: Prospective Evaluation and Risk Assessment). Painful TMD case status was determined by examination using established Research Diagnostic Criteria for TMD (RDC/TMD). Levels of omentin-1 in stored blood plasma samples were measured by using an enzyme linked immunosorbent assay. Binary logistic regression was used to calculate the odds ratios (ORs) and 95% confidence limits (CLs) for the association between omentin-1 and painful TMD. Models were adjusted for study site, age, sex, and body mass index. RESULTS: The unadjusted association between omentin-1 and chronic painful TMD was statistically nonsignificant (P = .072). Following adjustment for covariates, odds of TMD pain decreased 36% per standard deviation increase in circulating omentin-1 (adjusted OR = 0.64; 95% CL: 0.43, 0.96; P = .031). CONCLUSION: Circulating levels of omentin-1 were significantly lower in painful TMD cases than controls, suggesting that TMD pain is mediated by inflammatory pathways.

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Published In

J Oral Facial Pain Headache

DOI

ISSN

2333-0384

Publication Date

2016

Volume

30

Issue

3

Start / End Page

203 / 209

Location

United States

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Sex Factors
  • Pain Measurement
  • Male
  • Lectins
  • Humans
  • Headache
  • GPI-Linked Proteins
  • Female
 

Citation

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Harmon, J. B., Sanders, A. E., Wilder, R. S., Essick, G. K., Slade, G. D., Hartung, J. E., & Nackley, A. G. (2016). Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders. J Oral Facial Pain Headache, 30(3), 203–209. https://doi.org/10.11607/ofph.1608
Harmon, Jennifer B., Anne E. Sanders, Rebecca S. Wilder, Greg K. Essick, Gary D. Slade, Jane E. Hartung, and Andrea G. Nackley. “Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders.J Oral Facial Pain Headache 30, no. 3 (2016): 203–9. https://doi.org/10.11607/ofph.1608.
Harmon JB, Sanders AE, Wilder RS, Essick GK, Slade GD, Hartung JE, et al. Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders. J Oral Facial Pain Headache. 2016;30(3):203–9.
Harmon, Jennifer B., et al. “Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders.J Oral Facial Pain Headache, vol. 30, no. 3, 2016, pp. 203–09. Pubmed, doi:10.11607/ofph.1608.
Harmon JB, Sanders AE, Wilder RS, Essick GK, Slade GD, Hartung JE, Nackley AG. Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders. J Oral Facial Pain Headache. 2016;30(3):203–209.

Published In

J Oral Facial Pain Headache

DOI

ISSN

2333-0384

Publication Date

2016

Volume

30

Issue

3

Start / End Page

203 / 209

Location

United States

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Sex Factors
  • Pain Measurement
  • Male
  • Lectins
  • Humans
  • Headache
  • GPI-Linked Proteins
  • Female