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Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy.

Publication ,  Journal Article
Zhang, YS; Cai, X; Yao, J; Xing, W; Wang, LV; Xia, Y
Published in: Angewandte Chemie (International ed. in English)
January 2014

Degradation is among the most important properties of biomaterial scaffolds, which are indispensable for regenerative medicine. The currently used method relies on the measurement of mass loss across different samples and cannot track the degradation of an individual scaffold in situ. Here we report, for the first time, the use of multiscale photoacoustic microscopy to non-invasively monitor the degradation of an individual scaffold. We could observe alterations to the morphology and structure of a scaffold at high spatial resolution and deep penetration, and more significantly, quantify the degradation of an individual scaffold as a function of time, both in vitro and in vivo. In addition, the remodeling of vasculature inside a scaffold can be visualized simultaneously using a dual-wavelength scanning mode in a label-free manner. This optoacoustic method can be used to monitor the degradation of individual scaffolds, offering a new approach to non-invasively analyze and quantify biomaterial-tissue interactions in conjunction with the assessment of in vivo vascular parameters.

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Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

January 2014

Volume

53

Issue

1

Start / End Page

184 / 188

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Photoacoustic Techniques
  • Organic Chemistry
  • Microscopy
  • Humans
  • Biocompatible Materials
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

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MLA
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Zhang, Y. S., Cai, X., Yao, J., Xing, W., Wang, L. V., & Xia, Y. (2014). Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy. Angewandte Chemie (International Ed. in English), 53(1), 184–188. https://doi.org/10.1002/anie.201306282
Zhang, Yu Shrike, Xin Cai, Junjie Yao, Wenxin Xing, Lihong V. Wang, and Younan Xia. “Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy.Angewandte Chemie (International Ed. in English) 53, no. 1 (January 2014): 184–88. https://doi.org/10.1002/anie.201306282.
Zhang YS, Cai X, Yao J, Xing W, Wang LV, Xia Y. Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy. Angewandte Chemie (International ed in English). 2014 Jan;53(1):184–8.
Zhang, Yu Shrike, et al. “Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy.Angewandte Chemie (International Ed. in English), vol. 53, no. 1, Jan. 2014, pp. 184–88. Epmc, doi:10.1002/anie.201306282.
Zhang YS, Cai X, Yao J, Xing W, Wang LV, Xia Y. Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy. Angewandte Chemie (International ed in English). 2014 Jan;53(1):184–188.
Journal cover image

Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

January 2014

Volume

53

Issue

1

Start / End Page

184 / 188

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Photoacoustic Techniques
  • Organic Chemistry
  • Microscopy
  • Humans
  • Biocompatible Materials
  • 34 Chemical sciences
  • 03 Chemical Sciences